Modular Engineering of a Synthetic Biology-Based Platform for Sustainable Bioremediation of Residual Antibiotics in Aquatic Environments
[Display omitted] •FerTiG is designed as a multienzyme complex to degrade tetracycline residues;•GDH module fuels FerTiG to spontaneously degrade tetracycline residues;•Ferritin module renders FerTiG resilient to the environmental stresses;•FerTiG robustly eliminated tetracycline from multiple envir...
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| Vydáno v: | Engineering (Beijing, China) Ročník 53; s. 231 - 244 |
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| Hlavní autoři: | , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Elsevier Ltd
01.10.2025
Elsevier |
| Témata: | |
| ISSN: | 2095-8099 |
| On-line přístup: | Získat plný text |
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| Abstract | [Display omitted]
•FerTiG is designed as a multienzyme complex to degrade tetracycline residues;•GDH module fuels FerTiG to spontaneously degrade tetracycline residues;•Ferritin module renders FerTiG resilient to the environmental stresses;•FerTiG robustly eliminated tetracycline from multiple environment matrices;•FerTiG displays no eco- or biosafety concerns for application.
Tetracycline (TC) residues from anthropogenic activities undesirably present in nature as an emerging sustainability challenge and thereby require innovations in remediation technologies. Herein, as inspired by the microcompartment structure in living organisms, we adopt a synthetic biology approach to engineer the FerTiG, a modular enzyme assembly, to robustly scavenge TC residues with improved performance. The FerTiG consists of three functional modules, namely, a TC degradation module (Tet(X4)), a cofactor recycling module glucose dehydrogenase (GDH) , and a protection module (ferritin), to organize diverse catalytic processes simultaneously as a biological circuit. The incorporation of GDH suitably fuels the FerTiG-dependent TC degradation by regenerating expensive nicotinamide adenine dinucleotide phosphate (NADPH) cofactor with glucose. The ferritin shields the catalytic core of FerTiG to resiliently decompose TC under unfavorable conditions. Due to collaboration among functional modules, FerTiG strongly catalyzes the residual TC removal from multiple environmental matrices. The degradation pathways and environmental/biological safety of FerTiG are then elaborated, indicating the promising readiness for the application of FerTiG. In summary, this work presents a synthetic biology-based strategy to spontaneously impose residual antibiotic biodegradation for better sustainability management. The FerTiG is engineered as a proof-of-principle for TC removal; however, this ‘microcompartment-mimicking’ concept is of great interest in mitigating other sustainability challenges where modular catalytic machinery is applied. |
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| AbstractList | [Display omitted]
•FerTiG is designed as a multienzyme complex to degrade tetracycline residues;•GDH module fuels FerTiG to spontaneously degrade tetracycline residues;•Ferritin module renders FerTiG resilient to the environmental stresses;•FerTiG robustly eliminated tetracycline from multiple environment matrices;•FerTiG displays no eco- or biosafety concerns for application.
Tetracycline (TC) residues from anthropogenic activities undesirably present in nature as an emerging sustainability challenge and thereby require innovations in remediation technologies. Herein, as inspired by the microcompartment structure in living organisms, we adopt a synthetic biology approach to engineer the FerTiG, a modular enzyme assembly, to robustly scavenge TC residues with improved performance. The FerTiG consists of three functional modules, namely, a TC degradation module (Tet(X4)), a cofactor recycling module glucose dehydrogenase (GDH) , and a protection module (ferritin), to organize diverse catalytic processes simultaneously as a biological circuit. The incorporation of GDH suitably fuels the FerTiG-dependent TC degradation by regenerating expensive nicotinamide adenine dinucleotide phosphate (NADPH) cofactor with glucose. The ferritin shields the catalytic core of FerTiG to resiliently decompose TC under unfavorable conditions. Due to collaboration among functional modules, FerTiG strongly catalyzes the residual TC removal from multiple environmental matrices. The degradation pathways and environmental/biological safety of FerTiG are then elaborated, indicating the promising readiness for the application of FerTiG. In summary, this work presents a synthetic biology-based strategy to spontaneously impose residual antibiotic biodegradation for better sustainability management. The FerTiG is engineered as a proof-of-principle for TC removal; however, this ‘microcompartment-mimicking’ concept is of great interest in mitigating other sustainability challenges where modular catalytic machinery is applied. Tetracycline (TC) residues from anthropogenic activities undesirably present in nature as an emerging sustainability challenge and thereby require innovations in remediation technologies. Herein, as inspired by the microcompartment structure in living organisms, we adopt a synthetic biology approach to engineer the FerTiG, a modular enzyme assembly, to robustly scavenge TC residues with improved performance. The FerTiG consists of three functional modules, namely, a TC degradation module (Tet(X4)), a cofactor recycling module glucose dehydrogenase (GDH) , and a protection module (ferritin), to organize diverse catalytic processes simultaneously as a biological circuit. The incorporation of GDH suitably fuels the FerTiG-dependent TC degradation by regenerating expensive nicotinamide adenine dinucleotide phosphate (NADPH) cofactor with glucose. The ferritin shields the catalytic core of FerTiG to resiliently decompose TC under unfavorable conditions. Due to collaboration among functional modules, FerTiG strongly catalyzes the residual TC removal from multiple environmental matrices. The degradation pathways and environmental/biological safety of FerTiG are then elaborated, indicating the promising readiness for the application of FerTiG. In summary, this work presents a synthetic biology-based strategy to spontaneously impose residual antibiotic biodegradation for better sustainability management. The FerTiG is engineered as a proof-of-principle for TC removal; however, this ‘microcompartment-mimicking’ concept is of great interest in mitigating other sustainability challenges where modular catalytic machinery is applied. |
