A Critical Role of the IL-1β-IL-1R Signaling Pathway in Skin Inflammation and Psoriasis Pathogenesis

The IL-1 signaling pathway has been shown to play a critical role in the pathogenesis of chronic, autoinflammatory skin diseases such as psoriasis. However, the exact cellular and molecular mechanisms have not been fully understood. Here, we show that IL-1β is significantly elevated in psoriatic les...

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Veröffentlicht in:	Journal of investigative dermatology Jg. 139; H. 1; S. 146
Hauptverfasser:	Cai, Yihua, Xue, Feng, Quan, Chen, Qu, Minye, Liu, Na, Zhang, Yuan, Fleming, Chris, Hu, Xiaoling, Zhang, Huang-Ge, Weichselbaum, Ralph, Fu, Yang-Xin, Tieri, David, Rouchka, Eric C, Zheng, Jie, Yan, Jun
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.01.2019
Schlagworte:	Animals Cell Proliferation Enzyme-Linked Immunosorbent Assay Gene Expression Regulation Humans Inflammation - genetics Inflammation - metabolism Inflammation - pathology Interleukin-1beta - blood Interleukin-1beta - genetics Keratinocytes - metabolism Keratinocytes - pathology Mice Mice, Knockout Polymerase Chain Reaction Psoriasis - genetics Psoriasis - metabolism Psoriasis - pathology Receptors, Interleukin-1 Type I - biosynthesis Receptors, Interleukin-1 Type I - genetics RNA - genetics
ISSN:	1523-1747, 1523-1747
Online-Zugang:	Weitere Angaben
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