Phase I/II trial of bevacizumab and radiotherapy for locally advanced inoperable colorectal cancer: vasculature-independent radiosensitizing effect of bevacizumab

Anti-vascular endothelial growth factor therapy enhances the activity of radiotherapy in experimental models, and bevacizumab has therapeutic activity in patients with metastatic colorectal cancer. Twenty-two patients with locally advanced inoperable colorectal carcinomas (LA/I-CRC) were treated wit...

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Veröffentlicht in:	Clinical cancer research Jg. 15; H. 22; S. 7069
Hauptverfasser:	Koukourakis, Michael I, Giatromanolaki, Alexandra, Sheldon, Helen, Buffa, Francesca M, Kouklakis, George, Ragoussis, Ioannis, Sivridis, Efthimios, Harris, Adrian L
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.11.2009
Schlagworte:	Aged Aged, 80 and over Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal, Humanized Bevacizumab Biopsy Cell Line, Tumor Colorectal Neoplasms - drug therapy Colorectal Neoplasms - radiotherapy Combined Modality Therapy - methods Female Gene Expression Regulation, Neoplastic Humans Male Middle Aged Neoplasm Metastasis Radiation-Sensitizing Agents - therapeutic use Radiotherapy - methods Radiotherapy, Conformal - methods RNA, Messenger - metabolism Treatment Outcome
ISSN:	1078-0432, 1557-3265, 1557-3265
Online-Zugang:	Weitere Angaben
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