| Author | Ren, Hao Zhong, Jiahao Li, Yuze Li, Zemiao Zhao, Donghao Lian, Xinlei Liao, Xiaoping Zhang, Lin Jiang, Hongxia Qin, Meilin He, Qian Sun, Jian |
| Author_xml | – sequence: 1 givenname: Hao surname: Ren fullname: Ren, Hao email: hao.ren@scau.edu.cn organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 2 givenname: Meilin surname: Qin fullname: Qin, Meilin organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 3 givenname: Lin surname: Zhang fullname: Zhang, Lin organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 4 givenname: Zemiao surname: Li fullname: Li, Zemiao organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 5 givenname: Yuze surname: Li fullname: Li, Yuze organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 6 givenname: Qian surname: He fullname: He, Qian organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 7 givenname: Jiahao surname: Zhong fullname: Zhong, Jiahao organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 8 givenname: Donghao surname: Zhao fullname: Zhao, Donghao organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 9 givenname: Xinlei surname: Lian fullname: Lian, Xinlei organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 10 givenname: Hongxia surname: Jiang fullname: Jiang, Hongxia organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 11 givenname: Xiaoping surname: Liao fullname: Liao, Xiaoping organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China – sequence: 12 givenname: Jian surname: Sun fullname: Sun, Jian email: jiansun@scau.edu.cn organization: State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou 510642, China |
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| Cites_doi | 10.1016/j.mib.2019.10.008 10.1038/s41545-020-00087-x 10.1016/j.biotechadv.2011.05.020 10.1016/S1473-3099(20)30456-4 10.1021/nn403184u 10.1016/j.envint.2018.02.003 10.1016/j.eti.2021.101757 10.1016/j.envint.2024.108535 10.1016/j.watres.2023.119940 10.1021/ja0655690 10.1016/j.eti.2020.100630 10.1016/j.scitotenv.2021.152852 10.1042/bse0590001 10.1016/j.soilbio.2012.11.009 10.1074/jbc.M110.160580 10.1016/j.scitotenv.2020.141975 10.1016/j.ecoenv.2020.110214 10.1016/j.jhazmat.2021.125448 10.1016/j.envpol.2023.122904 10.1016/j.cmi.2019.06.030 10.1016/j.cej.2019.03.108 10.1002/ece3.6672 10.1016/j.envpol.2016.10.044 10.1021/acs.chemrev.7b00552 10.1016/j.cell.2023.07.038 10.1016/j.talanta.2020.121695 10.1021/acsabm.0c00961 10.1016/j.jenvman.2016.02.046 10.1016/j.scitotenv.2021.145291 10.1016/j.jhazmat.2017.11.036 10.1016/j.apcatb.2020.119218 10.1007/s10295-013-1325-z 10.1155/2017/1315497 10.1016/S1473-3099(18)30296-2 10.1021/acs.analchem.7b05217 10.1073/pnas.1503141112 10.1016/j.procbio.2008.06.004 10.1016/j.jhazmat.2024.134076 10.1021/bi0506066 10.1038/s41564-019-0496-4 10.1021/ja01595a084 10.1021/acsnano.8b04758 10.1016/j.jhazmat.2012.01.032 10.1186/s12302-021-00505-y 10.1016/j.chemosphere.2020.126351 10.1016/j.jhazmat.2020.122813 10.1007/s10311-013-0404-8 10.1016/j.envint.2023.108158 10.1016/j.jhazmat.2019.120807 10.1073/pnas.1717295115 10.1016/j.cej.2020.126363 10.1016/j.scitotenv.2024.173125 10.7150/thno.19738 10.1007/s10311-021-01295-8 10.1016/j.cej.2023.141576 10.4491/eer.2019.405 10.1016/j.scitotenv.2021.149360 10.1038/s42003-022-03465-y 10.1016/j.envpol.2018.10.029 10.1016/j.synbio.2018.05.001 10.1002/smll.201201492 10.1038/s41392-020-00326-0 10.1016/j.ecoenv.2021.113063 10.1016/S2542-5196(17)30141-9 |
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| Keywords | Tetracycline biodegradation Environmental remediation Modular enzyme assembly Living-organism-inspired system Antibiotic residues |
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| References | Cheng, Cheung, Liu, Chan, Wong, Zhang (b0215) 2022; 5 Hutchings, Truman, Wilkinson (b0005) 2019; 51 Sun, Ye, Jiao, Feng, Yu, Liu (b0095) 2018; 345 Kovalakova, Cizmas, McDonald, Marsalek, Feng, Sharma (b0055) 2020; 251 Ahmad, Zhu, Sun (b0285) 2021; 33 Hanna, Sun, Sun, Li, Yang, Ji (b0090) 2018; 114 Wen, Huang, Cao, Xu, Mi, Wang (b0125) 2020; 191 Bhagat, Kumar, Tyagi, Mohapatra (b0225) 2020; 3 McCormick, Fox, Smith, Bitler, Reichenthal, Origoni (b0300) 1956; 78 Huang, An, Moran, Liu (b0075) 2020; 399 Scaria, Anupama, Nidheesh (b0220) 2021; 771 Moore, Hughes, Wright (b0290) 2005; 44 Klein, Van Boeckel, Martinez, Pant, Gandra, Levin (b0020) 2018; 115 Ren, Pan, Zhong, Wang, Lu, He (b0150) 2023; 459 Roberts, Zembower (b0035) 2021; 21 Crowley, Cascio, Sawaya, Kopstein, Bobik, Yeates (b0170) 2010; 285 Iyer, Ananthanarayan (b0260) 2008; 43 Krishnan, Manikandan, Subbaiya, Biruntha, Govarthanan, Karmegam (b0105) 2021; 23 Hassan, Zhu, Lu, Alfalahi, Lu, Huang (b0230) 2020; 26 Uchida, Flenniken, Allen, Willits, Crowley, Brumfield (b0190) 2006; 128 Topal, Uslu Şenel, ÖBEK, Arslan Topal (b0115) 2016; 173 Daghrir, Drogui (b0085) 2013; 11 Zhang, Zhou, Chen, Wang, Cai (b0305) 2019; 369 Van Boeckel, Brower, Gilbert, Grenfell, Levin, Robinson (b0025) 2015; 112 Granados-Chinchilla, Rodríguez (b0050) 2017; 2017 Ju, Lin, Tian, Xie, Xu (b0210) 2020; 5 Tang, Yang, Yu, Xiong, Zhang (b0255) 2024; 185 Nelson, Levy (b0045) 2011; 124 Qin, Wang, Fu, Lai, Liu, Li (b0325) 2021; 414 Yang, Liu, Wang, Cao (b0335) 2013; 9 Chen, Liu, Zhang, Wu, Huang, Yang (b0310) 2020; 277 Wang, Dong, Zang, Zhao, Jiang, Jiang (b0275) 2023; 236 Lyu, Yang, Zhang, Ye, Wang (b0080) 2020; 266 Gao, Fan, Yan (b0205) 2017; 7 Tang, Caffrey, Nóbrega, Cork, Ronksley, Barkema (b0030) 2017; 1 Buckley, Henschke, Bergman, Skidmore, Klemm, Villanueva (b0040) 2019; 25 Fan, Jiang, Guan, He, Yang, Xie (b0175) 2018; 90 Shukla, Peoples, Ludwig, Maity, Derks, De Benedetti (b0245) 2023; 186 Xu, Zhang, Xiong, Zhu, Liao, Jiang (b0070) 2021; 753 Jeon, Kim, Choi, Shin, Cha, So (b0185) 2013; 7 Chen, Men, Sun, Zhang, Yuan, Hu (b0195) 2020; 3 He, Lin, Qin, Huang, Lu, Zheng (b0145) 2023; 179 Mazumder, Das, Sen, Bhattacharjee (b0240) 2020; 17 Naik, Singamaneni (b0160) 2017; 117 Menz, Olsson, Kümmerer (b0110) 2019; 379 Chen, Yang, Ke, Chen, Xie (b0130) 2022; 814 Wu, Dai, Feng, Karunaratne, Yang, Zhang (b0100) 2024; 341 Martín-Sanz, Valverde-Asenjo, de Santiago-Martín, Quintana-Nieto, González-Huecas, López-Lafuente (b0235) 2018; 243 Mann, Nehra, Rana, Dahiya (b0015) 2021; 2 Kamal, Saha, Singh, Pandey, Bhargava (b0165) 2024; 470 Xie, Yang, Li, Wu, Shen, Zhao (b0065) 2016; 219 He, Kai, Ding (b0315) 2021; 19 Maroga Mboula, Héquet, Gru, Colin, Andrès (b0120) 2012; 209–10 Wu, Liu, Liu, He, Arif, Li (b0280) 2024; 933 Zhong, Yang, Xiong, Cai, Lan, Ying (b0180) 2022; 229 Burns, DeForest, Marxsen, Sinsabaugh, Stromberger, Wallenstein (b0265) 2013; 58 Gomez, Delgado, Gonzalez (b0270) 2020; 10 Huo, Yang, Niu, Zhu, Zeng, Lai (b0320) 2021; 403 Allahverdiyeva, Yardım, Şentürk (b0295) 2021; 223 Fadeel, Bussy, Merino, Vázquez, Flahaut, Mouchet (b0330) 2018; 12 Mu, Zou, Yang, Wang, Xu, Huang (b0135) 2018; 3 Demain (b0060) 2014; 41 Zhang (b0200) 2011; 29 He, Cui, Zhang, Lin, Jia, Li (b0140) 2021; 799 Sun, Chen, Cui, Zhang, Liu, Cui (b0155) 2019; 4 Chatterjee, Modarai, Naylor, Boyd, Atun, Barlow (b0010) 2018; 18 Robinson (b0250) 2015; 59 Granados-Chinchilla (10.1016/j.eng.2025.03.033_b0050) 2017; 2017 Chen (10.1016/j.eng.2025.03.033_b0130) 2022; 814 Zhang (10.1016/j.eng.2025.03.033_b0200) 2011; 29 Iyer (10.1016/j.eng.2025.03.033_b0260) 2008; 43 Gomez (10.1016/j.eng.2025.03.033_b0270) 2020; 10 Buckley (10.1016/j.eng.2025.03.033_b0040) 2019; 25 Zhang (10.1016/j.eng.2025.03.033_b0305) 2019; 369 Mann (10.1016/j.eng.2025.03.033_b0015) 2021; 2 Van Boeckel (10.1016/j.eng.2025.03.033_b0025) 2015; 112 Maroga Mboula (10.1016/j.eng.2025.03.033_b0120) 2012; 209–10 Robinson (10.1016/j.eng.2025.03.033_b0250) 2015; 59 Fadeel (10.1016/j.eng.2025.03.033_b0330) 2018; 12 Yang (10.1016/j.eng.2025.03.033_b0335) 2013; 9 Klein (10.1016/j.eng.2025.03.033_b0020) 2018; 115 Sun (10.1016/j.eng.2025.03.033_b0095) 2018; 345 Daghrir (10.1016/j.eng.2025.03.033_b0085) 2013; 11 Wu (10.1016/j.eng.2025.03.033_b0280) 2024; 933 Mu (10.1016/j.eng.2025.03.033_b0135) 2018; 3 Xie (10.1016/j.eng.2025.03.033_b0065) 2016; 219 Ahmad (10.1016/j.eng.2025.03.033_b0285) 2021; 33 Nelson (10.1016/j.eng.2025.03.033_b0045) 2011; 124 Sun (10.1016/j.eng.2025.03.033_b0155) 2019; 4 Chen (10.1016/j.eng.2025.03.033_b0310) 2020; 277 Ju (10.1016/j.eng.2025.03.033_b0210) 2020; 5 Tang (10.1016/j.eng.2025.03.033_b0255) 2024; 185 Uchida (10.1016/j.eng.2025.03.033_b0190) 2006; 128 Scaria (10.1016/j.eng.2025.03.033_b0220) 2021; 771 Krishnan (10.1016/j.eng.2025.03.033_b0105) 2021; 23 McCormick (10.1016/j.eng.2025.03.033_b0300) 1956; 78 Qin (10.1016/j.eng.2025.03.033_b0325) 2021; 414 Kamal (10.1016/j.eng.2025.03.033_b0165) 2024; 470 Gao (10.1016/j.eng.2025.03.033_b0205) 2017; 7 Hassan (10.1016/j.eng.2025.03.033_b0230) 2020; 26 Wen (10.1016/j.eng.2025.03.033_b0125) 2020; 191 Chatterjee (10.1016/j.eng.2025.03.033_b0010) 2018; 18 Kovalakova (10.1016/j.eng.2025.03.033_b0055) 2020; 251 Chen (10.1016/j.eng.2025.03.033_b0195) 2020; 3 Fan (10.1016/j.eng.2025.03.033_b0175) 2018; 90 Zhong (10.1016/j.eng.2025.03.033_b0180) 2022; 229 Tang (10.1016/j.eng.2025.03.033_b0030) 2017; 1 Wang (10.1016/j.eng.2025.03.033_b0275) 2023; 236 Roberts (10.1016/j.eng.2025.03.033_b0035) 2021; 21 Bhagat (10.1016/j.eng.2025.03.033_b0225) 2020; 3 Martín-Sanz (10.1016/j.eng.2025.03.033_b0235) 2018; 243 He (10.1016/j.eng.2025.03.033_b0315) 2021; 19 Hutchings (10.1016/j.eng.2025.03.033_b0005) 2019; 51 He (10.1016/j.eng.2025.03.033_b0145) 2023; 179 Hanna (10.1016/j.eng.2025.03.033_b0090) 2018; 114 Mazumder (10.1016/j.eng.2025.03.033_b0240) 2020; 17 Burns (10.1016/j.eng.2025.03.033_b0265) 2013; 58 Wu (10.1016/j.eng.2025.03.033_b0100) 2024; 341 Demain (10.1016/j.eng.2025.03.033_b0060) 2014; 41 Crowley (10.1016/j.eng.2025.03.033_b0170) 2010; 285 Huo (10.1016/j.eng.2025.03.033_b0320) 2021; 403 Moore (10.1016/j.eng.2025.03.033_b0290) 2005; 44 He (10.1016/j.eng.2025.03.033_b0140) 2021; 799 Allahverdiyeva (10.1016/j.eng.2025.03.033_b0295) 2021; 223 Topal (10.1016/j.eng.2025.03.033_b0115) 2016; 173 Menz (10.1016/j.eng.2025.03.033_b0110) 2019; 379 Naik (10.1016/j.eng.2025.03.033_b0160) 2017; 117 Jeon (10.1016/j.eng.2025.03.033_b0185) 2013; 7 Ren (10.1016/j.eng.2025.03.033_b0150) 2023; 459 Xu (10.1016/j.eng.2025.03.033_b0070) 2021; 753 Cheng (10.1016/j.eng.2025.03.033_b0215) 2022; 5 Lyu (10.1016/j.eng.2025.03.033_b0080) 2020; 266 Shukla (10.1016/j.eng.2025.03.033_b0245) 2023; 186 Huang (10.1016/j.eng.2025.03.033_b0075) 2020; 399 |
| References_xml | – volume: 345 start-page: 131 year: 2018 end-page: 139 ident: b0095 article-title: Changes in tetracycline partitioning and bacteria/phage-comediated ARGs in microplastic-contaminated greenhouse soil facilitated by sophorolipid publication-title: J Hazard Mater – volume: 114 start-page: 131 year: 2018 end-page: 142 ident: b0090 article-title: Presence of antibiotic residues in various environmental compartments of Shandong province in eastern China: its potential for resistance development and ecological and human risk publication-title: Environ Int – volume: 186 start-page: 4059 year: 2023 end-page: 4073.e27 ident: b0245 article-title: An antibiotic from an uncultured bacterium binds to an immutable target publication-title: Cell – volume: 10 start-page: 10105 year: 2020 end-page: 10115 ident: b0270 article-title: Environmental factors affect the response of microbial extracellular enzyme activity in soils when determined as a function of water availability and temperature publication-title: Ecol Evol – volume: 17 year: 2020 ident: b0240 article-title: Kinetic analysis and parametric optimization for bioaugmentation of oil from oily wastewater with hydrocarbonoclastic publication-title: Environ Technol Innov – volume: 173 start-page: 1 year: 2016 end-page: 9 ident: b0115 article-title: Investigation of relationships between removals of tetracycline and