Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double‐Blind, Placebo‐Controlled, Crossover Study in Healthy Subjects
The psychedelic psilocybin is being investigated for the treatment of depression and anxiety. Unclear is whether antidepressant treatments interact with psilocybin. The present study used a double‐blind, placebo‐controlled, crossover design with two experimental test sessions to investigate the resp...
Uloženo v:
| Vydáno v: | Clinical pharmacology and therapeutics Ročník 111; číslo 4; s. 886 - 895 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
01.04.2022
|
| Témata: | |
| ISSN: | 0009-9236, 1532-6535, 1532-6535 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | The psychedelic psilocybin is being investigated for the treatment of depression and anxiety. Unclear is whether antidepressant treatments interact with psilocybin. The present study used a double‐blind, placebo‐controlled, crossover design with two experimental test sessions to investigate the response to psilocybin (25 mg) in healthy subjects after pretreatment with escitalopram or placebo. The treatment order was random and counterbalanced. Pretreatment consisted of 10 mg escitalopram daily for 7 days, followed by 20 mg daily for 7 days, including the day of psilocybin administration, or 14 days of placebo pretreatment before psilocybin administration. Psilocybin treatments were separated by at least 16 days. The outcome measures included self‐rating scales that evaluated subjective effects, autonomic effects, adverse effects, plasma brain‐derived neurotrophic factor (BDNF) levels, electrocardiogram QTc time, whole‐blood HTR2A and SCL6A4 gene expression, and pharmacokinetics. Escitalopram pretreatment had no relevant effect on positive mood effects of psilocybin but significantly reduced bad drug effects, anxiety, adverse cardiovascular effects, and other adverse effects of psilocybin compared with placebo pretreatment. Escitalopram did not alter the pharmacokinetics of psilocin. The half‐life of psychoactive free (unconjugated) psilocin was 1.8 hours (range 1.1–2.2 hours), consistent with the short duration of action of psilocybin. Escitalopram did not alter HTR2A or SCL6A4 gene expression before psilocybin administration, QTc intervals, or circulating BDNF levels before or after psilocybin administration. Further studies are needed with a longer antidepressant pretreatment time and patients with psychiatric disorders to further define interactions between antidepressants and psilocybin. |
|---|---|
| AbstractList | The psychedelic psilocybin is being investigated for the treatment of depression and anxiety. Unclear is whether antidepressant treatments interact with psilocybin. The present study used a double‐blind, placebo‐controlled, crossover design with two experimental test sessions to investigate the response to psilocybin (25 mg) in healthy subjects after pretreatment with escitalopram or placebo. The treatment order was random and counterbalanced. Pretreatment consisted of 10 mg escitalopram daily for 7 days, followed by 20 mg daily for 7 days, including the day of psilocybin administration, or 14 days of placebo pretreatment before psilocybin administration. Psilocybin treatments were separated by at least 16 days. The outcome measures included self‐rating scales that evaluated subjective effects, autonomic effects, adverse effects, plasma brain‐derived neurotrophic factor (BDNF) levels, electrocardiogram QTc time, whole‐blood HTR2A and SCL6A4 gene expression, and pharmacokinetics. Escitalopram pretreatment had no relevant effect on positive mood effects of psilocybin but significantly reduced bad drug effects, anxiety, adverse cardiovascular effects, and other adverse effects of psilocybin compared with placebo pretreatment. Escitalopram did not alter the pharmacokinetics of psilocin. The half‐life of psychoactive free (unconjugated) psilocin was 1.8 hours (range 