Liver Function Tests in Workers with Occupational Exposure to Polychlorinated Biphenyls (PCBs): Comparison with Yusho and Yu-Cheng
The results of liver function tests in a population manufacturing capacitors and transformers are presented. Two clinical field examinations were performed, one in 1976 when PCBs were still used in the manufacturing of the electrical equipment and one at the end of 1979, 2.5 years after discontinuat...
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| Veröffentlicht in: | Environmental health perspectives Jg. 60; S. 145 - 150 |
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| Format: | Journal Article |
| Sprache: | Englisch |
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United States
National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare
01.05.1985
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| ISSN: | 0091-6765, 1552-9924 |
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| Abstract | The results of liver function tests in a population manufacturing capacitors and transformers are presented. Two clinical field examinations were performed, one in 1976 when PCBs were still used in the manufacturing of the electrical equipment and one at the end of 1979, 2.5 years after discontinuation of PCBs use. A low prevalence of abnormal liver function tests was found and mean values for all tests were within normal laboratory ranges. At the initial examination, weak, but statistically significant correlations were found between log LDH and plasma levels of log HPCB (higher chlorinated congeners of polychlorinated biphenyls) and log TPCB (total polychlorinated biphenyls) among the female workers, while log γ-GTP correlated significantly only with log HPCB among the male workers. A significant increase to abnormal levels of γ-GTP was noted at the follow-up examination in both male and female workers, and preliminary results indicate significant correlations between γ-GTP and serum levels of PCBs among the male workers. These findings are in accordance with previously reported data on populations occupationally exposed to PCBs, but differ from hepatic biochemistry findings in accidental poisonings due to ingestion of cooking oil contaminated with PCBs and related compounds, i.e., polychlorinated dibenzofurans (PCDFs) and polychlorinated quaterphenyls (PCQs). Hence, the importance of considering the related compounds as etiologic factors in PCB poisoning is emphasized. |
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| AbstractList | Liver function tests were administered to a population manufacturing capacitors and transfomers. One clinical field examination was performed when PCBs were still used in such manufacturing, and one was conducted after discontinuation of PCB use. A low prevalence of abnormal liver function tests was found. A significant increase to abnormal levels of glutamyl transpeptidase and serum levels of PCBs in workers was documented in the second exam. Findings are in accordance with previously reported data in populations occupationally exposed to PCBs, but differ from hepatic biochemistry findings in accidental poisonings due to ingestion of cooking oil contaminated with PCBs and related compounds. The results of liver function tests in a population manufacturing capacitors and transformers are presented. Two clinical field examinations were performed, one in 1976 when PCBs were still used in the manufacturing of the electrical equipment and one at the end of 1979, 2.5 years after discontinuation of PCBs use. A low prevalence of abnormal liver function tests was found and mean values for all tests were within normal laboratory ranges. At the initial examination, weak, but statistically significant correlations were found between log LDH and plasma levels of log HPCB (higher chlorinated congeners of polychlorinated biphenyls) and log TPCB (total polychlorinated biphenyls) among the female workers, while log gamma-GTP correlated significantly only with log HPCB among the male workers. A significant increase to abnormal levels of gamma-GTP was noted at the follow-up examination in both male and female workers, and preliminary results indicate significant correlations between gamma-GTP and serum levels of PCBs among the male workers. These findings are in accordance with previously reported data on populations occupationally exposed to PCBs, but differ from hepatic biochemistry findings in accidental poisonings due to ingestion of cooking oil contaminated with PCBs and related compounds, i.e., polychlorinated dibenzofurans (PCDFs) and polychlorinated quaterphenyls (PCQs). Hence, the importance of considering the related compounds as etiologic factors in PCB poisoning is emphasized. The results of liver function tests in a population manufacturing capacitors and transformers are presented. Two clinical field examinations were performed, one in 1976 when PCBs were still used in the manufacturing of the electrical equipment and one at the end of 1979, 2.5 years after discontinuation of PCBs use. A low prevalence of abnormal liver function tests was found and mean values for all tests were within normal laboratory ranges. A significant increase to abnormal levels of gamma -GTP was noted at the follow-up examination in both male and female workers, and preliminary results indicate significant correlations between gamma -GTP and serum levels of PCBs among the male workers. These findings are in accordance with previously reported data on populations occupationally exposed to PCBs, but differ from hepatic biochemistry findings in accidental poisonings due to ingestion of cooking oil contaminated with PCBs and related compounds, i.e., polychlorinated dibenzofurans (PCDFs) and polychlorinated quaterphenyls (PCQs). Hence, the importance of considering the related compounds as etiologic factors in PCB poisoning is emphasized. The results of liver function tests in a population manufacturing capacitors and transformers are presented. Two clinical field examinations were performed, one in 1976 when PCBs were still used in the manufacturing of the electrical equipment and one at the end of 1979, 2.5 years after discontinuation of PCBs use. A low prevalence of abnormal liver function tests was found and mean values for all tests were within normal laboratory ranges. At the initial examination, weak, but statistically significant correlations were found between log LDH and plasma levels of log HPCB (higher chlorinated congeners of polychlorinated biphenyls) and log TPCB (total polychlorinated biphenyls) among the female workers, while log γ-GTP correlated significantly only with log HPCB among the male workers. A significant increase to abnormal levels of γ-GTP was noted at the follow-up examination in both male and female workers, and preliminary results indicate significant correlations between γ-GTP and serum levels of PCBs among the male workers. These findings are in accordance with previously reported data on populations occupationally exposed to PCBs, but differ from hepatic biochemistry findings in accidental poisonings due to ingestion of cooking oil contaminated with PCBs and related compounds, i.e., polychlorinated dibenzofurans (PCDFs) and polychlorinated quaterphenyls (PCQs). Hence, the importance of considering the related compounds as etiologic factors in PCB poisoning is emphasized. The results of liver function tests in a population manufacturing capacitors and transformers are presented. Two clinical field examinations were performed, one in 1976 when PCBs were still used in the manufacturing of the electrical equipment and one at the end of 1979, 2.5 years after discontinuation of PCBs use. A low prevalence of abnormal liver function tests was found and mean values for all tests were within normal laboratory ranges. At the initial examination, weak, but statistically significant correlations were found between log LDH and plasma levels of log HPCB (higher chlorinated congeners of polychlorinated biphenyls) and log TPCB (total polychlorinated biphenyls) among the female workers, while log gamma-GTP correlated significantly only with log HPCB among the male workers. A significant increase to abnormal levels of gamma-GTP was noted at the follow-up examination in both male and female workers, and preliminary results indicate significant correlations between gamma-GTP and serum levels of PCBs among the male workers. These findings are in accordance with previously reported data on populations occupationally exposed to PCBs, but differ from hepatic biochemistry findings in accidental poisonings due to ingestion of cooking oil contaminated with PCBs and related compounds, i.e., polychlorinated dibenzofurans (PCDFs) and polychlorinated quaterphenyls (PCQs). Hence, the importance of considering the related compounds as etiologic factors in PCB poisoning is emphasized.The results of liver function tests in a population manufacturing capacitors and transformers are presented. Two clinical field examinations were performed, one in 1976 when PCBs were still used in the manufacturing of the electrical equipment and one at