CCL5-Mediated Th2 Immune Polarization Promotes Metastasis in Luminal Breast Cancer

The tumor-promoting chemokine CCL5 has been implicated in malignant transformation of breast epithelial cells, with studies to date focusing mainly on basal-type breast cancers. In this study, we investigated the consequences of CCL5 deletion in the MMTV-PyMT transgenic mouse model of luminal breast...

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Vydáno v:	Cancer research (Chicago, Ill.) Ročník 75; číslo 20; s. 4312 - 4321
Hlavní autoři:	Zhang, Qianfei, Qin, Jilong, Zhong, Lin, Gong, Lei, Zhang, Bing, Zhang, Yan, Gao, Wei-Qiang
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 15.10.2015
Témata:	Animals Breast Neoplasms - genetics Breast Neoplasms - immunology Breast Neoplasms - metabolism Breast Neoplasms - pathology Case-Control Studies Cell Differentiation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Chemokine CCL5 - blood Chemokine CCL5 - deficiency Chemokine CCL5 - genetics Chemokine CCL5 - metabolism Disease Models, Animal Disease Progression DNA-Binding Proteins - genetics Female Gene Deletion Gene Expression Humans Interleukin-4 - genetics Interleukin-4 - metabolism Lung Neoplasms - secondary Mice Mice, Knockout Myeloid Cells - immunology Myeloid Cells - metabolism Neoplasm Metastasis Receptors, CCR3 - genetics Receptors, CCR3 - metabolism Signal Transduction Spheroids, Cellular T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Th2 Cells - cytology Th2 Cells - immunology Th2 Cells - metabolism Transcription Factors - genetics Tumor Cells, Cultured
ISSN:	1538-7445
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