Cationic pH-sensitive liposomes as tuberculosis subunit vaccine delivery systems: Effect of liposome composition on cellular innate immune responses

•Cationic pH-sensitive liposomes are effectively taken up by dendritic cells (DCs)•1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (EPC) improves DC activation.•EPC-based pH-sensitive liposomes effectively induce activation of DCs.•pH-sensitive liposomes trigger antigen-specific IFNγ production in T-c...

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Bibliographic Details
Published in:	International immunopharmacology Vol. 145; p. 113782
Main Authors:	Szachniewicz, M.M., Meijgaarden, K.E. van, Kavrik, E., Jiskoot, W., Bouwstra, J.A., Haks, M.C., Geluk, A., Ottenhoff, T.H.M.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 03.01.2025
Subjects:	Adjuvant Animals Antigens, Bacterial - immunology Cationic liposome Cations CD8-Positive T-Lymphocytes - immunology Cells, Cultured Cytokines - metabolism Dendritic cells Dendritic Cells - immunology Humans Hydrogen-Ion Concentration Immunity, Cellular Immunity, Innate Immunogenicity Liposomes Mycobacterium tuberculosis - immunology pH-sensitive liposome Tuberculosis Tuberculosis - immunology Tuberculosis - prevention & control Tuberculosis Vaccines - administration & dosage Tuberculosis Vaccines - immunology Vaccines, Subunit - administration & dosage Vaccines, Subunit - immunology CXCL PPD Cationic liposome MHC TNF IFN PDI GM-CSF FBS CCR7 Adjuvant TLR Th1 DOPC DOPE CD PE-Cy5 DOBAQ Dendritic cells BCG MACS IQR M−CSF CCL PBMC AER TB PAMP MDDC Tuberculosis APC Immunogenicity PE LAL CHEMS EPC Mtb DOTAP HLA Ig PCR pH-sensitive liposome DC
ISSN:	1567-5769, 1878-1705, 1878-1705
Online Access:	Get full text
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