Neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in protection against gentamicin-induced ototoxicity in guinea pigs

Despite that gentamicin is a very effective aminoglycoside, its potential ototoxicity which is of irreversible nature makes a challenge and limitation for its use. This study was designed to investigate possible neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in prot...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Pharmacological reports Ročník 67; číslo 2; s. 317 - 325
Hlavní autoři:	Draz, Eman I., Abdin, Amany A., Sarhan, Naglaa I., Gabr, Takwa A.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Cham Elsevier Urban & Partner Sp. z o.o 01.04.2015 Springer International Publishing
Témata:	Animals Antioxidants Antioxidants - pharmacology Catechols - pharmacology Cochlea - drug effects Cochlea - metabolism Drug Safety and Pharmacovigilance Evoked Potentials, Auditory, Brain Stem - drug effects Evoked Potentials, Auditory, Brain Stem - physiology Gentamicin Gentamicins - adverse effects Guinea Pigs Hearing Loss, Bilateral - chemically induced Hearing Loss, Bilateral - metabolism Hearing Loss, Bilateral - physiopathology Hearing Loss, Bilateral - prevention & control Nerve Growth Factor - metabolism Neuroprotective Agents - pharmacology Neurotrophic factors Organ of Corti - drug effects Organ of Corti - pathology Organ of Corti - ultrastructure Original Research Article Ototoxicity Oxidative Stress - drug effects Pharmacotherapy Pharmacy Receptor, trkA Silymarin Silymarin - pharmacology Antioxidants Silymarin Neurotrophic factors Gentamicin Ototoxicity
ISSN:	1734-1140, 2299-5684, 2299-5684
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!