Fasting or caloric restriction for Healthy Aging

Aging is associated with a host of biological changes that contribute to a progressive decline in cognitive and physical function, ultimately leading to a loss of independence, and increased risk of mortality. To date, prolonged caloric restriction (i.e., a reduction in caloric intake without malnut...

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Vydané v:	Experimental gerontology Ročník 48; číslo 10; s. 1003 - 1005
Hlavní autori:	Anton, Stephen, Leeuwenburgh, Christiaan
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Elsevier Inc 01.10.2013
Predmet:	Aging - physiology Caloric Restriction Fasting - physiology Humans Longevity - physiology
ISSN:	0531-5565, 1873-6815, 1873-6815
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Abstract	Aging is associated with a host of biological changes that contribute to a progressive decline in cognitive and physical function, ultimately leading to a loss of independence, and increased risk of mortality. To date, prolonged caloric restriction (i.e., a reduction in caloric intake without malnutrition) is the only non-genetic intervention that has consistently been found to extend both mean and maximal life span across a variety of species. Most individuals have difficulty sustaining prolonged caloric restriction, which has led to a search for alternative approaches that can produce similar to benefits as caloric restriction. A growing body of evidence indicates that fasting periods and intermittent fasting regimens in particular can trigger similar biological pathways as caloric restriction. For this reason, there is increasing scientific interest in further exploring the biological and metabolic effects of intermittent fasting periods, as well as whether long-term compliance may be improved by this type of dietary approach. This special will highlight the latest scientific findings related to the effects of both caloric restriction and intermittent fasting across various species including yeast, fruit flies, worms, rodents, primates, and humans. A specific emphasis is placed on translational research with findings from basic bench to bedside reviewed and practical clinical implications discussed.
AbstractList	Aging is associated with a host of biological changes that contribute to a progressive decline in cognitive and physical function, ultimately leading to a loss of independence, and increased risk of mortality. To date, prolonged caloric restriction (i.e., a reduction in caloric intake without malnutrition) is the only non-genetic intervention that has consistently been found to extend both mean and maximal life span across a variety of species. Most individuals have difficulty sustaining prolonged caloric restriction, which has led to a search for alternative approaches that can produce similar to benefits as caloric restriction. A growing body of evidence indicates that fasting periods and intermittent fasting regimens in particular can trigger similar biological pathways as caloric restriction. For this reason, there is increasing scientific interest in further exploring the biological and metabolic effects of intermittent fasting periods, as well as whether long-term compliance may be improved by this type of dietary approach. This special will highlight the latest scientific findings related to the effects of both caloric restriction and intermittent fasting across various species including yeast, fruit flies, worms, rodents, primates, and humans. A specific emphasis is placed on translational research with findings from basic bench to bedside reviewed and practical clinical implications discussed. Aging is associated with a host of biological changes that contribute to a progressive decline in cognitive and physical function, ultimately leading to a loss of independence, and increased risk of mortality. To date, prolonged caloric restriction (i.e., a reduction in caloric intake without malnutrition) is the only non-genetic intervention that has consistently been found to extend both mean and maximal life span across a variety of species. Most individuals have difficulty sustaining prolonged caloric restriction, which has led to a search for alternative approaches that can produce similar to benefits as caloric restriction. A growing body of evidence indicates that fasting periods and intermittent fasting regimens in particular can trigger similar biological pathways as caloric restriction. For this reason, there is increasing scientific interest in further exploring the biological and metabolic effects of intermittent fasting periods, as well as whether long-term compliance may be improved by this type of dietary approach. This special will highlight the latest scientific findings related to the effects of both caloric restriction and intermittent fasting across various species including yeast, fruit flies, worms, rodents, primates, and humans. A specific emphasis is placed on translational research with findings from basic bench to bedside reviewed and practical clinical implications discussed.Aging is associated with a host of biological changes that contribute to a progressive decline in cognitive and physical function, ultimately leading to a loss of independence, and increased risk of mortality. To date, prolonged caloric restriction (i.e., a reduction in caloric intake without malnutrition) is the only non-genetic intervention that has consistently been found to extend both mean and maximal life span across a variety of species. Most individuals have difficulty sustaining prolonged caloric restriction, which has led to a search for alternative approaches that can produce similar to benefits as caloric restriction. A growing body of evidence indicates that fasting periods and intermittent fasting regimens in particular can trigger similar biological pathways as caloric restriction. For this reason, there is increasing scientific interest in further exploring the biological and metabolic effects of intermittent fasting periods, as well as whether long-term compliance may be improved by this type of dietary approach. This special will highlight the latest scientific findings related to the effects of both caloric restriction and intermittent fasting across various species including yeast, fruit flies, worms, rodents, primates, and humans. A specific emphasis is placed on translational research with findings from basic bench to bedside reviewed and practical clinical implications discussed.