1.1–2.2 hours), consistent with the short duration of action of psilocybin. Escitalopram did not alter HTR2A or SCL6A4 gene expression before psilocybin administration, QTc intervals, or circulating BDNF levels before or after psilocybin administration. Further studies are needed with a longer antidepressant pretreatment time and patients with psychiatric disorders to further define interactions between antidepressants and psilocybin. The psychedelic psilocybin is being investigated for the treatment of depression and anxiety. Unclear is whether antidepressant treatments interact with psilocybin. The present study used a double-blind, placebo-controlled, crossover design with two experimental test sessions to investigate the response to psilocybin (25 mg) in healthy subjects after pretreatment with escitalopram or placebo. The treatment order was random and counterbalanced. Pretreatment consisted of 10 mg escitalopram daily for 7 days, followed by 20 mg daily for 7 days, including the day of psilocybin administration, or 14 days of placebo pretreatment before psilocybin administration. Psilocybin treatments were separated by at least 16 days. The outcome measures included self-rating scales that evaluated subjective effects, autonomic effects, adverse effects, plasma brain-derived neurotrophic factor (BDNF) levels, electrocardiogram QTc time, whole-blood HTR2A and SCL6A4 gene expression, and pharmacokinetics. Escitalopram pretreatment had no relevant effect on positive mood effects of psilocybin but significantly reduced bad drug effects, anxiety, adverse cardiovascular effects, and other adverse effects of psilocybin compared with placebo pretreatment. Escitalopram did not alter the pharmacokinetics of psilocin. The half-life of psychoactive free (unconjugated) psilocin was 1.8 hours (range 1.1-2.2 hours), consistent with the short duration of action of psilocybin. Escitalopram did not alter HTR2A or SCL6A4 gene expression before psilocybin administration, QTc intervals, or circulating BDNF levels before or after psilocybin administration. Further studies are needed with a longer antidepressant pretreatment time and patients with psychiatric disorders to further define interactions between antidepressants and psilocybin.The psychedelic psilocybin is being investigated for the treatment of depression and anxiety. Unclear is whether antidepressant treatments interact with psilocybin. The present study used a double-blind, placebo-controlled, crossover design with two experimental test sessions to investigate the response to psilocybin (25 mg) in healthy subjects after pretreatment with escitalopram or placebo. The treatment order was random and counterbalanced. Pretreatment consisted of 10 mg escitalopram daily for 7 days, followed by 20 mg daily for 7 days, including the day of psilocybin administration, or 14 days of placebo pretreatment before psilocybin administration. Psilocybin treatments were separated by at least 16 days. The outcome measures included self-rating scales that evaluated subjective effects, autonomic effects, adverse effects, plasma brain-derived neurotrophic factor (BDNF) levels, electrocardiogram QTc time, whole-blood HTR2A and SCL6A4 gene expression, and pharmacokinetics. Escitalopram pretreatment had no relevant effect on positive mood effects of psilocybin but significantly reduced bad drug effects, anxiety, adverse cardiovascular effects, and other adverse effects of psilocybin compared with placebo pretreatment. Escitalopram did not alter the pharmacokinetics of psilocin. The half-life of psychoactive free (unconjugated) psilocin was 1.8 hours (range 1.1-2.2 hours), consistent with the short duration of action of psilocybin. Escitalopram did not alter HTR2A or SCL6A4 gene expression before psilocybin administration, QTc intervals, or circulating BDNF levels before or after psilocybin administration. Further studies are needed with a longer antidepressant pretreatment time and patients with psychiatric disorders to further define interactions between antidepressants and psilocybin. |
