Nanoparticle brain delivery: a guide to verification methods

Many reports conclude nanoparticle (NP) brain entry based on bulk brain analysis. Bulk brain includes blood, cerebrospinal fluid and blood vessels within the brain contributing to the blood–brain and blood–cerebrospinal fluid barriers. Considering the brain as neurons, glia and their extracellular s...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nanomedicine (London, England) Ročník 15; číslo 4; s. 409 - 432
Hlavní autor: Yokel, Robert A
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Future Medicine Ltd 01.02.2020
Témata:
Alzheimer's disease
Antiretroviral drugs
Blood
Blood-brain barrier
blood–cerebrospinal fluid barrier
Brain
brain parenchyma
brain perfusion
capillary depletion
convection-enhanced delivery
microdialysis
Microscopy
mouse
nanoparticle
Nanoparticles
rat
Research methodology
mouse
blood–brain barrier
convection-enhanced delivery
microdialysis
rat
blood–cerebrospinal fluid barrier
nanoparticle
brain parenchyma
capillary depletion
in situ brain perfusion
ISSN:1743-5889, 1748-6963, 1748-6963
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract Many reports conclude nanoparticle (NP) brain entry based on bulk brain analysis. Bulk brain includes blood, cerebrospinal fluid and blood vessels within the brain contributing to the blood–brain and blood–cerebrospinal fluid barriers. Considering the brain as neurons, glia and their extracellular space (brain parenchyma), most studies did not show brain parenchymal NP entry. Blood–brain and blood–cerebrospinal fluid barriers anatomy and function are reviewed. Methods demonstrating brain parenchymal NP entry are presented. Results demonstrating bulk brain versus brain parenchymal entry are classified. Studies are reviewed, critiqued and classified to illustrate results demonstrating bulk brain versus parenchymal entry. Brain, blood and peripheral organ NP timecourses are compared and related to brain parenchymal entry evidence suggesting brain NP timecourse informs about brain parenchymal entry.
AbstractList Many reports conclude nanoparticle (NP) brain entry based on bulk brain analysis. Bulk brain includes blood, cerebrospinal fluid and blood vessels within the brain contributing to the blood-brain and blood-cerebrospinal fluid barriers. Considering the brain as neurons, glia and their extracellular space (brain parenchyma), most studies did not show brain parenchymal NP entry. Blood-brain and blood-cerebrospinal fluid barriers anatomy and function are reviewed. Methods demonstrating brain parenchymal NP entry are presented. Results demonstrating bulk brain versus brain parenchymal entry are classified. Studies are reviewed, critiqued and classified to illustrate results demonstrating bulk brain versus parenchymal entry. Brain, blood and peripheral organ NP timecourses are compared and related to brain parenchymal entry evidence suggesting brain NP timecourse informs about brain parenchymal entry.Many reports conclude nanoparticle (NP) brain entry based on bulk brain analysis. Bulk brain includes blood, cerebrospinal fluid and blood vessels within the brain contributing to the blood-brain and blood-cerebrospinal fluid barriers. Considering the brain as neurons, glia and their extracellular space (brain parenchyma), most studies did not show brain parenchymal NP entry. Blood-brain and blood-cerebrospinal fluid barriers anatomy and function are reviewed. Methods demonstrating brain parenchymal NP entry are presented. Results demonstrating bulk brain versus brain parenchymal entry are classified. Studies are reviewed, critiqued and classified to illustrate results demonstrating bulk brain versus parenchymal entry. Brain, blood and peripheral organ NP timecourses are compared and related to brain parenchymal entry evidence suggesting brain NP timecourse informs about brain parenchymal entry.
Many reports conclude nanoparticle (NP) brain entry based on bulk brain analysis. Bulk brain includes blood, cerebrospinal fluid and blood vessels within the brain contributing to the blood–brain and blood–cerebrospinal fluid barriers. Considering the brain as neurons, glia and their extracellular space (brain parenchyma), most studies did not show brain parenchymal NP entry. Blood–brain and blood–cerebrospinal fluid barriers anatomy and function are reviewed. Methods demonstrating brain parenchymal NP entry are presented. Results demonstrating bulk brain versus brain parenchymal entry are classified. Studies are reviewed, critiqued and classified to illustrate results demonstrating bulk brain versus parenchymal entry. Brain, blood and peripheral organ NP timecourses are compared and related to brain parenchymal entry evidence suggesting brain NP timecourse informs about brain parenchymal entry.
