Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties

•Ocular drug delivery is a field in which regular ADME tools are not useful.•Pharmacokinetics based dosing aid for ocular drug delivery is presented.•User-friendly dosing aid guides early stage design of delivery systems.•Guidance for the delivery route, dosing and formulation design is presented. O...

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Published in:Drug discovery today Vol. 24; no. 8; pp. 1446 - 1457
Main Authors: Subrizi, Astrid, del Amo, Eva M., Korzhikov-Vlakh, Viktor, Tennikova, Tatiana, Ruponen, Marika, Urtti, Arto
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.08.2019
Subjects:
Administration, Ophthalmic
Biological Availability
Drug Delivery Systems - methods
Eye - drug effects
Humans
Ophthalmic Solutions - therapeutic use
ISSN:1359-6446, 1878-5832, 1878-5832
Online Access:Get full text
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Abstract •Ocular drug delivery is a field in which regular ADME tools are not useful.•Pharmacokinetics based dosing aid for ocular drug delivery is presented.•User-friendly dosing aid guides early stage design of delivery systems.•Guidance for the delivery route, dosing and formulation design is presented. Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling. Successful drug delivery to ocular targets depends on ocular biology, drug properties, and formulation characteristics. A multifactorial design aid for ocular drug delivery is presented.
AbstractList •Ocular drug delivery is a field in which regular ADME tools are not useful.•Pharmacokinetics based dosing aid for ocular drug delivery is presented.•User-friendly dosing aid guides early stage design of delivery systems.•Guidance for the delivery route, dosing and formulation design is presented. Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling. Successful drug delivery to ocular targets depends on ocular biology, drug properties, and formulation characteristics. A multifactorial design aid for ocular drug delivery is presented.
Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling.Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling.
Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling.
Author Urtti, Arto
Subrizi, Astrid
Tennikova, Tatiana
del Amo, Eva M.
Korzhikov-Vlakh, Viktor
Ruponen, Marika
Author_xml – sequence: 1
  givenname: Astrid
  surname: Subrizi
  fullname: Subrizi, Astrid
  organization: School of Pharmacy, University of Eastern Finland, Kuopio, Finland
– sequence: 2
  givenname: Eva M.
  orcidid: 0000-0002-5705-4515
  surname: del Amo
  fullname: del Amo, Eva M.
  organization: School of Pharmacy, University of Manchester, Manchester, UK
– sequence: 3
  givenname: Viktor
  orcidid: 0000-0002-3509-3978
  surname: Korzhikov-Vlakh
  fullname: Korzhikov-Vlakh, Viktor
  organization: Institute of Chemistry, Saint-Petersburg State University, St Petersburg, Russian Federation
– sequence: 4
  givenname: Tatiana
  surname: Tennikova
  fullname: Tennikova, Tatiana
  organization: Institute of Chemistry, Saint-Petersburg State University, St Petersburg, Russian Federation
– sequence: 5
  givenname: Marika
  surname: Ruponen
  fullname: Ruponen, Marika
  organization: School of Pharmacy, University of Eastern Finland, Kuopio, Finland
– sequence: 6
  givenname: Arto
  surname: Urtti
  fullname: Urtti, Arto
  email: arto.urtti@uef.fi
  organization: School of Pharmacy, University of Eastern Finland, Kuopio, Finland
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30738982$$D View this record in MEDLINE/PubMed
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Cites_doi 10.2147/IJN.S162306
10.1021/acs.molpharmaceut.8b00038
10.1371/journal.pone.0029692
10.1002/jps.2600660905
10.1023/A:1022207026982
10.1016/j.jconrel.2010.08.028
10.1007/978-3-642-69222-2_2
10.1016/j.ejpb.2015.01.003
10.1007/s11095-004-7669-3
10.1002/jps.2600721108
10.1016/0378-5173(87)90092-5
10.1016/j.ejpb.2015.02.032
10.1016/0014-4835(80)90091-3
10.1089/jop.2010.0158
10.1016/0378-5173(85)90005-5
10.1016/0014-4835(91)90125-X
10.1002/jps.2600690544
10.1167/iovs.05-0165
10.1023/A:1012123411343
10.1016/j.ijpharm.2015.05.071
10.1016/S1350-9462(99)00016-6
10.1016/S0002-9394(14)77735-9
10.1615/CritRevTherDrugCarrierSyst.v21.i5.10
10.1021/acs.biomac.5b01526
10.1016/j.jconrel.2015.01.009
10.1167/iovs.10-5285
10.1080/10717544.2017.1375578
10.1038/eye.2008.21
10.1007/s11095-016-1993-2
10.1002/jps.2600660222
10.1021/acs.molpharmaceut.8b00280
10.1016/j.ejps.2018.03.023
10.1016/j.addr.2006.07.025
10.1002/jgm.1011
10.1007/s00417-015-3007-1
10.1080/10717544.2018.1458923
10.1016/j.ajo.2011.05.015
10.1016/0378-5173(90)90215-P
10.1167/iovs.07-0593
10.1023/A:1018938310628
10.1167/iovs.02-1068
10.1001/archopht.1992.01080140111037
10.1007/s11095-010-0132-8
10.1097/IAE.0b013e3180592c00
10.1111/j.1748-1716.1979.tb06421.x
10.1021/nn4046024
10.2147/IJN.S135133
10.1089/jop.2014.0082
10.1007/s13346-014-0196-9
10.3129/i08-076
10.1208/aapsj060325
10.1089/108076804772745455
10.1016/j.addr.2017.12.009
10.1007/s11095-006-9748-0
10.2217/nnm.12.202
10.1211/jpp.57.12.0005
10.1002/jbm.a.31769
10.1016/j.addr.2005.07.005
10.1016/S0039-6257(02)00302-8
10.1007/s12038-017-9677-6
10.1002/jps.2600620712
10.1016/j.biopha.2017.07.110
10.1002/jps.21124
10.1016/j.ejps.2018.03.034
10.1016/j.jconrel.2015.05.279
10.3109/10837450.2013.871034
10.1016/j.ejpb.2017.12.019
10.1167/iovs.02-1027
10.1167/iovs.04-1051
10.1016/j.ijpharm.2017.02.047
10.3109/02713688809031801
10.1016/0378-5173(89)90305-0
10.1016/j.ophtha.2016.07.033
10.1517/13543784.2012.681043
10.1016/j.actbio.2015.05.005
10.1002/jps.2600700915
10.1007/978-1-4615-2417-5_51
10.1089/jop.2014.0100
10.1089/jop.2014.0067
10.1002/mabi.201400250
10.1016/0039-6257(85)90109-2
10.1016/j.jssc.2018.08.036
10.1016/j.jconrel.2017.02.013
10.1016/j.actbio.2014.05.031
10.1016/j.jconrel.2013.01.018
10.1021/acs.molpharmaceut.5b00849
10.1002/jps.20625
10.1016/0002-9394(75)90145-2
10.1111/aos.13451
10.1089/108076801753162807
10.1167/iovs.10-5891
10.1016/j.ejpb.2004.12.007
10.1002/jps.2600651123
10.1016/j.actbio.2015.09.020
10.1016/S0378-5173(02)00234-X
10.1081/DDC-120016729
10.1002/jps.2600690407
10.1038/nrd3745
10.1016/j.ejpb.2016.10.015
10.1016/j.addr.2006.07.027
10.1016/j.preteyeres.2016.12.001
10.1016/j.ejps.2018.07.034
10.1021/js9802594
10.1016/S0142-9612(01)00284-8
10.1002/jps.2600690806
10.1080/17435390.2016.1181808
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References Ruponen, Urtti (bib0200) 2015; 96
Le Goff, Bishop (bib0320) 2008; 22
Estey (bib0330) 2006; 95
Sendelbeck (bib0220) 1975; 80
Jaffe (bib0480) 2000; 41
Balguri (bib0265) 2016; 109
Pan (bib0560) 2015; 201
Lee, Robinson (bib0510) 2004; 20
Conrad, Robinson (bib0050) 1977; 66
Merodio (bib0445) 2002; 23
Hutton-Smith (bib0305) 2018; 15
Symeonidis (bib0350) 2007; 27
Watsky (bib0080) 1988; 7
Huang (bib0065) 1989; 30
Lee (bib0245) 1985; 29
Urtti (bib0260) 1994; 11
Ahmed, Patton (bib0060) 1985; 26
Sieg, Robinson (bib0235) 1977; 66
Kijlstra, Kuizenga (bib0190) 1994; 350
Tornquist (bib0525) 1979; 106
Siegman (bib0410) 2015; 28
Bhattacharya (bib0370) 2017; 251
Peeters (bib0135) 2005; 46
Liu (bib0440) 2011; 52
Abu El-Asrar (bib0360) 2018; 96
Rowland, Tozer (bib0165) 1995
Pan (bib0460) 2011; 27
Urtti (bib0170) 2006; 58
Zhang (bib0470) 2015; 23
Bishop (bib0340) 2000; 19
Kim (bib0270) 2018; 268
Yeh (bib0015) 2018
Urtti (bib0075) 1985; 23
Prausnitz, Noonan (bib0110) 1998; 87
Xu (bib0140) 2013; 167
Pitkanen (bib0155) 2005; 46
Li (bib0275) 2018; 13
Sjöquist, Stjernschantz (bib0530) 2002; 47
Amrite, Kompella (bib0555) 2005; 57