| Author | Eckert, Anne Klaiber, Aaron Grünblatt, Edna Grandinetti, Tanja Kolaczynska, Karolina E. Varghese, Nimmy Liechti, Matthias E. Becker, Anna M. Toedtli, Vanja E. Duthaler, Urs Holze, Friederike |
| Author_xml | – sequence: 1 givenname: Anna M. surname: Becker fullname: Becker, Anna M. organization: University of Basel – sequence: 2 givenname: Friederike surname: Holze fullname: Holze, Friederike organization: University of Basel – sequence: 3 givenname: Tanja surname: Grandinetti fullname: Grandinetti, Tanja organization: University of Basel – sequence: 4 givenname: Aaron surname: Klaiber fullname: Klaiber, Aaron organization: University of Basel – sequence: 5 givenname: Vanja E. surname: Toedtli fullname: Toedtli, Vanja E. organization: University of Basel – sequence: 6 givenname: Karolina E. surname: Kolaczynska fullname: Kolaczynska, Karolina E. organization: University of Basel – sequence: 7 givenname: Urs orcidid: 0000-0002-7811-3932 surname: Duthaler fullname: Duthaler, Urs organization: University of Basel – sequence: 8 givenname: Nimmy orcidid: 0000-0001-8598-0535 surname: Varghese fullname: Varghese, Nimmy organization: University of Basel – sequence: 9 givenname: Anne surname: Eckert fullname: Eckert, Anne organization: University of Basel – sequence: 10 givenname: Edna surname: Grünblatt fullname: Grünblatt, Edna organization: University of Zurich – sequence: 11 givenname: Matthias E. orcidid: 0000-0002-1765-9659 surname: Liechti fullname: Liechti, Matthias E. email: matthias.liechti@usb.ch organization: University of Basel |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34743319$$D View this record in MEDLINE/PubMed |
| BookMark | eNo9kUtOHDEQhi0EghlA4gTISxZp8KOfy6EzCZGQMuKxbtnusmjkbg-2G9RZ5Qi5Qq7GSeIWQ1alqvqq_lL9S7Q_2AEQOqPkkhLCrtQ2XLK0LPbQgmacJXnGs320IIRUScV4foSW3j_HNK3K8hAd8bRIOafVAv1dqTEAXmsNKnhsNd74zlg1yW7AKx3A4bVXXRDGbp3osXV4Y4QCafHGQXAgQg9DwJEW-E4Mre27X9B-wV_tKA28__5zbboh5rupWKjtEJw1ZqZqZ723r1HlPoztNK-5AWHC04TvR_k833SCDrQwHk538Rg9fls_1DfJ7c_vP-rVbaJSSoqk4FpLoQuqJYEyi2_QlFdFTkgOTMmCKUWoZlIIqHRLQWQtg5yXqRac81TyY3TxsXfr7MsIPjR95xUYIwawo29YVmVRqMzTiJ7v0FH20DZb1_XCTc3nWyOQfABvnYHpf5-SZrariXY1s11NvXmYI_8H-G-NVQ |
| CitedBy_id | crossref_primary_10_1016_j_intimp_2024_111753 crossref_primary_10_1080_14656566_2023_2281582 crossref_primary_10_1177_02698811231190858 crossref_primary_10_3389_fpsyt_2024_1417977 crossref_primary_10_1007_s40519_025_01771_y crossref_primary_10_1016_j_phrs_2024_107085 crossref_primary_10_1177_02698811241237870 crossref_primary_10_1016_j_nsa_2025_105525 crossref_primary_10_3389_fphar_2024_1391689 crossref_primary_10_1111_bph_70088 crossref_primary_10_1016_j_psychres_2024_115886 crossref_primary_10_1177_02698811251319457 crossref_primary_10_1176_appi_ajp_20230682 crossref_primary_10_3389_fphar_2023_1221719 crossref_primary_10_1038_s41380_024_02743_x crossref_primary_10_3389_fpsyt_2023_1123424 crossref_primary_10_1097_MJT_0000000000001724 crossref_primary_10_1177_26331055241286518 crossref_primary_10_1038_s41398_023_02477_4 crossref_primary_10_1016_j_neubiorev_2024_105796 crossref_primary_10_3389_fpsyt_2022_1040217 crossref_primary_10_1177_07067437221111371 crossref_primary_10_1016_j_pnpbp_2025_111279 crossref_primary_10_3389_fpsyt_2024_1372650 crossref_primary_10_1097_YIC_0000000000000488 crossref_primary_10_1080_02791072_2024_2399128 crossref_primary_10_1017_S1092852924002268 crossref_primary_10_1002_cpt_3618 crossref_primary_10_1016_j_euroneuro_2023_07_011 crossref_primary_10_1016_j_euroneuro_2024_06_008 crossref_primary_10_1080_03007995_2024_2396536 crossref_primary_10_3390_biology12111380 crossref_primary_10_1192_j_eurpsy_2024_1806 crossref_primary_10_3389_fpsyt_2023_1042440 crossref_primary_10_3389_fpsyt_2022_1076459 crossref_primary_10_1186_s40337_024_01185_8 