A Novel Recombinant Enterovirus Type EV-A89 with Low Epidemic Strength in Xinjiang, China

Enterovirus A89 (EV-A89) is a novel member of the EV-A species. To date, only one full-length genome sequence (the prototype strain) has been published. Here, we report the molecular identification and genomic characterization of a Chinese EV-A89 strain, KSYPH-TRMH22F/XJ/CHN/2011, isolated in 2011 f...

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Published in:Scientific reports Vol. 5; no. 1; p. 18558
Main Authors: Fan, Qin, Zhang, Yong, Hu, Lan, Sun, Qiang, Cui, Hui, Yan, Dongmei, Sikandaner, Huerxidan, Tang, Haishu, Wang, Dongyan, Zhu, Zhen, Zhu, Shuangli, Xu, Wenbo
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 21.12.2015
Nature Publishing Group
Subjects:
631/181/2480
631/326/596/2554
631/326/596/2563
Child, Preschool
China
Chromosome Mapping
Enterovirus - genetics
Enterovirus - isolation & purification
Enterovirus - pathogenicity
Enterovirus Infections - blood
Enterovirus Infections - genetics
Enterovirus Infections - pathology
Enterovirus Infections - virology
Epidemics
Genome, Viral
Humanities and Social Sciences
Humans
Infant
Infant, Newborn
multidisciplinary
Phylogeny
RNA, Viral - genetics
RNA, Viral - isolation & purification
Science
Sequence Analysis, RNA
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:Enterovirus A89 (EV-A89) is a novel member of the EV-A species. To date, only one full-length genome sequence (the prototype strain) has been published. Here, we report the molecular identification and genomic characterization of a Chinese EV-A89 strain, KSYPH-TRMH22F/XJ/CHN/2011, isolated in 2011 from a contact of an acute flaccid paralysis (AFP) patient during AFP case surveillance in Xinjiang China. This was the first report of EV-A89 in China. The VP1 coding sequence of this strain demonstrated 93.2% nucleotide and 99.3% amino acid identity with the EV-A89 prototype strain. In the P2 and P3 regions, the Chinese EV-A89 strain demonstrated markedly higher identity than the prototype strains of EV-A76, EV-A90 and EV-A91, indicating that one or more recombination events between EV-A89 and these EV-A types might have occurred. Long-term evolution of these EV types originated from the same ancestor provides the spatial and temporal circumstances for recombination to occur. An antibody sero-prevalence survey against EV-A89 in two Xinjiang prefectures demonstrated low positive rates and low titres of EV-A89 neutralization antibody, suggesting limited range of transmission and exposure to the population. This study provides a solid foundation for further studies on the biological and pathogenic properties of EV-A89.
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ISSN:2045-2322
2045-2322
DOI:10.1038/srep18558