Skin permeation and metabolism of di(2-ethylhexyl) phthalate (DEHP)

•DEHP is extensively metabolized in vitro in human viable skin.•DEHP pass readily through human skin when emulsified in aqueous solution.•Percutaneous permeation of DEHP should be considered in risk assessments. Phthalates are suspected to be endocrine disruptors. Di(2-ethylhexyl) phthalate (DEHP) i...

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Bibliographic Details
Published in:	Toxicology letters Vol. 224; no. 1; pp. 47 - 53
Main Authors:	Hopf, N.B., Berthet, A., Vernez, D., Langard, E., Spring, P., Gaudin, R.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ireland Ltd 03.01.2014
Subjects:	117-81-7 DEHP Di(2-ethylhexyl) phthalate Diethylhexyl Phthalate - metabolism Human Humans Percutaneous permeation Permeability Skin Skin - metabolism 117-81-7 τ MEHP Kp DiNP J EFSA SC 5cx-MEPP BSA DiDP DBP GHS OECD DEHP TDI 5OH-MEHP ESI MBP 5oxo-MEHP HPLC Human TEWL DAD 2cx-MMHP Percutaneous permeation EU HGP Di(2-ethylhexyl) phthalate CV EPA Skin HMWP permeation coefficient permeation rate a high-performance liquid chromatograph stratum corneum mono-(2-ethylhexyl) phthalate diisononyl phthalate High-molecular-weight phthalates European Food Safety Authority diethyl hexyl phthalate mono-(2-ethyl-5-hydroxyhexyl) phthalate mono-(2-ethyl-5-carboxypentyl) phthalate mono(2-(carboxymethyl)hexyl) phthalate mono-butyl phthalate bovine serum albumin US Environmental Protection Agency Tolerable Daily Intake trans epidermal water loss diisodecyl phthalate coefficients of variation globally harmonized system of classification and labelling of chemicals di-butyl phthalate mono-(2-ethyl-5-oxohexyl) phthalate dermally absorbed dose lag time hairless guinea pig European Union electrospray interface Organisation for Economic Co-operation and Development
ISSN:	0378-4274, 1879-3169, 1879-3169
Online Access:	Get full text
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