crossref_primary_10_1016_j_bpsc_2024_01_007 crossref_primary_10_1016_j_bpsc_2024_02_001 crossref_primary_10_1016_j_drugalcdep_2025_112699 crossref_primary_10_1177_02698811231224217 crossref_primary_10_1177_02698811251368360 crossref_primary_10_1038_s41380_024_02830_z crossref_primary_10_3390_ph16010068 crossref_primary_10_1007_s00213_023_06517_1 crossref_primary_10_1176_appi_ajp_20230902 crossref_primary_10_7717_peerj_17517 crossref_primary_10_1038_s41386_023_01648_7 crossref_primary_10_1016_j_biopha_2023_115775 crossref_primary_10_1080_02791072_2024_2428241 crossref_primary_10_1002_cpt_2859 crossref_primary_10_1111_bcp_16349 crossref_primary_10_3390_pharmaceutics17040411 crossref_primary_10_7759_cureus_80707 crossref_primary_10_1016_j_neuropharm_2022_109257 crossref_primary_10_1038_s41386_022_01389_z crossref_primary_10_1177_02698811241278873 crossref_primary_10_1177_02698811221127954 crossref_primary_10_1016_j_jpsychires_2024_10_009 crossref_primary_10_1016_j_nsa_2024_104060 crossref_primary_10_1093_ijnp_pyac075 crossref_primary_10_1007_s43440_023_00550_9 crossref_primary_10_1016_j_jpain_2025_105507 crossref_primary_10_1007_s40262_024_01454_4 crossref_primary_10_1016_j_neuroscience_2024_01_001 crossref_primary_10_1016_j_jad_2023_03_083 crossref_primary_10_1016_j_nsa_2023_103929 crossref_primary_10_1177_02698811231211219 crossref_primary_10_1038_s41386_022_01297_2 crossref_primary_10_1016_j_nsa_2024_103938 crossref_primary_10_3389_fpsyt_2023_1305796 crossref_primary_10_1038_s41380_025_03169_9 crossref_primary_10_1093_pnasnexus_pgae560 crossref_primary_10_1007_s43440_023_00539_4 crossref_primary_10_1176_appi_ajp_20230914 crossref_primary_10_1002_cpt_2821 crossref_primary_10_1093_ijnp_pyaf035 crossref_primary_10_1186_s12868_024_00903_x crossref_primary_10_3389_fnins_2024_1420601 crossref_primary_10_1016_j_pnpbp_2025_111251 crossref_primary_10_1186_s40337_024_01125_6 crossref_primary_10_3389_fpsyt_2021_800072 crossref_primary_10_1038_s41598_024_53188_9 crossref_primary_10_1111_bcp_15887 crossref_primary_10_3389_fpsyt_2023_1199642 crossref_primary_10_1186_s13063_024_08268_6 crossref_primary_10_1038_s41386_023_01607_2 crossref_primary_10_1016_j_bbih_2025_101025 crossref_primary_10_1177_02698811241278769 crossref_primary_10_1016_j_neubiorev_2025_106132 crossref_primary_10_31883_pjfns_183995 crossref_primary_10_3390_jof11020099 |
| ContentType | Journal Article |
| Copyright | 2021 The Authors. published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. 2021 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. |
| Copyright_xml | – notice: 2021 The Authors. published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. – notice: 2021 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. |
| DBID | 24P CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1002/cpt.2487 |
| DatabaseName | Wiley Online Library Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1532-6535 |
| EndPage | 895 |
| ExternalDocumentID | 34743319 CPT2487 |
| Genre | article Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: University Hospital Basel and Mind Medicine |
| GroupedDBID | --- --K -Q- .55 .GJ 0R~ 1B1 1CY 1OB 1OC 24P 29B 33P 354 36B 39C 3O- 4.4 52O 53G 5GY 5RE 6J9 70F 8F7 AAESR AAHHS AAHQN AAIPD AAKAS AAMNL AANHP AANLZ AAONW AAQOH AAQQT AAWTL AAYCA AAYOK AAZKR ABCUV ABJNI ABLJU ABQWH ACBNA ACBWZ ACCFJ ACCZN ACGFO ACGFS ACGOF ACPOU ACRPL ACXQS ACYXJ ADBBV ADBTR ADKYN ADNMO ADXAS ADZCM ADZMN ADZOD AEEZP AEGXH AEIGN AENEX AEQDE AEUYR AFBPY AFFNX AFFPM AHBTC AI. AIAGR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMYDB ASPBG AVWKF AZFZN AZVAB BDRZF BFHJK BMXJE BRXPI C45 CAG COF CS3 DCZOG DPXWK DU5 EBS EE. EJD EMOBN F5P GODZA GWYGA HGLYW IH2 IHE J5H L7B LATKE LEEKS LITHE LOXES LSO LUTES LYRES M41 MEWTI N4W N9A NQ- O9- OPC OVD P2P P2W PALCI RIG RIWAO RJQFR RNTTT ROL RPZ SAMSI SEW SJN SUPJJ TEORI TWZ UHS VH1 WBKPD WH7 WOHZO WXSBR WYJ X7M Y6R YCJ YFH YOC YXB ZGI ZXP ZZTAW CGR CUY CVF ECM EIF NPM PKN 7X8 AAMMB AEFGJ AEYWJ AGHNM AGXDD AGYGG AIDQK AIDYY |
