Yeast Expression Systems: Overview and Recent Advances

Yeasts are outstanding hosts for the production of functional recombinant proteins with industrial or medical applications. Great attention has been emerged on yeast due to the inherent advantages and new developments in this host cell. For the production of each specific product, the most appropria...

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Published in:Molecular biotechnology Vol. 61; no. 5; pp. 365 - 384
Main Authors: Baghban, Roghayyeh, Farajnia, Safar, Rajabibazl, Masoumeh, Ghasemi, Younes, Mafi, AmirAli, Hoseinpoor, Reyhaneh, Rahbarnia, Leila, Aria, Maryam
Format: Journal Article
Language:English
Published: New York Springer US 01.05.2019
Springer Nature B.V
Subjects:
Baking yeast
Biochemistry
Biological Techniques
Biotechnology
Blastobotrys adeninivorans
Cell Biology
Chemistry
Chemistry and Materials Science
Fermentation
Hansenula polymorpha
hosts
Human Genetics
Kluyveromyces lactis
Kluyveromyces marxianus var. lactis
Komagataella pastoris
Pichia pastoris
Protein Science
Proteins
recombinant proteins
Review
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Yarrowia lipolytica
Yeast
yeasts
Expression system
Pichia pastoris
Hansenula polymorpha
Saccharomyces cerevisiae
Yarrowia lipolytica
ISSN:1073-6085, 1559-0305, 1559-0305
Online Access:Get full text
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Abstract Yeasts are outstanding hosts for the production of functional recombinant proteins with industrial or medical applications. Great attention has been emerged on yeast due to the inherent advantages and new developments in this host cell. For the production of each specific product, the most appropriate expression system should be identified and optimized both on the genetic and fermentation levels, considering the features of the host, vector and expression strategies. Currently, several new systems are commercially available; some of them are private and need licensing. The potential for secretory expression of heterologous proteins in yeast proposed this system as a candidate for the production of complex eukaryotic proteins. The common yeast expression hosts used for recombinant proteins’ expression include Saccharomyces cerevisiae, Pichia pastoris, Hansenula polymorpha, Yarrowia lipolytica, Arxula adeninivorans, Kluyveromyces lactis , and Schizosaccharomyces pombe . This review is dedicated to discuss on significant characteristics of the most common methylotrophic and non-methylotrophic yeast expression systems with an emphasis on their advantages and new developments.
AbstractList Yeasts are outstanding hosts for the production of functional recombinant proteins with industrial or medical applications. Great attention has been emerged on yeast due to the inherent advantages and new developments in this host cell. For the production of each specific product, the most appropriate expression system should be identified and optimized both on the genetic and fermentation levels, considering the features of the host, vector and expression strategies. Currently, several new systems are commercially available; some of them are private and need licensing. The potential for secretory expression of heterologous proteins in yeast proposed this system as a candidate for the production of complex eukaryotic proteins. The common yeast expression hosts used for recombinant proteins' expression include Saccharomyces cerevisiae, Pichia pastoris, Hansenula polymorpha, Yarrowia lipolytica, Arxula adeninivorans, Kluyveromyces lactis, and Schizosaccharomyces pombe. This review is dedicated to discuss on significant characteristics of the most common methylotrophic and non-methylotrophic yeast expression systems with an emphasis on their advantages and new developments.Yeasts are outstanding hosts for the production of functional recombinant proteins with industrial or medical applications. Great attention has been emerged on yeast due to the inherent advantages and new developments in this host cell. For the production of each specific product, the most appropriate expression system should be identified and optimized both on the genetic and fermentation levels, considering the features of the host, vector and expression strategies. Currently, several new systems are commercially available; some of them are private and need licensing. The potential for secretory expression of heterologous proteins in yeast proposed this system as a candidate for the production of complex eukaryotic proteins. The common yeast expression hosts used for recombinant proteins' expression include Saccharomyces cerevisiae, Pichia pastoris, Hansenula polymorpha, Yarrowia lipolytica, Arxula adeninivorans, Kluyveromyces lactis, and Schizosaccharomyces pombe. This review is dedicated to discuss on significant characteristics of the most common methylotrophic and non-methylotrophic yeast expression systems with an emphasis on their advantages and new developments.
