Improved cyclobutyl nabilone analogs as potent CB1 receptor agonists

In earlier work, we explored the SAR for the C3 side chain pharmacophore in the hexahydrocannabinol template represented by the drug nabilone, which resulted in the development of AM2389. In an effort for further optimization, we have merged features of nabilone and AM2389 and explored the C3 side c...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	European journal of medicinal chemistry Ročník 230; s. 114027 - 114037
Hlavní autori:	Papanastasiou, Ioannis P., Georgiadis, Markos-Orestis, Iliopoulos-Tsoutsouvas, Christos, Paronis, Carol A., Brust, Christina A., Tran, Ngan K., Ji, Lipin, Ma, Xiaoyu, Wood, JodiAnne T., Zvonok, Nikolai, Tong, Fei, Bohn, Laura M., Nikas, Spyros P., Makriyannis, Alexandros
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	ISSY-LES-MOULINEAUX Elsevier Masson SAS 15.02.2022 Elsevier
Predmet:	Cannabinoids CB1 receptor Chemistry, Medicinal Dronabinol - analogs & derivatives Dronabinol - pharmacology Life Sciences & Biomedicine Nabilone analogs Pharmacology & Pharmacy Receptor, Cannabinoid, CB1 - agonists SAR studies Science & Technology Structure-Activity Relationship SAR studies Cannabinoids Nabilone analogs CB1 receptor AM2389 SIDE-CHAIN LIGAND
ISSN:	0223-5234, 1768-3254, 1768-3254
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!