Author	Anton, Stephen Leeuwenburgh, Christiaan
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Cites_doi	10.1089/rej.2008.0712 10.1177/019262339602400618 10.1016/j.exger.2012.12.006 10.1093/ajcn/78.3.361 10.1001/jama.295.13.1539 10.1016/j.exger.2013.01.009 10.1152/ajpendo.00102.2007 10.1016/j.exger.2013.02.003 10.1016/j.exger.2012.12.005 10.1016/j.exger.2013.02.005 10.1016/j.exger.2013.03.004 10.1111/j.1474-9726.2009.00460.x 10.1093/eurheartj/ehi049 10.1016/j.exger.2013.02.016 10.1126/science.285.5432.1390 10.1016/j.exger.2013.03.010 10.1517/13543784.17.3.263 10.1016/j.exger.2013.02.021 10.1089/rej.2009.0892 10.1016/j.exger.2013.03.006 10.1093/gerona/glq168 10.1016/j.metabol.2008.02.016 10.1089/rej.2006.0535 10.1016/j.exger.2013.01.006 10.1016/j.exger.2013.04.002 10.1038/onc.2011.91 10.1016/j.yjmcc.2008.10.027 10.1096/fj.04-2870fje 10.1161/CIRCRESAHA.111.246108 10.1016/j.mad.2008.12.008 10.1097/gme.0b013e318250a287 10.1016/j.exger.2012.11.007 10.1016/j.exger.2013.02.018 10.1016/j.exger.2012.12.008 10.1093/jn/131.3.918S 10.1016/j.exger.2009.11.002 10.1038/oby.2007.148 10.1016/j.exger.2013.01.001 10.1126/science.1173635 10.2337/diabetes.54.1.1 10.2337/dc05-2565 10.1073/pnas.0308291101 10.1016/j.atherosclerosis.2008.05.036 10.1016/j.mad.2009.01.004 10.1073/pnas.081061898 10.1016/j.exger.2013.04.005 10.1093/jn/31.3.363 10.4061/2011/392510 10.1371/journal.pmed.0040076
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References	Devaraj, Wang-Polagruto, Polagruto, Keen, Jialal (bb0040) 2008; 57 Opalach, Rangaraju, Madorsky, Leeuwenburgh, Notterpek (bb0125) 2010; 13 Katare, Kakinuma, Arikawa, Yamasaki, Sato (bb0080) 2009; 46 Rochon, Bales, Ravussin, Redman, Holloszy, Racette, Roberts, Das, Romashkan, Galan, Hadley, Kraus (bb0140) 2011; 66 Avena, Murray, Gold (bb9035) 2013; 48 Kayo, Allison, Weindruch, Prolla (bb0085) 2001; 98 Mitchell, Robertson (bb9025) 2013; 48 Chung, Chung, Kim, Park, Choi, Kim, Lee, Yu (bb9020) 2013; 48 Barja, Sanchez-Roman (bb9015) 2013; 48 Lefevre, Redman, Heilbronn, Smith, Martin, Rood, Greenway, Williamson, Smith, Ravussin (bb0105) 2009; 203 Ceriello (bb0020) 2005; 26 Longo, Brandhorst, Wei, Hwang, Morgan (bb9075) 2013; 48 Arguin, Dionne, Senechal, Bouchard, Carpentier, Ardilouze, Tremblay, Leblanc, Brochu (bb0005) 2012; 19 Ja, Bruce, Hoxha, Carvalho, Yamada, Wang, Karayan, He, Brummel, Kapahi (bb9080) 2013; 48 Weindruch (bb0155) 1996; 24 Ceriello (bb0025) 2005; 54 Nelson, Liao, Johnson (bb9060) 2013; 48 Waters, Ward, Villareal (bb9030) 2013; 48 Hepple, Gouspillou (bb9040) 2013; 48 Aris, Alvers, Ferraiuolo, Fishwick, Hanvivatpong, Hu, Kirlew, Leonard, Losin, Marraffini, Seo, Swanberg, Westcott, Wood, Leeuwenburgh, Dunn (bb0175) 2013; 48 Han, Someya (bb9065) 2013; 48 Heilbronn, Ravussin (bb0065) 2003; 78 Weindruch, Kayo, Lee, Prolla (bb0160) 2001; 131 Tsubota, Kawashima, Ozawa, Shinmura, Inaba, Nakamura, Kawakita, Watanabe (bb9055) 2013; 48 Civitarese, Carling, Heilbronn, Hulver, Ukropcova, Deutsch, Smith, Ravussin (bb0180) 2007; 4 Nocera, Buford, Manini, Naugle, Leeuwenburgh, Pahor, Perri, Anton (bb0120) 2011; 2011 Lee, Klopp, Weindruch, Prolla (bb0100) 1999; 285 Carlson, Hoelzel (bb0015) 1946; 31 Shriner (bb9050) 2013; 48 Wohlgemuth, Seo, Marzetti, Lees, Leeuwenburgh (bb0170) 2010; 45 Lee, Longo (bb0095) 2011; 30 Levine, Klem, Kalarchian, Wing, Weissfeld, Qin, Marcus (bb0195) 2007; 15 Rangaraju, Hankins, Madorsky, Madorsky, Lee, Carter, Leeuwenburgh, Notterpek (bb0135) 2009; 8 Hofer, Fontana, Anton, Weiss, Villareal, Malayappan, Leeuwenburgh (bb0070) 2008; 11 Hofer, Servais, Seo, Marzetti, Hiona, Upadhyay, Wohlgemuth, Leeuwenburgh (bb0075) 2009; 130 Phillips, Leeuwenburgh (bb0130) 2005; 19 Marzetti, Carter, Wohlgemuth, Lees, Giovannini, Anderson, Quinn, Leeuwenburgh (bb0115) 2009; 130 Fontana, Meyer, Klein, Holloszy (bb0050) 2004; 101 Fontana, Villareal, Weiss, Racette, Steger-May, Klein, Holloszy (bb0185) 2007; 293 Lam, Peterson, Ravussin (bb9010) 2013; 48 Scheen (bb0150) 2008; 17 Kaeberlein, Delaney, Murakami, Chou, Carr, Schleit, Sutphin, An, Castanza, Fletcher, Goswami, Higgins, Holmberg, Hui, Jelic, Jeong, Kim, Klum, Liao, Lin, Lo, Miller, Moller, Peng, Pollard, Pradeep, Pruett, Rai, Ros, Schuster, Singh, Spector, Wende, Wang, Wasko, Olsen (bb9000) 2013; 48 Urbanski, Mattison, Roth, Ingram (bb9085) 2013; 48 Larson-Meyer, Heilbronn, Redman, Newcomer, Frisard, Anton, Smith, Alfonso, Ravussin (bb0090) 2006; 29 Heilbronn, de, Frisard, Delany, Larson-Meyer, Rood, Nguyen, Martin, Volaufova, Most, Greenway, Smith, Deutsch, Williamson, Ravussin (bb0190) 2006; 295 Park, Cypser, Kitzenberg (bb9005) 2013; 48 Dannecker, Liu, Rector, Thomas, Sayers, Leeuwenburgh, Ray (bb9070) 2013; 48 Notterpek, Lee (bb9045) 2013; 48 Wohlgemuth, Julian, Akin, Fried, Toscano, Leeuwenburgh, Dunn (bb0165) 2007; 10 Dutta, Calvani, Bernabei, Leeuwenburgh, Marzetti (bb0045) 2012; 110 Colman, Anderson, Johnson, Kastman, Kosmatka, Beasley, Allison, Cruzen, Simmons, Kemnitz, Weindruch (bb0035) 2009; 325 Scheen (bb0145) 2004; 29 Ceriello (10.1016/j.exger.2013.04.011_bb0020) 2005; 26 Hepple (10.1016/j.exger.2013.04.011_bb9040) 2013; 48 Aris (10.1016/j.exger.2013.04.011_bb0175) 2013; 48 Park (10.1016/j.exger.2013.04.011_bb9005) 2013; 48 Fontana (10.1016/j.exger.2013.04.011_bb0050) 2004; 101 Colman (10.1016/j.exger.2013.04.011_bb0035) 2009; 325 Arguin (10.1016/j.exger.2013.04.011_bb0005) 2012; 19 Weindruch (10.1016/j.exger.2013.04.011_bb0155) 1996; 24 Opalach (10.1016/j.exger.2013.04.011_bb0125) 2010; 13 Wohlgemuth (10.1016/j.exger.2013.04.011_bb0165) 2007; 10 Rangaraju (10.1016/j.exger.2013.04.011_bb0135) 2009; 8 Chung (10.1016/j.exger.2013.04.011_bb9020) 2013; 48 Notterpek (10.1016/j.exger.2013.04.011_bb9045) 2013; 48 Shriner (10.1016/j.exger.2013.04.011_bb9050) 2013; 48 Larson-Meyer (10.1016/j.exger.2013.04.011_bb0090) 2006; 29 Barja (10.1016/j.exger.2013.04.011_bb9015) 2013; 48 Lee (10.1016/j.exger.2013.04.011_bb0095) 2011; 30 Lee (10.1016/j.exger.2013.04.011_bb0100) 1999; 285 Heilbronn (10.1016/j.exger.2013.04.011_bb0190) 2006; 295 Hofer (10.1016/j.exger.2013.04.011_bb0075) 2009; 130 Kaeberlein (10.1016/j.exger.2013.04.011_bb9000) 2013; 48 Marzetti (10.1016/j.exger.2013.04.011_bb0115) 2009; 130 Wohlgemuth (10.1016/j.exger.2013.04.011_bb0170) 2010; 45 Ja (10.1016/j.exger.2013.04.011_bb9080) 2013; 48 Katare (10.1016/j.exger.2013.04.011_bb0080) 2009; 46 Fontana (10.1016/j.exger.2013.04.011_bb0185) 2007; 293 Weindruch (10.1016/j.exger.2013.04.011_bb0160) 2001; 131 Phillips (10.1016/j.exger.2013.04.011_bb0130) 2005; 19 Longo (10.1016/j.exger.2013.04.011_bb9075) 2013; 48 Nelson (10.1016/j.exger.2013.04.011_bb9060) 2013; 48 Scheen (10.1016/j.exger.2013.04.011_bb0145) 2004; 29 Carlson (10.1016/j.exger.2013.04.011_bb0015) 1946; 31 Lefevre (10.1016/j.exger.2013.04.011_bb0105) 2009; 203 Hofer (10.1016/j.exger.2013.04.011_bb0070) 2008; 11 Devaraj (10.1016/j.exger.2013.04.011_bb0040) 2008; 57 Urbanski (10.1016/j.exger.2013.04.011_bb9085) 2013; 48 Ceriello (10.1016/j.exger.2013.04.011_bb0025) 2005; 54 Han (10.1016/j.exger.2013.04.011_bb9065) 2013; 48 Mitchell (10.1016/j.exger.2013.04.011_bb9025) 2013; 48 Scheen (10.1016/j.exger.2013.04.011_bb0150) 2008; 17 Lam (10.1016/j.exger.2013.04.011_bb9010) 2013; 48 Tsubota (10.1016/j.exger.2013.04.011_bb9055) 2013; 48 Levine (10.1016/j.exger.2013.04.011_bb0195) 2007; 15 Dannecker (10.1016/j.exger.2013.04.011_bb9070) 2013; 48 Civitarese (10.1016/j.exger.2013.04.011_bb0180) 2007; 4 Rochon (10.1016/j.exger.2013.04.011_bb0140) 2011; 66 Avena (10.1016/j.exger.2013.04.011_bb9035) 2013; 48 Kayo (10.1016/j.exger.2013.04.011_bb0085) 2001; 98 Nocera (10.1016/j.exger.2013.04.011_bb0120) 2011; 2011 Waters (10.1016/j.exger.2013.04.011_bb9030) 2013; 48 Heilbronn (10.1016/j.exger.2013.04.011_bb0065) 2003; 78 Dutta (10.1016/j.exger.2013.04.011_bb0045) 2012; 110 22013527 - J Aging Res. 2011;2011:392510 11309484 - Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5093-8 8994305 - Toxicol Pathol. 1996 Nov-Dec;24(6):742-5 19903516 - Exp Gerontol. 2010 Feb;45(2):138-48 23403040 - Exp Gerontol. 2013 Oct;48(10):1129-35 15618047 - Eur Heart J. 2005 Feb;26(4):328-31 23201549 - Exp Gerontol. 2013 Oct;48(10):1049-53 18602635 - Atherosclerosis. 2009 Mar;203(1):206-13 21021020 - J Nutr. 1946 Mar;31:363-75 17665967 - Rejuvenation Res. 2007 Sep;10(3):281-92 23454634 - Exp Gerontol. 2013 Oct;48(10):1091-5 23266375 - Exp Gerontol. 2013 Oct;48(10):1101-6 11238786 - J Nutr. 2001 Mar;131(3):918S-923S 23454633 - Exp Gerontol. 2013 Oct;48(10):1120-8 20923909 - J Gerontol A Biol Sci Med Sci. 2011 Jan;66(1):97-108 21516129 - Oncogene. 2011 Jul 28;30(30):3305-16 17341128 - PLoS Med. 2007 Mar;4(3):e76 23376627 - Exp Gerontol. 2013 Oct;48(10):1043-8 17389710 - Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E197-202 22499902 - Circ Res. 2012 Apr 13;110(8):1125-38 15616004 - Diabetes. 2005 Jan;54(1):1-7 23535488 - Exp Gerontol. 2013 Oct;48(10):1062-7 23454735 - Exp Gerontol. 2013 Oct;48(10):1030-42 23588119 - Exp Gerontol. 2013 Oct;48(10):1096-100 12936916 - Am J Clin Nutr. 2003 Sep;78(3):361-9 19059263 - J Mol Cell Cardiol. 2009 Mar;46(3):405-12 18321226 - Expert Opin Investig Drugs. 2008 Mar;17(3):263-7 19396981 - Mech Ageing Dev. 2009 Apr;130(4):272-80 23624181 - Exp Gerontol. 2013 Oct;48(10):1018-24 17495203 - Obesity (Silver Spring). 2007 May;15(5):1267-77 20230280 - Rejuvenation Res. 2010 Feb;13(1):65-74 23462461 - Exp Gerontol. 2013 Oct;48(10):1014-7 15257254 - Minerva Endocrinol. 2004 Jun;29(2):31-45 23318475 - Exp Gerontol. 2013 Oct;48(10):1136-9 23403042 - Exp Gerontol. 2013 Oct;48(10):1054-61 18729811 - Rejuvenation Res. 2008 Aug;11(4):793-9 23523973 - Exp Gerontol. 2013 Oct;48(10):1075-84 23235143 - Exp Gerontol. 2013 Oct;48(10):1006-13 23267844 - Exp Gerontol. 2013 Oct;48(10):1068-74 23337777 - Exp Gerontol. 2013 Oct;48(10):1107-19 23562825 - Exp Gerontol. 2013 Oct;48(10):1025-9 19590001 - Science. 2009 Jul 10;325(5937):201-4 22735163 - Menopause. 2012 Aug;19(8):870-6 19239416 - Aging Cell. 2009 Apr;8(2):178-91 10464095 - Science. 1999 Aug 27;285(5432):1390-3 18502272 - Metabolism. 2008 Jun;57(6):867-70 15665035 - FASEB J. 2005 Apr;19(6):668-70 19428447 - Mech Ageing Dev. 2009 May;130(5):297-307 23267845 - Exp Gerontol. 2013 Oct;48(10):1085-90 16732018 - Diabetes Care. 2006 Jun;29(6):1337-44 16595757 - JAMA. 2006 Apr 5;295(13):1539-48 15096581 - Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6659-63
