An Investigation into Cell-Free DNA in Different Common Cancers

Diagnosis is the most important step in different diseases, especially in cancers and blood malignancies. There are different methods in order to better diagnose of cancer, but many of them are invasive and also, some of them are not useful for immediate diagnosis. Cell-free DNA (cfDNA) or liquid bi...

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Veröffentlicht in:	Molecular biotechnology Jg. 66; H. 12; S. 3462 - 3474
Hauptverfasser:	Nafar, Samira, Hosseini, Kamran, Shokrgozar, Negin, Farahmandi, Amir Yousef, Alamdari-Palangi, Vahab, Saber Sichani, Ali, Fallahi, Jafar
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Springer US 01.12.2024 Springer Nature B.V
Schlagworte:	Biochemistry Biological Techniques Biomarkers Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Biopsy Biotechnology Blood Blood cancer blood serum Breast cancer Breast carcinoma breast neoplasms Cancer Cell Biology Chemistry Chemistry and Materials Science Circulating Tumor DNA - blood Circulating Tumor DNA - genetics Deoxyribonucleic acid Diagnosis Disease management DNA Hepatocellular carcinoma hepatoma Human Genetics Humans Invasiveness Liquid Biopsy - methods Liver cancer Lung cancer Lung carcinoma lung neoplasms Malignancy Morbidity Neoplasms - blood Neoplasms - diagnosis Neoplasms - genetics Peripheral blood Protein Science Review Paper Solid tumors Tumor cells Tumors Cell-free DNA Biomarker Cancer
ISSN:	1073-6085, 1559-0305, 1559-0305
Online-Zugang:	Volltext
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Zusammenfassung:	Diagnosis is the most important step in different diseases, especially in cancers and blood malignancies. There are different methods in order to better diagnose of cancer, but many of them are invasive and also, some of them are not useful for immediate diagnosis. Cell-free DNA (cfDNA) or liquid biopsy easily accessible in peripheral blood is one of the non-invasive prognostic biomarkers in various areas of cancer management. In fact, amounts of cfDNA in serum or plasma can be used for diagnosis. In this review, we have considered some cancers such as hepatocellular carcinoma, lung cancer, breast cancer, and hematologic malignancies to compare the various methods of cfDNA diagnosis. Highlights The result of early diagnosis along with correct treatment decreases morbidity. Cell-free DNA is a non-invasive way of diagnosing the presence of tumor cells in earlier stages of cancer. DNA released from both solid tumors and hematologic malignancies is usable in this method. Genetic feature of cancer cells at different stages can help in prescribing the amount and type of drugs.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1073-6085 1559-0305 1559-0305
DOI:	10.1007/s12033-023-00976-9