Natarajan (bib0550) 2014; 8
Ranta (bib0520) 2010; 148
Del Amo (bib0315) 2017; 57
Hennessy (bib0005) 2011; 152
Abdelkader, Mansou (bib0210) 2015; 20
Longwell (bib0195) 1976; 65
Gomes dos Santos (bib0435) 2006; 23
Kanjickal, Lopina (bib0250) 2004; 21
Maurice (bib0405) 2001; 17
Kalam, Alshamsan (bib0230) 2017; 94
Wong (bib0535) 2014; 4
Sieg, Robinson (bib0175) 1981; 70
Del Amo (bib0300) 2015; 95
Smith (bib0495) 1992; 110
Bourges (bib0395) 2003; 44
El-Kamel (bib0240) 2002; 241
Lee (bib0565) 2017; 12
Peynshaert (bib0150) 2017; 24
Pitkanen (bib0430) 2004; 6
Haghjou (bib0310) 2011; 6
Kholdebarin (bib0010) 2008; 43
Vurgese (bib0130) 2012; 7
Jackson (bib0145) 2003; 44
Ahmed, Patton (bib0085) 1987; 38
Martens (bib0415) 2013; 8
Nichols (bib0185) 1985; 26
Egbu (bib0385) 2018; 124
Kidron (bib0100) 2010; 27
Doane (bib0040) 1978; 85
Kowluru (bib0355) 2012; 21
Du (bib0455) 2017; 42
Amrite (bib0515) 2008; 49
Chrai (bib0070) 1973; 62
Rozier (bib0285) 1989; 57
Kane, Green (bib0500) 2015; 31
Schoenwald, Stewart (bib0225) 1980; 69
Natarajan (bib0545) 2012; 7
Toropainen (bib0090) 2007; 9
Andres-Guerrero (bib0400) 2015; 211
Cheng (bib0540) 2014; 10
Ranta, Urtti (bib0580) 2006; 58
Denlinger (bib0335) 1980; 31
Araie, Maurice (bib0345) 1991; 52
Huang (bib0045) 1983; 72
Horibe (bib0120) 1997; 14
Schmidl (bib0030) 2015; 31
Maurice, Mishima (bib0020) 1984; 69
Li (bib0575) 2004; 21
Conrad, Robinson (bib0505) 1980; 69
Ludwig (bib0205) 2005; 57
Ramsay (bib0105) 2018; 119
Allison (bib0255) 2008; 97
Li (bib0450) 2016; 10
Zhang (bib0025) 2012; 11
Vellonen (bib0095) 2018; 126
Bhagat (bib0490) 2014; 30
Swindle (bib0375) 2008; 87A
Lee (bib0295) 1975; 14
Hamalainen (bib0115) 1997; 38
Hosoya (bib0125) 2005; 60
Stay (bib0420) 2003; 20
Ko (bib0160) 2017; 124
Chang-Lin (bib0485) 2011; 52
Awwad (bib0465) 2017; 522
Xie (bib0380) 2015; 490
Hutton-Smith (bib0570) 2016; 13
Zhang (bib0215) 2016; 17
Miller (bib0055) 1980; 69
Charoo (bib0290) 2003; 29
Manna (bib0475) 2015; 253
Yu (bib0280) 2018; 25
Famili (bib0390) 2014; 14
Urtti (bib0035) 1990; 61
Deng (bib0180) 2016; 33
Heikkinen (bib0365) 2018; 123
Huang (bib0425) 2018; 118
Rimpelä (bib0325) 2018; 15
Urtti (10.1016/j.drudis.2019.02.001_bib0260) 1994; 11
Gomes dos Santos (10.1016/j.drudis.2019.02.001_bib0435) 2006; 23
Xie (10.1016/j.drudis.2019.02.001_bib0380) 2015; 490
Allison (10.1016/j.drudis.2019.02.001_bib0255) 2008; 97
Martens (10.1016/j.drudis.2019.02.001_bib0415) 2013; 8
Andres-Guerrero (10.1016/j.drudis.2019.02.001_bib0400) 2015; 211
Kidron (10.1016/j.drudis.2019.02.001_bib0100) 2010; 27
Chang-Lin (10.1016/j.drudis.2019.02.001_bib0485) 2011; 52
Nichols (10.1016/j.drudis.2019.02.001_bib0185) 1985; 26
Schmidl (10.1016/j.drudis.2019.02.001_bib0030) 2015; 31
Balguri (10.1016/j.drudis.2019.02.001_bib0265) 2016; 109
Charoo (10.1016/j.drudis.2019.02.001_bib0290) 2003; 29
Ranta (10.1016/j.drudis.2019.02.001_bib0520) 2010; 148
Prausnitz (10.1016/j.drudis.2019.02.001_bib0110) 1998; 87
Amrite (10.1016/j.drudis.2019.02.001_bib0555) 2005; 57
Rozier (10.1016/j.drudis.2019.02.001_bib0285) 1989; 57
Siegman (10.1016/j.drudis.2019.02.001_bib0410) 2015; 28
Pan (10.1016/j.drudis.2019.02.001_bib0560) 2015; 201
Tornquist (10.1016/j.drudis.2019.02.001_bib0525) 1979; 106
Le Goff (10.1016/j.drudis.2019.02.001_bib0320) 2008; 22
Cheng (10.1016/j.drudis.2019.02.001_bib0540) 2014; 10
Natarajan (10.1016/j.drudis.2019.02.001_bib0545) 2012; 7
Ahmed (10.1016/j.drudis.2019.02.001_bib0085) 1987; 38
Rowland (10.1016/j.drudis.2019.02.001_bib0165) 1995
Famili (10.1016/j.drudis.2019.02.001_bib0390) 2014; 14
Zhang (10.1016/j.drudis.2019.02.001_bib0470) 2015; 23
Huang (10.1016/j.drudis.2019.02.001_bib0065) 1989; 30
Kowluru (10.1016/j.drudis.2019.02.001_bib0355) 2012; 21
Watsky (10.1016/j.drudis.2019.02.001_bib0080) 1988; 7
Ko (10.1016/j.drudis.2019.02.001_bib0160) 2017; 124
Bhattacharya (10.1016/j.drudis.2019.02.001_bib0370) 2017; 251
Du (10.1016/j.drudis.2019.02.001_bib0455) 2017; 42
Wong (10.1016/j.drudis.2019.02.001_bib0535) 2014; 4
Ruponen (10.1016/j.drudis.2019.02.001_bib0200) 2015; 96
Pitkanen (10.1016/j.drudis.2019.02.001_bib0155) 2005; 46
Kholdebarin (10.1016/j.drudis.2019.02.001_bib0010) 2008; 43
Peynshaert (10.1016/j.drudis.2019.02.001_bib0150) 2017; 24
Stay (10.1016/j.drudis.2019.02.001_bib0420) 2003; 20
Hosoya (10.1016/j.drudis.2019.02.001_bib0125) 2005; 60
Schoenwald (10.1016/j.drudis.2019.02.001_bib0225) 1980; 69
Lee (10.1016/j.drudis.2019.02.001_bib0295) 1975; 14
Miller (10.1016/j.drudis.2019.02.001_bib0055) 1980; 69
Ludwig (10.1016/j.drudis.2019.02.001_bib0205) 2005; 57
Pitkanen (10.1016/j.drudis.2019.02.001_bib0430) 2004; 6
Pan (10.1016/j.drudis.2019.02.001_bib0460) 2011; 27
Maurice (10.1016/j.drudis.2019.02.001_bib0020) 1984; 69
Ramsay (10.1016/j.drudis.2019.02.001_bib0105) 2018; 119
Jackson (10.1016/j.drudis.2019.02.001_bib0145) 2003; 44
Egbu (10.1016/j.drudis.2019.02.001_bib0385) 2018; 124
Bourges (10.1016/j.drudis.2019.02.001_bib0395) 2003; 44
Liu (10.1016/j.drudis.2019.02.001_bib0440) 2011; 52
Bishop (10.1016/j.drudis.2019.02.001_bib0340) 2000; 19
Li (10.1016/j.drudis.2019.02.001_bib0275) 2018; 13
Awwad (10.1016/j.drudis.2019.02.001_bib0465) 2017; 522
Conrad (10.1016/j.drudis.2019.02.001_bib0050) 1977; 66
Horibe (10.1016/j.drudis.2019.02.001_bib0120) 1997; 14
Urtti (10.1016/j.drudis.2019.02.001_bib0035) 1990; 61
Rimpelä (10.1016/j.drudis.2019.02.001_bib0325) 2018; 15
Lee (10.1016/j.drudis.2019.02.001_bib0510) 2004; 20
Huang (10.1016/j.drudis.2019.02.001_bib0425) 2018; 118
Ranta (10.1016/j.drudis.2019.02.001_bib0580) 2006; 58
Amrite (10.1016/j.drudis.2019.02.001_bib0515) 2008; 49
Peeters (10.1016/j.drudis.2019.02.001_bib0135) 2005; 46
Yeh (10.1016/j.drudis.2019.02.001_bib0015) 2018
Vellonen (10.1016/j.drudis.2019.02.001_bib0095) 2018; 126
Bhagat (10.1016/j.drudis.2019.02.001_bib0490) 2014; 30
Doane (10.1016/j.drudis.2019.02.001_bib0040) 1978; 85
Yu (10.1016/j.drudis.2019.02.001_bib0280) 2018; 25
Kanjickal (10.1016/j.drudis.2019.02.001_bib0250) 2004; 21
Zhang (10.1016/j.drudis.2019.02.001_bib0025) 2012; 11
Hamalainen (10.1016/j.drudis.2019.02.001_bib0115) 1997; 38
Deng (10.1016/j.drudis.2019.02.001_bib0180) 2016; 33
Abu El-Asrar (10.1016/j.drudis.2019.02.001_bib0360) 2018; 96
Hennessy (10.1016/j.drudis.2019.02.001_bib0005) 2011; 152
Sieg (10.1016/j.drudis.2019.02.001_bib0235) 1977; 66
Merodio (10.1016/j.drudis.2019.02.001_bib0445) 2002; 23
Denlinger (10.1016/j.drudis.2019.02.001_bib0335) 1980; 31
Kalam (10.1016/j.drudis.2019.02.001_bib0230) 2017; 94
Sjöquist (10.1016/j.drudis.2019.02.001_bib0530) 2002; 47
Chrai (10.1016/j.drudis.2019.02.001_bib0070) 1973; 62
Urtti (10.1016/j.drudis.2019.02.001_bib0170) 2006; 58
Urtti (10.1016/j.drudis.2019.02.001_bib0075) 1985; 23
Lee (10.1016/j.drudis.2019.02.001_bib0245) 1985; 29
Huang (10.1016/j.drudis.2019.02.001_bib0045) 1983; 72
Zhang (10.1016/j.drudis.2019.02.001_bib0215) 2016; 17
Lee (10.1016/j.drudis.2019.02.001_bib0565) 2017; 12
Kijlstra (10.1016/j.drudis.2019.02.001_bib0190) 1994; 350
Natarajan (10.1016/j.drudis.2019.02.001_bib0550) 2014; 8
Ahmed (10.1016/j.drudis.2019.02.001_bib0060) 1985; 26
Vurgese (10.1016/j.drudis.2019.02.001_bib0130) 2012; 7
Heikkinen (10.1016/j.drudis.2019.02.001_bib0365) 2018; 123
Hutton-Smith (10.1016/j.drudis.2019.02.001_bib0570) 2016; 13
El-Kamel (10.1016/j.drudis.2019.02.001_bib0240) 2002; 241
Del Amo (10.1016/j.drudis.2019.02.001_bib0300) 2015; 95
Maurice (10.1016/j.drudis.2019.02.001_bib0405) 2001; 17
Jaffe (10.1016/j.drudis.2019.02.001_bib0480) 2000; 41
Li (10.1016/j.drudis.2019.02.001_bib0450) 2016; 10
Hutton-Smith (10.1016/j.drudis.2019.02.001_bib0305) 2018; 15
Li (10.1016/j.drudis.2019.02.001_bib0575) 2004; 21
