Neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in protection against gentamicin-induced ototoxicity in guinea pigs

Despite that gentamicin is a very effective aminoglycoside, its potential ototoxicity which is of irreversible nature makes a challenge and limitation for its use. This study was designed to investigate possible neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in prot...

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Veröffentlicht in:Pharmacological reports Jg. 67; H. 2; S. 317 - 325
Hauptverfasser: Draz, Eman I., Abdin, Amany A., Sarhan, Naglaa I., Gabr, Takwa A.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Cham Elsevier Urban & Partner Sp. z o.o 01.04.2015
Springer International Publishing
Schlagworte:
Animals
Antioxidants
Antioxidants - pharmacology
Catechols - pharmacology
Cochlea - drug effects
Cochlea - metabolism
Drug Safety and Pharmacovigilance
Evoked Potentials, Auditory, Brain Stem - drug effects
Evoked Potentials, Auditory, Brain Stem - physiology
Gentamicin
Gentamicins - adverse effects
Guinea Pigs
Hearing Loss, Bilateral - chemically induced
Hearing Loss, Bilateral - metabolism
Hearing Loss, Bilateral - physiopathology
Hearing Loss, Bilateral - prevention & control
Nerve Growth Factor - metabolism
Neuroprotective Agents - pharmacology
Neurotrophic factors
Organ of Corti - drug effects
Organ of Corti - pathology
Organ of Corti - ultrastructure
Original Research Article
Ototoxicity
Oxidative Stress - drug effects
Pharmacotherapy
Pharmacy
Receptor, trkA
Silymarin
Silymarin - pharmacology
Antioxidants
Silymarin
Neurotrophic factors
Gentamicin
Ototoxicity
ISSN:1734-1140, 2299-5684, 2299-5684
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Abstract Despite that gentamicin is a very effective aminoglycoside, its potential ototoxicity which is of irreversible nature makes a challenge and limitation for its use. This study was designed to investigate possible neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in protection against gentamicin-induced ototoxicity. Twenty pigmented guinea pigs were divided into four equal groups, where group I served as normal control group. The other groups received gentamicin (120mg/kg/day, ip) for 19 days where group II given vehicle of 1% CMC, group III and group IV were pre-treated 2h before gentamicin by 4-methylcatechol (10μg/kg, ip) and silymarin (100mg/kg, oral gavage), respectively. The main findings indicated that silymarin exhibited restoration of nerve growth factor (NGF) levels and increased tropomyosin-related kinase receptors-A (Trk-A) m-RNA expression in cochlear tissue and preservation of hair cells of organ of Corti by scanning electron microscopy (SEM) with significant decrease in auditory brainstem response (ABR) threshold compared to 4-methylcatechol. Only silymarin caused significant amelioration in oxidative stress state by reducing malondialdehyde (MDA) levels and increasing catalase activity. Silymarin exerts superiority over 4-methylcatechol when recommended as protective agent against gentamicin ototoxicity based on its efficient neurotrophic and antioxidant activities.
AbstractList Despite that gentamicin is a very effective aminoglycoside, its potential ototoxicity which is of irreversible nature makes a challenge and limitation for its use. This study was designed to investigate possible neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in protection against gentamicin-induced ototoxicity. Twenty pigmented guinea pigs were divided into four equal groups, where group I served as normal control group. The other groups received gentamicin (120 mg/kg/day, ip) for 19 days where group II given vehicle of 1% CMC, group III and group IV were pre-treated 2h before gentamicin by 4-methylcatechol (10 μg/kg, ip) and silymarin (100mg/kg, oral gavage), respectively. The main findings indicated that silymarin exhibited restoration of nerve growth factor (NGF) levels and increased tropomyosin-related kinase receptors-A (Trk-A) m-RNA expression in cochlear tissue and preservation of hair cells of organ of Corti by scanning electron microscopy (SEM) with significant decrease in auditory brainstem response (ABR) threshold compared to 4-methylcatechol. Only silymarin caused significant amelioration in oxidative stress state by reducing malondialdehyde (MDA) levels and increasing catalase activity. Silymarin exerts superiority over 4-methylcatechol when recommended as protective agent against gentamicin ototoxicity based on its efficient neurotrophic and antioxidant activities.
