Neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in protection against gentamicin-induced ototoxicity in guinea pigs

Despite that gentamicin is a very effective aminoglycoside, its potential ototoxicity which is of irreversible nature makes a challenge and limitation for its use. This study was designed to investigate possible neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in prot...

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Veröffentlicht in:	Pharmacological reports Jg. 67; H. 2; S. 317 - 325
Hauptverfasser:	Draz, Eman I., Abdin, Amany A., Sarhan, Naglaa I., Gabr, Takwa A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Cham Elsevier Urban & Partner Sp. z o.o 01.04.2015 Springer International Publishing
Schlagworte:	Animals Antioxidants Antioxidants - pharmacology Catechols - pharmacology Cochlea - drug effects Cochlea - metabolism Drug Safety and Pharmacovigilance Evoked Potentials, Auditory, Brain Stem - drug effects Evoked Potentials, Auditory, Brain Stem - physiology Gentamicin Gentamicins - adverse effects Guinea Pigs Hearing Loss, Bilateral - chemically induced Hearing Loss, Bilateral - metabolism Hearing Loss, Bilateral - physiopathology Hearing Loss, Bilateral - prevention & control Nerve Growth Factor - metabolism Neuroprotective Agents - pharmacology Neurotrophic factors Organ of Corti - drug effects Organ of Corti - pathology Organ of Corti - ultrastructure Original Research Article Ototoxicity Oxidative Stress - drug effects Pharmacotherapy Pharmacy Receptor, trkA Silymarin Silymarin - pharmacology Antioxidants Silymarin Neurotrophic factors Gentamicin Ototoxicity
ISSN:	1734-1140, 2299-5684, 2299-5684
Online-Zugang:	Volltext
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