A Review on Advanced CRISPR-Based Genome-Editing Tools: Base Editing and Prime Editing

In the field of medicine, it is axiomatic that the need of a precise gene-editing tool is critical to employ therapeutic approaches toward pathogenic mutations, occurring in human genome. Today we know that most of genetic defects are caused by single-base pair substitutions in genomic DNA. The abil...

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Bibliographic Details
Published in:	Molecular biotechnology Vol. 65; no. 6; pp. 849 - 860
Main Authors:	Saber Sichani, Ali, Ranjbar, Maryam, Baneshi, Maryam, Torabi Zadeh, Farid, Fallahi, Jafar
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.06.2023 Springer Nature B.V
Subjects:	Animals Biochemistry Biological Techniques Biotechnology Cell Biology Chemistry Chemistry and Materials Science CRISPR CRISPR-Cas systems CRISPR-Cas Systems - genetics Deoxyribonucleic acid DNA Editing gene editing Gene Editing - methods Gene sequencing Gene therapy genes Genetic diversity Genetic modification Genetic Therapy Genetic variance Genome editing Genomes Human Genetics Humans Mammals - genetics medicine Mutation Nuclease nucleases Nucleotide sequence Prospective Studies Protein Science Reproducibility of Results Review Paper Prime editing CRISPR/Cas9 Gene editing CRISPR-based tools Base editing
ISSN:	1073-6085, 1559-0305, 1559-0305
Online Access:	Get full text
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