missMethyl: an R package for analyzing data from Illumina’s HumanMethylation450 platform

DNA methylation is one of the most commonly studied epigenetic modifications due to its role in both disease and development. The Illumina HumanMethylation450 BeadChip is a cost-effective way to profile >450 000 CpGs across the human genome, making it a popular platform for profiling DNA methylat...

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Vydáno v:Bioinformatics (Oxford, England) Ročník 32; číslo 2; s. 286 - 288
Hlavní autoři: Phipson, Belinda, Maksimovic, Jovana, Oshlack, Alicia
Médium: Journal Article
Jazyk:angličtina
Vydáno: England 15.01.2016
Témata:
Computational Biology - methods
CpG Islands
DNA Methylation
Genome, Human
Humans
Oligonucleotide Array Sequence Analysis - methods
Software
ISSN:1367-4803, 1367-4811, 1367-4811
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Shrnutí:DNA methylation is one of the most commonly studied epigenetic modifications due to its role in both disease and development. The Illumina HumanMethylation450 BeadChip is a cost-effective way to profile >450 000 CpGs across the human genome, making it a popular platform for profiling DNA methylation. Here we introduce missMethyl, an R package with a suite of tools for performing normalization, removal of unwanted variation in differential methylation analysis, differential variability testing and gene set analysis for the 450K array. Availability and implementation: missMethyl is an R package available from the Bioconductor project at www.bioconductor.org. Contact:  alicia.oshlack@mcri.edu.au Supplementary information:  Supplementary data are available at Bioinformatics online.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1367-4803
1367-4811
1367-4811
DOI:10.1093/bioinformatics/btv560