degradation products and physicochemical parameters in municipal wastewater treatment plant publication-title: J Environ Manage – volume: 814 year: 2022 ident: b0130 article-title: A comprehensive review on biodegradation of tetracyclines: current research progress and prospect publication-title: Sci Total Environ – volume: 799 year: 2021 ident: b0140 article-title: Reducing tetracycline antibiotics residues in aqueous environments using publication-title: Sci Total Environ – volume: 1 start-page: E316 year: 2017 end-page: E327 ident: b0030 article-title: Restricting the use of antibiotics in food-producing animals and its associations with antibiotic resistance in food-producing animals and human beings: a systematic review and meta-analysis publication-title: Lancet Planet Health – volume: 124 start-page: 117 year: 2011 end-page: 132 ident: b0045 article-title: The history of the tetracyclines publication-title: Ann N Y Acad Sci – volume: 3 start-page: 196 year: 2018 end-page: 203 ident: b0135 article-title: A genetically engineered publication-title: Synth Syst Biotechnol – volume: 44 start-page: 11829 year: 2005 end-page: 11835 ident: b0290 article-title: Tigecycline is modified by the flavin-dependent monooxygenase publication-title: Biochemistry – volume: 209–10 start-page: 355 year: 2012 end-page: 364 ident: b0120 article-title: Assessment of the efficiency of photocatalysis on tetracycline biodegradation publication-title: J Hazard Mater – volume: 933 year: 2024 ident: b0280 article-title: Unveiling antibiotic contamination in surface water: a study of the Huaihe River Basin’s Huaibei Plain, a significant Chinese herbal medicine planting region publication-title: Sci Total Environ – volume: 21 start-page: 10 year: 2021 end-page: 11 ident: b0035 article-title: Global increases in antibiotic consumption: a concerning trend for who targets publication-title: Lancet Infect Dis – volume: 285 start-page: 37838 year: 2010 end-page: 37846 ident: b0170 article-title: Structural insight into the mechanisms of transport across the publication-title: J Biol Chem – volume: 236 year: 2023 ident: b0275 article-title: Antibiotic residues of drinking-water and its human exposure risk assessment in rural eastern China publication-title: Water Res – volume: 78 start-page: 3547 year: 1956 end-page: 3548 ident: b0300 article-title: On the nature of the reversible isomerizations occurring in the tetracycline family publication-title: J Am Chem Soc – volume: 191 year: 2020 ident: b0125 article-title: Heterologous expression of the tetracycline resistance gene publication-title: Ecotoxicol Environ Saf – volume: 459 year: 2023 ident: b0150 article-title: An antibiotic-destructase-activated Fenton-like catalyst for synergistic removal of tetracycline residues from aquatic environment publication-title: Chem Eng J – volume: 12 start-page: 10582 year: 2018 end-page: 10620 ident: b0330 article-title: Safety assessment of graphene-based materials: focus on human health and the environment publication-title: ACS Nano – volume: 753 year: 2021 ident: b0070 article-title: Occurrence, fate, and risk assessment of typical tetracycline antibiotics in the aquatic environment: a review publication-title: Sci Total Environ – volume: 41 start-page: 185 year: 2014 end-page: 201 ident: b0060 article-title: Importance of microbial natural products and the need to revitalize their discovery publication-title: J Ind Microbiol Biotechnol – volume: 223 year: 2021 ident: b0295 article-title: Electrooxidation of tetracycline antibiotic demeclocycline at unmodified boron-doped diamond electrode and its enhancement determination in surfactant-containing media publication-title: Talanta – volume: 2 year: 2021 ident: b0015 article-title: Antibiotic resistance in agriculture: perspectives on upcoming strategies to overcome upsurge in resistance publication-title: Curr Res Microb Sci – volume: 90 start-page: 5671 year: 2018 end-page: 5677 ident: b0175 article-title: Fenobody: a ferritin-displayed nanobody with high apparent affinity and half-life extension publication-title: Anal Chem – volume: 369 start-page: 745 year: 2019 end-page: 757 ident: b0305 article-title: Coupling of heterogeneous advanced oxidation processes and photocatalysis in efficient degradation of tetracycline hydrochloride by Fe-based MOFs: synergistic effect and degradation pathway publication-title: Chem Eng J – volume: 18 start-page: E368 year: 2018 end-page: E378 ident: b0010 article-title: Quantifying drivers of antibiotic resistance in humans: a systematic review publication-title: Lancet Infect Dis – volume: 9 start-page: 1635 year: 2013 end-page: 1653 ident: b0335 article-title: Biosafety and bioapplication of nanomaterials by designing protein-nanoparticle interactions publication-title: Small – volume: 128 start-page: 16626 year: 2006 end-page: 16633 ident: b0190 article-title: Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles publication-title: J Am Chem Soc – volume: 3 start-page: 7158 year: 2020 end-page: 7167 ident: b0195 article-title: Supreme catalytic properties of enzyme nanoparticles based on ferritin self-assembly publication-title: ACS Appl Bio Mater – volume: 19 start-page: 4563 year: 2021 end-page: 4601 ident: b0315 article-title: Heterojunction photocatalysts for degradation of the tetracycline antibiotic: a review publication-title: Environ Chem Lett – volume: 58 start-page: 216 year: 2013 end-page: 234 ident: b0265 article-title: Soil enzymes in a changing environment: current knowledge and future directions publication-title: Soil Biol Biochem – volume: 2017 year: 2017 ident: b0050 article-title: Tetracyclines in food and feedingstuffs: from regulation to analytical methods, bacterial resistance, and environmental and health implications publication-title: J Anal Methods Chem – volume: 5 start-page: 231 year: 2020 ident: b0210 article-title: NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications publication-title: Signal Transduct Target Ther – volume: 399 year: 2020 ident: b0075 article-title: Recognition of typical antibiotic residues in environmental media related to groundwater in