The frequency and impact of ROS1 rearrangement on clinical outcomes in never smokers with lung adenocarcinoma

To determine the frequency and predictive impact of ROS1 rearrangements on treatment outcomes in never-smoking patients with lung adenocarcinoma. We concurrently analyzed ROS1 and ALK rearrangements and mutations in the epidermal growth factor receptor (EGFR), and KRAS in 208 never smokers with lung...

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Vydáno v:	Annals of oncology Ročník 24; číslo 9; s. 2364
Hlavní autoři:	Kim, H R, Lim, S M, Kim, H J, Hwang, S K, Park, J K, Shin, E, Bae, M K, Ou, S-H I, Wang, J, Jewell, S S, Kang, D R, Soo, R A, Haack, H, Kim, J H, Shim, H S, Cho, B C
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 01.09.2013
Témata:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma of Lung Adult Aged Anaplastic Lymphoma Kinase Antigens, Differentiation, B-Lymphocyte - genetics Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Cell Line, Tumor Cell Survival - drug effects Crizotinib Disease-Free Survival ErbB Receptors - genetics Female Gefitinib Gene Frequency - genetics Gene Rearrangement - genetics Glutamates - pharmacology Glutamates - therapeutic use Guanine - analogs & derivatives Guanine - pharmacology Guanine - therapeutic use Histocompatibility Antigens Class II - genetics Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Male Middle Aged Mutation - genetics Pemetrexed Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins p21(ras) Pyrazoles - pharmacology Pyridines - pharmacology Pyrimidines - pharmacology Quinazolines - pharmacology ras Proteins - genetics Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Smoking Treatment Outcome ROS1 outcome lung adenocarcinoma never smoker
ISSN:	1569-8041, 1569-8041
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