An Investigation into Cell-Free DNA in Different Common Cancers

Diagnosis is the most important step in different diseases, especially in cancers and blood malignancies. There are different methods in order to better diagnose of cancer, but many of them are invasive and also, some of them are not useful for immediate diagnosis. Cell-free DNA (cfDNA) or liquid bi...

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Bibliographic Details
Published in:Molecular biotechnology Vol. 66; no. 12; pp. 3462 - 3474
Main Authors: Nafar, Samira, Hosseini, Kamran, Shokrgozar, Negin, Farahmandi, Amir Yousef, Alamdari-Palangi, Vahab, Saber Sichani, Ali, Fallahi, Jafar
Format: Journal Article
Language:English
Published: New York Springer US 01.12.2024
Springer Nature B.V
Subjects:
Biochemistry
Biological Techniques
Biomarkers
Biomarkers, Tumor - blood
Biomarkers, Tumor - genetics
Biopsy
Biotechnology
Blood
Blood cancer
blood serum
Breast cancer
Breast carcinoma
breast neoplasms
Cancer
Cell Biology
Chemistry
Chemistry and Materials Science
Circulating Tumor DNA - blood
Circulating Tumor DNA - genetics
Deoxyribonucleic acid
Diagnosis
Disease management
DNA
Hepatocellular carcinoma
hepatoma
Human Genetics
Humans
Invasiveness
Liquid Biopsy - methods
Liver cancer
Lung cancer
Lung carcinoma
lung neoplasms
Malignancy
Morbidity
Neoplasms - blood
Neoplasms - diagnosis
Neoplasms - genetics
Peripheral blood
Protein Science
Review Paper
Solid tumors
Tumor cells
Tumors
Cell-free DNA
Biomarker
Cancer
ISSN:1073-6085, 1559-0305, 1559-0305
Online Access:Get full text
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Summary:Diagnosis is the most important step in different diseases, especially in cancers and blood malignancies. There are different methods in order to better diagnose of cancer, but many of them are invasive and also, some of them are not useful for immediate diagnosis. Cell-free DNA (cfDNA) or liquid biopsy easily accessible in peripheral blood is one of the non-invasive prognostic biomarkers in various areas of cancer management. In fact, amounts of cfDNA in serum or plasma can be used for diagnosis. In this review, we have considered some cancers such as hepatocellular carcinoma, lung cancer, breast cancer, and hematologic malignancies to compare the various methods of cfDNA diagnosis. Highlights The result of early diagnosis along with correct treatment decreases morbidity. Cell-free DNA is a non-invasive way of diagnosing the presence of tumor cells in earlier stages of cancer. DNA released from both solid tumors and hematologic malignancies is usable in this method. Genetic feature of cancer cells at different stages can help in prescribing the amount and type of drugs.
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ISSN:1073-6085
1559-0305
1559-0305
DOI:10.1007/s12033-023-00976-9