Analysis of RNA Interference Targeted Against Human Antigen R (HuR) to Reduce Vascular Endothelial Growth Factor (VEGF) Protein Expression in Human Retinal Pigment Epithelial Cells

VEGF-A or vascular endothelial growth factor-A is an important factor in enabling neovascularization and angiogenesis. VEGF-A is regulated transcriptionally as well as post transcriptionally. Human antigen R (HuR) belonging to the embryonic lethal abnormal vision (ELAV) family is a key regulator pro...

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Bibliographic Details
Published in:	Molecular biotechnology Vol. 66; no. 10; pp. 2972 - 2984
Main Authors:	Supe, Shibani, Dighe, Vikas, Upadhya, Archana, Singh, Kavita
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.10.2024 Springer Nature B.V
Subjects:	Angiogenesis Antigens Biochemistry Biological Techniques Biotechnology Cell Biology Cell Line Chemistry Chemistry and Materials Science Diabetes mellitus Diabetic retinopathy Down-Regulation ELAV-Like Protein 1 - genetics ELAV-Like Protein 1 - metabolism Epithelial Cells - metabolism Epithelium family Gene expression Gene sequencing Growth factors Human Genetics Humans HuR protein Original Paper Pigments Protein Science protein synthesis Proteins Reagents Real time Retina Retinal pigment epithelium Retinal Pigment Epithelium - cytology Retinal Pigment Epithelium - metabolism Retinopathy RNA Interference RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RNA-mediated interference siRNA therapeutics transcription (genetics) Transfection Vascular endothelial growth factor vascular endothelial growth factor A Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascularization vision Western blotting siRNA RNA interference VEGF-A HuR/ELAV
ISSN:	1073-6085, 1559-0305, 1559-0305
Online Access:	Get full text
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