Despite that gentamicin is a very effective aminoglycoside, its potential ototoxicity which is of irreversible nature makes a challenge and limitation for its use. This study was designed to investigate possible neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in protection against gentamicin-induced ototoxicity.BACKGROUNDDespite that gentamicin is a very effective aminoglycoside, its potential ototoxicity which is of irreversible nature makes a challenge and limitation for its use. This study was designed to investigate possible neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in protection against gentamicin-induced ototoxicity.Twenty pigmented guinea pigs were divided into four equal groups, where group I served as normal control group. The other groups received gentamicin (120 mg/kg/day, ip) for 19 days where group II given vehicle of 1% CMC, group III and group IV were pre-treated 2h before gentamicin by 4-methylcatechol (10 μg/kg, ip) and silymarin (100mg/kg, oral gavage), respectively. The main findings indicated that silymarin exhibited restoration of nerve growth factor (NGF) levels and increased tropomyosin-related kinase receptors-A (Trk-A) m-RNA expression in cochlear tissue and preservation of hair cells of organ of Corti by scanning electron microscopy (SEM) with significant decrease in auditory brainstem response (ABR) threshold compared to 4-methylcatechol. Only silymarin caused significant amelioration in oxidative stress state by reducing malondialdehyde (MDA) levels and increasing catalase activity.METHODS AND RESULTSTwenty pigmented guinea pigs were divided into four equal groups, where group I served as normal control group. The other groups received gentamicin (120 mg/kg/day, ip) for 19 days where group II given vehicle of 1% CMC, group III and group IV were pre-treated 2h before gentamicin by 4-methylcatechol (10 μg/kg, ip) and silymarin (100mg/kg, oral gavage), respectively. The main findings indicated that silymarin exhibited restoration of nerve growth factor (NGF) levels and increased tropomyosin-related kinase receptors-A (Trk-A) m-RNA expression in cochlear tissue and preservation of hair cells of organ of Corti by scanning electron microscopy (SEM) with significant decrease in auditory brainstem response (ABR) threshold compared to 4-methylcatechol. Only silymarin caused significant amelioration in oxidative stress state by reducing malondialdehyde (MDA) levels and increasing catalase activity.Silymarin exerts superiority over 4-methylcatechol when recommended as protective agent against gentamicin ototoxicity based on its efficient neurotrophic and antioxidant activities.CONCLUSIONSSilymarin exerts superiority over 4-methylcatechol when recommended as protective agent against gentamicin ototoxicity based on its efficient neurotrophic and antioxidant activities.
Despite that gentamicin is a very effective aminoglycoside, its potential ototoxicity which is of irreversible nature makes a challenge and limitation for its use. This study was designed to investigate possible neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in protection against gentamicin-induced ototoxicity. Twenty pigmented guinea pigs were divided into four equal groups, where group I served as normal control group. The other groups received gentamicin (120mg/kg/day, ip) for 19 days where group II given vehicle of 1% CMC, group III and group IV were pre-treated 2h before gentamicin by 4-methylcatechol (10μg/kg, ip) and silymarin (100mg/kg, oral gavage), respectively. The main findings indicated that silymarin exhibited restoration of nerve growth factor (NGF) levels and increased tropomyosin-related kinase receptors-A (Trk-A) m-RNA expression in cochlear tissue and preservation of hair cells of organ of Corti by scanning electron microscopy (SEM) with significant decrease in auditory brainstem response (ABR) threshold compared to 4-methylcatechol. Only silymarin caused significant amelioration in oxidative stress state by reducing malondialdehyde (MDA) levels and increasing catalase activity. Silymarin exerts superiority over 4-methylcatechol when recommended as protective agent against gentamicin ototoxicity based on its efficient neurotrophic and antioxidant activities.