| ID | FETCH-LOGICAL-c4107-73ffbaf71fb0e85153f13976006e2cb72cc01f2baae9fd1ea5d2e6384fa3334b3 |
| IEDL.DBID | 24P |
| ISICitedReferencesCount | 109 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000720948200001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0009-9236 1532-6535 |
| IngestDate | Thu Oct 02 12:07:58 EDT 2025 Wed Feb 19 02:25:52 EST 2025 Wed Jan 22 16:26:34 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| License | Attribution-NonCommercial 2021 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4107-73ffbaf71fb0e85153f13976006e2cb72cc01f2baae9fd1ea5d2e6384fa3334b3 |
| Notes | Trial registry: ClinicalTrials.gov (NCT03912974). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 |
| ORCID | 0000-0002-7811-3932 0000-0001-8598-0535 0000-0002-1765-9659 |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fcpt.2487 |
| PMID | 34743319 |
| PQID | 2595107864 |
| PQPubID | 23479 |
| PageCount | 10 |
| ParticipantIDs | proquest_miscellaneous_2595107864 pubmed_primary_34743319 wiley_primary_10_1002_cpt_2487_CPT2487 |
| PublicationCentury | 2000 |
| PublicationDate | April 2022 |
| PublicationDateYYYYMMDD | 2022-04-01 |
| PublicationDate_xml | – month: 04 year: 2022 text: April 2022 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Clinical pharmacology and therapeutics |
| PublicationTitleAlternate | Clin Pharmacol Ther |
| PublicationYear | 2022 |
| References | 2015; 78 2021; 27 2017; 8 2002; 19 2019; 10 1976 2016; 30 1996; 73 2020; 14 2007; 31 2017; 234 1978 2021; 1164 1992; 7 2021; 35 2018; 9 2020; 4 2010; 27 2021; 78 2006; 24 2021; 238 2020; 45 2019; 359 2011; 25 2014; 7 2010; 5 2014; 202 2009; 16 2021; 46 2011; 218 2017; 27 2021; 184 2021; 384 2018; 23 1996; 14 2010; 44 2021; 10 1997; 72 2016; 3 2015; 29 2019; 85 2018; 235 2017; 56 2019 2006; 187 2017; 18 2012; 7 2016; 26 2001; 158 |
| References_xml | – volume: 35 start-page: 353 year: 2021 end-page: 361 article-title: Optimal dosing for psilocybin pharmacotherapy: considering weight‐adjusted and fixed dosing approaches publication-title: J. Psychopharmacol. – volume: 14 start-page: 425 year: 1996 end-page: 436 article-title: Chronic administration of serotonergic antidepressants attenuates the subjective effects of LSD in humans publication-title: Neuropsychopharmacology – volume: 1164 start-page: 122486 year: 2021 article-title: Development and validation of an LC‐MS/MS method for the bioanalysis of psilocybin's main metabolites, psilocin and 4‐hydroxyindole‐3‐acetic acid, in human plasma publication-title: J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. – volume: 9 start-page: 897 year: 2018 article-title: Predicting responses to psychedelics: a prospective study publication-title: Front. Pharmacol. – volume: 30 start-page: 1165 year: 2016 end-page: 1180 article-title: Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life‐threatening cancer: a randomized controlled trial publication-title: J. Psychopharmacol. – volume: 218 start-page: 649 year: 2011 end-page: 665 article-title: Psilocybin occasioned mystical‐type experiences: immediate and persisting dose‐related effects publication-title: Psychopharmacology – volume: 85 start-page: 1474 year: 2019 end-page: 1483 article-title: Pharmacokinetics and subjective effects of a novel oral LSD formulation in healthy subjects publication-title: Br. J. Clin. Pharmacol. – volume: 7 start-page: 157 year: 2014 end-page: 164 article-title: Psilocybin‐occasioned mystical experiences in the treatment of tobacco addiction publication-title: Curr. Drug Abuse Rev. – volume: 359 start-page: 342 year: 2019 end-page: 352 article-title: Changes in brain metabolites related to stress resilience: metabolomic analysis of the hippocampus in a rat model of depression publication-title: Behav. Brain Res. – volume: 10 start-page: 78 year: 2021 end-page: 85 article-title: Exposure‐response