Toropainen (10.1016/j.drudis.2019.02.001_bib0090) 2007; 9
Xu (10.1016/j.drudis.2019.02.001_bib0140) 2013; 167
Estey (10.1016/j.drudis.2019.02.001_bib0330) 2006; 95
Conrad (10.1016/j.drudis.2019.02.001_bib0505) 1980; 69
Sendelbeck (10.1016/j.drudis.2019.02.001_bib0220) 1975; 80
Swindle (10.1016/j.drudis.2019.02.001_bib0375) 2008; 87A
Del Amo (10.1016/j.drudis.2019.02.001_bib0315) 2017; 57
Abdelkader (10.1016/j.drudis.2019.02.001_bib0210) 2015; 20
Longwell (10.1016/j.drudis.2019.02.001_bib0195) 1976; 65
Manna (10.1016/j.drudis.2019.02.001_bib0475) 2015; 253
Smith (10.1016/j.drudis.2019.02.001_bib0495) 1992; 110
Kane (10.1016/j.drudis.2019.02.001_bib0500) 2015; 31
Haghjou (10.1016/j.drudis.2019.02.001_bib0310) 2011; 6
Sieg (10.1016/j.drudis.2019.02.001_bib0175) 1981; 70
Araie (10.1016/j.drudis.2019.02.001_bib0345) 1991; 52
Symeonidis (10.1016/j.drudis.2019.02.001_bib0350) 2007; 27
Kim (10.1016/j.drudis.2019.02.001_bib0270) 2018; 268
References_xml – volume: 29
  start-page: 215
  year: 2003
  end-page: 221
  ident: bib0290
  article-title: Ophthalmic delivery of ciprofloxacin hydrochloride from different polymer formulations:
  publication-title: Drug Dev. Ind. Pharm.
– volume: 72
  start-page: 1272
  year: 1983
  end-page: –1279
  ident: bib0045
  article-title: Corneal penetration behavior of β-blocking agents II: Assessment of barrier contributions
  publication-title: J. Pharm. Sci.
– volume: 60
  start-page: 227
  year: 2005
  end-page: 240
  ident: bib0125
  article-title: Roles of the conjunctiva in ocular drug delivery: a review of conjunctival transport mechanisms and their regulation
  publication-title: Eur. J. Pharm. Biopharm.
– volume: 148
  start-page: 42
  year: 2010
  end-page: 48
  ident: bib0520
  article-title: Barrier analysis of periocular drug delivery to the posterior segment
  publication-title: J. Control. Release
– volume: 28
  start-page: 45
  year: 2015
  end-page: 54
  ident: bib0410
  article-title: Encapsulation of PEGylated low-molecular-weight PEI polyplexes in hyaluronic acid hydrogels reduces aggregation
  publication-title: Acta Biomater.
– volume: 26
  start-page: 584
  year: 1985
  end-page: 587
  ident: bib0060
  article-title: Importance of the noncorneal absorption route in topical ophthalmic drug delivery
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 490
  start-page: 375
  year: 2015
  end-page: 383
  ident: bib0380
  article-title: An injectable thermosensitive polymeric hydrogel for sustained release of Avastin1 to treat posterior segment disease
  publication-title: Int. J. Pharm.
– volume: 43
  start-page: 454
  year: 2008
  end-page: 461
  ident: bib0010
  article-title: Multicenter study of compliance and drop administration in glaucoma
  publication-title: Can. J. Ophthalmol.
– volume: 11
  start-page: 1278
  year: 1994
  end-page: 1282
  ident: bib0260
  article-title: Controlled ocular timolol delivery: systemic absorption and intraocular pressure effects in humans
  publication-title: Pharm. Res.
– volume: 20
  start-page: 43
  year: 2004
  end-page: 53
  ident: bib0510
  article-title: Drug delivery to the posterior segment of the eye II: sevelopment and validation of a simple pharmacokinetic model for subconjunctival injection
  publication-title: J. Ocul. Pharmacol. Ther.
– volume: 95
  start-page: 215
  year: 2015
  end-page: 226
  ident: bib0300
  article-title: Intravitreal clearance and volume of distribution of compounds in rabbits: In silico prediction and pharmacokinetic simulations for drug development
  publication-title: Eur. J. Pharm. Biopharm.
– volume: 57
  start-page: 134
  year: 2017
  end-page: 185
  ident: bib0315
  article-title: Pharmacokinetic aspects of retinal drug delivery
  publication-title: Prog. Retin. Eye Res.
– volume: 31
  start-page: 11
  year: 2015
  end-page: 16
  ident: bib0500
  article-title: Ocular pharmacokinetics of fluocinolone acetonide following iluvien implantation in the vitreous humor of rabbits
  publication-title: J. Ocul. Pharmacol.
– volume: 24
  start-page: 1384
  year: 2017
  end-page: 1394
  ident: bib0150
  article-title: Toward rational design of gene carriers: a novel ex vivo model to study the vitreoretinal interface as a barrier
  publication-title: Drug Delivery
– volume: 23
  start-page: 1587
  year: 2002
  end-page: 1594
  ident: bib0445
  article-title: Ocular disposition and tolerance of ganciclovir-loaded albumin nanoparticles after intravitreal injection in rats
  publication-title: Biomaterials
– volume: 167
  start-page: 76
  year: 2013
  end-page: 84
  ident: bib0140
  article-title: Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivo
  publication-title: J. Control. Release
– volume: 13
  start-page: 2941
  year: 2016
  end-page: –2950
  ident: bib0570
  article-title: A mechanistic model of the intravitreal pharmacokinetics of large molecules and the pharmacodynamic suppression of ocular vascular endothelial growth factor levels by ranibizumab in patients with neovascular age-related macular degeneration
  publication-title: Mol. Pharm.
– volume: 19
  start-page: 323
  year: 2000
  end-page: 344
  ident: bib0340
  article-title: Structural macromolecules and supramolecular organisation of the vitreous gel
  publication-title: Prog. Retin. Eye Res.
– volume: 52
  start-page: 4789
  year: 2011
  end-page: 4794
  ident: bib0440
  article-title: A lipid nanoparticle system improves siRNA efficacy in RPE cells and a laser-induced murine CNV model
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 27
  start-page: 1398
  year: 2010
  end-page: 1407
  ident: bib0100
  article-title: Prediction of the corneal permeability of drug-like compounds
  publication-title: Pharm. Res.
– volume: 12
  year: 2017
  ident: bib0565
  article-title: Apatinib-loaded nanoparticles suppress vascular endothelial growth factor-induced angiogenesis and experimental corneal neovascularization
  publication-title: Int. J. Nanomedicine
– volume: 10
  start-page: 1152
  year: 2016
  end-page: 1159
  ident: bib0450
  article-title: Poly(ortho ester) nanoparticles targeted for chronic intraocular diseases: ocular safety and localization after intravitreal injection
  publication-title: Nanotoxicology
– volume: 7
  start-page: e29692
  year: 2012
  ident: bib0130
  article-title: Scleral thickness in human eyes
  publication-title: PLoS One
– volume: 52
  start-page: 27
  year: 1991
  end-page: 39
  ident: bib0345
  article-title: The loss of fluorescein, fluorescein glucuronide and fluorescein isothiocyanate dextran from the vitreous by the anterior and retinal pathways
  publication-title: Exp. Eye Res.
– volume: 17
  start-page: 393
  year: 2001
  end-page: 401
  ident: bib0405
  article-title: Review: practical issues in intravitreal drug delivery
  publication-title: J. Ocul. Pharmacol. Ther.
– volume: 31
  start-page: 63
  year: 2015
  end-page: 77
  ident: bib0030
  article-title: Pharmacotherapy of glaucoma
  publication-title: J. Ocul. Pharmacol. Ther.
– volume: 350
  start-page: 299
  year: 1994
  end-page: 308
  ident: bib0190
  article-title: Analysis and function of the human tear proteins
  publication-title: Adv. Exp. Med. Biol.
– volume: 8
  start-page: 1955
  year: 2013
  end-page: 1968
  ident: bib0415
  article-title: Measuring the intravitreal mobility of nanomedicines with single-particle tracking microscopy
  publication-title: Nanomedicine
– volume: 110
  start-page: 255
  year: 1992
  end-page: 258
  ident: bib0495
  article-title: Intravitreal sustained-release ganciclovir
  publication-title: Arch. Ophthalmol.