Author Yokel, Robert A
AuthorAffiliation 1Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536-0596, USA
AuthorAffiliation_xml – name: 1Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536-0596, USA
Author_xml – sequence: 1
  givenname: Robert A
  orcidid: 0000-0001-5188-3972
  surname: Yokel
  fullname: Yokel, Robert A
  organization: Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY40536-0596, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31999236$$D View this record in MEDLINE/PubMed
BookMark eNp1kMtrFTEUh4NU7EOXbmXATTejeczkIW6k1AeUdqPrkMeJpswk1yQj9L83t7e6KHR1Hny_w-E7RUcpJ0DoNcHvKCXifUrrSDFRIyZcPUMnRExy5Iqzo_uejbOU6hid1nqL8SwpwS_QMSNKKcr4Cfp4bVLemdKiW2CwxcQ0eFjiHyh3HwYz_Nyih6HloS9iiM60mNOwQvuVfX2JngezVHj1UM_Qj8-X3y--jlc3X75dfLoa3URwGxmbLQaLLQ5BBcvVZBi3ghvlvZCzEIZSZac5KOFl8NyE2UiJIcxeCms8O0Pnh7u7kn9vUJteY3WwLCZB3qqmbOq8xDPv6NtH6G3eSurfaTpJQcTMJ9qpNw_UZlfwelfiasqd_uelA-MBcCXXWiD8RwjWe--6e9d773rvvfPsEe9iu3fVutLlyZQ6pMLWtgLVRUgO9GHqf0UXEzyR_Qsoh5lG
CitedBy_id crossref_primary_10_1016_j_wneu_2020_08_161
crossref_primary_10_1080_17435390_2020_1770887
crossref_primary_10_1007_s11095_022_03222_0
crossref_primary_10_1038_s44160_024_00560_2
crossref_primary_10_1073_pnas_2309811121
crossref_primary_10_1002_wnan_1767
crossref_primary_10_1016_j_envres_2024_119473
crossref_primary_10_3390_ijms23020760
crossref_primary_10_3390_pharmaceutics13081258
crossref_primary_10_3390_pharmaceutics15010204
crossref_primary_10_1007_s12274_022_5302_6
crossref_primary_10_3390_ijms232012401
crossref_primary_10_3390_nano12132267
crossref_primary_10_3390_pharmaceutics15020443
crossref_primary_10_1016_j_cjche_2021_05_005
Cites_doi 10.1021/nn305193d
10.1016/j.biomaterials.2013.12.100
10.1039/C3NR04878K
10.1080/10717544.2018.1435749
10.1021/mp5008376
10.1016/j.nano.2017.11.008
10.1021/acsnano.5b07573
10.1021/bc500315j
10.1097/00006123-199810000-00089
10.1016/j.ejpb.2012.05.002
10.1016/j.biomaterials.2014.01.042
10.1002/smll.201503396
10.1016/0378-5173(90)90047-8
10.1016/j.jconrel.2011.05.010
10.1016/j.arabjc.2018.03.019
10.3109/17435390.2013.842267
10.2217/nnm.10.74
10.2217/nnm-2017-0082
10.3109/17435390.2011.552811
10.1016/j.ejps.2018.01.028
10.1038/nmeth.1991
10.1134/S1062359014030042
10.2147/IJN.S32514
10.2147/IJN.S54750
10.3109/09553002.2014.931612
10.3109/10717544.2011.596583
10.1158/0008-5472.CAN-05-3535
10.1002/jps.21939
10.3109/03639045.2012.727828
10.1371/journal.pone.0133921
10.2174/1381612823666170111112550
10.1215/15228517-2006-001
10.1158/0008-5472.CAN-18-2998
10.1007/978-1-4939-6688-2_13
10.1006/phrs.2000.0695
10.1002/jemt.22637
10.1021/acsbiomaterials.8b00335
10.1371/journal.pone.0160705
10.1016/j.yrtph.2015.11.004
10.1016/j.yhbeh.2018.12.011
10.1016/j.nano.2012.08.002
10.1016/j.biomaterials.2016.01.021
10.1016/j.ejpb.2010.12.029
10.1039/C4NR05061D
10.1039/C8NR07182A
10.1016/j.micron.2014.09.004
10.1002/jat.2758
10.1080/10717544.2017.1410263
10.1016/j.ejps.2014.06.024
10.3171/2017.2.JNS162273
10.1208/s12248-008-9018-7
10.1289/ehp.9030
10.1021/jacs.7b01118
10.1021/acsami.8b11782
10.18632/oncotarget.17976
10.1039/C7TB01385J
10.1002/wnan.1330
10.1039/C6NH00082G
10.1117/1.NPh.3.1.010901
10.1016/j.ijbiomac.2016.04.076
10.1166/jbn.2015.2142
10.2147/IJN.S29369
10.1007/s13311-017-0520-4
10.1016/j.ijpharm.2005.11.040
10.1166/jnn.2006.424
10.1088/0957-4484/21/48/485102
10.1002/jbm.a.36145
10.2147/IJN.S23025
10.1038/nn.3892
10.1023/A:1010931127745
10.1002/jbio.201400025
10.1002/adhm.201900543
10.1016/j.jsb.2008.07.003
10.1016/j.colsurfb.2017.10.062
10.4081/ejh.2016.2751
10.1016/j.brainres.2004.12.007
10.1371/journal.pone.0132266
10.1021/ja411096m
10.1186/s40360-018-0249-7
10.1016/j.biomaterials.2014.03.068
