Improved cyclobutyl nabilone analogs as potent CB1 receptor agonists

In earlier work, we explored the SAR for the C3 side chain pharmacophore in the hexahydrocannabinol template represented by the drug nabilone, which resulted in the development of AM2389. In an effort for further optimization, we have merged features of nabilone and AM2389 and explored the C3 side c...

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Bibliographic Details
Published in:	European journal of medicinal chemistry Vol. 230; pp. 114027 - 114037
Main Authors:	Papanastasiou, Ioannis P., Georgiadis, Markos-Orestis, Iliopoulos-Tsoutsouvas, Christos, Paronis, Carol A., Brust, Christina A., Tran, Ngan K., Ji, Lipin, Ma, Xiaoyu, Wood, JodiAnne T., Zvonok, Nikolai, Tong, Fei, Bohn, Laura M., Nikas, Spyros P., Makriyannis, Alexandros
Format:	Journal Article
Language:	English
Published:	ISSY-LES-MOULINEAUX Elsevier Masson SAS 15.02.2022 Elsevier
Subjects:	Cannabinoids CB1 receptor Chemistry, Medicinal Dronabinol - analogs & derivatives Dronabinol - pharmacology Life Sciences & Biomedicine Nabilone analogs Pharmacology & Pharmacy Receptor, Cannabinoid, CB1 - agonists SAR studies Science & Technology Structure-Activity Relationship SAR studies Cannabinoids Nabilone analogs CB1 receptor AM2389 SIDE-CHAIN LIGAND
ISSN:	0223-5234, 1768-3254, 1768-3254
Online Access:	Get full text
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