– year: 2018
  ident: bib0015
  article-title: Suprachoroidal injection of triamcinolone acetonide, cls-ta, for macular edema due to noninfectious uveitis: a randomized, phase 2 study (DOGWOOD)
  publication-title: Retina
– volume: 38
  start-page: 627
  year: 1997
  end-page: 634
  ident: bib0115
  article-title: Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 70
  start-page: 1026
  year: 1981
  end-page: 1029
  ident: bib0175
  article-title: Mechanistic studies on trans-corneal permeation of fluorometholone
  publication-title: J. Pharm. Sci.
– volume: 268
  start-page: 102
  year: 2018
  end-page: 107
  ident: bib0270
  article-title: Amine-grafted SBA-15 for ophthalmic delivery of dexamethasone
  publication-title: J. Solid State Chem.
– volume: 20
  start-page: 96
  year: 2003
  end-page: 102
  ident: bib0420
  article-title: Computer simulation of convective and diffusive transport of controlled-release drugs in the vitreous humor
  publication-title: Pharm. Res.
– volume: 69
  year: 1984
  ident: bib0020
  article-title: Ocular pharmacokinetics
  publication-title: Pharmacol. Eye
– volume: 33
  start-page: 2680
  year: 2016
  end-page: 2690
  ident: bib0180
  article-title: General pharmacokinetic model for topically administered ocular drug dosage forms
  publication-title: Pharm. Res.
– volume: 15
  start-page: 2770
  year: 2018
  end-page: –2784
  ident: bib0305
  article-title: Theoretical insights into the retinal dynamics of vascular endothelial growth factor in patients treated with ranibizumab, based on an ocular pharmacokinetic/pharmacodynamic model
  publication-title: Mol. Pharm.
– volume: 23
  start-page: 271
  year: 2015
  end-page: 281
  ident: bib0470
  article-title: Sustained intravitreal delivery of dexamethasone using an injectable and biodegradable thermogel
  publication-title: Acta Biomater.
– volume: 14
  start-page: 1719
  year: 2014
  end-page: 1729
  ident: bib0390
  article-title: A combined micelle and poly(serinol hexamethylene urea)-co-poly(n-isopropylacrylamide) reverse thermal gel as an injectable ocular drug delivery system
  publication-title: Macromol. Biosci.
– volume: 118
  start-page: 124
  year: 2018
  end-page: 133
  ident: bib0425
  article-title: Effects of enzymatic degradation on dynamic mechanical properties of the vitreous and intravitreal nanoparticle mobility
  publication-title: Eur. J. Pharm. Sci.
– volume: 11
  start-page: 541
  year: 2012
  end-page: 559
  ident: bib0025
  article-title: Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma
  publication-title: Nat. Rev. Drug Discov.
– volume: 46
  start-page: 641
  year: 2005
  ident: bib0155
  article-title: Permeability of retinal pigment epithelium: effects of permeant molecular weight and lipophilicity
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 8
  start-page: 419
  year: 2014
  end-page: 429
  ident: bib0550
  article-title: Sustained drug release in nanomedicine: a long-acting nanocarrier-based formulation for glaucoma
  publication-title: ACS Nano
– volume: 97
  start-page: 2022
  year: 2008
  end-page: 2035
  ident: bib0255
  article-title: Effect of structural relaxation on the preparation and drug release behavior of poly(lactic-co-glycolic) acid microparticle drug delivery systems
  publication-title: J. Pharm. Sci.
– volume: 49
  start-page: 320
  year: 2008
  end-page: 332
  ident: bib0515
  article-title: Modeling of corneal and retinal pharmacokinetics after periocular drug administration
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 94
  start-page: 402
  year: 2017
  end-page: 411
  ident: bib0230
  article-title: Poly (
  publication-title: Biomed. Pharmacother.
– volume: 65
  start-page: 1654
  year: 1976
  end-page: 1657
  ident: bib0195
  article-title: Effect of topically applied pilocarpine on tear film
  publication-title: J. Pharm. Sci.
– volume: 46
  start-page: 3553
  year: 2005
  end-page: 3561
  ident: bib0135
  article-title: Vitreous: a barrier to nonviral ocular gene therapy
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 58
  start-page: 1164
  year: 2006
  end-page: 1181
  ident: bib0580
  article-title: Transscleral drug delivery to the posterior eye: prospects of pharmacokinetic modeling
  publication-title: Adv. Drug Deliv. Rev.
– volume: 6
  year: 2004
  ident: bib0430
  article-title: Neural retina limits the nonviral gene transfer to retinal pigment epithelium in an
  publication-title: AAPS J.
– volume: 13
  start-page: 3975
  year: 2018
  end-page: 3987
  ident: bib0275
  article-title: Montmorillonite/chitosan nanoparticles as a novel controlled-release topical ophthalmic delivery system for the treatment of glaucoma
  publication-title: Int. J. Nanomed.
– volume: 58
  start-page: 1131
  year: 2006
  end-page: 1135
  ident: bib0170
  article-title: Challenges and obstacles of ocular pharmacokinetics and drug delivery
  publication-title: Adv. Drug Deliv. Rev.
– volume: 66
  start-page: 219
  year: 1977
  ident: bib0050
  article-title: Aqueous chamber drug distribution volume measurement in rabbits
  publication-title: J. Pharm. Sci.
– volume: 96
  start-page: e27
  year: 2018
  end-page: e37
  ident: bib0360
  article-title: Differential expression and localization of human tissue inhibitors of metalloproteinases in proliferative diabetic retinopathy
  publication-title: Acta Ophthalmol
– volume: 27
  start-page: 219
  year: 2011
  end-page: 224
  ident: bib0460
  article-title: Comparison of long-acting bevacizumab formulations in the treatment of choroidal neovascularization in a rat model
  publication-title: J. Ocul. Pharmacol. Ther.
– volume: 522
  start-page: 119
  year: 2017
  end-page: 127
  ident: bib0465
  article-title: Sustained release ophthalmic dexamethasone:
  publication-title: Int. J. Pharm.
– volume: 22
  start-page: 1214
  year: 2008
  end-page: 1222
  ident: bib0320
  article-title: Adult vitreous structure and postnatal changes
  publication-title: Eye
– volume: 31
  start-page: 67
  year: 1980
  end-page: 79
  ident: bib0335
  article-title: Age-related-changes in the vitreous and lens of rhesus-monkeys (Macaca-Mulatta)
  publication-title: Exp. Eye Res.
– volume: 62
  start-page: 1112
  year: 1973
  end-page: 1121
  ident: bib0070
  article-title: Lacrimal and instilled fluid dynamics in rabbit eyes
  publication-title: J. Pharm. Sci.
– volume: 9
  start-page: 208
  year: 2007
  end-page: 216
  ident: bib0090
  article-title: Corneal epithelium as a platform for secretion of transgene products after transfection with liposomal gene eyedrops
  publication-title: J. Gene Med.
– volume: 29
  start-page: 335
  year: 1985
  end-page: 348
  ident: bib0245
  article-title: Ocular drug bioavailability from topically applied liposomes
  publication-title: Surv. Ophthalmol.
– volume: 26
  start-page: 464
  year: 1985
  end-page: 473
  ident: bib0185
  article-title: Demonstration of the mucous layer of the tear film by electron-microscopy
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 21
  start-page: 797
  year: 2012
  end-page: 805
  ident: bib0355
  article-title: Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9
  publication-title: Expert Opin. Invest. Drugs
– volume: 30
  start-page: 684
  year: 1989
  end-page: 689
  ident: bib0065
  article-title: Paracellular permeability of corneal and conjunctival epithelia
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 6
  start-page: 317
  year: 2011
  end-page: 329
  ident: bib0310
  article-title: Sustained release intraocular drug delivery devices for treatment of uveitis
  publication-title: J. Ophthal. Vis. Res.
– volume: 38
  start-page: 9
  year: 1987
  end-page: 21
  ident: bib0085
  article-title: Disposition of timolol and inulin in the rabbit eye following corneal versus non-corneal absorption
  publication-title: Int. J. Pharm.
– volume: 211
  start-page: 105
  year: 2015
  end-page: 117
  ident: bib0400
  article-title: Novel biodegradable polyesteramide microspheres for controlled drug delivery in ophthalmology
  publication-title: J. Control. Release
– volume: 44
  start-page: 3562
  year: 2003
  end-page: 3569
  ident: bib0395
  article-title: Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 57
  start-page: 1595
  year: 2005
  end-page: 1639
  ident: bib0205
  article-title: The use of mucoadhesive polymers in ocular drug delivery
  publication-title: Adv. Drug Deliv. Rev.
– volume: 20
  start-page: 410
  year: 2015
  end-page: –416
  ident: bib0210
  article-title: Comparative studies for ciprofloxacin hydrochloride pre-formed gels and thermally triggered (in situ) gels:
  publication-title: Pharm. Dev. Technol.
– volume: 23
  start-page: 147
  year: 1985
  end-page: 161
  ident: bib0075
  article-title: Systemic absorption of ocular pilocarpine is modified by polymer matrices
  publication-title: Int. J. Pharm.
– volume: 21
  start-page: 345
  year: 2004
  end-page: 386
  ident: bib0250
  article-title: Modeling of drug release from polymeric delivery systems – a review
  publication-title: Crit. Rev. Ther. Drug Carrier Syst.
– volume: 30
  start-page: 854
  year: 2014
  end-page: 858
  ident: bib0490
  article-title: Comparison of the release profile and pharmacokinetics of intact and fragmented dexamethasone intravitreal implants in rabbit eyes
  publication-title: J. Ocul. Pharmacol. Ther.
