In vitro skin permeation of potassium hexachloroplatinate and a comparison with potassium tetrachloroplatinate

Halogenated platinum salts are known respiratory sensitizers in the workplace, and occupational exposure to platinum via the respiratory system and skin has been reported. The aim of this study was to compare the permeability and skin retention of potassium hexachloroplatinate to previously publishe...

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Vydáno v:Toxicology letters Ročník 381; s. 13 - 19
Hlavní autoři: Franken, Anja, Bosch, Barbara Sylvia, van der Merwe, Cornelius Johannes, Du Plessis, Jeanetta, Du Plessis, Johannes Lodewykus
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 15.05.2023
Témata:
Caucasian skin
Chlorides
Female
Franz diffusion cell
Humans
Platinum - toxicity
Platinum Compounds
Platinum group metals
Skin
Skin permeation
Skin retention
Platinum group metals
Franz diffusion cell
Skin permeation
Skin retention
Caucasian skin
ISSN:0378-4274, 1879-3169, 1879-3169
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Shrnutí:Halogenated platinum salts are known respiratory sensitizers in the workplace, and occupational exposure to platinum via the respiratory system and skin has been reported. The aim of this study was to compare the permeability and skin retention of potassium hexachloroplatinate to previously published data of potassium tetrachloroplatinate. Experiments were performed using female Caucasian skin and Franz diffusion cells with the application of 0.3 mg Pt/mL in the donor solution for 24-h. After 8-h of exposure, 1.87 ng/cm2 of Pt was detected in the receptor solution with exposure to potassium hexachloroplatinate, whereas 0.47 ng/cm2 was detected with exposure to potassium tetrachloroplatinate. After 24-h of exposure the Pt retention in the skin was 1861.60 ng/cm2 and 1486.32 ng/cm2 with exposure to potassium hexa- and tetrachloroplatinate respectively. The faster rate of Pt permeation from exposure to potassium hexachloroplatinate was confirmed by the flux and permeability coefficient values. The results indicate a higher permeability and skin retention of Pt when exposed to potassium hexachloroplatinate, confirming a higher risk associated with occupational exposure to this platinum compound relative to potassium tetrachloroplatinate. •Significantly higher Pt permeation through the skin after 8- and 12-h of exposure to potassium hexachloroplatinate.•Exposure to K2PtCl6 resulted in significantly higher mass of Pt retained inside the skin compared to exposure to K2PtCl4.•Pt skin permeation was significantly faster with exposure to K2PtCl6 as shown by larger flux values and shorter lag time.•The increased risk of skin permeation when occupationally exposed to K2PtCl6 could contribute to the allergic response.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0378-4274
1879-3169
1879-3169
DOI:10.1016/j.toxlet.2023.04.007