China (2009–2019) publication-title: J Hazard Mater – volume: 25 start-page: 1213 year: 2019 end-page: 1225 ident: b0040 article-title: Impact of vaccination on antibiotic usage: a systematic review and meta-analysis publication-title: Clin Microbiol Infect – volume: 219 start-page: 182 year: 2016 end-page: 190 ident: b0065 article-title: Changes in antibiotic concentrations and antibiotic resistome during commercial composting of animal manures publication-title: Environ Pollut – volume: 179 year: 2023 ident: b0145 article-title: TET-Yeasate: an engineered yeast whole-cell lysate-based approach for high performance tetracycline degradation publication-title: Environ Int – volume: 243 start-page: 1861 year: 2018 end-page: 1866 ident: b0235 article-title: Enzyme activity indicates soil functionality affectation with low levels of trace elements publication-title: Environ Pollut – volume: 23 year: 2021 ident: b0105 article-title: Removal of emerging micropollutants originating from pharmaceuticals and personal care products (PPCPs) in water and wastewater by advanced oxidation processes: a review publication-title: Environ Technol Innov – volume: 379 year: 2019 ident: b0110 article-title: Antibiotic residues in livestock manure: does the EU risk assessment sufficiently protect against microbial toxicity and selection of resistant bacteria in the environment? publication-title: J Hazard Mater – volume: 403 year: 2021 ident: b0320 article-title: A direct Z-scheme oxygen vacant BWO/oxygen-enriched graphitic carbon nitride polymer heterojunction with enhanced photocatalytic activity publication-title: Chem Eng J – volume: 112 start-page: 5649 year: 2015 end-page: 5654 ident: b0025 article-title: Global trends in antimicrobial use in food animals publication-title: Proc Natl Acad Sci USA – volume: 229 year: 2022 ident: b0180 article-title: Hydrolytic transformation mechanism of tetracycline antibiotics: reaction kinetics, products identification and determination in WWTPs publication-title: Ecotoxicol Environ Saf – volume: 470 year: 2024 ident: b0165 article-title: Biodegradation of ciprofloxacin using machine learning tools: kinetics and modelling publication-title: J Hazard Mater – volume: 266 year: 2020 ident: b0080 article-title: Antibiotics in soil and water in China—a systematic review and source analysis publication-title: Environ Pollut – volume: 7 start-page: 3207 year: 2017 end-page: 3227 ident: b0205 article-title: Iron oxide nanozyme: a multifunctional enzyme mimetic for biomedical applications publication-title: Theranostics – volume: 5 start-page: 522 year: 2022 ident: b0215 article-title: Functional and phylogenetic analysis of publication-title: Commun Biol – volume: 341 year: 2024 ident: b0100 article-title: Persistence and potential risks of tetracyclines and their transformation products in two typical different animal manure composting treatments publication-title: Environ Pollut – volume: 185 year: 2024 ident: b0255 article-title: Current insights and future perspectives of ultraviolet radiation (UV) exposure: friends and foes to the skin and beyond the skin publication-title: Environ Int – volume: 51 start-page: 72 year: 2019 end-page: 80 ident: b0005 article-title: Antibiotics: past, present and future publication-title: Curr Opin Microbiol – volume: 29 start-page: 715 year: 2011 end-page: 725 ident: b0200 article-title: Substrate channeling and enzyme complexes for biotechnological applications publication-title: Biotechnol Adv – volume: 277 year: 2020 ident: b0310 article-title: Enhanced full solar spectrum photocatalysis by nitrogen-doped graphene quantum dots decorated BiO publication-title: Appl Catal B – volume: 115 start-page: E3463 year: 2018 end-page: E3470 ident: b0020 article-title: Global increase and geographic convergence in antibiotic consumption between 2000 and 2015 publication-title: Proc Natl Acad Sci USA – volume: 43 start-page: 1019 year: 2008 end-page: 1032 ident: b0260 article-title: Enzyme stability and stabilization? Aqueous and non-aqueous environment publication-title: Process Biochem – volume: 414 year: 2021 ident: b0325 article-title: Gold nanoparticles-modified MnFe publication-title: J Hazard Mater – volume: 3 start-page: 42 year: 2020 ident: b0225 article-title: Proclivities for prevalence and treatment of antibiotics in the ambient water: a review publication-title: npj Clean Water – volume: 117 start-page: 12581 year: 2017 end-page: 12588 ident: b0160 article-title: Introduction: bioinspired and biomimetic materials publication-title: Chem Rev – volume: 251 year: 2020 ident: b0055 article-title: Occurrence and toxicity of antibiotics in the aquatic environment: a review publication-title: Chemosphere – volume: 33 start-page: 64 year: 2021 ident: b0285 article-title: Environmental fate of tetracycline antibiotics: degradation pathway mechanisms, challenges, and perspectives publication-title: Environ Sci Eur – volume: 11 start-page: 209 year: 2013 end-page: 227 ident: b0085 article-title: Tetracycline antibiotics in the environment: a review publication-title: Environ Chem Lett – volume: 4 start-page: 1457 year: 2019 end-page: 1464 ident: b0155 article-title: Plasmid-encoded publication-title: Nat Microbiol – volume: 26 year: 2020 ident: b0230 article-title: Removal of antibiotics from wastewater and its problematic effects on microbial communities by bioelectrochemical technology: current knowledge and future perspectives publication-title: Environ Eng Res – volume: 7 start-page: 7462 year: 2013 end-page: 7471 ident: b0185 article-title: Designed nanocage displaying ligand-specific peptide bunches for high affinity and biological activity publication-title: ACS Nano – volume: 771 year: 2021 ident: b0220 article-title: Tetracyclines in the environment: an overview on the occurrence, fate, toxicity, detection, removal methods, and sludge management publication-title: Sci Total Environ – volume: 59 start-page: 1 year: 2015 end-page: 41 ident: b0250 article-title: Enzymes: principles and biotechnological applications publication-title: Essays Biochem – volume: 51 start-page: 72 year: 2019 ident: 