10.1002/cplu.201500156
10.2217/nnm-2017-0181
10.1016/j.biotechadv.2013.11.006
10.1016/j.bbamem.2008.10.022
10.1016/j.jconrel.2015.10.047
10.1016/S0378-5173(00)00639-6
10.1016/j.biomaterials.2018.06.024
10.1073/pnas.1003388107
10.1007/s13346-014-0208-9
10.1021/acsnano.6b05070
10.1016/j.nano.2015.03.009
10.2217/nnm-2017-0022
10.1038/jcbfm.2011.197
10.1146/annurev-biochem-060815-014801
10.1007/s11095-014-1593-y
10.1016/j.biomaterials.2012.06.063
10.3171/2014.10.JNS14229
10.1002/cmdc.201800262
10.1117/1.JBO.19.9.096003
10.1016/0006-8993(95)01143-9
10.1016/j.matlet.2016.01.006
10.1021/acsbiomaterials.8b01334
10.1016/j.ejpb.2013.08.011
10.1016/j.biomaterials.2015.02.083
10.1021/acs.nanolett.9b00752
10.2147/IJN.S133832
10.1016/j.biomaterials.2014.07.054
10.1002/mabi.201800340
10.3109/1061186X.2013.829077
10.1215/15228517-2007-019
10.1080/10717544.2016.1233590
10.1016/j.ijpharm.2018.06.031
10.2217/nnm.11.46
10.1186/s12951-015-0133-1
10.1002/smll.201701631
10.1016/j.jconrel.2019.01.005
10.1039/C4CS00014E
10.1021/acsami.6b00811
10.1111/j.1471-4159.1990.tb04886.x
10.2147/IJN.S32526
10.1208/s12249-014-0080-4
10.1016/j.jvir.2010.02.027
10.3109/10717544.2012.714812
10.1007/978-3-319-22536-4_16
10.2147/IJN.S193258
10.1007/s11095-014-1469-1
10.1016/j.eurpolymj.2017.11.038
10.1111/nan.12085
10.1021/la0257337
10.1080/08958370490439597
10.1016/j.ijpharm.2011.06.030
10.2217/nnm.12.209
10.1021/acschemneuro.6b00207
10.1007/s11095-011-0641-0
ContentType Journal Article
Copyright 2020 Robert A Yokel
2020. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: 2020 Robert A Yokel
– notice: 2020. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID AAYXX
CITATION
NPM
3V.
7X7
7XB
88E
8AO
8FI
8FJ
8FK
ABUWG
AFKRA
BENPR
CCPQU
EHMNL
FYUFA
GHDGH
K9.
M0S
M1P
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
7X8
DOI 10.2217/nnm-2019-0169
DatabaseName CrossRef
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central
ProQuest One
UK & Ireland Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
ProQuest Health & Medical Collection
Medical Database
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
DatabaseTitle CrossRef
PubMed
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Pharma Collection
ProQuest Central China
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Health & Medical Research Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
UK & Ireland Database
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic

PubMed
ProQuest One Academic Middle East (New)
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
EISSN 1748-6963
EndPage 432
ExternalDocumentID 31999236
10_2217_nnm_2019_0169
Genre Journal Article
GroupedDBID -
0R
123
29M
34G
39C
3V.
53G
70G
7X7
88E
8AO
8FI
8FJ
ABUWG
ACGFS
ADBBV
AENEX
AFKRA
AHMBA
ALMA_UNASSIGNED_HOLDINGS
BBAFP
BENPR
BPHCQ
BVXVI
CS3
DU5
EBS
EHMNL
F5P
FYUFA
HZ
IAO
IEA
IHR
INH
INR
M1P
MV1
NTCAX
O9-
P2P
PQQKQ
PRINS
PSQYO
RFM
---
0R~
4.4
AAWFG
AAYXX
ABJNI
ABNDM
ACGFO
ACWKX
AFFHD
AFFYO
CCPQU
CITATION
EJD
FD6
H13
HMCUK
HZ~
ITC
M4Z
OVD
PHGZM
PHGZT
PJZUB
PPXIY
PROAC
RPM
TDBHL
TEORI
TFL
TFMDE
TMEDX
UKHRP
~ZZ
ALIPV
NPM
7XB
8FK
K9.
PKEHL
PQEST
PQUKI
7X8
PUEGO
ID FETCH-LOGICAL-c410t-335b0eb0b0ff9fb694a36b76a9dd78577a229b45f97d8fd6af5a880ef5d87bad3
IEDL.DBID 7X7
ISICitedReferencesCount 23
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000532198200007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1743-5889
1748-6963
IngestDate Fri Sep 05 06:51:44 EDT 2025
Tue Oct 07 05:41:19 EDT 2025
Thu Jan 02 22:58:59 EST 2025
Sat Nov 29 06:14:01 EST 2025
Tue Nov 18 20:51:21 EST 2025
Tue Jan 05 21:37:48 EST 2021
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Keywords mouse