analysis to assess the concentration‐QTc relationship of psilocybin/psilocin publication-title: Clin. Pharmacol. Drug Dev. – volume: 184 start-page: 2779 year: 2021 end-page: 92 article-title: Psychedelic‐inspired drug discovery using an engineered biosensor publication-title: Cell – volume: 27 start-page: 940 year: 2017 end-page: 944 article-title: Escitalopram plasma levels and antidepressant response publication-title: Eur. Neuropsychopharmacol. – year: 2019 article-title: Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels publication-title: Neuropsychopharmacology – volume: 8 start-page: 974 year: 2017 article-title: Quality of acute psychedelic experience predicts therapeutic efficacy of psilocybin for treatment‐resistant depression publication-title: Front. Pharmacol. – volume: 25 start-page: 1434 year: 2011 end-page: 1452 article-title: Acute, subacute and long‐term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies publication-title: J. Psychopharmacology – volume: 187 start-page: 268 year: 2006 end-page: 283 article-title: Psilocybin can occasion mystical‐type experiences having substantial and sustained personal meaning and spiritual significance publication-title: Psychopharmacology – volume: 235 start-page: 399 year: 2018 end-page: 408 article-title: Psilocybin with psychological support for treatment‐resistant depression: six‐month follow‐up publication-title: Psychopharmacology – volume: 44 start-page: 1205 year: 2010 end-page: 1213 article-title: Clinical variations modulate patterns of gene expression and define blood biomarkers in major depression publication-title: J. Psychiatr. Res. – volume: 18 start-page: 5 year: 2017 end-page: 28 article-title: Consensus paper of the WFSBP Task Force on Genetics: genetics, epigenetics and gene expression markers of major depressive disorder and antidepressant response publication-title: World J. Biol. Psychiatry – volume: 10 start-page: 1234 year: 2019 article-title: Modulation of serum brain‐derived neurotrophic factor by a single dose of ayahuasca: observation from a randomized controlled trial publication-title: Front. Psychol. – volume: 202 start-page: 513 year: 2014 end-page: 520 article-title: Safety and efficacy of lysergic acid diethylamide‐assisted psychotherapy for anxiety associated with life‐threatening diseases publication-title: J. Nerv. Ment. Dis. – volume: 78 start-page: 544 year: 2015 end-page: 553 article-title: Acute effects of lysergic acid diethylamide in healthy subjects publication-title: Biol. Psychiatry – year: 1976 – volume: 158 start-page: 78 year: 2001 end-page: 85 article-title: The effect of paroxetine on 5‐HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study publication-title: Am. J. Psychiatry – volume: 234 start-page: 1499 year: 2017 end-page: 1510 article-title: Alterations in conciousness and mystical‐type experiences after acute LSD in humans publication-title: Psychopharmacology – volume: 7 year: 2012 article-title: Prediction of psilocybin response in healthy volunteers publication-title: PLoS One – volume: 72 start-page: 175 year: 1997 end-page: 184 article-title: Determination of psilocin and 4‐hydroxyindole‐3‐acetic acid in plasma by HPLC‐ECD and pharmacokinetic profiles of oral and intravenous psilocybin in man publication-title: Pharm. Acta Helv. – volume: 78 start-page: 481 year: 2021 end-page: 489 article-title: Effects of psilocybin‐assisted therapy on major depressive disorder: a randomized clinical trial publication-title: JAMA Psychiatry – volume: 45 start-page: 462 year: 2020 end-page: 471 article-title: Distinct acute effects of LSD, MDMA, and D‐amphetamine in healthy subjects publication-title: Neuropsychopharmacology – volume: 46 start-page: 537 year: 2021 end-page: 544 article-title: Acute dose‐dependent effects of lysergic acid diethylamide in a double‐blind placebo‐controlled study in healthy subjects publication-title: Neuropsychopharmacology – volume: 31 start-page: 628 year: 2007 end-page: 632 article-title: Altered HDAC5 and CREB mRNA expressions in the peripheral leukocytes of major depression publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry – volume: 56 start-page: 1543 year: 2017 end-page: 1554 article-title: Pharmacokinetics of escalating doses of oral psilocybin in healthy adults publication-title: Clin. Pharmacokinet. – volume: 26 start-page: 1327 year: 2016 end-page: 1337 article-title: Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens publication-title: Eur. Neuropsychopharmacol. – volume: 30 start-page: 1181 year: 2016 end-page: 1197 article-title: Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life‐threatening cancer: a randomized double‐blind trial publication-title: J. Psychopharmacol. – volume: 29 start-page: 1182 year: 2015 end-page: 1190 article-title: Validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin publication-title: J. Psychopharmacol. – volume: 16 start-page: 627 year: 2009 end-page: 634 article-title: Gene expression as peripheral biomarkers for sporadic Alzheimer's disease publication-title: J. Alzheimers Dis. – volume: 73 start-page: 229 year: 1996 end-page: 233 article-title: Alterations in response to LSD in humans associated with chronic administration of tricyclic antidepressants, monoamine oxidase inhibitors or lithium publication-title: Behav. Brain Res. – volume: 3 start-page: 619 year: 2016 end-page: 627 article-title: Psilocybin with psychological support for treatment‐resistant depression: an open‐label feasibility study publication-title: Lancet Psychiatry – volume: 23 start-page: 3170 year: 2018 end-page: 3182 article-title: Psychedelics promote structural and functional neural plasticity publication-title: Cell Rep. – volume: 24 start-page: 36 year: 2006 end-page: 40 article-title: Direct detection of serum psilocin glucuronide by LC/MS and LC/MS/MS: time‐courses of total and free (unconjugated) psilocin concentrations in serum specimens of a “magic mushroom” user publication-title: Forens. Toxicol. – volume: 14 start-page: 82 year: 2020 article-title: The role of BDNF on neural plasticity in depression publication-title: Front. Cell. Neurosci. – volume: 4 start-page: 461 year: 2020 end-page: 466 article-title: Low doses of LSD acutely increases BDNF blood plasma levels in healthy volunteers publication-title: ACS Pharmacol. Transl. Sci. – volume: 27 start-page: 586 year: 2010 end-page: 589 article-title: Effects of a b‐blocker on the cardiovascular response to MDMA (ecstasy) publication-title: Emerg. Med. J. – volume: 35 start-page: 362 year: 2021 end-page: 374 article-title: Acute subjective effects in LSD‐ and MDMA‐assisted psychotherapy publication-title: J. Psychopharmacol. – volume: 19 start-page: 17 year: 2002 end-page: 26 article-title: Selective serotonin reuptake inhibitor discontinuation syndrome: a review publication-title: Adv. Ther. – volume: 5 year: 2010 article-title: Psychometric evaluation of the altered states of consciousness rating scale (OAV) publication-title: PLoS One – article-title: Serotonin toxicity of serotonergic psychedelics publication-title: Psychopharmacology – volume: 27 start-page: 1025 year: 2021 end-page: 1033 article-title: MDMA‐assisted therapy for severe PTSD: a randomized, double‐blind, placebo‐controlled phase 3 study publication-title: Nat. Med. – volume: 7 start-page: 241 year: 1992 end-page: 243 article-title: Human hallucinogen interactions with drugs affecting serotonergic neurotransmission publication-title: Neuropsychopharmacology – year: 1978 – volume: 238 start-page: 581 issue: 2 year: 2021 end-page: 588 article-title: Discontinuation of medications classified as reuptake inhibitors affects treatment response of MDMA‐assisted psychotherapy publication-title: Psychopharmacology – volume: 384 start-page: 1402 year: 2021 end-page: 1411 article-title: Trial of psilocybin versus escitalopram for depression publication-title: N. Engl. J. Med. |
