A Systematic Review of the Potential of Pichia pastoris (Komagataella phaffii) as an Alternative Host for Biologics Production

The methylotrophic yeast Pichia pastoris is garnering interest as a chassis cell factory for the manufacture of recombinant proteins because it effectively satisfies the requirements of both laboratory and industrial set up. The optimisation of P. pastoris cultivation is still necessary due to strai...

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Vydané v:Molecular biotechnology Ročník 66; číslo 7; s. 1621 - 1639
Hlavní autori: Vijayakumar, Vijay Elakkya, Venkataraman, Krishnan
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: New York Springer US 01.07.2024
Springer Nature B.V
Predmet:
alternative hosts
Biochemistry
Biological Products - metabolism
Biological Techniques
Biotechnology
Cell Biology
Chemistry
Chemistry and Materials Science
CRISPR
CRISPR-Cas Systems
Gene dosage
Genetic diversity
Genetic engineering
Genetic Engineering - methods
Human Genetics
Komagataella pastoris
manufacturing
Methanol
peptides
Pichia
Pichia - genetics
Pichia - metabolism
Pichia pastoris
Process engineering
Protein engineering
Protein Science
Proteins
Recombinant Proteins - genetics
Recombinant Proteins - metabolism
Review
Saccharomycetales - genetics
Saccharomycetales - metabolism
Systematic review
therapeutics
Yeast
yeasts
2A peptide system
Proteolysis
Secretion
Recombinant proteins
CRISPR/Cas
Promoters
Codon optimization
Pichia pastoris
ISSN:1073-6085, 1559-0305, 1559-0305
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Abstract The methylotrophic yeast Pichia pastoris is garnering interest as a chassis cell factory for the manufacture of recombinant proteins because it effectively satisfies the requirements of both laboratory and industrial set up. The optimisation of P. pastoris cultivation is still necessary due to strain- and product-specific problems such as promoter strength, methanol utilisation type, and culturing conditions to realize the high yields of heterologous protein(s) of interest. Techniques integrating genetic and process engineering have been used to overcome these problems. Insight into the Pichia as an expression system utilizing MUT pathway and the development of methanol free systems are highlighted in this systematic review. Recent developments in the improved production of proteins in P. pastoris by (i) diverse genetic engineering such as codon optimization and gene dosage; (ii) cultivating tactics including co-expression of chaperones; (iii) advances in the use of the 2A peptide system, and (iv) CRISPR/Cas technologies are widely discussed. We believe that by combining these strategies, P. pastoris will become a formidable platform for the production of high value therapeutic proteins. Graphical Abstract
AbstractList The methylotrophic yeast Pichia pastoris is garnering interest as a chassis cell factory for the manufacture of recombinant proteins because it effectively satisfies the requirements of both laboratory and industrial set up. The optimisation of P. pastoris cultivation is still necessary due to strain- and product-specific problems such as promoter strength, methanol utilisation type, and culturing conditions to realize the high yields of heterologous protein(s) of interest. Techniques integrating genetic and process engineering have been used to overcome these problems. Insight into the Pichia as an expression system utilizing MUT pathway and the development of methanol free systems are highlighted in this systematic review. Recent developments in the improved production of proteins in P. pastoris by (i) diverse genetic engineering such as codon optimization and gene dosage; (ii) cultivating tactics including co-expression of chaperones; (iii) advances in the use of the 2A peptide system, and (iv) CRISPR/Cas technologies are widely discussed. We believe that by combining these strategies, P. pastoris will become a formidable platform for the production of high value therapeutic proteins.The methylotrophic yeast Pichia pastoris is garnering interest as a chassis cell factory for the manufacture of recombinant proteins because it effectively satisfies the requirements of both laboratory and industrial set up. The optimisation of P. pastoris cultivation is still necessary due to strain- and product-specific problems such as promoter strength, methanol utilisation type, and culturing conditions to realize the high yields of heterologous protein(s) of interest. Techniques integrating genetic and process engineering have been used to overcome these problems. Insight into the Pichia as an expression system utilizing MUT pathway and the development of methanol free systems are highlighted in this systematic review. Recent developments in the improved production of proteins in P. pastoris by (i) diverse genetic engineering such as codon optimization and gene dosage; (ii) cultivating tactics including co-expression of chaperones; (iii) advances in the use of the 2A peptide system, and (iv) CRISPR/Cas technologies are widely discussed. We believe that by combining these strategies, P. pastoris will become a formidable platform for the production of high value therapeutic proteins.