blood–brain barrier
convection-enhanced delivery
microdialysis
rat
blood–cerebrospinal fluid barrier
nanoparticle
brain parenchyma
capillary depletion
in situ brain perfusion
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c410t-335b0eb0b0ff9fb694a36b76a9dd78577a229b45f97d8fd6af5a880ef5d87bad3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0001-5188-3972
OpenAccessLink https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2019-0169
PMID 31999236
PQID 2487175642
PQPubID 54598
PageCount 24
ParticipantIDs proquest_miscellaneous_2348808056
proquest_journals_2487175642
pubmed_primary_31999236
crossref_primary_10_2217_nnm_2019_0169
crossref_citationtrail_10_2217_nnm_2019_0169
futurescience_futuremedicine_10_2217_nnm_2019_0169
ProviderPackageCode RFM
NTCAX
70G
PublicationCentury 2000
PublicationDate 2020-02-01
PublicationDateYYYYMMDD 2020-02-01
PublicationDate_xml – month: 02
  year: 2020
  text: 2020-02-01
  day: 01
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle Nanomedicine (London, England)
PublicationTitleAlternate Nanomedicine (Lond)
PublicationYear 2020
Publisher Future Medicine Ltd
Publisher_xml – name: Future Medicine Ltd
References e_1_3_4_3_1
e_1_3_4_110_1
e_1_3_4_133_1
e_1_3_4_114_1
e_1_3_4_61_1
e_1_3_4_84_1
e_1_3_4_137_1
e_1_3_4_118_1
e_1_3_4_42_1
e_1_3_4_80_1
e_1_3_4_23_1
e_1_3_4_46_1
e_1_3_4_69_1
e_1_3_4_27_1
e_1_3_4_65_1
e_1_3_4_88_1
e_1_3_4_121_1
e_1_3_4_140_1
e_1_3_4_102_1
e_1_3_4_125_1
e_1_3_4_144_1
e_1_3_4_72_1
e_1_3_4_95_1
e_1_3_4_106_1
e_1_3_4_129_1
e_1_3_4_53_1
e_1_3_4_91_1
e_1_3_4_30_1
e_1_3_4_11_1
e_1_3_4_76_1
e_1_3_4_99_1
e_1_3_4_38_1
e_1_3_4_57_1
e_1_3_4_19_1
De Lorenzo AJD (e_1_3_4_33_1) 1970
e_1_3_4_132_1
e_1_3_4_113_1
e_1_3_4_136_1
e_1_3_4_62_1
e_1_3_4_117_1
e_1_3_4_85_1
e_1_3_4_20_1
e_1_3_4_6_1
e_1_3_4_81_1
e_1_3_4_24_1
e_1_3_4_43_1
e_1_3_4_66_1
e_1_3_4_47_1
e_1_3_4_89_1
e_1_3_4_143_1
e_1_3_4_120_1
e_1_3_4_147_1
e_1_3_4_124_1
e_1_3_4_73_1
e_1_3_4_105_1
e_1_3_4_96_1
e_1_3_4_128_1
e_1_3_4_31_1
e_1_3_4_109_1
e_1_3_4_50_1
e_1_3_4_92_1
e_1_3_4_12_1
e_1_3_4_35_1
e_1_3_4_58_1
Zhu J (e_1_3_4_79_1) 2019; 74
e_1_3_4_54_1
Takasato Y (e_1_3_4_68_1) 1984; 247
e_1_3_4_16_1
e_1_3_4_39_1
e_1_3_4_77_1
e_1_3_4_131_1
e_1_3_4_112_1
e_1_3_4_135_1
e_1_3_4_116_1
e_1_3_4_63_1
e_1_3_4_86_1
e_1_3_4_9_1
e_1_3_4_139_1
e_1_3_4_40_1
e_1_3_4_82_1
e_1_3_4_5_1
e_1_3_4_21_1
Gopinath PG (e_1_3_4_34_1) 1978; 23
e_1_3_4_44_1
e_1_3_4_25_1
e_1_3_4_48_1
e_1_3_4_67_1
Mitkovski M (e_1_3_4_101_1) 2012; 3
e_1_3_4_29_1
e_1_3_4_142_1
Gage GJ (e_1_3_4_15_1) 2012; 65
e_1_3_4_100_1
e_1_3_4_123_1
e_1_3_4_104_1
e_1_3_4_127_1
e_1_3_4_74_1
e_1_3_4_97_1
e_1_3_4_108_1
Ohno K (e_1_3_4_7_1) 1978; 235
e_1_3_4_51_1
e_1_3_4_93_1
e_1_3_4_13_1
e_1_3_4_59_1
e_1_3_4_55_1
e_1_3_4_32_1
e_1_3_4_17_1
Yokel RA (e_1_3_4_70_1) 2018
e_1_3_4_78_1
e_1_3_4_36_1
Healy AT (e_1_3_4_28_1) 2015; 6
e_1_3_4_4_1
e_1_3_4_130_1
e_1_3_4_111_1
e_1_3_4_134_1
e_1_3_4_115_1
e_1_3_4_138_1
e_1_3_4_83_1
e_1_3_4_64_1
e_1_3_4_8_1
e_1_3_4_119_1
e_1_3_4_41_1
e_1_3_4_60_1
e_1_3_4_45_1
e_1_3_4_22_1
e_1_3_4_49_1
e_1_3_4_87_1
e_1_3_4_26_1
e_1_3_4_141_1
e_1_3_4_122_1
e_1_3_4_103_1
e_1_3_4_145_1
e_1_3_4_94_1
e_1_3_4_126_1
e_1_3_4_75_1
e_1_3_4_107_1
Israel LL (e_1_3_4_146_1) 2019; 13
e_1_3_4_52_1
e_1_3_4_90_1
e_1_3_4_71_1
e_1_3_4_10_1
e_1_3_4_98_1
e_1_3_4_14_1
e_1_3_4_37_1
e_1_3_4_56_1
e_1_3_4_18_1
References_xml – ident: e_1_3_4_115_1
  doi: 10.1021/nn305193d
– ident: e_1_3_4_19_1
  doi: 10.1016/j.biomaterials.2013.12.100
– volume: 247
  start-page: H484
  issue: 3
  year: 1984
  ident: e_1_3_4_68_1
  article-title: An in situ brain perfusion technique to study cerebrovascular transport in the rat
  publication-title: Am. J. Physiol.
