Modular Engineering of a Synthetic Biology-Based Platform for Sustainable Bioremediation of Residual Antibiotics in Aquatic Environments
[Display omitted] •FerTiG is designed as a multienzyme complex to degrade tetracycline residues;•GDH module fuels FerTiG to spontaneously degrade tetracycline residues;•Ferritin module renders FerTiG resilient to the environmental stresses;•FerTiG robustly eliminated tetracycline from multiple envir...
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| Published in: | Engineering (Beijing, China) Vol. 53; pp. 231 - 244 |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier Ltd
01.10.2025
Elsevier |
| Subjects: | |
| ISSN: | 2095-8099 |
| Online Access: | Get full text |
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| Abstract | [Display omitted]
•FerTiG is designed as a multienzyme complex to degrade tetracycline residues;•GDH module fuels FerTiG to spontaneously degrade tetracycline residues;•Ferritin module renders FerTiG resilient to the environmental stresses;•FerTiG robustly eliminated tetracycline from multiple environment matrices;•FerTiG displays no eco- or biosafety concerns for application.
Tetracycline (TC) residues from anthropogenic activities undesirably present in nature as an emerging sustainability challenge and thereby require innovations in remediation technologies. Herein, as inspired by the microcompartment structure in living organisms, we adopt a synthetic biology approach to engineer the FerTiG, a modular enzyme assembly, to robustly scavenge TC residues with improved performance. The FerTiG consists of three functional modules, namely, a TC degradation module (Tet(X4)), a cofactor recycling module glucose dehydrogenase (GDH) , and a protection module (ferritin), to organize diverse catalytic processes simultaneously as a biological circuit. The incorporation of GDH suitably fuels the FerTiG-dependent TC degradation by regenerating expensive nicotinamide adenine dinucleotide phosphate (NADPH) cofactor with glucose. The ferritin shields the catalytic core of FerTiG to resiliently decompose TC under unfavorable conditions. Due to collaboration among functional modules, FerTiG strongly catalyzes the residual TC removal from multiple environmental matrices. The degradation pathways and environmental/biological safety of FerTiG are then elaborated, indicating the promising readiness for the application of FerTiG. In summary, this work presents a synthetic biology-based strategy to spontaneously impose residual antibiotic biodegradation for better sustainability management. The FerTiG is engineered as a proof-of-principle for TC removal; however, this ‘microcompartment-mimicking’ concept is of great interest in mitigating other sustainability challenges where modular catalytic machinery is applied. |
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| AbstractList | [Display omitted]
•FerTiG is designed as a multienzyme complex to degrade tetracycline residues;•GDH module fuels FerTiG to spontaneously degrade tetracycline residues;•Ferritin module renders FerTiG resilient to the environmental stresses;•FerTiG robustly eliminated tetracycline from multiple environment matrices;•FerTiG displays no eco- or biosafety concerns for application.
Tetracycline (TC) residues from anthropogenic activities undesirably present in nature as an emerging sustainability challenge and thereby require innovations in remediation technologies. Herein, as inspired by the microcompartment structure in living organisms, we adopt a synthetic biology approach to engineer the FerTiG, a modular enzyme assembly, to robustly scavenge TC residues with improved performance. The FerTiG consists of three functional modules, namely, a TC degradation module (Tet(X4)), a cofactor recycling module glucose dehydrogenase (GDH) , and a protection module (ferritin), to organize diverse catalytic processes simultaneously as a biological circuit. The incorporation of GDH suitably fuels the FerTiG-dependent TC degradation by regenerating expensive nicotinamide adenine dinucleotide phosphate (NADPH) cofactor with glucose. The ferritin shields the catalytic core of FerTiG to resiliently decompose TC under unfavorable conditions. Due to collaboration among functional modules, FerTiG strongly catalyzes the residual TC removal from multiple environmental matrices. The degradation pathways and environmental/biological safety of FerTiG are then elaborated, indicating the promising readiness for the application of FerTiG. In summary, this work presents a synthetic biology-based strategy to spontaneously impose residual antibiotic biodegradation for better sustainability management. The FerTiG is engineered as a proof-of-principle for TC removal; however, this ‘microcompartment-mimicking’ concept is of great interest in mitigating other sustainability challenges where modular catalytic machinery is applied. Tetracycline (TC) residues from anthropogenic activities undesirably present in nature as an emerging sustainability challenge and thereby require innovations in remediation technologies. Herein, as inspired by the microcompartment structure in living organisms, we adopt a synthetic biology approach to engineer the FerTiG, a modular enzyme assembly, to robustly scavenge TC residues with improved performance. The FerTiG consists of three functional modules, namely, a TC degradation module (Tet(X4)), a cofactor recycling module glucose dehydrogenase (GDH) , and a protection module (ferritin), to organize diverse catalytic processes simultaneously as a biological circuit. The incorporation of GDH suitably fuels the FerTiG-dependent TC degradation by regenerating expensive nicotinamide adenine dinucleotide phosphate (NADPH) cofactor with glucose. The ferritin shields the catalytic core of FerTiG to resiliently decompose TC under unfavorable conditions. Due to collaboration among functional modules, FerTiG strongly catalyzes the residual TC removal from multiple environmental matrices. The degradation pathways and environmental/biological safety of FerTiG are then elaborated, indicating the promising readiness for the application of FerTiG. In summary, this work presents a synthetic biology-based strategy to spontaneously impose residual antibiotic biodegradation for better sustainability management. The FerTiG is engineered as a proof-of-principle for TC removal; however, this ‘microcompartment-mimicking’ concept is of great interest in mitigating other sustainability challenges where modular catalytic machinery is applied. |
| Author | Ren, Hao Zhong, Jiahao Li, Yuze Li, Zemiao Zhao, Donghao Lian, Xinlei Liao, Xiaoping Zhang, Lin Jiang, Hongxia Qin, Meilin He, Qian Sun, Jian |
| Author_xml | – sequence: 1 givenname: Hao surname: Ren fullname: Ren, Hao email: hao.ren@scau.edu.cn organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 2 givenname: Meilin surname: Qin fullname: Qin, Meilin organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 3 givenname: Lin surname: Zhang fullname: Zhang, Lin organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 4 givenname: Zemiao surname: Li fullname: Li, Zemiao organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 5 givenname: Yuze surname: Li fullname: Li, Yuze organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 6 givenname: Qian surname: He fullname: He, Qian organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 7 givenname: Jiahao surname: Zhong fullname: Zhong, Jiahao organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 8 givenname: Donghao surname: Zhao fullname: Zhao, Donghao organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 9 givenname: Xinlei surname: Lian fullname: Lian, Xinlei organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 10 givenname: Hongxia surname: Jiang fullname: Jiang, Hongxia organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 11 givenname: Xiaoping surname: Liao fullname: Liao, Xiaoping organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 12 givenname: Jian surname: Sun fullname: Sun, Jian email: jiansun@scau.edu.cn organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China |
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| Keywords | Tetracycline biodegradation Environmental remediation Modular enzyme assembly Living-organism-inspired system Antibiotic residues |
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•FerTiG is designed as a multienzyme complex to degrade tetracycline residues;•GDH module fuels FerTiG to spontaneously degrade tetracycline... Tetracycline (TC) residues from anthropogenic activities undesirably present in nature as an emerging sustainability challenge and thereby require innovations... |
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| SubjectTerms | Antibiotic residues Environmental remediation Living-organism-inspired system Modular enzyme assembly Tetracycline biodegradation |
| Title | Modular Engineering of a Synthetic Biology-Based Platform for Sustainable Bioremediation of Residual Antibiotics in Aquatic Environments |
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