References_xml	– volume: 110 start-page: 1125 year: 2012 end-page: 1138 ident: bb0045 article-title: Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities publication-title: Circ. Res. – volume: 66 start-page: 97 year: 2011 end-page: 108 ident: bb0140 article-title: Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy publication-title: J. Gerontol.A Biol. Sci. Med. Sci. – volume: 48 start-page: 1014 year: 2013 end-page: 1017 ident: bb9005 article-title: Dietary restriction in C. elegans: Recent advances publication-title: Exp. Gerontol. – volume: 15 start-page: 1267 year: 2007 end-page: 1277 ident: bb0195 article-title: Weight gain prevention among women publication-title: Obesity (Silver Spring) – volume: 48 start-page: 1075 year: 2013 end-page: 1084 ident: bb9040 article-title: Facts and controversies in our understanding of how caloric restriction impacts the mitochondrion publication-title: Exp. Gerontol. – volume: 29 start-page: 1337 year: 2006 end-page: 1344 ident: bb0090 article-title: Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects publication-title: Diabetes Care – volume: 295 start-page: 1539 year: 2006 end-page: 1548 ident: bb0190 article-title: Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial publication-title: JAMA – volume: 48 start-page: 1120 year: 2013 end-page: 1128 ident: bb9075 article-title: Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression publication-title: Exp. Gerontol. – volume: 48 start-page: 1107 year: 2013 end-page: 1119 ident: bb0175 article-title: Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast publication-title: Exp. Gerontol. – volume: 29 start-page: 31 year: 2004 end-page: 45 ident: bb0145 article-title: Management of the metabolic syndrome publication-title: Minerva Endocrinol. – volume: 285 start-page: 1390 year: 1999 end-page: 1393 ident: bb0100 article-title: Gene expression profile of aging and its retardation by caloric restriction publication-title: Science – volume: 4 start-page: e76 year: 2007 ident: bb0180 article-title: Calorie restriction increases muscle mitochondrial biogenesis in healthy humans publication-title: PLoS Med. – volume: 48 start-page: 1003 year: 2013 end-page: 1005 ident: bb9000 article-title: Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae publication-title: Exp. Gerontol. – volume: 31 start-page: 363 year: 1946 end-page: 375 ident: bb0015 article-title: Apparent prolongation of the life span of rats by intermittent fasting publication-title: J. Nutr. – volume: 48 start-page: 1068 year: 2013 end-page: 1074 ident: bb9050 article-title: Food addiction: Detox and abstinence reinterpreted? publication-title: Exp. Gerontol. – volume: 48 start-page: 1043 year: 2013 end-page: 1048 ident: bb9025 article-title: Benefits of short-term dietary restriction in mammals publication-title: Exp. Gerontol. – volume: 54 start-page: 1 year: 2005 end-page: 7 ident: bb0025 article-title: Postprandial hyperglycemia and diabetes complications: is it time to treat? publication-title: Diabetes – volume: 325 start-page: 201 year: 2009 end-page: 204 ident: bb0035 article-title: Caloric restriction delays disease onset and mortality in rhesus monkeys publication-title: Science – volume: 78 start-page: 361 year: 2003 end-page: 369 ident: bb0065 article-title: Calorie restriction and aging: review of the literature and implications for studies in humans publication-title: Am. J. Clin. Nutr. – volume: 48 start-page: 1018 year: 2013 end-page: 1024 ident: bb9010 article-title: Resveratrol vs. calorie restriction: Data from rodents to humans publication-title: Exp. Gerontol. – volume: 10 start-page: 281 year: 2007 end-page: 292 ident: bb0165 article-title: Autophagy in the heart and liver during normal aging and calorie restriction publication-title: Rejuvenation Res. – volume: 48 start-page: 1030 year: 2013 end-page: 1042 ident: bb9015 article-title: Regulation of longevity and oxidative stress by nutritional interventions: Role of methionine restriction publication-title: Exp. Gerontol. – volume: 130 start-page: 297 year: 2009 end-page: 307 ident: bb0075 article-title: Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: effects of aging and lifelong calorie restriction publication-title: Mech. Ageing Dev. – volume: 17 start-page: 263 year: 2008 end-page: 267 ident: bb0150 article-title: The future of obesity: new drugs versus lifestyle interventions publication-title: Expert. Opin. Investig. Drugs – volume: 19 start-page: 668 year: 2005 end-page: 670 ident: bb0130 article-title: Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction publication-title: FASEB J. – volume: 48 start-page: 1129 year: 2013 end-page: 1135 ident: bb9080 article-title: High carbohydrate–low protein consumption maximizes Drosophila lifespan publication-title: Exp. Gerontol. – volume: 203 start-page: 206 year: 2009 end-page: 213 ident: bb0105 