The methylotrophic yeast Pichia pastoris is garnering interest as a chassis cell factory for the manufacture of recombinant proteins because it effectively satisfies the requirements of both laboratory and industrial set up. The optimisation of P. pastoris cultivation is still necessary due to strain- and product-specific problems such as promoter strength, methanol utilisation type, and culturing conditions to realize the high yields of heterologous protein(s) of interest. Techniques integrating genetic and process engineering have been used to overcome these problems. Insight into the Pichia as an expression system utilizing MUT pathway and the development of methanol free systems are highlighted in this systematic review. Recent developments in the improved production of proteins in P. pastoris by (i) diverse genetic engineering such as codon optimization and gene dosage; (ii) cultivating tactics including co-expression of chaperones; (iii) advances in the use of the 2A peptide system, and (iv) CRISPR/Cas technologies are widely discussed. We believe that by combining these strategies, P. pastoris will become a formidable platform for the production of high value therapeutic proteins.
The methylotrophic yeast Pichia pastoris is garnering interest as a chassis cell factory for the manufacture of recombinant proteins because it effectively satisfies the requirements of both laboratory and industrial set up. The optimisation of P. pastoris cultivation is still necessary due to strain- and product-specific problems such as promoter strength, methanol utilisation type, and culturing conditions to realize the high yields of heterologous protein(s) of interest. Techniques integrating genetic and process engineering have been used to overcome these problems. Insight into the Pichia as an expression system utilizing MUT pathway and the development of methanol free systems are highlighted in this systematic review. Recent developments in the improved production of proteins in P. pastoris by (i) diverse genetic engineering such as codon optimization and gene dosage; (ii) cultivating tactics including co-expression of chaperones; (iii) advances in the use of the 2A peptide system, and (iv) CRISPR/Cas technologies are widely discussed. We believe that by combining these strategies, P. pastoris will become a formidable platform for the production of high value therapeutic proteins. Graphical Abstract
Author Vijayakumar, Vijay Elakkya
Venkataraman, Krishnan
Author_xml – sequence: 1
  givenname: Vijay Elakkya
  surname: Vijayakumar
  fullname: Vijayakumar, Vijay Elakkya
  organization: Centre for Bio-Separation Technology (CBST), Vellore Institute of Technology (VIT)
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  givenname: Krishnan
  orcidid: 0000-0002-2900-8474
  surname: Venkataraman
  fullname: Venkataraman, Krishnan
  email: bmkrishna1@yahoo.com, krishnan.v@vit.ac.in
  organization: Centre for Bio-Separation Technology (CBST), Vellore Institute of Technology (VIT)
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37400712$$D View this record in MEDLINE/PubMed
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IsPeerReviewed true
IsScholarly true
Issue 7
Keywords 2A peptide system
Proteolysis
Secretion
Recombinant proteins
CRISPR/Cas
Promoters
Codon optimization
Pichia pastoris
Language English
License 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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Snippet The methylotrophic yeast Pichia pastoris is garnering interest as a chassis cell factory for the manufacture of recombinant proteins because it effectively...
The methylotrophic yeast Pichia pastoris is garnering interest as a chassis cell factory for the manufacture of recombinant proteins because it effectively...
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SubjectTerms alternative hosts
Biochemistry
Biological Products - metabolism
Biological Techniques
Biotechnology
Cell Biology
Chemistry
Chemistry and Materials Science
CRISPR
CRISPR-Cas Systems
Gene dosage
Genetic diversity
Genetic engineering
Genetic Engineering - methods
Human Genetics
Komagataella pastoris
manufacturing
Methanol
peptides
Pichia
Pichia - genetics
Pichia - metabolism
Pichia pastoris
Process engineering
Protein engineering
Protein Science
Proteins
Recombinant Proteins - genetics
Recombinant Proteins - metabolism
Review
Saccharomycetales - genetics
Saccharomycetales - metabolism
Systematic review
therapeutics
Yeast
yeasts
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Title A Systematic Review of the Potential of Pichia pastoris (Komagataella phaffii) as an Alternative Host for Biologics Production
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