KIR2DL4 (CD158d) genotype influences expression and function in NK cells

The expression and function of the NK cell receptor KIR2DL4 are controversial. Two common alleles of the transmembrane domain of KIR2DL4 exist. The 10A allele with 10 adenines at the end of the transmembrane exon encodes a full length receptor, whereas the 9A allele has only 9 adenines resulting in...

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Vydáno v:	The Journal of immunology (1950) Ročník 171; číslo 4; s. 1768
Hlavní autoři:	Goodridge, Jodie P, Witt, Campbell S, Christiansen, Frank T, Warren, Hilary S
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 15.08.2003
Témata:	Alleles Antibodies, Monoclonal - metabolism Antigen-Antibody Reactions - genetics CD56 Antigen - biosynthesis Cell Line, Transformed Cell Membrane - genetics Cell Membrane - immunology Cell Membrane - metabolism Cells, Cultured Cytotoxicity, Immunologic - genetics Exons - immunology Gene Expression Regulation - immunology Genotype Humans Immunoglobulins - genetics Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Lymphocyte Activation - genetics Molecular Sequence Data Protein Structure, Tertiary - genetics Receptors, Immunologic - biosynthesis Receptors, Immunologic - genetics Receptors, Immunologic - immunology Receptors, Immunologic - physiology Receptors, KIR Receptors, KIR2DL4 Transfection Tumor Cells, Cultured
ISSN:	0022-1767
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