article-title: Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals publication-title: Atherosclerosis – volume: 48 start-page: 1062 year: 2013 end-page: 1067 ident: bb9035 article-title: Comparing the effects of food restriction and overeating on brain reward systems publication-title: Exp. Gerontol. – volume: 57 start-page: 867 year: 2008 end-page: 870 ident: bb0040 article-title: High-fat, energy-dense, fast-food-style breakfast results in an increase in oxidative stress in metabolic syndrome publication-title: Metabolism – volume: 293 start-page: E197 year: 2007 end-page: E202 ident: bb0185 article-title: Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial publication-title: Am. J. Physiol Endocrinol. Metab – volume: 101 start-page: 6659 year: 2004 end-page: 6663 ident: bb0050 article-title: Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 30 start-page: 3305 year: 2011 end-page: 3316 ident: bb0095 article-title: Fasting vs. dietary restriction in cellular protection and cancer treatment: from model organisms to patients publication-title: Oncogene – volume: 131 start-page: 918S year: 2001 end-page: 923S ident: bb0160 article-title: Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice publication-title: J. Nutr. – volume: 45 start-page: 138 year: 2010 end-page: 148 ident: bb0170 article-title: Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise publication-title: Exp. Gerontol. – volume: 13 start-page: 65 year: 2010 end-page: 74 ident: bb0125 article-title: Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves publication-title: Rejuvenation Res. – volume: 48 start-page: 1136 year: 2013 end-page: 1139 ident: bb9085 article-title: Dehydroepiandrosterone sulfate (DHEAS) as an endocrine marker of aging in calorie restriction studies publication-title: Exp. Gerontol. – volume: 11 start-page: 793 year: 2008 end-page: 799 ident: bb0070 article-title: Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans publication-title: Rejuvenation Res. – volume: 8 start-page: 178 year: 2009 end-page: 191 ident: bb0135 article-title: Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging publication-title: Aging Cell – volume: 19 start-page: 870 year: 2012 end-page: 876 ident: bb0005 article-title: Short- and long-term effects of continuous versus intermittent restrictive diet approaches on body composition and the metabolic profile in overweight and obese postmenopausal women: a pilot study publication-title: Menopause – volume: 48 start-page: 1049 year: 2013 end-page: 1053 ident: bb9020 article-title: Recent advances in calorie restriction research on aging publication-title: Exp. Gerontol. – volume: 26 start-page: 328 year: 2005 end-page: 331 ident: bb0020 article-title: Acute hyperglycaemia: a ‘new’ risk factor during myocardial infarction publication-title: Eur. Heart J. – volume: 46 start-page: 405 year: 2009 end-page: 412 ident: bb0080 article-title: Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathway publication-title: J. Mol. Cell. Cardiol. – volume: 48 start-page: 1101 year: 2013 end-page: 1106 ident: bb9070 article-title: The effect of fasting on indicators of muscle damage publication-title: Exp. Gerontol. – volume: 2011 start-page: 392510 year: 2011 ident: bb0120 article-title: The impact of behavioral intervention on obesity mediated declines in mobility function: implications for longevity publication-title: J. Aging Res. – volume: 24 start-page: 742 year: 1996 end-page: 745 ident: bb0155 article-title: The retardation of aging by caloric restriction: studies in rodents and primates publication-title: Toxicol. Pathol. – volume: 130 start-page: 272 year: 2009 end-page: 280 ident: bb0115 article-title: Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction publication-title: Mech. Ageing Dev. – volume: 48 start-page: 1054 year: 2013 end-page: 1061 ident: bb9030 article-title: Weight loss in obese adults 65 years and older: A review of the controversy publication-title: Exp. Gerontol. – volume: 98 start-page: 5093 year: 2001 end-page: 5098 ident: bb0085 article-title: Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 48 start-page: 1096 year: 2013 end-page: 1100 ident: bb9055 article-title: Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders publication-title: Exp. Gerontol. – volume: 48 start-page: 1091 year: 2013 end-page: 1095 ident: bb9065 article-title: Maintaining good hearing: Calorie restriction, Sirt3, and glutathione publication-title: Am. J. Clin. Nutr. – volume: 48 start-page: 1025 year: 2013 end-page: 1029 ident: bb9060 article-title: Genetic variation in responses to dietary restriction — An unbiased tool for hypothesis testing publication-title: Exp. Gerontol. – volume: 48 start-page: 1085 year: 2013 end-page: 1090 ident: bb9045 article-title: Dietary restriction supports peripheral nerve health by enhancing endogenous protein quality control mechanisms publication-title: Exp. Gerontol. – volume: 11 start-page: 793 year: 2008 ident: 10.1016/j.exger.2013.04.011_bb0070 article-title: Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans publication-title: Rejuvenation Res. doi: 10.1089/rej.2008.0712 – volume: 24 start-page: 742 year: 1996 ident: 10.1016/j.exger.2013.04.011_bb0155 article-title: The retardation of aging by caloric restriction: studies in rodents and primates publication-title: Toxicol. Pathol. doi: 10.1177/019262339602400618 – volume: 48 start-page: 1101 year: 2013 ident: 10.1016/j.exger.2013.04.011_bb9070 article-title: The effect of fasting on indicators of muscle damage publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2012.12.006 – volume: 78 start-page: 361 year: 2003 ident: 10.1016/j.exger.2013.04.011_bb0065 article-title: Calorie restriction and aging: review of the literature and implications for studies in humans publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/78.3.361 – volume: 295 start-page: 1539 year: 2006 ident: 10.1016/j.exger.2013.04.011_bb0190 article-title: Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial publication-title: JAMA doi: 10.1001/jama.295.13.1539 – volume: 48 start-page: 1043 year: 2013 ident: 10.1016/j.exger.2013.04.011_bb9025 article-title: Benefits of short-term dietary restriction in mammals publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2013.01.009 – volume: 293 start-page: E197 year: 2007 ident: 10.1016/j.exger.2013.04.011_bb0185 article-title: Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial publication-title: Am. J. Physiol Endocrinol. Metab doi: 10.1152/ajpendo.00102.2007 – volume: 48 start-page: 1129 year: 2013 ident: 10.1016/j.exger.2013.04.011_bb9080 article-title: High carbohydrate–low protein consumption maximizes Drosophila lifespan publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2013.02.003 – volume: 48 start-page: 1068 year: 2013 ident: 10.1016/j.exger.2013.04.011_bb9050 article-title: Food addiction: Detox and abstinence reinterpreted? publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2012.12.005 – volume: 48 start-page: 1054 year: 2013 ident: 10.1016/j.exger.2013.04.011_bb9030 article-title: Weight loss in obese adults 65 years and older: A review of the controversy publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2013.02.005 – volume: 48 start-page: 1003 year: 2013 ident: 10.1016/j.exger.2013.04.011_bb9000 article-title: Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae publication-title: Exp. Gerontol. – volume: 48 start-page: 1075 year: 2013 ident: 10.1016/j.exger.2013.04.011_bb9040 article-title: Facts and controversies in our understanding of how caloric restriction impacts the mitochondrion publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2013.03.004 – volume: 8 start-page: 178 year: 2009 ident: 10.1016/j.exger.2013.04.011_bb0135 article-title: Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging publication-title: Aging Cell doi: 10.1111/j.1474-9726.2009.00460.x – volume: 26 start-page: 328 year: 2005 ident: 10.1016/j.exger.2013.04.011_bb0020 article-title: Acute hyperglycaemia: a ‘new’ risk factor during myocardial infarction publication-title: Eur. Heart J. doi: 10.1093/eurheartj/ehi049 – volume: 48 start-page: 1120 year: 2013 ident: 10.1016/j.exger.2013.04.011_bb9075 article-title: Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2013.02.016 – volume: 285 start-page: 1390 year: 1999 ident: 10.1016/j.exger.2013.04.011_bb0100 article-title: Gene expression profile of aging and its retardation by caloric restriction publication-title: Science doi: 10.1126/science.285.5432.1390 – volume: 48 start-page: 1025 year: 2013 ident: 10.1016/j.exger.2013.04.011_bb9060 article-title: Genetic variation in responses to dietary restriction — An unbiased tool for hypothesis testing publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2013.03.010 – volume: 17 start-page: 263 year: 2008 ident: 10.1016/j.exger.2013.04.011_bb0150 article-title: The future of obesity: new drugs versus lifestyle interventions publication-title: Expert. Opin. Investig. Drugs doi: 10.1517/13543784.17.3.263 – volume: 48 start-page: 1030 year: 2013 ident: 10.1016/j.exger.2013.04.011_bb9015 article-title: Regulation of longevity and oxidative stress by nutritional interventions: Role of methionine restriction publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2013.02.021 – volume: 13 start-page: 65 year: 2010 ident: 10.1016/j.exger.2013.04.011_bb0125 article-title: Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves publication-title: Rejuvenation Res. doi: 10.1089/rej.2009.0892 – volume: 48 start-page: 1062 year: 2013 ident: 10.1016/j.exger.2013.04.011_bb9035 article-title: Comparing the effects of food restriction and overeating on brain reward systems publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2013.03.006 – volume: 66 start-page: 97 year: 2011 ident: 10.1016/j.exger.2013.04.011_bb0140 article-title: Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy publication-title: J. Gerontol.A Biol. Sci. Med. Sci. doi: 10.1093/gerona/glq168 – volume: 57 start-page: 867 year: 2008 ident: 10.1016/j.exger.2013.04.011_bb0040 article-title: High-fat, energy-dense, fast-food-style breakfast results in an increase in