Reduced Intracortical Facilitation to TMS in Both Isolated REM Sleep Behavior Disorder (RBD) and Early Parkinson’s Disease with RBD

Background: a reduced intracortical facilitation (ICF), a transcranial magnetic stimulation (TMS) measure largely mediated by glutamatergic neurotransmission, was observed in subjects affected by isolated REM sleep behavior disorder (iRBD). However, direct comparison between iRBD and Parkinson’s dis...

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Vydáno v:Journal of clinical medicine Ročník 11; číslo 9; s. 2291
Hlavní autoři: Lanza, Giuseppe, Cosentino, Filomena Irene Ilaria, Lanuzza, Bartolo, Tripodi, Mariangela, Aricò, Debora, Figorilli, Michela, Puligheddu, Monica, Fisicaro, Francesco, Bella, Rita, Ferri, Raffaele, Pennisi, Manuela
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 20.04.2022
MDPI
Témata:
Behavior disorders
Clinical medicine
Magnetic fields
Neurons
Parkinson's disease
REM sleep
Sleep
Transcranial magnetic stimulation
parkinsonian syndrome
transcranial magnetic stimulation
neurotransmitters
REM sleep behavior disorder
cortical excitability
ISSN:2077-0383, 2077-0383
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Shrnutí:Background: a reduced intracortical facilitation (ICF), a transcranial magnetic stimulation (TMS) measure largely mediated by glutamatergic neurotransmission, was observed in subjects affected by isolated REM sleep behavior disorder (iRBD). However, direct comparison between iRBD and Parkinson’s disease (PD) with RBD is currently lacking. Methods: resting motor threshold, contralateral cortical silent period, amplitude and latency of motor evoked potentials, short-interval intracortical inhibition, and intracortical facilitation (ICF) were recorded from 15 drug-naïve iRBD patients, 15 drug-naïve PD with RBD patients, and 15 healthy participants from the right First Dorsal Interosseous muscle. REM sleep atonia index (RAI), Mini Mental State Examination (MMSE), Geriatric Depression Scale (GDS), and Epworth Sleepiness Scale (ESS) were assessed. Results: Groups were similar for sex, age, education, and patients for RBD duration and RAI. Neurological examination, MMSE, ESS, and GDS were normal in iRBD patients and controls; ESS scored worse in PD patients, but with no difference between groups at post hoc analysis. Compared to controls, both patient groups exhibited a significantly decreased ICF, without difference between them. Conclusions: iRBD and PD with RBD shared a reduced ICF, thus suggesting the involvement of glutamatergic transmission both in subjects at risk for degeneration and in those with an overt α-synucleinopathy.
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ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11092291