Lig3-dependent rescue of mouse viability and DNA double-strand break repair by catalytically inactive Lig4

Abstract Recent studies have revealed a structural role for DNA ligase 4 (Lig4) in the maintenance of a repair complex during non-homologous end joining (NHEJ) of DNA double-strand breaks. In cultured cell lines, catalytically inactive Lig4 can partially alleviate the severe DNA repair phenotypes ob...

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Veröffentlicht in:	Nucleic acids research Jg. 53; H. 2
Hauptverfasser:	Medina-Suárez, David, Han, Li, O’Reilly, Sandra, Liu, Jiali, Wei, Chao, Brenière, Manon, Goff, Noah J, Chen, Chen, Modesti, Mauro, Meek, Katheryn, Harrington, Bonnie, Yu, Kefei
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Oxford University Press 14.12.2024
Schlagworte:	Animals Catalytic Domain Cell Nucleus - enzymology DNA Breaks, Double-Stranded DNA End-Joining Repair DNA Ligase ATP DNA Ligases - chemistry DNA Ligases - genetics DNA Ligases - metabolism DNA Ligases - physiology DNA Repair Life Sciences Mice Nucleic Acid Enzymes Point Mutation Poly-ADP-Ribose Binding Proteins
ISSN:	0305-1048, 1362-4962, 1362-4962
Online-Zugang:	Volltext
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