– ident: e_1_3_4_120_1
  doi: 10.1039/C3NR04878K
– ident: e_1_3_4_138_1
  doi: 10.1080/10717544.2018.1435749
– volume: 3
  start-page: 372
  year: 2012
  ident: e_1_3_4_101_1
  article-title: Investigations into potential extrasynaptic communication between the dopaminergic and nitrergic systems
  publication-title: Front. Physiol. Membr. Physiol. Biophys.
– ident: e_1_3_4_124_1
  doi: 10.1021/mp5008376
– ident: e_1_3_4_27_1
  doi: 10.1016/j.nano.2017.11.008
– ident: e_1_3_4_51_1
  doi: 10.1021/acsnano.5b07573
– ident: e_1_3_4_89_1
  doi: 10.1021/bc500315j
– ident: e_1_3_4_5_1
  doi: 10.1097/00006123-199810000-00089
– ident: e_1_3_4_65_1
  doi: 10.1016/j.ejpb.2012.05.002
– ident: e_1_3_4_117_1
  doi: 10.1016/j.biomaterials.2014.01.042
– ident: e_1_3_4_67_1
  doi: 10.1002/smll.201503396
– ident: e_1_3_4_103_1
  doi: 10.1016/0378-5173(90)90047-8
– ident: e_1_3_4_71_1
  doi: 10.1016/j.jconrel.2011.05.010
– ident: e_1_3_4_56_1
  doi: 10.1016/j.arabjc.2018.03.019
– ident: e_1_3_4_37_1
  doi: 10.3109/17435390.2013.842267
– ident: e_1_3_4_107_1
  doi: 10.2217/nnm.10.74
– ident: e_1_3_4_135_1
  doi: 10.2217/nnm-2017-0082
– ident: e_1_3_4_17_1
  doi: 10.3109/17435390.2011.552811
– ident: e_1_3_4_136_1
  doi: 10.1016/j.ejps.2018.01.028
– ident: e_1_3_4_96_1
  doi: 10.1038/nmeth.1991
– ident: e_1_3_4_16_1
  doi: 10.1134/S1062359014030042
– ident: e_1_3_4_74_1
  doi: 10.2147/IJN.S32514
– ident: e_1_3_4_116_1
  doi: 10.2147/IJN.S54750
– ident: e_1_3_4_6_1
  doi: 10.3109/09553002.2014.931612
– ident: e_1_3_4_111_1
  doi: 10.3109/10717544.2011.596583
– ident: e_1_3_4_83_1
  doi: 10.1158/0008-5472.CAN-05-3535
– ident: e_1_3_4_38_1
  doi: 10.1002/jps.21939
– ident: e_1_3_4_77_1
  doi: 10.3109/03639045.2012.727828
– ident: e_1_3_4_93_1
  doi: 10.1371/journal.pone.0133921
– ident: e_1_3_4_95_1
  doi: 10.2174/1381612823666170111112550
– ident: e_1_3_4_86_1
  doi: 10.1215/15228517-2006-001
– ident: e_1_3_4_92_1
  doi: 10.1158/0008-5472.CAN-18-2998
– ident: e_1_3_4_98_1
  doi: 10.1007/978-1-4939-6688-2_13
– ident: e_1_3_4_104_1
  doi: 10.1006/phrs.2000.0695
– volume: 23
  start-page: 596
  issue: 5
  year: 1978
  ident: e_1_3_4_34_1
  article-title: Target site of intranasally sprayed substances and their transport across the nasal mucosa: a new insight into the intransal route of drug-delivery
  publication-title: Curr. Ther. Res.
– ident: e_1_3_4_47_1
  doi: 10.1002/jemt.22637
– ident: e_1_3_4_143_1
  doi: 10.1021/acsbiomaterials.8b00335
– ident: e_1_3_4_22_1
  doi: 10.1371/journal.pone.0160705
– ident: e_1_3_4_58_1
  doi: 10.1016/j.yrtph.2015.11.004
– ident: e_1_3_4_84_1
  doi: 10.1016/j.yhbeh.2018.12.011
– ident: e_1_3_4_18_1
  doi: 10.1016/j.nano.2012.08.002
– ident: e_1_3_4_48_1
  doi: 10.1016/j.biomaterials.2016.01.021
– ident: e_1_3_4_20_1
  doi: 10.1016/j.ejpb.2010.12.029
– ident: e_1_3_4_123_1
  doi: 10.1039/C4NR05061D
– ident: e_1_3_4_24_1
  doi: 10.1039/C8NR07182A
– start-page: 151
  volume-title: Taste and Smell in Vertebrates
  year: 1970
  ident: e_1_3_4_33_1
– ident: e_1_3_4_62_1
  doi: 10.1016/j.micron.2014.09.004
– ident: e_1_3_4_112_1
  doi: 10.1002/jat.2758