– volume: 41
  start-page: 3569
  year: 2000
  end-page: 3575
  ident: bib0480
  article-title: Safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained delivery device
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 61
  start-page: 241
  year: 1990
  end-page: 249
  ident: bib0035
  article-title: Controlled drug delivery devices for experimental ocular studies with timolol. 2. Ocular and systemic absorption in rabbits
  publication-title: Int. J. Pharm.
– volume: 126
  start-page: 3
  year: 2018
  end-page: 22
  ident: bib0095
  article-title: Expression, activity and pharmacokinetic impact of ocular transporters
  publication-title: Adv. Drug Deliv. Rev.
– volume: 47
  start-page: S6
  year: 2002
  end-page: S12
  ident: bib0530
  article-title: Ocular and systemic pharmacokinetics of latanoprost in humans
  publication-title: Surv. Ophthalmol.
– volume: 27
  start-page: 1279
  year: 2007
  end-page: 1285
  ident: bib0350
  article-title: Correlation of the extent and duration of rhegmatogenous retinal detachment with the expression of matrix metalloproteinases in the vitreous
  publication-title: Retina
– volume: 87A
  start-page: 656
  year: 2008
  end-page: 665
  ident: bib0375
  article-title: In situ formation of hydrogels as vitreous substitutes: viscoelastic comparison to porcine vitreous
  publication-title: J. Biomed. Mater. Res. A
– volume: 253
  start-page: 1297
  year: 2015
  end-page: 1305
  ident: bib0475
  article-title: Biodegradable chitosan and polylactic acid-based intraocular micro-implant for sustained release of methotrexate into vitreous: analysis of pharmacokinetics and toxicity in rabbit eyes
  publication-title: Graefes Arch. Clin. Exp. Ophthalmol.
– volume: 96
  start-page: 442
  year: 2015
  end-page: 446
  ident: bib0200
  article-title: Undefined role of mucus as a barrier in ocular drug delivery
  publication-title: Eur. J. Pharm. Biopharm.
– volume: 69
  start-page: 875
  year: 1980
  end-page: 884
  ident: bib0505
  article-title: Mechanisms of anterior segment absorption of pilocarpine following subconjunctival injection in albino rabbits
  publication-title: J. Pharm. Sci.
– volume: 25
  start-page: 888
  year: 2018
  end-page: 899
  ident: bib0280
  article-title: Improving the topical ocular pharmacokinetics of lyophilized cyclosporine A-loaded micelles: formulation,
  publication-title: Drug Deliv.
– volume: 106
  start-page: 425
  year: 1979
  end-page: 430
  ident: bib0525
  article-title: Capillary-permeability in cat choroid, studied with the single injection technique .2
  publication-title: Acta Physiol. Scand.
– volume: 14
  start-page: 43
  year: 1975
  end-page: 46
  ident: bib0295
  article-title: The long-acting Ocusert-pilocarpine system in the management of glaucoma
  publication-title: Invest. Ophthalmol.
– volume: 7
  start-page: 483
  year: 1988
  ident: bib0080
  article-title: Comparison of conjunctival and corneal surface-areas in rabbit and human
  publication-title: Curr. Eye Res.
– volume: 44
  start-page: 2141
  year: 2003
  end-page: 2146
  ident: bib0145
  article-title: Human retinal molecular weight exclusion limit and estimate of species variation
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 152
  start-page: 982
  year: 2011
  end-page: –988
  ident: bib0005
  article-title: A video study of drop instillation in both glaucoma and retina patients with visual impairment
  publication-title: Am. J. Ophthalmol.
– volume: 69
  start-page: 615
  year: 1980
  end-page: 616
  ident: bib0055
  article-title: Pilocarpine ocular distribution volume
  publication-title: J. Pharm. Sci.
– volume: 85
  start-page: 383
  year: 1978
  end-page: 386
  ident: bib0040
  article-title: Penetration routes of topically applied eye medications
  publication-title: Am. J. Ophthalmol.
– volume: 7
  start-page: 123
  year: 2012
  end-page: 131
  ident: bib0545
  article-title: Nanomedicine for glaucoma: liposomes provide sustained release of latanoprost in the eye
  publication-title: Int. J. Nanomed.
– volume: 57
  start-page: 163
  year: 1989
  end-page: 168
  ident: bib0285
  article-title: Gelrite
  publication-title: Int. J. Pharm.
– volume: 23
  start-page: 770
  year: 2006
  end-page: 781
  ident: bib0435
  article-title: Oligonucleotide-polyethylenimine complexes targeting retinal cells: structural analysis and application to anti-TGFbeta-2 therapy
  publication-title: Pharm. Res.
– volume: 14
  start-page: 1246
  year: 1997
  end-page: 1251
  ident: bib0120
  article-title: Polar solute transport across the pigmented rabbit conjunctiva: size dependence and the influence of 8-bromo cyclic adenosine monophosphate
  publication-title: Pharm. Res.
– volume: 57
  start-page: 1555
  year: 2005
  end-page: –1563
  ident: bib0555
  article-title: Size-dependent disposition of nanoparticles and microparticles following subconjunctival administration
  publication-title: J. Pharm. Pharmacol.
– volume: 15
  start-page: 2174
  year: 2018
  end-page: 2179
  ident: bib0325
  article-title: Binding of small molecule drugs to porcine vitreous humor
  publication-title: Mol. Pharm.
– volume: 69
  start-page: 391
  year: 1980
  end-page: 394
  ident: bib0225
  article-title: Effect of particle-size on ophthalmic bioavailability of dexamethasone suspensions in rabbits
  publication-title: J. Pharm. Sci.
– volume: 66
  start-page: 1222
  year: 1977
  end-page: 1228
  ident: bib0235
  article-title: Vehicle effects on ocular drug bioavailability .2. evaluation of pilocarpine
  publication-title: J. Pharm. Sci.
– volume: 119
  start-page: 83
  year: 2018
  end-page: 89
  ident: bib0105
  article-title: Corneal and conjunctival drug permeability: Systematic comparison and pharmacokinetic impact in the eye
  publication-title: Eur. J. Pharm. Sci.
– volume: 123
  start-page: 106
  year: 2018
  end-page: 110
  ident: bib0365
  article-title: Esterase activity in porcine and albino rabbit ocular tissues
  publication-title: Eur. J. Pharm. Sci.
– volume: 124
  start-page: 105
  year: 2017
  end-page: 117
  ident: bib0160
  article-title: Associations with retinal pigment epithelium thickness measures in a large cohort results from the UK biobank
  publication-title: Ophthalmology
– volume: 52
  start-page: 80
  year: 2011
  end-page: 86
  ident: bib0485
  article-title: Pharmacokinetics and pharmacodynamics of a sustained-release dexamethasone intravitreal implant
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 4
  start-page: 303
  year: 2014
  end-page: 309
  ident: bib0535
  article-title: Nanomedicine for glaucoma: sustained release latanoprost offers a new therapeutic option with substantial benefits over eyedrops
  publication-title: Drug Deliv. Transl. Res.
– volume: 95
  start-page: 1626
  year: 2006
  end-page: 1639
  ident: bib0330
  article-title: BSA degradation under acidic conditions: a model for protein instability during release from PLGA delivery systems
  publication-title: J. Pharm. Sci.
– volume: 80
  start-page: 274
  year: 1975
  end-page: 283
  ident: bib0220
  article-title: Comparative distribution of pilocarpine in ocular tissues of the rabbit during administration by eyedrop or by membrane-controlled delivery systems
  publication-title: Am. J. Ophthalmol.
– volume: 10
  start-page: 4360
  year: 2014
  end-page: 4366
  ident: bib0540
  article-title: Sustained delivery of latanoprost by thermosensitive chitosan-gelatin-based hydrogel for controlling ocular hypertension
  publication-title: Acta Biomater.
– volume: 124
  start-page: 95
  year: 2018
  end-page: 103
  ident: bib0385
  article-title: Antibody loaded collapsible hyaluronic acid hydrogels for intraocular delivery
  publication-title: Eur. J. Pharm. Biopharm.
– volume: 87
  start-page: 1479
  year: 1998
  end-page: 1488
  ident: bib0110
  article-title: Permeability of cornea, sclera, and conjunctiva: A literature analysis for drug delivery to the eye
  publication-title: J. Pharm. Sci.
– volume: 241
  start-page: 47
  year: 2002
  end-page: 55
  ident: bib0240
  article-title: and
  publication-title: Int. J. Pharm.
– volume: 17
  start-page: 798
  year: 2016
  end-page: 807
  ident: bib0215
  article-title: Fabrication of a micellar supramolecular hydrogel for ocular drug delivery
  publication-title: Biomacromolecules
– year: 1995
  ident: bib0165
  article-title: Clinical Pharmacokinetics. Concepts and Applications
– volume: 21
  start-page: 2175
  year: 2004
  end-page: 2184
  ident: bib0575
  article-title: Assessment of subconjunctival delivery with model ionic permeants and magnetic resonance imaging
  publication-title: Pharm. Res.
– volume: 42
  start-page: 299
  year: 2017
  end-page: 309
  ident: bib0455
  article-title: Enhanced delivery of biodegradable mPEG-PLGA-PLL nanoparticles loading Cy3-labelled PDGF-BB siRNA by UTMD to rat retina
  publication-title: J. Biosci.
– volume: 251
  start-page: 37
  year: 2017
  end-page: 48
  ident: bib0370
  article-title: Differentially cleaving peptides as a strategy for controlled drug release in human retinal pigment epithelial cells
  publication-title: J. Control. Release
– volume: 201
  start-page: 32
  year: 2015
  end-page: 40
  ident: bib0560
  article-title: Corticosteroid-loaded biodegradable nanoparticles for prevention of corneal allograft rejection in rats
  publication-title: J. Control. Release
– volume: 109
  start-page: 224
  year: 2016
  end-page: 235
  ident: bib0265
  article-title: Topical ophthalmic lipid nanoparticle formulations (SLN, NLC) of indomethacin for delivery to the posterior segment ocular tissues
  publication-title: Eur. J. Pharm. Biopharm.
