Exosomes as a biomarker platform for detecting epidermal growth factor receptor-positive high-grade gliomas

OBJECTIVE High-grade glial brain tumors are often characterized by an elevated expression of the tumorigenic epidermal growth factor receptor variant III ( EGFRvIII). The authors sought to establish a clinically adaptive protocol as a noninvasive diagnostic tool for EGFRvIII detection through serum...

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Veröffentlicht in:	Journal of neurosurgery Jg. 128; H. 4; S. 1091
Hauptverfasser:	Manda, Sasidhar Venkata, Kataria, Yogesh, Tatireddy, Babul Reddy, Ramakrishnan, Balasubramaniam, Ratnam, Boola Gnana, Lath, Rahul, Ranjan, Alok, Ray, Amitava
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.04.2018
Schlagworte:	TCGA = The Cancer Genome Atlas circulatory biomarkers GBM = glioblastoma oncology EGFRvIII = epidermal growth factor receptor variant III OS = overall survival PPV = positive predictive value exosomes NPV = negative predictive value TEM = transmission electron microscopy EGFRvIII RT = reverse transcription GAPDH = glyceraldehyde 3-phosphate dehydrogenase EGFR = epidermal growth factor receptor liquid biopsy PCR = polymerase chain reaction
ISSN:	1933-0693, 1933-0693
Online-Zugang:	Weitere Angaben
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