oxidative stress in metabolic syndrome publication-title: Metabolism doi: 10.1016/j.metabol.2008.02.016 – volume: 10 start-page: 281 year: 2007 ident: 10.1016/j.exger.2013.04.011_bb0165 article-title: Autophagy in the heart and liver during normal aging and calorie restriction publication-title: Rejuvenation Res. doi: 10.1089/rej.2006.0535 – volume: 48 start-page: 1091 year: 2013 ident: 10.1016/j.exger.2013.04.011_bb9065 article-title: Maintaining good hearing: Calorie restriction, Sirt3, and glutathione publication-title: Am. J. Clin. Nutr. – volume: 48 start-page: 1107 year: 2013 ident: 10.1016/j.exger.2013.04.011_bb0175 article-title: Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2013.01.006 – volume: 48 start-page: 1096 year: 2013 ident: 10.1016/j.exger.2013.04.011_bb9055 article-title: Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2013.04.002 – volume: 30 start-page: 3305 year: 2011 ident: 10.1016/j.exger.2013.04.011_bb0095 article-title: Fasting vs. dietary restriction in cellular protection and cancer treatment: from model organisms to patients publication-title: Oncogene doi: 10.1038/onc.2011.91 – volume: 46 start-page: 405 year: 2009 ident: 10.1016/j.exger.2013.04.011_bb0080 article-title: Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathway publication-title: J. Mol. Cell. Cardiol. doi: 10.1016/j.yjmcc.2008.10.027 – volume: 19 start-page: 668 year: 2005 ident: 10.1016/j.exger.2013.04.011_bb0130 article-title: Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction publication-title: FASEB J. doi: 10.1096/fj.04-2870fje – volume: 110 start-page: 1125 year: 2012 ident: 10.1016/j.exger.2013.04.011_bb0045 article-title: Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.111.246108 – volume: 130 start-page: 272 year: 2009 ident: 10.1016/j.exger.2013.04.011_bb0115 article-title: Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction publication-title: Mech. Ageing Dev. doi: 10.1016/j.mad.2008.12.008 – volume: 19 start-page: 870 year: 2012 ident: 10.1016/j.exger.2013.04.011_bb0005 article-title: Short- and long-term effects of continuous versus intermittent restrictive diet approaches on body composition and the metabolic profile in overweight and obese postmenopausal women: a pilot study publication-title: Menopause doi: 10.1097/gme.0b013e318250a287 – volume: 48 start-page: 1049 year: 2013 ident: 10.1016/j.exger.2013.04.011_bb9020 article-title: Recent advances in calorie restriction research on aging publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2012.11.007 – volume: 48 start-page: 1014 year: 2013 ident: 10.1016/j.exger.2013.04.011_bb9005 article-title: Dietary restriction in C. elegans: Recent advances publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2013.02.018 – volume: 48 start-page: 1085 year: 2013 ident: 10.1016/j.exger.2013.04.011_bb9045 article-title: Dietary restriction supports peripheral nerve health by enhancing endogenous protein quality control mechanisms publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2012.12.008 – volume: 131 start-page: 918S year: 2001 ident: 10.1016/j.exger.2013.04.011_bb0160 article-title: Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice publication-title: J. Nutr. doi: 10.1093/jn/131.3.918S – volume: 45 start-page: 138 year: 2010 ident: 10.1016/j.exger.2013.04.011_bb0170 article-title: Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2009.11.002 – volume: 15 start-page: 1267 year: 2007 ident: 10.1016/j.exger.2013.04.011_bb0195 article-title: Weight gain prevention among women publication-title: Obesity (Silver Spring) doi: 10.1038/oby.2007.148 – volume: 48 start-page: 1136 year: 2013 ident: 10.1016/j.exger.2013.04.011_bb9085 article-title: Dehydroepiandrosterone sulfate (DHEAS) as an endocrine marker of aging in calorie restriction studies publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2013.01.001 – volume: 325 start-page: 201 year: 2009 ident: 10.1016/j.exger.2013.04.011_bb0035 article-title: Caloric restriction delays disease onset and mortality in rhesus monkeys publication-title: Science doi: 10.1126/science.1173635 – volume: 54 start-page: 1 year: 2005 ident: 10.1016/j.exger.2013.04.011_bb0025 article-title: Postprandial hyperglycemia and diabetes complications: is it time to treat? publication-title: Diabetes doi: 10.2337/diabetes.54.1.1 – volume: 29 start-page: 1337 year: 2006 ident: 10.1016/j.exger.2013.04.011_bb0090 article-title: Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects publication-title: Diabetes Care doi: 10.2337/dc05-2565 – volume: 29 start-page: 31 year: 2004 ident: 10.1016/j.exger.2013.04.011_bb0145 article-title: Management of the metabolic syndrome publication-title: Minerva Endocrinol. – volume: 101 start-page: 6659 year: 2004 ident: 10.1016/j.exger.2013.04.011_bb0050 article-title: Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0308291101 – volume: 203 start-page: 206 year: 2009 ident: 10.1016/j.exger.2013.04.011_bb0105 article-title: Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2008.05.036 – volume: 130 start-page: 297 year: 2009 ident: 