– volume: 13
  start-page: 3975
  year: 2018
  ident: 10.1016/j.drudis.2019.02.001_bib0275
  article-title: Montmorillonite/chitosan nanoparticles as a novel controlled-release topical ophthalmic delivery system for the treatment of glaucoma
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S162306
– volume: 15
  start-page: 2174
  year: 2018
  ident: 10.1016/j.drudis.2019.02.001_bib0325
  article-title: Binding of small molecule drugs to porcine vitreous humor
  publication-title: Mol. Pharm.
  doi: 10.1021/acs.molpharmaceut.8b00038
– volume: 7
  start-page: e29692
  year: 2012
  ident: 10.1016/j.drudis.2019.02.001_bib0130
  article-title: Scleral thickness in human eyes
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0029692
– volume: 66
  start-page: 1222
  year: 1977
  ident: 10.1016/j.drudis.2019.02.001_bib0235
  article-title: Vehicle effects on ocular drug bioavailability .2. evaluation of pilocarpine
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.2600660905
– volume: 20
  start-page: 96
  year: 2003
  ident: 10.1016/j.drudis.2019.02.001_bib0420
  article-title: Computer simulation of convective and diffusive transport of controlled-release drugs in the vitreous humor
  publication-title: Pharm. Res.
  doi: 10.1023/A:1022207026982
– volume: 26
  start-page: 584
  year: 1985
  ident: 10.1016/j.drudis.2019.02.001_bib0060
  article-title: Importance of the noncorneal absorption route in topical ophthalmic drug delivery
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 148
  start-page: 42
  year: 2010
  ident: 10.1016/j.drudis.2019.02.001_bib0520
  article-title: Barrier analysis of periocular drug delivery to the posterior segment
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2010.08.028
– volume: 69
  year: 1984
  ident: 10.1016/j.drudis.2019.02.001_bib0020
  article-title: Ocular pharmacokinetics
  publication-title: Pharmacol. Eye
  doi: 10.1007/978-3-642-69222-2_2
– volume: 95
  start-page: 215
  year: 2015
  ident: 10.1016/j.drudis.2019.02.001_bib0300
  article-title: Intravitreal clearance and volume of distribution of compounds in rabbits: In silico prediction and pharmacokinetic simulations for drug development
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2015.01.003
– volume: 21
  start-page: 2175
  year: 2004
  ident: 10.1016/j.drudis.2019.02.001_bib0575
  article-title: Assessment of subconjunctival delivery with model ionic permeants and magnetic resonance imaging
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-004-7669-3
– volume: 72
  start-page: 1272
  year: 1983
  ident: 10.1016/j.drudis.2019.02.001_bib0045
  article-title: Corneal penetration behavior of β-blocking agents II: Assessment of barrier contributions
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.2600721108
– volume: 38
  start-page: 9
  year: 1987
  ident: 10.1016/j.drudis.2019.02.001_bib0085
  article-title: Disposition of timolol and inulin in the rabbit eye following corneal versus non-corneal absorption
  publication-title: Int. J. Pharm.
  doi: 10.1016/0378-5173(87)90092-5
– volume: 96
  start-page: 442
  year: 2015
  ident: 10.1016/j.drudis.2019.02.001_bib0200
  article-title: Undefined role of mucus as a barrier in ocular drug delivery
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2015.02.032
– volume: 31
  start-page: 67
  year: 1980
  ident: 10.1016/j.drudis.2019.02.001_bib0335
  article-title: Age-related-changes in the vitreous and lens of rhesus-monkeys (Macaca-Mulatta)
  publication-title: Exp. Eye Res.
  doi: 10.1016/0014-4835(80)90091-3
– volume: 27
  start-page: 219
  year: 2011
  ident: 10.1016/j.drudis.2019.02.001_bib0460
  article-title: Comparison of long-acting bevacizumab formulations in the treatment of choroidal neovascularization in a rat model
  publication-title: J. Ocul. Pharmacol. Ther.
  doi: 10.1089/jop.2010.0158
– volume: 23
  start-page: 147
  year: 1985
  ident: 10.1016/j.drudis.2019.02.001_bib0075
  article-title: Systemic absorption of ocular pilocarpine is modified by polymer matrices
  publication-title: Int. J. Pharm.
  doi: 10.1016/0378-5173(85)90005-5
– volume: 52
  start-page: 27
  year: 1991
  ident: 10.1016/j.drudis.2019.02.001_bib0345
  article-title: The loss of fluorescein, fluorescein glucuronide and fluorescein isothiocyanate dextran from the vitreous by the anterior and retinal pathways
  publication-title: Exp. Eye Res.
  doi: 10.1016/0014-4835(91)90125-X
– volume: 69
  start-page: 615
  year: 1980
  ident: 10.1016/j.drudis.2019.02.001_bib0055
  article-title: Pilocarpine ocular distribution volume
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.2600690544
– volume: 46
  start-page: 3553
  year: 2005
  ident: 10.1016/j.drudis.2019.02.001_bib0135
  article-title: Vitreous: a barrier to nonviral ocular gene therapy
  publication-title: Invest. Ophthalmol. Vis. Sci.
  doi: 10.1167/iovs.05-0165
– volume: 14
  start-page: 1246
  year: 1997
  ident: 10.1016/j.drudis.2019.02.001_bib0120
  article-title: Polar solute transport across the pigmented rabbit conjunctiva: size dependence and the influence of 8-bromo cyclic adenosine monophosphate
  publication-title: Pharm. Res.
  doi: 10.1023/A:1012123411343
– volume: 490
  start-page: 375
  year: 2015
  ident: 10.1016/j.drudis.2019.02.001_bib0380
  article-title: An injectable thermosensitive polymeric hydrogel for sustained release of Avastin1 to treat posterior segment disease
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2015.05.071
– volume: 19
  start-page: 323
  year: 2000
  ident: 10.1016/j.drudis.2019.02.001_bib0340
  article-title: Structural macromolecules and supramolecular organisation of the vitreous gel
  publication-title: Prog. Retin. Eye Res.
  doi: 10.1016/S1350-9462(99)00016-6
– volume: 85
  start-page: 383
  year: 1978
  ident: 10.1016/j.drudis.2019.02.001_bib0040
  article-title: Penetration routes of topically applied eye medications
  publication-title: Am. J. Ophthalmol.
  doi: 10.1016/S0002-9394(14)77735-9
– volume: 21
  start-page: 345
  year: 2004
  ident: 10.1016/j.drudis.2019.02.001_bib0250
  article-title: Modeling of drug release from polymeric delivery systems – a review
  publication-title: Crit. Rev. Ther. Drug Carrier Syst.
  doi: 10.1615/CritRevTherDrugCarrierSyst.v21.i5.10
– volume: 17
  start-page: 798
  year: 2016
  ident: 10.1016/j.drudis.2019.02.001_bib0215
  article-title: Fabrication of a micellar supramolecular hydrogel for ocular drug delivery
  publication-title: Biomacromolecules
  doi: 10.1021/acs.biomac.5b01526
– volume: 201
  start-page: 32
  year: 2015
  ident: 10.1016/j.drudis.2019.02.001_bib0560
  article-title: Corticosteroid-loaded biodegradable nanoparticles for prevention of corneal allograft rejection in rats
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2015.01.009
– volume: 52
  start-page: 80
  year: 2011
  ident: 10.1016/j.drudis.2019.02.001_bib0485
  article-title: Pharmacokinetics and pharmacodynamics of a sustained-release dexamethasone intravitreal implant
  publication-title: Invest. Ophthalmol. Vis. Sci.
  doi: 10.1167/iovs.10-5285
– volume: 6
  start-page: 317
  year: 2011
  ident: 10.1016/j.drudis.2019.02.001_bib0310
  article-title: Sustained release intraocular drug delivery devices for treatment of uveitis
  publication-title: J. Ophthal. Vis. Res.
– volume: 24
  start-page: 1384
  year: 2017
  ident: 10.1016/j.drudis.2019.02.001_bib0150
  article-title: Toward rational design of gene carriers: a novel ex vivo model to study the vitreoretinal interface as a barrier
  publication-title: Drug Delivery
  doi: 10.1080/10717544.2017.1375578
– volume: 22
  start-page: 1214
  year: 2008
  ident: 10.1016/j.drudis.2019.02.001_bib0320
  article-title: Adult vitreous structure and postnatal changes
  publication-title: Eye
  doi: 10.1038/eye.2008.21
– volume: 33
  start-page: 2680
  year: 2016
  ident: 10.1016/j.drudis.2019.02.001_bib0180
  article-title: General pharmacokinetic model for topically administered ocular drug dosage forms
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-016-1993-2
– volume: 66
  start-page: 219
  year: 1977
  ident: 10.1016/j.drudis.2019.02.001_bib0050
  article-title: Aqueous chamber drug distribution volume measurement in rabbits
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.2600660222
– volume: 15
  start-page: 2770
  year: 2018
  ident: 10.1016/j.drudis.2019.02.001_bib0305
  article-title: Theoretical insights into the retinal dynamics of vascular endothelial growth factor in patients treated with ranibizumab, based on an ocular pharmacokinetic/pharmacodynamic model
  publication-title: Mol. Pharm.
  doi: 10.1021/acs.molpharmaceut.8b00280
– volume: 118
  start-page: 124
  year: 2018
  ident: 10.1016/j.drudis.2019.02.001_bib0425
  article-title: Effects of enzymatic degradation on dynamic mechanical properties of the vitreous and intravitreal nanoparticle mobility
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2018.03.023
– volume: 58
  start-page: 1164
  year: 2006
  ident: 10.1016/j.drudis.2019.02.001_bib0580
  article-title: Transscleral drug delivery to the posterior eye: prospects of pharmacokinetic modeling
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2006.07.025
– volume: 9
  start-page: 208
  year: 2007
  ident: 10.1016/j.drudis.2019.02.001_bib0090
  article-title: Corneal epithelium as a platform for secretion of transgene products after transfection with liposomal gene eyedrops
  publication-title: J. Gene Med.
