The Impact of the CYP2D6 "Enhancer" Single Nucleotide Polymorphism on CYP2D6 Activity

rs5758550 has been associated with enhanced transcription and suggested to be a useful marker of CYP2D6 activity. As there are limited and inconsistent data regarding the utility of this distant "enhancer" single nucleotide polymorphism (SNP), our goal was to further assess the impact of r...

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Bibliographic Details

Published in:	Clinical pharmacology and therapeutics Vol. 111; no. 3; p. 646
Main Authors:	Dinh, Jean C, Boone, Erin C, Staggs, Vincent S, Pearce, Robin E, Wang, Wendy Y, Gaedigk, Roger, Leeder, James Steven, Gaedigk, Andrea
Format:	Journal Article
Language:	English
Published:	United States 01.03.2022
Subjects:	Adolescent Alleles Atomoxetine Hydrochloride - therapeutic use Child Cytochrome P-450 CYP2D6 - genetics Dextromethorphan - therapeutic use Genotype Haplotypes - genetics Humans Pharmacogenomic Testing - methods Phenotype Polymorphism, Single Nucleotide - genetics
ISSN:	1532-6535, 1532-6535
Online Access:	Get more information
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