A comparison of silica and porous graphitic carbon as support materials for a chiral selector in HPLC

The tartaramide based chiral selector 2 was synthesized, coated onto porous graphitic carbon (PGC), and evaluated as a chiral stationary phase for HPLC. Its performance was compared to the silica based sorbent 1, containing the same chiral moiety. The retention and separation characteristics of the...

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Veröffentlicht in:Tetrahedron: asymmetry Jg. 13; H. 20; S. 2235 - 2240
Hauptverfasser: Oxelbark, Joakim, Claeson, Sofia
Format: Journal Article
Sprache:Englisch
Veröffentlicht: OXFORD Elsevier Ltd 18.10.2002
Elsevier
Schlagworte:
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Chemistry, Physical
Physical Sciences
Science & Technology
ENANTIOMERIC SEPARATION
SUPERCRITICAL-FLUID CHROMATOGRAPHY
DERIVATIVES
AMINO-ACIDS
STATIONARY PHASES
ISSN:0957-4166, 1362-511X, 1362-511X
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Zusammenfassung:The tartaramide based chiral selector 2 was synthesized, coated onto porous graphitic carbon (PGC), and evaluated as a chiral stationary phase for HPLC. Its performance was compared to the silica based sorbent 1, containing the same chiral moiety. The retention and separation characteristics of the two columns were found to be correlated, but separation factors and column efficiencies were constantly lower on the PGC column. Coating of PGC as a novel and simple means to evaluate chiral selectors was evaluated. Graphic
ISSN:0957-4166
1362-511X
1362-511X
DOI:10.1016/S0957-4166(02)00585-2