Background Despite that gentamicin is a very effective aminoglycoside, its potential ototoxicity which is of irreversible nature makes a challenge and limitation for its use. This study was designed to investigate possible neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in protection against gentamicin-induced ototoxicity. Methods and results Twenty pigmented guinea pigs were divided into four equal groups, where group I served as normal control group. The other groups received gentamicin (120 mg/kg/day, ip ) for 19 days where group II given vehicle of 1% CMC, group III and group IV were pre-treated 2 h before gentamicin by 4-methylcatechol (10 μg/kg, ip ) and silymarin (100 mg/kg, oral gavage), respectively. The main findings indicated that silymarin exhibited restoration of nerve growth factor (NGF) levels and increased tropomyosin-related kinase receptors-A (Trk-A) m-RNA expression in cochlear tissue and preservation of hair cells of organ of Corti by scanning electron microscopy (SEM) with significant decrease in auditory brainstem response (ABR) threshold compared to 4-methylcatechol. Only silymarin caused significant amelioration in oxidative stress state by reducing malondialdehyde (MDA) levels and increasing catalase activity. Conclusions Silymarin exerts superiority over 4-methylcatechol when recommended as protective agent against gentamicin ototoxicity based on its efficient neurotrophic and antioxidant activities.
Author Abdin, Amany A.
Sarhan, Naglaa I.
Draz, Eman I.
Gabr, Takwa A.
Author_xml – sequence: 1
  givenname: Eman I.
  surname: Draz
  fullname: Draz, Eman I.
  organization: Department of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Tanta University, Tanta, Egypt
– sequence: 2
  givenname: Amany A.
  surname: Abdin
  fullname: Abdin, Amany A.
  email: amanyabdin@med.tanta.edu.eg, amanynhr@hotmail.com
  organization: Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt
– sequence: 3
  givenname: Naglaa I.
  surname: Sarhan
  fullname: Sarhan, Naglaa I.
  organization: Department of Histology, Faculty of Medicine, Tanta University, Tanta, Egypt
– sequence: 4
  givenname: Takwa A.
  surname: Gabr
  fullname: Gabr, Takwa A.
  organization: Department of Audiology, Faculty of Medicine, Tanta University, Tanta, Egypt
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Issue 2
Keywords Antioxidants
Silymarin
Neurotrophic factors
Gentamicin
Ototoxicity
Language English
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Snippet Despite that gentamicin is a very effective aminoglycoside, its potential ototoxicity which is of irreversible nature makes a challenge and limitation for its...
Background Despite that gentamicin is a very effective aminoglycoside, its potential ototoxicity which is of irreversible nature makes a challenge and...
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StartPage 317
SubjectTerms Animals
Antioxidants
Antioxidants - pharmacology
Catechols - pharmacology
Cochlea - drug effects
Cochlea - metabolism
Drug Safety and Pharmacovigilance
Evoked Potentials, Auditory, Brain Stem - drug effects
Evoked Potentials, Auditory, Brain Stem - physiology
Gentamicin
Gentamicins - adverse effects
Guinea Pigs
Hearing Loss, Bilateral - chemically induced
Hearing Loss, Bilateral - metabolism
Hearing Loss, Bilateral - physiopathology
Hearing Loss, Bilateral - prevention & control
Nerve Growth Factor - metabolism
Neuroprotective Agents - pharmacology
Neurotrophic factors
Organ of Corti - drug effects
Organ of Corti - pathology
Organ of Corti - ultrastructure
Original Research Article
Ototoxicity
Oxidative Stress - drug effects
Pharmacotherapy
Pharmacy
Receptor, trkA
Silymarin
Silymarin - pharmacology
Title Neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in protection against gentamicin-induced ototoxicity in guinea pigs
URI https://dx.doi.org/10.1016/j.pharep.2014.10.007
https://link.springer.com/article/10.1016/j.pharep.2014.10.007
https://www.ncbi.nlm.nih.gov/pubmed/25712657
https://www.proquest.com/docview/1658707550
Volume 67
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