  doi: 10.1002/jgm.1011
– volume: 253
  start-page: 1297
  year: 2015
  ident: 10.1016/j.drudis.2019.02.001_bib0475
  article-title: Biodegradable chitosan and polylactic acid-based intraocular micro-implant for sustained release of methotrexate into vitreous: analysis of pharmacokinetics and toxicity in rabbit eyes
  publication-title: Graefes Arch. Clin. Exp. Ophthalmol.
  doi: 10.1007/s00417-015-3007-1
– volume: 25
  start-page: 888
  year: 2018
  ident: 10.1016/j.drudis.2019.02.001_bib0280
  article-title: Improving the topical ocular pharmacokinetics of lyophilized cyclosporine A-loaded micelles: formulation, in vitro and in vivo studies
  publication-title: Drug Deliv.
  doi: 10.1080/10717544.2018.1458923
– volume: 152
  start-page: 982
  year: 2011
  ident: 10.1016/j.drudis.2019.02.001_bib0005
  article-title: A video study of drop instillation in both glaucoma and retina patients with visual impairment
  publication-title: Am. J. Ophthalmol.
  doi: 10.1016/j.ajo.2011.05.015
– volume: 61
  start-page: 241
  year: 1990
  ident: 10.1016/j.drudis.2019.02.001_bib0035
  article-title: Controlled drug delivery devices for experimental ocular studies with timolol. 2. Ocular and systemic absorption in rabbits
  publication-title: Int. J. Pharm.
  doi: 10.1016/0378-5173(90)90215-P
– volume: 49
  start-page: 320
  year: 2008
  ident: 10.1016/j.drudis.2019.02.001_bib0515
  article-title: Modeling of corneal and retinal pharmacokinetics after periocular drug administration
  publication-title: Invest. Ophthalmol. Vis. Sci.
  doi: 10.1167/iovs.07-0593
– year: 2018
  ident: 10.1016/j.drudis.2019.02.001_bib0015
  article-title: Suprachoroidal injection of triamcinolone acetonide, cls-ta, for macular edema due to noninfectious uveitis: a randomized, phase 2 study (DOGWOOD)
  publication-title: Retina
– volume: 11
  start-page: 1278
  year: 1994
  ident: 10.1016/j.drudis.2019.02.001_bib0260
  article-title: Controlled ocular timolol delivery: systemic absorption and intraocular pressure effects in humans
  publication-title: Pharm. Res.
  doi: 10.1023/A:1018938310628
– volume: 44
  start-page: 3562
  year: 2003
  ident: 10.1016/j.drudis.2019.02.001_bib0395
  article-title: Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles
  publication-title: Invest. Ophthalmol. Vis. Sci.
  doi: 10.1167/iovs.02-1068
– volume: 110
  start-page: 255
  year: 1992
  ident: 10.1016/j.drudis.2019.02.001_bib0495
  article-title: Intravitreal sustained-release ganciclovir
  publication-title: Arch. Ophthalmol.
  doi: 10.1001/archopht.1992.01080140111037
– volume: 27
  start-page: 1398
  year: 2010
  ident: 10.1016/j.drudis.2019.02.001_bib0100
  article-title: Prediction of the corneal permeability of drug-like compounds
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-010-0132-8
– volume: 27
  start-page: 1279
  year: 2007
  ident: 10.1016/j.drudis.2019.02.001_bib0350
  article-title: Correlation of the extent and duration of rhegmatogenous retinal detachment with the expression of matrix metalloproteinases in the vitreous
  publication-title: Retina
  doi: 10.1097/IAE.0b013e3180592c00
– volume: 106
  start-page: 425
  year: 1979
  ident: 10.1016/j.drudis.2019.02.001_bib0525
  article-title: Capillary-permeability in cat choroid, studied with the single injection technique .2
  publication-title: Acta Physiol. Scand.
  doi: 10.1111/j.1748-1716.1979.tb06421.x
– volume: 8
  start-page: 419
  year: 2014
  ident: 10.1016/j.drudis.2019.02.001_bib0550
  article-title: Sustained drug release in nanomedicine: a long-acting nanocarrier-based formulation for glaucoma
  publication-title: ACS Nano
  doi: 10.1021/nn4046024
– volume: 7
  start-page: 123
  year: 2012
  ident: 10.1016/j.drudis.2019.02.001_bib0545
  article-title: Nanomedicine for glaucoma: liposomes provide sustained release of latanoprost in the eye
  publication-title: Int. J. Nanomed.
– volume: 12
  year: 2017
  ident: 10.1016/j.drudis.2019.02.001_bib0565
  article-title: Apatinib-loaded nanoparticles suppress vascular endothelial growth factor-induced angiogenesis and experimental corneal neovascularization
  publication-title: Int. J. Nanomedicine
  doi: 10.2147/IJN.S135133
– volume: 30
  start-page: 854
  year: 2014
  ident: 10.1016/j.drudis.2019.02.001_bib0490
  article-title: Comparison of the release profile and pharmacokinetics of intact and fragmented dexamethasone intravitreal implants in rabbit eyes
  publication-title: J. Ocul. Pharmacol. Ther.
  doi: 10.1089/jop.2014.0082
– volume: 4
  start-page: 303
  year: 2014
  ident: 10.1016/j.drudis.2019.02.001_bib0535
  article-title: Nanomedicine for glaucoma: sustained release latanoprost offers a new therapeutic option with substantial benefits over eyedrops
  publication-title: Drug Deliv. Transl. Res.
  doi: 10.1007/s13346-014-0196-9
– volume: 43
  start-page: 454
  year: 2008
  ident: 10.1016/j.drudis.2019.02.001_bib0010
  article-title: Multicenter study of compliance and drop administration in glaucoma
  publication-title: Can. J. Ophthalmol.
  doi: 10.3129/i08-076
– volume: 6
  year: 2004
  ident: 10.1016/j.drudis.2019.02.001_bib0430
  article-title: Neural retina limits the nonviral gene transfer to retinal pigment epithelium in an in vitro bovine eye model
  publication-title: AAPS J.
  doi: 10.1208/aapsj060325
– volume: 20
  start-page: 43
  year: 2004
  ident: 10.1016/j.drudis.2019.02.001_bib0510
  article-title: Drug delivery to the posterior segment of the eye II: sevelopment and validation of a simple pharmacokinetic model for subconjunctival injection
  publication-title: J. Ocul. Pharmacol. Ther.
  doi: 10.1089/108076804772745455
– volume: 30
  start-page: 684
  year: 1989
  ident: 10.1016/j.drudis.2019.02.001_bib0065
  article-title: Paracellular permeability of corneal and conjunctival epithelia
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 126
  start-page: 3
  year: 2018
  ident: 10.1016/j.drudis.2019.02.001_bib0095
  article-title: Expression, activity and pharmacokinetic impact of ocular transporters
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2017.12.009
– volume: 23
  start-page: 770
  year: 2006
  ident: 10.1016/j.drudis.2019.02.001_bib0435
  article-title: Oligonucleotide-polyethylenimine complexes targeting retinal cells: structural analysis and application to anti-TGFbeta-2 therapy
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-006-9748-0
– volume: 8
  start-page: 1955
  year: 2013
  ident: 10.1016/j.drudis.2019.02.001_bib0415
  article-title: Measuring the intravitreal mobility of nanomedicines with single-particle tracking microscopy
  publication-title: Nanomedicine
  doi: 10.2217/nnm.12.202
– volume: 57
  start-page: 1555
  year: 2005
  ident: 10.1016/j.drudis.2019.02.001_bib0555
  article-title: Size-dependent disposition of nanoparticles and microparticles following subconjunctival administration
  publication-title: J. Pharm. Pharmacol.
  doi: 10.1211/jpp.57.12.0005
– volume: 87A
  start-page: 656
  year: 2008
  ident: 10.1016/j.drudis.2019.02.001_bib0375
  article-title: In situ formation of hydrogels as vitreous substitutes: viscoelastic comparison to porcine vitreous
  publication-title: J. Biomed. Mater. Res. A
  doi: 10.1002/jbm.a.31769
– volume: 38
  start-page: 627
  year: 1997
  ident: 10.1016/j.drudis.2019.02.001_bib0115
  article-title: Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 57
  start-page: 1595
  year: 2005
  ident: 10.1016/j.drudis.2019.02.001_bib0205
  article-title: The use of mucoadhesive polymers in ocular drug delivery
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2005.07.005
– volume: 47
  start-page: S6
  issue: Suppl. 1
  year: 2002
  ident: 10.1016/j.drudis.2019.02.001_bib0530
  article-title: Ocular and systemic pharmacokinetics of latanoprost in humans
  publication-title: Surv. Ophthalmol.
  doi: 10.1016/S0039-6257(02)00302-8
– volume: 42
  start-page: 299
  year: 2017
  ident: 10.1016/j.drudis.2019.02.001_bib0455
  article-title: Enhanced delivery of biodegradable mPEG-PLGA-PLL nanoparticles loading Cy3-labelled PDGF-BB siRNA by UTMD to rat retina
  publication-title: J. Biosci.
