Functional genomic analysis identifies drug targetable pathways in invasive and metastatic cutaneous squamous cell carcinoma

Although cutaneous squamous cell carcinoma (cSCC) is treatable in the majority of cases, deadly invasive and metastatic cases do occur. To date there are neither reliable predictive biomarkers of disease progression nor FDA-approved targeted therapies as standard of care. To address these issues, we...

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Veröffentlicht in:	Cold Spring Harbor molecular case studies Jg. 6; H. 4
Hauptverfasser:	Anderson, Ashley N, McClanahan, Danielle, Jacobs, James, Jeng, Sophia, Vigoda, Myles, Blucher, Aurora S, Zheng, Christina, Yoo, Yeon Jung, Hale, Carolyn, Ouyang, Xiaoming, Clayburgh, Daniel, Andersen, Peter, Tyner, Jeffrey W, Bar, Anna, Lucero, Olivia M, Leitenberger, Justin J, McWeeney, Shannon K, Kulesz-Martin, Molly
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.08.2020
Schlagworte:	Aged Aged, 80 and over Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Survival - genetics Disease Progression Exome Sequencing - methods Gene Expression - genetics Gene Expression Regulation, Neoplastic - genetics Genomics - methods Humans Male Middle Aged Mutation - genetics Receptor, EphA6 - antagonists & inhibitors Receptor, EphA6 - metabolism Receptor, EphA7 - antagonists & inhibitors Receptor, EphA7 - metabolism Signal Transduction - genetics Skin Neoplasms - genetics Small Molecule Libraries - pharmacology squamous cell carcinoma of the skin
ISSN:	2373-2873, 2373-2873
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