| SSID | ssj0004988 |
| Score | 2.6405375 |
| Snippet | The psychedelic psilocybin is being investigated for the treatment of depression and anxiety. Unclear is whether antidepressant treatments interact with... |
| SourceID | proquest pubmed wiley |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 886 |
| SubjectTerms | Antidepressive Agents - adverse effects Brain-Derived Neurotrophic Factor - genetics Citalopram - adverse effects Cross-Over Studies Double-Blind Method Escitalopram Healthy Volunteers Humans Psilocybin - adverse effects |
| Title | Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double‐Blind, Placebo‐Controlled, Crossover Study in Healthy Subjects |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fcpt.2487 https://www.ncbi.nlm.nih.gov/pubmed/34743319 https://www.proquest.com/docview/2595107864 |
| Volume | 111 |
| WOSCitedRecordID | wos000720948200001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NitswEBbttode-t9tttsyhZJT3I0lxbKP2bBLLw2ipJCbkWwJArt2sJOCe-oj9BX6an2SnbHyQ6GHQi8ytiVjM5Lmm_HMN4x94K6cjK11UWxtFkmV2MjyEk2VQipjBWpM4_tiE2o-T5fLTO-iKikXJvBDHBxutDL6_ZoWuLHtxZE0tFhvPnKE2_fZgzgWKZVt4FIfcyKzNN1XUUMQk-yJZ8f8Yj_yb6DyT4zaK5nrJ__zek_Z4x20hGmYC8_YPVc9Z0MduKm7ESyOqVbtCIagj6zV3Qv2a1psNw4Cm3ELtQfdrlDTdWg6w5QqicMVqkty9qwbcwt1A5pc8LYG3bhDvDpgbwNfTFXWt6vvrhwBQnR7437_-HmJH4Xnu1F4YRbC5G-o14y0NYWTAkU2dvSYkCHVAe5t5CxqX7Kv11eL2adoV78hKiRalZES3lvjVezt2CGymwhPeBMhVuJ4YRUvinHsuTXGZb6MnZmU3OF-IL0RQkgrXrGTqq7cawZxMimFk6UVQkmDEIyi61wsrMy4Sks-YO_3osxxfdBPD1O5etvmaN7htqPSRA7YaZBxvg5EHrmQihLGsgEb9qI83AhczjxHIeYkxHymF3Q8-9eOb9gjTnkSfYjPOTvZNFv3lj0svm1WbfOun6nYqmWK7Vx_vgOBSPK8 |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NitswEB6220J76X-76a8KJae4G0uKZdNTGnbZ0m0wJYW9GcmSILBrBztZcE99hL5CX61P0hk7Tij0UOjJ2JaMzUgz34xnvgF4y52djI1xQWhMEkgVmcBwi65KLpU2Ai2m9m2zCTWfxxcXSXoA7_tamI4fYhdwo53R6mva4BSQPt6zhuar9TuOePsG3JRoZGiRc5nuiyKTOO7bqCGKiXrm2TE_7mf-DVX-CVJbK3N677_e7z7c3YJLNu1WwwM4cMVDGKYdO3UzYot9sVU9YkOW7nmrm0fwc5pv1o51fMY1Kz1L6yXaugadZzalXuLsBA0mhXtWlb5iZcVSCsKbkqWV22WsMxyt2Rdd2PJq-c3ZEUOQbi7dr-8_PuBX4fl2Fl6YdYnylzRqRvaaEkoZ5TY29JiuRqphqN0oXFQ_hq-nJ4vZWbDt4BDkEv3KQAnvjfYq9GbsENtNhCfEiSArcjw3iuf5OPTcaO0Sb0OnJ5Y71AjSayGENOIJHBZl4Y6AhdHECietEUJJjSCM8utcKIxMuIotH8CbXpYZ7hD67aELV27qDB08VDwqjuQAnnZCzlYdlUcmpKKSsWQAw1aWuxsdmzPPUIgZCTGbpQs6PvvXga_h9tni83l2_nH-6Tnc4VQ10Sb8vIDDdbVxL-FWfr1e1tWrdtn-Bn9t9LM |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NitswEBbbbSl76X93018VSk5xN5Zky6anNN3Q0hJESWFvRrIkCOzawU4W3FMfoa_QV9sn2Rk7Tij0UOjJ2JaMzUgz34xnviHkLXM2GhvjgtCYNBAyNoFhFlyVXEhtOFhM7dtmE3I-T87PU3VA3ve1MB0_xC7ghjuj1de4wd3K-tM9a2i-Wr9jgLdvkdsikiEuaSbUvigyTZK-jRqgmLhnnh2z037m31DlnyC1tTKz-__1fg_IvS24pJNuNTwkB654RIaqY6duRnSxL7aqR3RI1Z63unlMfk_yzdrRjs-4pqWnql6CrWvAeaYT7CVOz8BgYrhnVelLWlZUYRDelFRVbpexTmG0pt90YcvL5Q9nRxRAurlw1z9_fYCvgvPtLLgw7RLlL3DUFO01JpRSzG1s8DFdjVRDQbthuKh-Qr7PzhbTT8G2g0OQC_ArA8m9N9rL0JuxA2wXcY-IE0BW7FhuJMvzceiZ0dql3oZOR5Y50AjCa865MPwpOSzKwp0QGsaR5U5Yw7kUGkAY5te5kBuRMplYNiBvellmsEPwt4cuXLmpM3DwQPHIJBYDctwJOVt1VB4ZFxJLxtIBGbay3N3o2JxZBkLMUIjZVC3w-OxfB74md9XHWfb18_zLc3LEsGiizfd5QQ7X1ca9JHfyq_Wyrl61q_YGNcj0Nw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Acute+Effects+of+Psilocybin+After+Escitalopram+or+Placebo+Pretreatment+in+a+Randomized%2C+Double%E2%80%90Blind%2C+Placebo%E2%80%90Controlled%2C+Crossover+Study+in+Healthy+Subjects&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.au=Becker%2C+Anna+M.&rft.au=Holze%2C+Friederike&rft.au=Grandinetti%2C+Tanja&rft.au=Klaiber%2C+Aaron&rft.date=2022-04-01&rft.issn=0009-9236&rft.eissn=1532-6535&rft.volume=111&rft.issue=4&rft.spage=886&rft.epage=895&rft_id=info:doi/10.1002%2Fcpt.2487&rft.externalDBID=10.1002%252Fcpt.2487&rft.externalDocID=CPT2487 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0009-9236&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0009-9236&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0009-9236&client=summon |