Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase

Central infusion of angiotensin IV or its more stable analogues facilitates memory retention and retrieval in normal animals and reverses amnesia induced by scopolamine or by bilateral perforant pathway lesions. These peptides bind with high affinity and specificity to a novel binding site designate...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 276; no. 52; p. 48623
Main Authors:	Albiston, A L, McDowall, S G, Matsacos, D, Sim, P, Clune, E, Mustafa, T, Lee, J, Mendelsohn, F A, Simpson, R J, Connolly, L M, Chai, S Y
Format:	Journal Article
Language:	English
Published:	United States 28.12.2001
Subjects:	Aminopeptidases - antagonists & inhibitors Aminopeptidases - genetics Aminopeptidases - isolation & purification Aminopeptidases - metabolism Angiotensin II - analogs & derivatives Angiotensin II - chemistry Angiotensin II - metabolism Angiotensin Receptor Antagonists Animals Autoradiography Brain - cytology Brain - enzymology Brain - metabolism Cell Line Cystinyl Aminopeptidase Hemoglobins - metabolism Humans Immunohistochemistry In Situ Hybridization Iodine Radioisotopes - chemistry Iodine Radioisotopes - metabolism Mice Mice, Inbred C57BL Peptide Fragments - metabolism Radioligand Assay Receptors, Angiotensin - genetics Receptors, Angiotensin - isolation & purification Receptors, Angiotensin - metabolism Recombinant Fusion Proteins - metabolism Transfection
ISSN:	0021-9258
Online Access:	Get more information
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