10.1016/j.eng.2025.03.033_b0005 article-title: Antibiotics: past, present and future publication-title: Curr Opin Microbiol doi: 10.1016/j.mib.2019.10.008 – volume: 3 start-page: 42 issue: 1 year: 2020 ident: 10.1016/j.eng.2025.03.033_b0225 article-title: Proclivities for prevalence and treatment of antibiotics in the ambient water: a review publication-title: npj Clean Water doi: 10.1038/s41545-020-00087-x – volume: 29 start-page: 715 issue: 6 year: 2011 ident: 10.1016/j.eng.2025.03.033_b0200 article-title: Substrate channeling and enzyme complexes for biotechnological applications publication-title: Biotechnol Adv doi: 10.1016/j.biotechadv.2011.05.020 – volume: 21 start-page: 10 issue: 1 year: 2021 ident: 10.1016/j.eng.2025.03.033_b0035 article-title: Global increases in antibiotic consumption: a concerning trend for who targets publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(20)30456-4 – volume: 7 start-page: 7462 issue: 9 year: 2013 ident: 10.1016/j.eng.2025.03.033_b0185 article-title: Designed nanocage displaying ligand-specific peptide bunches for high affinity and biological activity publication-title: ACS Nano doi: 10.1021/nn403184u – volume: 114 start-page: 131 year: 2018 ident: 10.1016/j.eng.2025.03.033_b0090 article-title: Presence of antibiotic residues in various environmental compartments of Shandong province in eastern China: its potential for resistance development and ecological and human risk publication-title: Environ Int doi: 10.1016/j.envint.2018.02.003 – volume: 23 year: 2021 ident: 10.1016/j.eng.2025.03.033_b0105 article-title: Removal of emerging micropollutants originating from pharmaceuticals and personal care products (PPCPs) in water and wastewater by advanced oxidation processes: a review publication-title: Environ Technol Innov doi: 10.1016/j.eti.2021.101757 – volume: 185 year: 2024 ident: 10.1016/j.eng.2025.03.033_b0255 article-title: Current insights and future perspectives of ultraviolet radiation (UV) exposure: friends and foes to the skin and beyond the skin publication-title: Environ Int doi: 10.1016/j.envint.2024.108535 – volume: 236 year: 2023 ident: 10.1016/j.eng.2025.03.033_b0275 article-title: Antibiotic residues of drinking-water and its human exposure risk assessment in rural eastern China publication-title: Water Res doi: 10.1016/j.watres.2023.119940 – volume: 128 start-page: 16626 issue: 51 year: 2006 ident: 10.1016/j.eng.2025.03.033_b0190 article-title: Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles publication-title: J Am Chem Soc doi: 10.1021/ja0655690 – volume: 17 year: 2020 ident: 10.1016/j.eng.2025.03.033_b0240 article-title: Kinetic analysis and parametric optimization for bioaugmentation of oil from oily wastewater with hydrocarbonoclastic Rhodococcus pyridinivorans F5 strain publication-title: Environ Technol Innov doi: 10.1016/j.eti.2020.100630 – volume: 814 year: 2022 ident: 10.1016/j.eng.2025.03.033_b0130 article-title: A comprehensive review on biodegradation of tetracyclines: current research progress and prospect publication-title: Sci Total Environ doi: 10.1016/j.scitotenv.2021.152852 – volume: 59 start-page: 1 year: 2015 ident: 10.1016/j.eng.2025.03.033_b0250 article-title: Enzymes: principles and biotechnological applications publication-title: Essays Biochem doi: 10.1042/bse0590001 – volume: 58 start-page: 216 year: 2013 ident: 10.1016/j.eng.2025.03.033_b0265 article-title: Soil enzymes in a changing environment: current knowledge and future directions publication-title: Soil Biol Biochem doi: 10.1016/j.soilbio.2012.11.009 – volume: 285 start-page: 37838 issue: 48 year: 2010 ident: 10.1016/j.eng.2025.03.033_b0170 article-title: Structural insight into the mechanisms of transport across the Salmonella enterica Pdu microcompartment shell publication-title: J Biol Chem doi: 10.1074/jbc.M110.160580 – volume: 753 year: 2021 ident: 10.1016/j.eng.2025.03.033_b0070 article-title: Occurrence, fate, and risk assessment of typical tetracycline antibiotics in the aquatic environment: a review publication-title: Sci Total Environ doi: 10.1016/j.scitotenv.2020.141975 – volume: 191 year: 2020 ident: 10.1016/j.eng.2025.03.033_b0125 article-title: Heterologous expression of the tetracycline resistance gene tetX to enhance degradability and safety in doxycycline degradation publication-title: Ecotoxicol Environ Saf doi: 10.1016/j.ecoenv.2020.110214 – volume: 414 year: 2021 ident: 10.1016/j.eng.2025.03.033_b0325 article-title: Gold nanoparticles-modified MnFe2O4 with synergistic catalysis for photo-Fenton degradation of tetracycline under neutral ph publication-title: J Hazard Mater doi: 10.1016/j.jhazmat.2021.125448 – volume: 341 year: 2024 ident: 10.1016/j.eng.2025.03.033_b0100 article-title: Persistence and potential risks of tetracyclines and their transformation products in two typical different animal manure composting treatments publication-title: Environ Pollut doi: 10.1016/j.envpol.2023.122904 – volume: 25 start-page: 1213 issue: 10 year: 2019 ident: 10.1016/j.eng.2025.03.033_b0040 article-title: Impact of vaccination on antibiotic usage: a systematic review and meta-analysis publication-title: Clin Microbiol Infect doi: 10.1016/j.cmi.2019.06.030 – volume: 369 start-page: 745 year: 2019 ident: 10.1016/j.eng.2025.03.033_b0305 article-title: Coupling of heterogeneous advanced oxidation processes and photocatalysis in efficient degradation of tetracycline hydrochloride by Fe-based MOFs: synergistic effect and degradation pathway publication-title: Chem Eng J doi: 10.1016/j.cej.2019.03.108 – volume: 10 start-page: 10105 issue: 18 year: 2020 ident: 10.1016/j.eng.2025.03.033_b0270 article-title: Environmental factors affect the response of microbial extracellular enzyme activity in soils when determined as a function of water availability and temperature publication-title: Ecol Evol doi: 10.1002/ece3.6672 – volume: 219 start-page: 182 year: 2016 ident: 10.1016/j.eng.2025.03.033_b0065 article-title: Changes in antibiotic concentrations and antibiotic resistome during commercial composting of animal manures publication-title: Environ Pollut doi: 10.1016/j.envpol.2016.10.044 – volume: 117 