– ident: e_1_3_4_134_1
  doi: 10.1080/10717544.2017.1410263
– ident: e_1_3_4_118_1
  doi: 10.1016/j.ejps.2014.06.024
– ident: e_1_3_4_31_1
  doi: 10.3171/2017.2.JNS162273
– ident: e_1_3_4_11_1
  doi: 10.1208/s12248-008-9018-7
– ident: e_1_3_4_36_1
  doi: 10.1289/ehp.9030
– ident: e_1_3_4_42_1
  doi: 10.1021/jacs.7b01118
– ident: e_1_3_4_55_1
  doi: 10.1021/acsami.8b11782
– ident: e_1_3_4_129_1
  doi: 10.18632/oncotarget.17976
– ident: e_1_3_4_131_1
  doi: 10.1039/C7TB01385J
– ident: e_1_3_4_46_1
  doi: 10.1002/wnan.1330
– ident: e_1_3_4_125_1
  doi: 10.1039/C6NH00082G
– ident: e_1_3_4_39_1
  doi: 10.1117/1.NPh.3.1.010901
– ident: e_1_3_4_128_1
  doi: 10.1016/j.ijbiomac.2016.04.076
– ident: e_1_3_4_80_1
  doi: 10.1166/jbn.2015.2142
– start-page: 281
  volume-title: Nanotoxicity: Methods and Protocols
  year: 2018
  ident: e_1_3_4_70_1
– ident: e_1_3_4_99_1
  doi: 10.2147/IJN.S29369
– ident: e_1_3_4_30_1
  doi: 10.1007/s13311-017-0520-4
– ident: e_1_3_4_105_1
  doi: 10.1016/j.ijpharm.2005.11.040
– volume: 74
  start-page: 39
  issue: 1
  year: 2019
  ident: e_1_3_4_79_1
  article-title: Intranasal administration of pullulan-based nanoparticles for enhanced delivery of adriamycin into the brain: in vitro and in vivo evaluation
  publication-title: Pharmazie
– ident: e_1_3_4_64_1
  doi: 10.1166/jnn.2006.424
– ident: e_1_3_4_106_1
  doi: 10.1088/0957-4484/21/48/485102
– ident: e_1_3_4_132_1
  doi: 10.1002/jbm.a.36145
– ident: e_1_3_4_82_1
  doi: 10.2147/IJN.S23025
– ident: e_1_3_4_97_1
  doi: 10.1038/nn.3892
– ident: e_1_3_4_8_1
  doi: 10.1023/A:1010931127745
– ident: e_1_3_4_45_1
  doi: 10.1002/jbio.201400025
– ident: e_1_3_4_147_1
  doi: 10.1002/adhm.201900543
– ident: e_1_3_4_61_1
  doi: 10.1016/j.jsb.2008.07.003
– ident: e_1_3_4_141_1
  doi: 10.1016/j.colsurfb.2017.10.062
– ident: e_1_3_4_102_1
  doi: 10.4081/ejh.2016.2751
– ident: e_1_3_4_85_1
  doi: 10.1016/j.brainres.2004.12.007
– ident: e_1_3_4_90_1
  doi: 10.1371/journal.pone.0132266
– ident: e_1_3_4_13_1
  doi: 10.1021/ja411096m
– ident: e_1_3_4_142_1
  doi: 10.1186/s40360-018-0249-7
– ident: e_1_3_4_121_1
  doi: 10.1016/j.biomaterials.2014.03.068
– volume: 235
  start-page: H299
  issue: 3
  year: 1978
  ident: e_1_3_4_7_1
  article-title: Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat
  publication-title: Am. J. Physiol.
– ident: e_1_3_4_44_1
  doi: 10.1002/cplu.201500156
– ident: e_1_3_4_133_1
  doi: 10.2217/nnm-2017-0181
– ident: e_1_3_4_59_1
  doi: 10.1016/j.biotechadv.2013.11.006
– ident: e_1_3_4_9_1
  doi: 10.1016/j.bbamem.2008.10.022
– ident: e_1_3_4_49_1
  doi: 10.1016/j.jconrel.2015.10.047
– ident: e_1_3_4_21_1
  doi: 10.1016/S0378-5173(00)00639-6
– ident: e_1_3_4_91_1
  doi: 10.1016/j.biomaterials.2018.06.024
– ident: e_1_3_4_108_1
  doi: 10.1073/pnas.1003388107
– ident: e_1_3_4_119_1
  doi: 10.1007/s13346-014-0208-9
– ident: e_1_3_4_127_1
  doi: 10.1021/acsnano.6b05070
– ident: e_1_3_4_26_1
  doi: 10.1016/j.nano.2015.03.009
– ident: e_1_3_4_130_1
  doi: 10.2217/nnm-2017-0022
– ident: e_1_3_4_10_1
  doi: 10.1038/jcbfm.2011.197
– ident: e_1_3_4_40_1
  doi: 10.1146/annurev-biochem-060815-014801
