A comparison of silica and porous graphitic carbon as support materials for a chiral selector in HPLC

The tartaramide based chiral selector 2 was synthesized, coated onto porous graphitic carbon (PGC), and evaluated as a chiral stationary phase for HPLC. Its performance was compared to the silica based sorbent 1, containing the same chiral moiety. The retention and separation characteristics of the...

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Published in:Tetrahedron: asymmetry Vol. 13; no. 20; pp. 2235 - 2240
Main Authors: Oxelbark, Joakim, Claeson, Sofia
Format: Journal Article
Language:English
Published: OXFORD Elsevier Ltd 18.10.2002
Elsevier
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ISSN:0957-4166, 1362-511X, 1362-511X
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Abstract The tartaramide based chiral selector 2 was synthesized, coated onto porous graphitic carbon (PGC), and evaluated as a chiral stationary phase for HPLC. Its performance was compared to the silica based sorbent 1, containing the same chiral moiety. The retention and separation characteristics of the two columns were found to be correlated, but separation factors and column efficiencies were constantly lower on the PGC column. Coating of PGC as a novel and simple means to evaluate chiral selectors was evaluated. Graphic
AbstractList The tartaramide based chiral selector 2 was synthesized, coated onto porous graphitic carbon (PGC), and evaluated as a chiral stationary phase for HPLC. Its performance was compared to the silica based sorbent 1, containing the same chiral moiety. The retention and separation characteristics of the two columns were found to be correlated, but separation factors and column efficiencies were constantly lower on the PGC column. Coating of PGC as a novel and simple means to evaluate chiral selectors was evaluated. Graphic
The tartaramide based chiral selector 2 was synthesized, coated onto porous graphitic carbon (PGC), and evaluated as a chiral stationary phase for HPLC. Its performance was compared to the silica based sorbent 1 containing the same chiral moiety. The retention and separation characteristics of the two columns were found to be correlated, but separation factors and column efficiencies were constantly lower on the PGC column. Coating of PGC as a novel and simple means to evaluate chiral selectors was evaluated.
The tartaramide based chiral selector 2 was synthesized, coated onto porous graphitic carbon (PGC), and evaluated as a chiral stationary phase for HPLC. Its performance was compared to the silica based sorbent 1 containing the same chiral moiety. The retention and separation characteristics of the two columns were found to be correlated, but separation factors and column efficiencies were constantly lower on the PGC column. Coating of PGC as a novel and simple means to evaluate chiral selectors was evaluated. (C) 2002 Elsevier Science Ltd. All rights reserved.
ArticleNumber 0957
Author Claeson, Sofia
Oxelbark, Joakim
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Keywords ENANTIOMERIC SEPARATION
SUPERCRITICAL-FLUID CHROMATOGRAPHY
DERIVATIVES
AMINO-ACIDS
STATIONARY PHASES
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Snippet The tartaramide based chiral selector 2 was synthesized, coated onto porous graphitic carbon (PGC), and evaluated as a chiral stationary phase for HPLC. Its...
The tartaramide based chiral selector 2 was synthesized, coated onto porous graphitic carbon (PGC), and evaluated as a chiral stationary phase for HPLC. Its...
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SubjectTerms Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Chemistry, Physical
Physical Sciences
Science & Technology
Title A comparison of silica and porous graphitic carbon as support materials for a chiral selector in HPLC
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