KIR2DL4 (CD158d) genotype influences expression and function in NK cells

The expression and function of the NK cell receptor KIR2DL4 are controversial. Two common alleles of the transmembrane domain of KIR2DL4 exist. The 10A allele with 10 adenines at the end of the transmembrane exon encodes a full length receptor, whereas the 9A allele has only 9 adenines resulting in...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 171; no. 4; p. 1768
Main Authors:	Goodridge, Jodie P, Witt, Campbell S, Christiansen, Frank T, Warren, Hilary S
Format:	Journal Article
Language:	English
Published:	United States 15.08.2003
Subjects:	Alleles Antibodies, Monoclonal - metabolism Antigen-Antibody Reactions - genetics CD56 Antigen - biosynthesis Cell Line, Transformed Cell Membrane - genetics Cell Membrane - immunology Cell Membrane - metabolism Cells, Cultured Cytotoxicity, Immunologic - genetics Exons - immunology Gene Expression Regulation - immunology Genotype Humans Immunoglobulins - genetics Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Lymphocyte Activation - genetics Molecular Sequence Data Protein Structure, Tertiary - genetics Receptors, Immunologic - biosynthesis Receptors, Immunologic - genetics Receptors, Immunologic - immunology Receptors, Immunologic - physiology Receptors, KIR Receptors, KIR2DL4 Transfection Tumor Cells, Cultured
ISSN:	0022-1767
Online Access:	Get more information
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