start-page: 12581 issue: 20 year: 2017 ident: 10.1016/j.eng.2025.03.033_b0160 article-title: Introduction: bioinspired and biomimetic materials publication-title: Chem Rev doi: 10.1021/acs.chemrev.7b00552 – volume: 186 start-page: 4059 issue: 19 year: 2023 ident: 10.1016/j.eng.2025.03.033_b0245 article-title: An antibiotic from an uncultured bacterium binds to an immutable target publication-title: Cell doi: 10.1016/j.cell.2023.07.038 – volume: 223 year: 2021 ident: 10.1016/j.eng.2025.03.033_b0295 article-title: Electrooxidation of tetracycline antibiotic demeclocycline at unmodified boron-doped diamond electrode and its enhancement determination in surfactant-containing media publication-title: Talanta doi: 10.1016/j.talanta.2020.121695 – volume: 3 start-page: 7158 issue: 10 year: 2020 ident: 10.1016/j.eng.2025.03.033_b0195 article-title: Supreme catalytic properties of enzyme nanoparticles based on ferritin self-assembly publication-title: ACS Appl Bio Mater doi: 10.1021/acsabm.0c00961 – volume: 173 start-page: 1 year: 2016 ident: 10.1016/j.eng.2025.03.033_b0115 article-title: Investigation of relationships between removals of tetracycline and degradation products and physicochemical parameters in municipal wastewater treatment plant publication-title: J Environ Manage doi: 10.1016/j.jenvman.2016.02.046 – volume: 771 year: 2021 ident: 10.1016/j.eng.2025.03.033_b0220 article-title: Tetracyclines in the environment: an overview on the occurrence, fate, toxicity, detection, removal methods, and sludge management publication-title: Sci Total Environ doi: 10.1016/j.scitotenv.2021.145291 – volume: 345 start-page: 131 year: 2018 ident: 10.1016/j.eng.2025.03.033_b0095 article-title: Changes in tetracycline partitioning and bacteria/phage-comediated ARGs in microplastic-contaminated greenhouse soil facilitated by sophorolipid publication-title: J Hazard Mater doi: 10.1016/j.jhazmat.2017.11.036 – volume: 277 year: 2020 ident: 10.1016/j.eng.2025.03.033_b0310 article-title: Enhanced full solar spectrum photocatalysis by nitrogen-doped graphene quantum dots decorated BiO2-X nanosheets: ultrafast charge transfer and molecular oxygen activation publication-title: Appl Catal B doi: 10.1016/j.apcatb.2020.119218 – volume: 41 start-page: 185 issue: 2 year: 2014 ident: 10.1016/j.eng.2025.03.033_b0060 article-title: Importance of microbial natural products and the need to revitalize their discovery publication-title: J Ind Microbiol Biotechnol doi: 10.1007/s10295-013-1325-z – volume: 2017 year: 2017 ident: 10.1016/j.eng.2025.03.033_b0050 article-title: Tetracyclines in food and feedingstuffs: from regulation to analytical methods, bacterial resistance, and environmental and health implications publication-title: J Anal Methods Chem doi: 10.1155/2017/1315497 – volume: 18 start-page: E368 issue: 12 year: 2018 ident: 10.1016/j.eng.2025.03.033_b0010 article-title: Quantifying drivers of antibiotic resistance in humans: a systematic review publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(18)30296-2 – volume: 90 start-page: 5671 issue: 9 year: 2018 ident: 10.1016/j.eng.2025.03.033_b0175 article-title: Fenobody: a ferritin-displayed nanobody with high apparent affinity and half-life extension publication-title: Anal Chem doi: 10.1021/acs.analchem.7b05217 – volume: 112 start-page: 5649 issue: 18 year: 2015 ident: 10.1016/j.eng.2025.03.033_b0025 article-title: Global trends in antimicrobial use in food animals publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1503141112 – volume: 124 start-page: 117 year: 2011 ident: 10.1016/j.eng.2025.03.033_b0045 article-title: The history of the tetracyclines publication-title: Ann N Y Acad Sci – volume: 43 start-page: 1019 issue: 10 year: 2008 ident: 10.1016/j.eng.2025.03.033_b0260 article-title: Enzyme stability and stabilization? Aqueous and non-aqueous environment publication-title: Process Biochem doi: 10.1016/j.procbio.2008.06.004 – volume: 470 year: 2024 ident: 10.1016/j.eng.2025.03.033_b0165 article-title: Biodegradation of ciprofloxacin using machine learning tools: kinetics and modelling publication-title: J Hazard Mater doi: 10.1016/j.jhazmat.2024.134076 – volume: 44 start-page: 11829 issue: 35 year: 2005 ident: 10.1016/j.eng.2025.03.033_b0290 article-title: Tigecycline is modified by the flavin-dependent monooxygenase tetX publication-title: Biochemistry doi: 10.1021/bi0506066 – volume: 4 start-page: 1457 issue: 9 year: 2019 ident: 10.1016/j.eng.2025.03.033_b0155 article-title: Plasmid-encoded tet(X) genes that confer high-level tigecycline resistance in Escherichia coli publication-title: Nat Microbiol doi: 10.1038/s41564-019-0496-4 – volume: 2 year: 2021 ident: 10.1016/j.eng.2025.03.033_b0015 article-title: Antibiotic resistance in agriculture: perspectives on upcoming strategies to overcome upsurge in resistance publication-title: Curr Res Microb Sci – volume: 78 start-page: 3547 issue: 14 year: 1956 ident: 10.1016/j.eng.2025.03.033_b0300 article-title: On the nature of the reversible isomerizations occurring in the tetracycline family publication-title: J Am Chem Soc doi: 10.1021/ja01595a084 – volume: 12 start-page: 10582 issue: 11 year: 2018 ident: 10.1016/j.eng.2025.03.033_b0330 article-title: Safety assessment of graphene-based materials: focus on human health and the environment publication-title: ACS Nano doi: 10.1021/acsnano.8b04758 – volume: 209–10 start-page: 355 year: 2012 ident: 10.1016/j.eng.2025.03.033_b0120 article-title: Assessment of the efficiency of photocatalysis on tetracycline biodegradation publication-title: J Hazard Mater doi: 10.1016/j.jhazmat.2012.01.032 – volume: 33 start-page: 64 issue: 1 year: 2021 ident: 10.1016/j.eng.2025.03.033_b0285 article-title: Environmental fate of tetracycline antibiotics: degradation pathway mechanisms, challenges, and perspectives publication-title: Environ Sci Eur doi: 10.1186/s12302-021-00505-y – volume: 251 year: 2020 ident: 10.1016/j.eng.2025.03.033_b0055 article-title: Occurrence and toxicity of antibiotics in the aquatic environment: a review publication-title: Chemosphere doi: 10.1016/j.chemosphere.2020.126351 – volume: 399 year: 2020 ident: 