– ident: e_1_3_4_94_1
– ident: e_1_3_4_50_1
  doi: 10.1007/s11095-014-1593-y
– ident: e_1_3_4_113_1
  doi: 10.1016/j.biomaterials.2012.06.063
– ident: e_1_3_4_29_1
  doi: 10.3171/2014.10.JNS14229
– ident: e_1_3_4_137_1
  doi: 10.1002/cmdc.201800262
– ident: e_1_3_4_100_1
  doi: 10.1117/1.JBO.19.9.096003
– ident: e_1_3_4_3_1
  doi: 10.1016/0006-8993(95)01143-9
– ident: e_1_3_4_126_1
  doi: 10.1016/j.matlet.2016.01.006
– ident: e_1_3_4_57_1
  doi: 10.1021/acsbiomaterials.8b01334
– ident: e_1_3_4_114_1
  doi: 10.1016/j.ejpb.2013.08.011
– ident: e_1_3_4_72_1
  doi: 10.1016/j.biomaterials.2015.02.083
– ident: e_1_3_4_63_1
  doi: 10.1021/acs.nanolett.9b00752
– volume: 13
  start-page: 1253
  issue: 2
  year: 2019
  ident: e_1_3_4_146_1
  article-title: A combination of tri-Leucine and angiopep-2 drives a polyanionic polymalic acid nanodrug platform across the blood–brain barrier
  publication-title: ACS Nano
– ident: e_1_3_4_60_1
  doi: 10.2147/IJN.S133832
– ident: e_1_3_4_122_1
  doi: 10.1016/j.biomaterials.2014.07.054
– ident: e_1_3_4_144_1
  doi: 10.1002/mabi.201800340
– ident: e_1_3_4_53_1
  doi: 10.3109/1061186X.2013.829077
– ident: e_1_3_4_81_1
  doi: 10.1215/15228517-2007-019
– ident: e_1_3_4_54_1
  doi: 10.1080/10717544.2016.1233590
– ident: e_1_3_4_139_1
  doi: 10.1016/j.ijpharm.2018.06.031
– ident: e_1_3_4_110_1
  doi: 10.2217/nnm.11.46
– ident: e_1_3_4_14_1
  doi: 10.1186/s12951-015-0133-1
– ident: e_1_3_4_41_1
  doi: 10.1002/smll.201701631
– volume: 65
  start-page: 3564
  issue: 65
  year: 2012
  ident: e_1_3_4_15_1
  article-title: Whole animal perfusion fixation for rodents
  publication-title: J. Vis. Exp.
– ident: e_1_3_4_75_1
  doi: 10.1016/j.jconrel.2019.01.005
– ident: e_1_3_4_66_1
  doi: 10.1039/C4CS00014E
– ident: e_1_3_4_43_1
  doi: 10.1021/acsami.6b00811
– ident: e_1_3_4_69_1
  doi: 10.1111/j.1471-4159.1990.tb04886.x
– ident: e_1_3_4_23_1
  doi: 10.2147/IJN.S32526
– ident: e_1_3_4_78_1
  doi: 10.1208/s12249-014-0080-4
– ident: e_1_3_4_87_1
  doi: 10.1016/j.jvir.2010.02.027
– ident: e_1_3_4_76_1
  doi: 10.3109/10717544.2012.714812
– ident: e_1_3_4_12_1
  doi: 10.1007/978-3-319-22536-4_16
– ident: e_1_3_4_145_1
  doi: 10.2147/IJN.S193258
– ident: e_1_3_4_73_1
  doi: 10.1007/s11095-014-1469-1
– ident: e_1_3_4_140_1
  doi: 10.1016/j.eurpolymj.2017.11.038
– ident: e_1_3_4_4_1
  doi: 10.1111/nan.12085
– ident: e_1_3_4_25_1
  doi: 10.1021/la0257337
– ident: e_1_3_4_35_1
  doi: 10.1080/08958370490439597
– ident: e_1_3_4_109_1
  doi: 10.1016/j.ijpharm.2011.06.030
– ident: e_1_3_4_88_1
  doi: 10.2217/nnm.12.209
– ident: e_1_3_4_52_1
  doi: 10.1021/acschemneuro.6b00207
– volume: 6
  start-page: S59
  issue: 1
  year: 2015
  ident: e_1_3_4_28_1
  article-title: Convection-enhanced drug delivery for gliomas
  publication-title: Surg. Neurol. Int.
– ident: e_1_3_4_32_1
  doi: 10.1007/s11095-011-0641-0
SSID ssj0058210
Score 2.395316
SecondaryResourceType review_article
Snippet Many reports conclude nanoparticle (NP) brain entry based on bulk brain analysis. Bulk brain includes blood, cerebrospinal fluid and blood vessels within the...