the end of 1979, 2.5 years after discontinuation of PCBs use. A low prevalence of abnormal liver function tests was found and mean values for all tests were within normal laboratory ranges. At the initial examination, weak, but statistically significant correlations were found between log LDH and plasma levels of log HPCB (higher chlorinated congeners of polychlorinated biphenyls) and log TPCB (total polychlorinated biphenyls) among the female workers, while log gamma-GTP correlated significantly only with log HPCB among the male workers. A significant increase to abnormal levels of gamma-GTP was noted at the follow-up examination in both male and female workers, and preliminary results indicate significant correlations between gamma-GTP and serum levels of PCBs among the male workers. These findings are in accordance with previously reported data on populations occupationally exposed to PCBs, but differ from hepatic biochemistry findings in accidental poisonings due to ingestion of cooking oil contaminated with PCBs and related compounds, i.e., polychlorinated dibenzofurans (PCDFs) and polychlorinated quaterphenyls (PCQs). Hence, the importance of considering the related compounds as etiologic factors in PCB poisoning is emphasized. |
| Author | Fischbein, Alf |
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| References | 6775528 - Am J Epidemiol. 1980 Oct;112(4):553-63 407043 - Clin Pharmacol Ther. 1977 Aug;22(2):140-6 13151867 - J Am Med Assoc. 1954 Apr 24;154(17):1417-8 6799628 - J Occup Med. 1982 Feb;24(2):109-14 821401 - Arch Environ Health. 1976 Jul-Aug;31(4):189-94 4346789 - Arch Environ Health. 1972 Nov;25(5):354-64 6451237 - Br J Ind Med. 1981 Feb;38(1):55-60 6422745 - Am J Ind Med. 1984;5(1-2):133-45 173869 - J Natl Cancer Inst. 1975 Dec;55(6):1453-9 4346086 - Gan. 1972 Dec;63(6):805 110206 - Ann N Y Acad Sci. 1979 May 31;320:703-15 6422750 - Am J Ind Med. 1984;5(1-2):59-68 6422749 - Am J Ind Med. 1984;5(1-2):45-58 6797353 - Arch Environ Health. 1981 Nov-Dec;36(6):321-6 4215571 - Chem Biol Interact. 1974 Nov;9(5):341-50 6802767 - Int Arch Occup Environ Health. 1982 Feb;49(3-4):199-208 4341899 - Toxicol Appl Pharmacol. 1972 Sep;23(1):112-22 6422747 - Am J Ind Med. 1984;5(1-2):19-30 6787990 - Arch Environ Health. 1981 May-Jun;36(3):120-9 6128023 - Br J Ind Med. 1982 Nov;39(4):361-9 2863133 - Environ Health Perspect. 1985 May;60:165-84 6230932 - Am J Ind Med. 1984;5(1-2):81-115 |
| References_xml | – reference: 4215571 - Chem Biol Interact. 1974 Nov;9(5):341-50 – reference: 2863133 - Environ Health Perspect. 1985 May;60:165-84 – reference: 110206 - Ann N Y Acad Sci. 1979 May 31;320:703-15 – reference: 4346086 - Gan. 1972 Dec;63(6):805 – reference: 6230932 - Am J Ind Med. 1984;5(1-2):81-115 – reference: 4346789 - Arch Environ Health. 1972 Nov;25(5):354-64 – reference: 407043 - Clin Pharmacol Ther. 1977 Aug;22(2):140-6 – reference: 821401 - Arch Environ Health. 1976 Jul-Aug;31(4):189-94 – reference: 6802767 - Int Arch Occup Environ Health. 1982 Feb;49(3-4):199-208 – reference: 6422750 - Am J Ind Med. 1984;5(1-2):59-68 – reference: 6422749 - Am J Ind Med. 1984;5(1-2):45-58 – reference: 6775528 - Am J Epidemiol. 1980 Oct;112(4):553-63 – reference: 6787990 - Arch Environ Health. 1981 May-Jun;36(3):120-9 – reference: 6797353 - Arch Environ Health. 1981 Nov-Dec;36(6):321-6 – reference: 4341899 - Toxicol Appl Pharmacol. 1972 Sep;23(1):112-22 – reference: 6422745 - Am J Ind Med. 1984;5(1-2):133-45 – reference: 6799628 - J Occup Med. 1982 Feb;24(2):109-14 – reference: 173869 - J Natl Cancer Inst. 1975 Dec;55(6):1453-9 – reference: 6422747 - Am J Ind Med. 1984;5(1-2):19-30 – reference: 6451237 - Br J Ind Med. 1981 Feb;38(1):55-60 – reference: 6128023 - Br J Ind Med. 1982 Nov;39(4):361-9 – reference: 13151867 - J Am Med Assoc. 1954 Apr 24;154(17):1417-8 |
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| SubjectTerms | Adult Biologic Indicators of Human Toxicity Blood plasma Capacitors Chemical and Drug Induced Liver Injury Correlations Dielectric materials Electricity Female Follow-Up Studies gamma-Glutamyltransferase - analysis Humans Liver Liver function Liver Function Tests Male Metabolism Middle Aged Occupational Diseases - chemically induced Poisoning Polychlorinated biphenyls Polychlorinated Biphenyls - adverse effects Polychlorinated Biphenyls - blood Polychlorinated Biphenyls - poisoning |
| Title | Liver Function Tests in Workers with Occupational Exposure to Polychlorinated Biphenyls (PCBs): Comparison with Yusho and Yu-Cheng |
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