Mammalian target of rapamycin (mTOR) as a potential therapeutic target in various diseases

Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase that belongs to Phosphatidylinositol-3-kinase related kinase superfamily. The signaling pathways of mTOR are integrated through the protein complexes of mTORC1 and mTORC2. mTORC1 controls protein synthesis, cell growth, prolif...

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Published in:Inflammopharmacology Vol. 25; no. 3; pp. 293 - 312
Main Authors: Kaur, Avileen, Sharma, Saurabh
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 01.06.2017
Subjects:
Allergology
Animals
Biomedical and Life Sciences
Biomedicine
Cell Proliferation - physiology
Dermatology
Gastroenterology
Humans
Immunology
Pharmacology/Toxicology
Review
Rheumatology
Signal Transduction - physiology
TOR Serine-Threonine Kinases - metabolism
Mammalian target of rapamycin (mTOR)
Cell growth
Proliferation
Phosphatidylinositol-3-kinase (PI3K)
Autophagy
ISSN:0925-4692, 1568-5608, 1568-5608
Online Access:Get full text
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Summary:Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase that belongs to Phosphatidylinositol-3-kinase related kinase superfamily. The signaling pathways of mTOR are integrated through the protein complexes of mTORC1 and mTORC2. mTORC1 controls protein synthesis, cell growth, proliferation, autophagy, cell metabolism, and stress responses, whereas mTORC2 seems to regulate cell survival and polarity. Dysregulation of the mTOR pathway has been implicated in the pathophysiology of a number of disease conditions, including cancer, cardiovascular, neurodegenerative, and various renal diseases. The hyperactivation of the mTOR pathway leads to increase in cell growth and proliferation and also has been documented to stimulate tumor growth. Therefore, investigation of the involvement of mTOR and its downstream pathways in various diseases intensively preoccupied scientific community. The present review is focussed on recent advances in the understanding of the mTOR signaling pathway and its role in health and various diseases.
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ISSN:0925-4692
1568-5608
1568-5608
DOI:10.1007/s10787-017-0336-1