SourceID proquest
pubmed
crossref
futurescience
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 409
SubjectTerms Alzheimer's disease
Antiretroviral drugs
Blood
Blood-brain barrier
blood–cerebrospinal fluid barrier
Brain
brain parenchyma
brain perfusion
capillary depletion
convection-enhanced delivery
microdialysis
Microscopy
mouse
nanoparticle
Nanoparticles
rat
Research methodology
Title Nanoparticle brain delivery: a guide to verification methods
URI http://dx.doi.org/10.2217/nnm-2019-0169
https://www.ncbi.nlm.nih.gov/pubmed/31999236
https://www.proquest.com/docview/2487175642
https://www.proquest.com/docview/2348808056
Volume 15
WOSCitedRecordID wos000532198200007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1748-6963
  dateEnd: 20210131
  omitProxy: false
  ssIdentifier: ssj0058210
  issn: 1743-5889
  databaseCode: 7X7
  dateStart: 20060601
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1748-6963
  dateEnd: 20210131
  omitProxy: false
  ssIdentifier: ssj0058210
  issn: 1743-5889
  databaseCode: BENPR
  dateStart: 20060601
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: UK & Ireland Database
  customDbUrl:
  eissn: 1748-6963
  dateEnd: 20210131
  omitProxy: false
  ssIdentifier: ssj0058210
  issn: 1743-5889
  databaseCode: EHMNL
  dateStart: 20060601
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/ukireland
  providerName: ProQuest
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8QwEB58HRTx_VhfRBBPll2TtklEEBXF0yKisLeSNokI2lV3V_DfO9NmVz2sFy-FttMS-s1MZtLJfAAHKZe6lVcljdpF8XHLoM3lInKqpbz30ieqqMgmZLutOh19GxbceqGscugTK0dtuwWtkTc5RtY41WG4fPb6FhFrFP1dDRQakzBNtNmk57IzSrhoD2jYECmiRCld99jkGIU3y_IFFYQ28BxTrfOPOWm-buYRJqDxgWc1AV0v_nfoS7AQQk92XuvKMky4cgXmfjQkXIVTdLaYRdcSLCf6CGbdM9VufJ4wwx4HT9axfpfhBaoxqmBlNQt1bw0erq_uL2-iwK8QFQhKPxIiyVsuR6i81z5PdWxEmsvUaGulSqQ0nOs8TryWVnmbGp8YNHfnE4t4GivWYarslm4TmBK-MLHF2MTo2KeJjiV6BsNlGiPqQjfgaPiFsyI0HycOjOcMkxACJENAMgIkI0AacDgSf627bowT5L_gyuqzYV3CuId2hjhlwWJ72TdIDdgf3UZbox8opnTdAcoIcncKY8YGbNS6MBqeoH4OXKRbf798G2Y5ZexV3fcOTPXfB24XZoqP_lPvfa9S3-qo9mD64qp9e_cFAuD5vA
linkProvider ProQuest
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3NTxQxFH8BNAFjVBB0EbAmyskJSzszbYnGGIRAwA0HTPZWOtOWkODMyu5q-Kf4G3lvPlY8rDcOHGem07yZ_t5X-z4A3qdc6m5WhTRqH8XbXYs8l4nIq64KIciQqLxqNiF7PdXv65MZuGlzYSisspWJlaB2ZU575FscLWtUdWgufxn8iqhrFJ2uti00algc-es_6LINPx9-w_X9wPn-3unuQdR0FYhyJGUUCZFkXZ8hgSHokKU6tiLNZGq1c1IlUlrOdRYnQUungkttSCyC3IfE4VdYJ3DeWXiEclySsyf7EwePck6bBEwRJUrpuqYnR6t_qyh-IiApYWibYqvv6MCndfGQRuFNN3Qrhbf__KH9qhfwrDGt2deaFxZhxhdL8OROwcWX8AmVSTlouIVl1B6DOX9JsSnXO8yy8_GF82xUMrxBMVQVbFndZXu4DD_uhfwVmCvKwr8GpkTIbezQ9rI6DmmiY4mSz3KZxohqoTvwsV1RkzfF1anHx6VBJ4sAYBAAhgBgCAAd2JwMH9RVRaYN5P_Aw9RXbdzFtJfWWlyYRiINzV9QdODd5DHKEjogsoUvxzhGkDhXaBN34FWNvQl5gupVcJGu_n_ytzB_cPr92Bwf9o7ewAKn3Ykqxn0N5kZXY78Oj_Pfo4vh1UbFOgzO7huAtxfoVnY
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VLUJUFW_KQgEjQU9Eu7Xj2EYghGhXrVpWPYDUm3FiG1UqydLdBfWv9dcxk8dSDsutB45JHMuJv3nY_mYG4GXGlRnmNaXRhCTdHjqUuVwkQQ91jFFFqYu62IQaj_XxsTlagYsuFoZolZ1OrBW1rwraIx9w9KzR1KG7PIgtLeJoZ_R-8iOhClJ00tqV02ggchDOf-Hybfpufwfn-hXno93PH_eStsJAUuCwZokQMh-GHAcbo4l5ZlInslxlznivtFTKcW7yVEajvI4-c1E6BHyI0uMXOS-w32uwSlWdZA9Wd_c-jQ87O0ARqG04pkik1qbJ8MlxDTAoy-8ITwof2iam9SWLuN6kEmnN33K3tzZ_o9v_84-7A7dap5t9aKTkLqyE8h6sXUrFeB_eopmpJq0csZwKZzAfTom1cv6GOfZtfuIDm1UMbxC7qgY0a-pvTx_AlysZ_kPolVUZHgHTIhYu9eiVOZPGTJpUoU50XGUp4l2YPrzuZtcWbdp1qv5xanH5RWCwCAZLYLAEhj5sLZpPmnwjyxryv6Bim6uOkbHspc0OI7bVVVP7ByB9eLF4jFqGjo5cGao5thGk6DV6y33YaHC4GJ6gTBZcZI__3flzuIG4s4f744MncJPTtkVNft-E3uxsHp7C9eLn7GR69qyVIwZfrxqBvwFDMmCT
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Nanoparticle+brain+delivery%3A+a+guide+to+verification+methods&rft.jtitle=Nanomedicine+%28London%2C+England%29&rft.au=Yokel%2C+Robert+A&rft.date=2020-02-01&rft.pub=Future+Medicine+Ltd&rft.issn=1743-5889&rft.eissn=1748-6963&rft.volume=15&rft.issue=4&rft.spage=409&rft_id=info:doi/10.2217%2Fnnm-2019-0169&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1743-5889&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1743-5889&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1743-5889&client=summon