Neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in protection against gentamicin-induced ototoxicity in guinea pigs

Despite that gentamicin is a very effective aminoglycoside, its potential ototoxicity which is of irreversible nature makes a challenge and limitation for its use. This study was designed to investigate possible neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in prot...

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Bibliographic Details
Published in:Pharmacological reports Vol. 67; no. 2; pp. 317 - 325
Main Authors: Draz, Eman I., Abdin, Amany A., Sarhan, Naglaa I., Gabr, Takwa A.
Format: Journal Article
Language:English
Published: Cham Elsevier Urban & Partner Sp. z o.o 01.04.2015
Springer International Publishing
Subjects:
Animals
Antioxidants
Antioxidants - pharmacology
Catechols - pharmacology
Cochlea - drug effects
Cochlea - metabolism
Drug Safety and Pharmacovigilance
Evoked Potentials, Auditory, Brain Stem - drug effects
Evoked Potentials, Auditory, Brain Stem - physiology
Gentamicin
Gentamicins - adverse effects
Guinea Pigs
Hearing Loss, Bilateral - chemically induced
Hearing Loss, Bilateral - metabolism
Hearing Loss, Bilateral - physiopathology
Hearing Loss, Bilateral - prevention & control
Nerve Growth Factor - metabolism
Neuroprotective Agents - pharmacology
Neurotrophic factors
Organ of Corti - drug effects
Organ of Corti - pathology
Organ of Corti - ultrastructure
Original Research Article
Ototoxicity
Oxidative Stress - drug effects
Pharmacotherapy
Pharmacy
Receptor, trkA
Silymarin
Silymarin - pharmacology
Antioxidants
Silymarin
Neurotrophic factors
Gentamicin
Ototoxicity
ISSN:1734-1140, 2299-5684, 2299-5684
Online Access:Get full text
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Summary:Despite that gentamicin is a very effective aminoglycoside, its potential ototoxicity which is of irreversible nature makes a challenge and limitation for its use. This study was designed to investigate possible neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in protection against gentamicin-induced ototoxicity. Twenty pigmented guinea pigs were divided into four equal groups, where group I served as normal control group. The other groups received gentamicin (120mg/kg/day, ip) for 19 days where group II given vehicle of 1% CMC, group III and group IV were pre-treated 2h before gentamicin by 4-methylcatechol (10μg/kg, ip) and silymarin (100mg/kg, oral gavage), respectively. The main findings indicated that silymarin exhibited restoration of nerve growth factor (NGF) levels and increased tropomyosin-related kinase receptors-A (Trk-A) m-RNA expression in cochlear tissue and preservation of hair cells of organ of Corti by scanning electron microscopy (SEM) with significant decrease in auditory brainstem response (ABR) threshold compared to 4-methylcatechol. Only silymarin caused significant amelioration in oxidative stress state by reducing malondialdehyde (MDA) levels and increasing catalase activity. Silymarin exerts superiority over 4-methylcatechol when recommended as protective agent against gentamicin ototoxicity based on its efficient neurotrophic and antioxidant activities.
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ISSN:1734-1140
2299-5684
2299-5684
DOI:10.1016/j.pharep.2014.10.007