10.1016/j.eng.2025.03.033_b0075 article-title: Recognition of typical antibiotic residues in environmental media related to groundwater in China (2009–2019) publication-title: J Hazard Mater doi: 10.1016/j.jhazmat.2020.122813 – volume: 11 start-page: 209 issue: 3 year: 2013 ident: 10.1016/j.eng.2025.03.033_b0085 article-title: Tetracycline antibiotics in the environment: a review publication-title: Environ Chem Lett doi: 10.1007/s10311-013-0404-8 – volume: 179 year: 2023 ident: 10.1016/j.eng.2025.03.033_b0145 article-title: TET-Yeasate: an engineered yeast whole-cell lysate-based approach for high performance tetracycline degradation publication-title: Environ Int doi: 10.1016/j.envint.2023.108158 – volume: 379 year: 2019 ident: 10.1016/j.eng.2025.03.033_b0110 article-title: Antibiotic residues in livestock manure: does the EU risk assessment sufficiently protect against microbial toxicity and selection of resistant bacteria in the environment? publication-title: J Hazard Mater doi: 10.1016/j.jhazmat.2019.120807 – volume: 115 start-page: E3463 issue: 15 year: 2018 ident: 10.1016/j.eng.2025.03.033_b0020 article-title: Global increase and geographic convergence in antibiotic consumption between 2000 and 2015 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1717295115 – volume: 403 year: 2021 ident: 10.1016/j.eng.2025.03.033_b0320 article-title: A direct Z-scheme oxygen vacant BWO/oxygen-enriched graphitic carbon nitride polymer heterojunction with enhanced photocatalytic activity publication-title: Chem Eng J doi: 10.1016/j.cej.2020.126363 – volume: 933 year: 2024 ident: 10.1016/j.eng.2025.03.033_b0280 article-title: Unveiling antibiotic contamination in surface water: a study of the Huaihe River Basin’s Huaibei Plain, a significant Chinese herbal medicine planting region publication-title: Sci Total Environ doi: 10.1016/j.scitotenv.2024.173125 – volume: 7 start-page: 3207 issue: 13 year: 2017 ident: 10.1016/j.eng.2025.03.033_b0205 article-title: Iron oxide nanozyme: a multifunctional enzyme mimetic for biomedical applications publication-title: Theranostics doi: 10.7150/thno.19738 – volume: 19 start-page: 4563 issue: 6 year: 2021 ident: 10.1016/j.eng.2025.03.033_b0315 article-title: Heterojunction photocatalysts for degradation of the tetracycline antibiotic: a review publication-title: Environ Chem Lett doi: 10.1007/s10311-021-01295-8 – volume: 266 issue: Pt 1 year: 2020 ident: 10.1016/j.eng.2025.03.033_b0080 article-title: Antibiotics in soil and water in China—a systematic review and source analysis publication-title: Environ Pollut – volume: 459 year: 2023 ident: 10.1016/j.eng.2025.03.033_b0150 article-title: An antibiotic-destructase-activated Fenton-like catalyst for synergistic removal of tetracycline residues from aquatic environment publication-title: Chem Eng J doi: 10.1016/j.cej.2023.141576 – volume: 26 issue: 1 year: 2020 ident: 10.1016/j.eng.2025.03.033_b0230 article-title: Removal of antibiotics from wastewater and its problematic effects on microbial communities by bioelectrochemical technology: current knowledge and future perspectives publication-title: Environ Eng Res doi: 10.4491/eer.2019.405 – volume: 799 year: 2021 ident: 10.1016/j.eng.2025.03.033_b0140 article-title: Reducing tetracycline antibiotics residues in aqueous environments using tet(X) degrading enzymes expressed in Pichia pastoris publication-title: Sci Total Environ doi: 10.1016/j.scitotenv.2021.149360 – volume: 5 start-page: 522 issue: 1 year: 2022 ident: 10.1016/j.eng.2025.03.033_b0215 article-title: Functional and phylogenetic analysis of tetX variants to design a new classification system publication-title: Commun Biol doi: 10.1038/s42003-022-03465-y – volume: 243 start-page: 1861 issue: Pt B year: 2018 ident: 10.1016/j.eng.2025.03.033_b0235 article-title: Enzyme activity indicates soil functionality affectation with low levels of trace elements publication-title: Environ Pollut doi: 10.1016/j.envpol.2018.10.029 – volume: 3 start-page: 196 issue: 3 year: 2018 ident: 10.1016/j.eng.2025.03.033_b0135 article-title: A genetically engineered Escherichia coli that senses and degrades tetracycline antibiotic residue publication-title: Synth Syst Biotechnol doi: 10.1016/j.synbio.2018.05.001 – volume: 9 start-page: 1635 issue: 9–10 year: 2013 ident: 10.1016/j.eng.2025.03.033_b0335 article-title: Biosafety and bioapplication of nanomaterials by designing protein-nanoparticle interactions publication-title: Small doi: 10.1002/smll.201201492 – volume: 5 start-page: 231 issue: 1 year: 2020 ident: 10.1016/j.eng.2025.03.033_b0210 article-title: NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications publication-title: Signal Transduct Target Ther doi: 10.1038/s41392-020-00326-0 – volume: 229 year: 2022 ident: 10.1016/j.eng.2025.03.033_b0180 article-title: Hydrolytic transformation mechanism of tetracycline antibiotics: reaction kinetics, products identification and determination in WWTPs publication-title: Ecotoxicol Environ Saf doi: 10.1016/j.ecoenv.2021.113063 – volume: 1 start-page: E316 issue: 8 year: 2017 ident: 10.1016/j.eng.2025.03.033_b0030 article-title: Restricting the use of antibiotics in food-producing animals and its associations with antibiotic resistance in food-producing animals and human beings: a systematic review and meta-analysis publication-title: Lancet Planet Health doi: 10.1016/S2542-5196(17)30141-9 |
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•FerTiG is designed as a multienzyme complex to degrade tetracycline residues;•GDH module fuels FerTiG to spontaneously degrade tetracycline... Tetracycline (TC) residues from anthropogenic activities undesirably present in nature as an emerging sustainability challenge and thereby require innovations... |
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| SubjectTerms | Antibiotic residues Environmental remediation Living-organism-inspired system Modular enzyme assembly Tetracycline biodegradation |
| Title | Modular Engineering of a Synthetic Biology-Based Platform for Sustainable Bioremediation of Residual Antibiotics in Aquatic Environments |
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