Yeasts are outstanding hosts for the production of functional recombinant proteins with industrial or medical applications. Great attention has been emerged on yeast due to the inherent advantages and new developments in this host cell. For the production of each specific product, the most appropriate expression system should be identified and optimized both on the genetic and fermentation levels, considering the features of the host, vector and expression strategies. Currently, several new systems are commercially available; some of them are private and need licensing. The potential for secretory expression of heterologous proteins in yeast proposed this system as a candidate for the production of complex eukaryotic proteins. The common yeast expression hosts used for recombinant proteins’ expression include Saccharomyces cerevisiae, Pichia pastoris, Hansenula polymorpha, Yarrowia lipolytica, Arxula adeninivorans, Kluyveromyces lactis, and Schizosaccharomyces pombe. This review is dedicated to discuss on significant characteristics of the most common methylotrophic and non-methylotrophic yeast expression systems with an emphasis on their advantages and new developments.
Yeasts are outstanding hosts for the production of functional recombinant proteins with industrial or medical applications. Great attention has been emerged on yeast due to the inherent advantages and new developments in this host cell. For the production of each specific product, the most appropriate expression system should be identified and optimized both on the genetic and fermentation levels, considering the features of the host, vector and expression strategies. Currently, several new systems are commercially available; some of them are private and need licensing. The potential for secretory expression of heterologous proteins in yeast proposed this system as a candidate for the production of complex eukaryotic proteins. The common yeast expression hosts used for recombinant proteins’ expression include Saccharomyces cerevisiae, Pichia pastoris, Hansenula polymorpha, Yarrowia lipolytica, Arxula adeninivorans, Kluyveromyces lactis , and Schizosaccharomyces pombe . This review is dedicated to discuss on significant characteristics of the most common methylotrophic and non-methylotrophic yeast expression systems with an emphasis on their advantages and new developments.
Author Baghban, Roghayyeh
Rahbarnia, Leila
Rajabibazl, Masoumeh
Aria, Maryam
Ghasemi, Younes
Farajnia, Safar
Hoseinpoor, Reyhaneh
Mafi, AmirAli
Author_xml – sequence: 1
  givenname: Roghayyeh
  surname: Baghban
  fullname: Baghban, Roghayyeh
  organization: Medical Biotechnology Department, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Research Committee, Tabriz University of Medical Sciences, Biotechnology Research Center, Tabriz University of Medical Sciences
– sequence: 2
  givenname: Safar
  surname: Farajnia
  fullname: Farajnia, Safar
  email: farajnias@tbzmed.ac.ir
  organization: Biotechnology Research Center, Tabriz University of Medical Sciences, Drug Applied Research Center, Tabriz University of Medical Sciences
– sequence: 3
  givenname: Masoumeh
  surname: Rajabibazl
  fullname: Rajabibazl, Masoumeh
  email: rajabi_m@sbmu.ac.ir
  organization: Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences
– sequence: 4
  givenname: Younes
  surname: Ghasemi
  fullname: Ghasemi, Younes
  organization: Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shiraz University of Medical Science
– sequence: 5
  givenname: AmirAli
  surname: Mafi
  fullname: Mafi, AmirAli
  organization: Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences
– sequence: 6
  givenname: Reyhaneh
  surname: Hoseinpoor
  fullname: Hoseinpoor, Reyhaneh
  organization: Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences
– sequence: 7
  givenname: Leila
  surname: Rahbarnia
  fullname: Rahbarnia, Leila
  organization: Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences
– sequence: 8
  givenname: Maryam
  surname: Aria
  fullname: Aria, Maryam
  organization: Biotechnology Research Center, Tabriz University of Medical Sciences
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30805909$$D View this record in MEDLINE/PubMed
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Molecular Biotechnology is a copyright of Springer, (2019). All Rights Reserved.
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Pichia pastoris
Hansenula polymorpha
Saccharomyces cerevisiae
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Snippet Yeasts are outstanding hosts for the production of functional recombinant proteins with industrial or medical applications. Great attention has been emerged on...
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SubjectTerms Baking yeast
Biochemistry
Biological Techniques
Biotechnology
Blastobotrys adeninivorans
Cell Biology
Chemistry
Chemistry and Materials Science
Fermentation
Hansenula polymorpha
hosts
Human Genetics
Kluyveromyces lactis
Kluyveromyces marxianus var. lactis
Komagataella pastoris
Pichia pastoris
Protein Science
Proteins
recombinant proteins
Review
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Yarrowia lipolytica
Yeast
yeasts
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Title Yeast Expression Systems: Overview and Recent Advances
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