10.1016/j.exger.2013.04.011_bb0075 article-title: Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: effects of aging and lifelong calorie restriction publication-title: Mech. Ageing Dev. doi: 10.1016/j.mad.2009.01.004 – volume: 98 start-page: 5093 year: 2001 ident: 10.1016/j.exger.2013.04.011_bb0085 article-title: Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.081061898 – volume: 48 start-page: 1018 year: 2013 ident: 10.1016/j.exger.2013.04.011_bb9010 article-title: Resveratrol vs. calorie restriction: Data from rodents to humans publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2013.04.005 – volume: 31 start-page: 363 year: 1946 ident: 10.1016/j.exger.2013.04.011_bb0015 article-title: Apparent prolongation of the life span of rats by intermittent fasting publication-title: J. Nutr. doi: 10.1093/jn/31.3.363 – volume: 2011 start-page: 392510 year: 2011 ident: 10.1016/j.exger.2013.04.011_bb0120 article-title: The impact of behavioral intervention on obesity mediated declines in mobility function: implications for longevity publication-title: J. Aging Res. doi: 10.4061/2011/392510 – volume: 4 start-page: e76 year: 2007 ident: 10.1016/j.exger.2013.04.011_bb0180 article-title: Calorie restriction increases muscle mitochondrial biogenesis in healthy humans publication-title: PLoS Med. doi: 10.1371/journal.pmed.0040076 – reference: 23267845 - Exp Gerontol. 2013 Oct;48(10):1085-90 – reference: 19059263 - J Mol Cell Cardiol. 2009 Mar;46(3):405-12 – reference: 23376627 - Exp Gerontol. 2013 Oct;48(10):1043-8 – reference: 15257254 - Minerva Endocrinol. 2004 Jun;29(2):31-45 – reference: 19396981 - Mech Ageing Dev. 2009 Apr;130(4):272-80 – reference: 18321226 - Expert Opin Investig Drugs. 2008 Mar;17(3):263-7 – reference: 23201549 - Exp Gerontol. 2013 Oct;48(10):1049-53 – reference: 22735163 - Menopause. 2012 Aug;19(8):870-6 – reference: 16595757 - JAMA. 2006 Apr 5;295(13):1539-48 – reference: 8994305 - Toxicol Pathol. 1996 Nov-Dec;24(6):742-5 – reference: 11238786 - J Nutr. 2001 Mar;131(3):918S-923S – reference: 15096581 - Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6659-63 – reference: 17389710 - Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E197-202 – reference: 23462461 - Exp Gerontol. 2013 Oct;48(10):1014-7 – reference: 23562825 - Exp Gerontol. 2013 Oct;48(10):1025-9 – reference: 23624181 - Exp Gerontol. 2013 Oct;48(10):1018-24 – reference: 23403042 - Exp Gerontol. 2013 Oct;48(10):1054-61 – reference: 23454634 - Exp Gerontol. 2013 Oct;48(10):1091-5 – reference: 16732018 - Diabetes Care. 2006 Jun;29(6):1337-44 – reference: 12936916 - Am J Clin Nutr. 2003 Sep;78(3):361-9 – reference: 23318475 - Exp Gerontol. 2013 Oct;48(10):1136-9 – reference: 17341128 - PLoS Med. 2007 Mar;4(3):e76 – reference: 22013527 - J Aging Res. 2011;2011:392510 – reference: 20923909 - J Gerontol A Biol Sci Med Sci. 2011 Jan;66(1):97-108 – reference: 18502272 - Metabolism. 2008 Jun;57(6):867-70 – reference: 23454633 - Exp Gerontol. 2013 Oct;48(10):1120-8 – reference: 21516129 - Oncogene. 2011 Jul 28;30(30):3305-16 – reference: 20230280 - Rejuvenation Res. 2010 Feb;13(1):65-74 – reference: 10464095 - Science. 1999 Aug 27;285(5432):1390-3 – reference: 19239416 - Aging Cell. 2009 Apr;8(2):178-91 – reference: 23588119 - Exp Gerontol. 2013 Oct;48(10):1096-100 – reference: 18729811 - Rejuvenation Res. 2008 Aug;11(4):793-9 – reference: 23454735 - Exp Gerontol. 2013 Oct;48(10):1030-42 – reference: 15616004 - Diabetes. 2005 Jan;54(1):1-7 – reference: 19903516 - Exp Gerontol. 2010 Feb;45(2):138-48 – reference: 19590001 - Science. 2009 Jul 10;325(5937):201-4 – reference: 23267844 - Exp Gerontol. 2013 Oct;48(10):1068-74 – reference: 18602635 - Atherosclerosis. 2009 Mar;203(1):206-13 – reference: 17665967 - Rejuvenation Res. 2007 Sep;10(3):281-92 – reference: 22499902 - Circ Res. 2012 Apr 13;110(8):1125-38 – reference: 23403040 - Exp Gerontol. 2013 Oct;48(10):1129-35 – reference: 23535488 - Exp Gerontol. 2013 Oct;48(10):1062-7 – reference: 17495203 - Obesity (Silver Spring). 2007 May;15(5):1267-77 – reference: 19428447 - Mech Ageing Dev. 2009 May;130(5):297-307 – reference: 23266375 - Exp Gerontol. 2013 Oct;48(10):1101-6 – reference: 11309484 - Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5093-8 – reference: 15665035 - FASEB J. 2005 Apr;19(6):668-70 – reference: 23337777 - Exp Gerontol. 2013 Oct;48(10):1107-19 – reference: 23235143 - Exp Gerontol. 2013 Oct;48(10):1006-13 – reference: 23523973 - Exp Gerontol. 2013 Oct;48(10):1075-84 – reference: 15618047 - Eur Heart J. 2005 Feb;26(4):328-31 – reference: 21021020 - J Nutr. 1946 Mar;31:363-75
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Snippet	Aging is associated with a host of biological changes that contribute to a progressive decline in cognitive and physical function, ultimately leading to a loss...
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SubjectTerms	Aging - physiology Caloric Restriction Fasting - physiology Humans Longevity - physiology
Title	Fasting or caloric restriction for Healthy Aging
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