Lig3-dependent rescue of mouse viability and DNA double-strand break repair by catalytically inactive Lig4

Abstract Recent studies have revealed a structural role for DNA ligase 4 (Lig4) in the maintenance of a repair complex during non-homologous end joining (NHEJ) of DNA double-strand breaks. In cultured cell lines, catalytically inactive Lig4 can partially alleviate the severe DNA repair phenotypes ob...

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Vydané v:	Nucleic acids research Ročník 53; číslo 2
Hlavní autori:	Medina-Suárez, David, Han, Li, O’Reilly, Sandra, Liu, Jiali, Wei, Chao, Brenière, Manon, Goff, Noah J, Chen, Chen, Modesti, Mauro, Meek, Katheryn, Harrington, Bonnie, Yu, Kefei
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Oxford University Press 14.12.2024
Predmet:	Animals Catalytic Domain Cell Nucleus - enzymology DNA Breaks, Double-Stranded DNA End-Joining Repair DNA Ligase ATP DNA Ligases - chemistry DNA Ligases - genetics DNA Ligases - metabolism DNA Ligases - physiology DNA Repair Life Sciences Mice Nucleic Acid Enzymes Point Mutation Poly-ADP-Ribose Binding Proteins
ISSN:	0305-1048, 1362-4962, 1362-4962
On-line prístup:	Získať plný text
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