Human exposure to neonicotinoid insecticides and the evaluation of their potential toxicity: An overview

Neonicotinoid insecticides have become the fastest growing class of insecticides over the past few decades. The insecticidal activity of neonicotinoids is attributed to their agonist action on nicotinic acetylcholine receptors (nAChRs). Because of the special selective action on nAChRs in central ne...

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Veröffentlicht in:	Chemosphere (Oxford) Jg. 192; S. 59 - 65
Hauptverfasser:	Han, Wenchao, Tian, Ying, Shen, Xiaoming
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.02.2018
Schlagworte:	agonists Animals application methods central nervous system crops Ecotoxicology - methods Exposure levels Health Human health effects Humans insecticidal properties Insecticides - toxicity insects metabolites neonicotinoid insecticides Neonicotinoids Neonicotinoids - toxicity nicotinic receptors pets risk Toxicity Neonicotinoids Human health effects Exposure levels Toxicity
ISSN:	0045-6535, 1879-1298, 1879-1298
Online-Zugang:	Volltext
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Abstract	Neonicotinoid insecticides have become the fastest growing class of insecticides over the past few decades. The insecticidal activity of neonicotinoids is attributed to their agonist action on nicotinic acetylcholine receptors (nAChRs). Because of the special selective action on nAChRs in central nervous system of insects, and versatility in application methods, neonicotinoids are used to protect crops and pets from insect attacks globally. Although neonicotinoids are considered low toxicity to mammals and humans in comparison with traditional insecticides, more and more studies show exposure to neonicotinoids pose potential risk to mammals and even humans. In recent years, neonicotinoids and their metabolites have been successfully detected in various human biological samples. Meanwhile, many studies have focused on the health effects of neonicotinoids on humans. Our aims here are to review studies on human neonicotinoid exposure levels, health effect, evaluation of potential toxicity and to suggest possible directions for future research. •Neonicotinoids, as a novel class of insecticides, are used widely.•Neonicotinoids have been detected in human urine, serum, and hair.•In vivo/vitro studies suggested toxicity of neonicotinoids.•Large-scale epidemiological studies on human health effects are needed.
AbstractList	Neonicotinoid insecticides have become the fastest growing class of insecticides over the past few decades. The insecticidal activity of neonicotinoids is attributed to their agonist action on nicotinic acetylcholine receptors (nAChRs). Because of the special selective action on nAChRs in central nervous system of insects, and versatility in application methods, neonicotinoids are used to protect crops and pets from insect attacks globally. Although neonicotinoids are considered low toxicity to mammals and humans in comparison with traditional insecticides, more and more studies show exposure to neonicotinoids pose potential risk to mammals and even humans. In recent years, neonicotinoids and their metabolites have been successfully detected in various human biological samples. Meanwhile, many studies have focused on the health effects of neonicotinoids on humans. Our aims here are to review studies on human neonicotinoid exposure levels, health effect, evaluation of potential toxicity and to suggest possible directions for future research. Neonicotinoid insecticides have become the fastest growing class of insecticides over the past few decades. The insecticidal activity of neonicotinoids is attributed to their agonist action on nicotinic acetylcholine receptors (nAChRs). Because of the special selective action on nAChRs in central nervous system of insects, and versatility in application methods, neonicotinoids are used to protect crops and pets from insect attacks globally. Although neonicotinoids are considered low toxicity to mammals and humans in comparison with traditional insecticides, more and more studies show exposure to neonicotinoids pose potential risk to mammals and even humans. In recent years, neonicotinoids and their metabolites have been successfully detected in various human biological samples. Meanwhile, many studies have focused on the health effects of neonicotinoids on humans. Our aims here are to review studies on human neonicotinoid exposure levels, health effect, evaluation of potential toxicity and to suggest possible directions for future research.Neonicotinoid insecticides have become the fastest growing class of insecticides over the past few decades. The insecticidal activity of neonicotinoids is attributed to their agonist action on nicotinic acetylcholine receptors (nAChRs). Because of the special selective action on nAChRs in central nervous system of insects, and versatility in application methods, neonicotinoids are used to protect crops and pets from insect attacks globally. Although neonicotinoids are considered low toxicity to mammals and humans in comparison with traditional insecticides, more and more studies show exposure to neonicotinoids pose potential risk to mammals and even humans. In recent years, neonicotinoids and their metabolites have been successfully detected in various human biological samples. Meanwhile, many studies have focused on the health effects of neonicotinoids on humans. Our aims here are to review studies on human neonicotinoid exposure levels, health effect, evaluation of potential toxicity and to suggest possible directions for future research. Neonicotinoid insecticides have become the fastest growing class of insecticides over the past few decades. The insecticidal activity of neonicotinoids is attributed to their agonist action on nicotinic acetylcholine receptors (nAChRs). Because of the special selective action on nAChRs in central nervous system of insects, and versatility in application methods, neonicotinoids are used to protect crops and pets from insect attacks globally. Although neonicotinoids are considered low toxicity to mammals and humans in comparison with traditional insecticides, more and more studies show exposure to neonicotinoids pose potential risk to mammals and even humans. In recent years, neonicotinoids and their metabolites have been successfully detected in various human biological samples. Meanwhile, many studies have focused on the health effects of neonicotinoids on humans. Our aims here are to review studies on human neonicotinoid exposure levels, health effect, evaluation of potential toxicity and to suggest possible directions for future research. •Neonicotinoids, as a novel class of insecticides, are used widely.•Neonicotinoids have been detected in human urine, serum, and hair.•In vivo/vitro studies suggested toxicity of neonicotinoids.•Large-scale epidemiological studies on human health effects are needed.
Author	Shen, Xiaoming Han, Wenchao Tian, Ying
Author_xml	– sequence: 1 givenname: Wenchao surname: Han fullname: Han, Wenchao organization: MOE and Shanghai Key Laboratory of Children's Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China – sequence: 2 givenname: Ying orcidid: 0000-0003-3225-7962 surname: Tian fullname: Tian, Ying email: tianmiejp@sjtu.edu.cn organization: MOE and Shanghai Key Laboratory of Children's Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China – sequence: 3 givenname: Xiaoming surname: Shen fullname: Shen, Xiaoming email: xmshen@shsmu.edu.cn organization: MOE and Shanghai Key Laboratory of Children's Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29100122$$D View this record in MEDLINE/PubMed
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Snippet	Neonicotinoid insecticides have become the fastest growing class of insecticides over the past few decades. The insecticidal activity of neonicotinoids is...
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SubjectTerms	agonists Animals application methods central nervous system crops Ecotoxicology - methods Exposure levels Health Human health effects Humans insecticidal properties Insecticides - toxicity insects metabolites neonicotinoid insecticides Neonicotinoids Neonicotinoids - toxicity nicotinic receptors pets risk Toxicity
Title	Human exposure to neonicotinoid insecticides and the evaluation of their potential toxicity: An overview
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