When Can Nonrandomized Studies Support Valid Inference Regarding Effectiveness or Safety of New Medical Treatments?

The randomized controlled trial (RCT) is the gold standard for evaluating the causal effects of medications. Limitations of RCTs have led to increasing interest in using real‐world evidence (RWE) to augment RCT evidence and inform decision making on medications. Although RWE can be either randomized...

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Bibliographic Details

Published in:	Clinical pharmacology and therapeutics Vol. 111; no. 1; pp. 108 - 115
Main Authors:	Franklin, Jessica M., Platt, Richard, Dreyer, Nancy A., London, Alex John, Simon, Gregory E., Watanabe, Jonathan H., Horberg, Michael, Hernandez, Adrian, Califf, Robert M.
Format:	Journal Article
Language:	English
Published:	United States 01.01.2022
Subjects:	Bias Confounding Factors, Epidemiologic Data Analysis Evidence-Based Medicine Humans Non-Randomized Controlled Trials as Topic - methods Therapeutics - adverse effects
ISSN:	0009-9236, 1532-6535, 1532-6535
Online Access:	Get full text
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