  doi: 10.1007/s12038-017-9677-6
– volume: 62
  start-page: 1112
  year: 1973
  ident: 10.1016/j.drudis.2019.02.001_bib0070
  article-title: Lacrimal and instilled fluid dynamics in rabbit eyes
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.2600620712
– volume: 94
  start-page: 402
  year: 2017
  ident: 10.1016/j.drudis.2019.02.001_bib0230
  article-title: Poly (d,l-lactide-co-glycolide) nanoparticles for sustained release of tacrolimus in rabbit eyes
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2017.07.110
– volume: 97
  start-page: 2022
  year: 2008
  ident: 10.1016/j.drudis.2019.02.001_bib0255
  article-title: Effect of structural relaxation on the preparation and drug release behavior of poly(lactic-co-glycolic) acid microparticle drug delivery systems
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.21124
– volume: 119
  start-page: 83
  year: 2018
  ident: 10.1016/j.drudis.2019.02.001_bib0105
  article-title: Corneal and conjunctival drug permeability: Systematic comparison and pharmacokinetic impact in the eye
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2018.03.034
– volume: 211
  start-page: 105
  year: 2015
  ident: 10.1016/j.drudis.2019.02.001_bib0400
  article-title: Novel biodegradable polyesteramide microspheres for controlled drug delivery in ophthalmology
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2015.05.279
– volume: 20
  start-page: 410
  year: 2015
  ident: 10.1016/j.drudis.2019.02.001_bib0210
  article-title: Comparative studies for ciprofloxacin hydrochloride pre-formed gels and thermally triggered (in situ) gels: in vitro and in vivo appraisal using a bacterial keratitis model in rabbits
  publication-title: Pharm. Dev. Technol.
  doi: 10.3109/10837450.2013.871034
– volume: 124
  start-page: 95
  year: 2018
  ident: 10.1016/j.drudis.2019.02.001_bib0385
  article-title: Antibody loaded collapsible hyaluronic acid hydrogels for intraocular delivery
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2017.12.019
– volume: 44
  start-page: 2141
  year: 2003
  ident: 10.1016/j.drudis.2019.02.001_bib0145
  article-title: Human retinal molecular weight exclusion limit and estimate of species variation
  publication-title: Invest. Ophthalmol. Vis. Sci.
  doi: 10.1167/iovs.02-1027
– volume: 46
  start-page: 641
  year: 2005
  ident: 10.1016/j.drudis.2019.02.001_bib0155
  article-title: Permeability of retinal pigment epithelium: effects of permeant molecular weight and lipophilicity
  publication-title: Invest. Ophthalmol. Vis. Sci.
  doi: 10.1167/iovs.04-1051
– volume: 41
  start-page: 3569
  year: 2000
  ident: 10.1016/j.drudis.2019.02.001_bib0480
  article-title: Safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained delivery device
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 522
  start-page: 119
  year: 2017
  ident: 10.1016/j.drudis.2019.02.001_bib0465
  article-title: Sustained release ophthalmic dexamethasone: In vitro in vivo correlations derived from the PK-Eye
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2017.02.047
– volume: 7
  start-page: 483
  year: 1988
  ident: 10.1016/j.drudis.2019.02.001_bib0080
  article-title: Comparison of conjunctival and corneal surface-areas in rabbit and human
  publication-title: Curr. Eye Res.
  doi: 10.3109/02713688809031801
– volume: 26
  start-page: 464
  year: 1985
  ident: 10.1016/j.drudis.2019.02.001_bib0185
  article-title: Demonstration of the mucous layer of the tear film by electron-microscopy
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 57
  start-page: 163
  year: 1989
  ident: 10.1016/j.drudis.2019.02.001_bib0285
  article-title: Gelrite®: A novel, ion-activated, in-situ gelling polymer for ophthalmic vehicles. Effect on bioavailability of timolol
  publication-title: Int. J. Pharm.
  doi: 10.1016/0378-5173(89)90305-0
– volume: 124
  start-page: 105
  year: 2017
  ident: 10.1016/j.drudis.2019.02.001_bib0160
  article-title: Associations with retinal pigment epithelium thickness measures in a large cohort results from the UK biobank
  publication-title: Ophthalmology
  doi: 10.1016/j.ophtha.2016.07.033
– volume: 21
  start-page: 797
  year: 2012
  ident: 10.1016/j.drudis.2019.02.001_bib0355
  article-title: Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9
  publication-title: Expert Opin. Invest. Drugs
  doi: 10.1517/13543784.2012.681043
– volume: 23
  start-page: 271
  year: 2015
  ident: 10.1016/j.drudis.2019.02.001_bib0470
  article-title: Sustained intravitreal delivery of dexamethasone using an injectable and biodegradable thermogel
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2015.05.005
– volume: 70
  start-page: 1026
  year: 1981
  ident: 10.1016/j.drudis.2019.02.001_bib0175
  article-title: Mechanistic studies on trans-corneal permeation of fluorometholone
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.2600700915
– volume: 350
  start-page: 299
  year: 1994
  ident: 10.1016/j.drudis.2019.02.001_bib0190
  article-title: Analysis and function of the human tear proteins
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-1-4615-2417-5_51
– volume: 31
  start-page: 11
  year: 2015
  ident: 10.1016/j.drudis.2019.02.001_bib0500
  article-title: Ocular pharmacokinetics of fluocinolone acetonide following iluvien implantation in the vitreous humor of rabbits
  publication-title: J. Ocul. Pharmacol.
  doi: 10.1089/jop.2014.0100
– volume: 31
  start-page: 63
  year: 2015
  ident: 10.1016/j.drudis.2019.02.001_bib0030
  article-title: Pharmacotherapy of glaucoma
  publication-title: J. Ocul. Pharmacol. Ther.
  doi: 10.1089/jop.2014.0067
– volume: 14
  start-page: 1719
  year: 2014
  ident: 10.1016/j.drudis.2019.02.001_bib0390
  article-title: A combined micelle and poly(serinol hexamethylene urea)-co-poly(n-isopropylacrylamide) reverse thermal gel as an injectable ocular drug delivery system
  publication-title: Macromol. Biosci.
  doi: 10.1002/mabi.201400250
– volume: 29
  start-page: 335
  year: 1985
  ident: 10.1016/j.drudis.2019.02.001_bib0245
  article-title: Ocular drug bioavailability from topically applied liposomes
  publication-title: Surv. Ophthalmol.
  doi: 10.1016/0039-6257(85)90109-2
– volume: 268
  start-page: 102
  year: 2018
  ident: 10.1016/j.drudis.2019.02.001_bib0270
  article-title: Amine-grafted SBA-15 for ophthalmic delivery of dexamethasone
  publication-title: J. Solid State Chem.
  doi: 10.1016/j.jssc.2018.08.036
– volume: 251
  start-page: 37
  year: 2017
  ident: 10.1016/j.drudis.2019.02.001_bib0370
  article-title: Differentially cleaving peptides as a strategy for controlled drug release in human retinal pigment epithelial cells
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2017.02.013
– volume: 10
  start-page: 4360
  year: 2014
  ident: 10.1016/j.drudis.2019.02.001_bib0540
  article-title: Sustained delivery of latanoprost by thermosensitive chitosan-gelatin-based hydrogel for controlling ocular hypertension
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2014.05.031
– volume: 14
  start-page: 43
  year: 1975
  ident: 10.1016/j.drudis.2019.02.001_bib0295
  article-title: The long-acting Ocusert-pilocarpine system in the management of glaucoma
  publication-title: Invest. Ophthalmol.
– volume: 167
  start-page: 76
  year: 2013
  ident: 10.1016/j.drudis.2019.02.001_bib0140
  article-title: Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivo
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2013.01.018
– volume: 13
  start-page: 2941
  year: 2016
  ident: 10.1016/j.drudis.2019.02.001_bib0570
  article-title: A mechanistic model of the intravitreal pharmacokinetics of large molecules and the pharmacodynamic suppression of ocular vascular endothelial growth factor levels by ranibizumab in patients with neovascular age-related macular degeneration
  publication-title: Mol. Pharm.
  doi: 10.1021/acs.molpharmaceut.5b00849
– volume: 95
  start-page: 1626
  year: 2006
  ident: 10.1016/j.drudis.2019.02.001_bib0330
  article-title: BSA degradation under acidic conditions: a model for protein instability during release from PLGA delivery systems
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.20625
– volume: 80
  start-page: 274
  year: 1975
  ident: 10.1016/j.drudis.2019.02.001_bib0220
  article-title: Comparative distribution of pilocarpine in ocular tissues of the rabbit during administration by eyedrop or by membrane-controlled delivery systems
  publication-title: Am. J. Ophthalmol.
  doi: 10.1016/0002-9394(75)90145-2
– volume: 96
  start-page: e27
  year: 2018
  ident: 10.1016/j.drudis.2019.02.001_bib0360
  article-title: Differential expression and localization of human tissue inhibitors of metalloproteinases in proliferative diabetic retinopathy
  publication-title: Acta Ophthalmol
  doi: 10.1111/aos.13451
– volume: 17
  start-page: 393
  year: 2001
  ident: 10.1016/j.drudis.2019.02.001_bib0405
  article-title: Review: practical issues in intravitreal drug delivery
  publication-title: J. Ocul. Pharmacol. Ther.
  doi: 10.1089/108076801753162807
– volume: 52
  start-page: 4789
  year: 2011
  ident: 10.1016/j.drudis.2019.02.001_bib0440
  article-title: A lipid nanoparticle system improves siRNA efficacy in RPE cells and a laser-induced murine CNV model
  publication-title: Invest. Ophthalmol. Vis. Sci.
  doi: 10.1167/iovs.10-5891
– volume: 60
  start-page: 227
  year: 2005
  ident: 10.1016/j.drudis.2019.02.001_bib0125
  article-title: Roles of the conjunctiva in ocular drug delivery: a review of conjunctival transport mechanisms and their regulation
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2004.12.007
– volume: 65
  start-page: 1654
  year: 1976
  ident: 10.1016/j.drudis.2019.02.001_bib0195
  article-title: Effect of topically applied pilocarpine on tear film
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.2600651123
– year: 1995
  ident: 10.1016/j.drudis.2019.02.001_bib0165
– volume: 28
  start-page: 45
  year: 2015
  ident: 10.1016/j.drudis.2019.02.001_bib0410
  article-title: Encapsulation of PEGylated low-molecular-weight PEI polyplexes in hyaluronic acid hydrogels reduces aggregation
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2015.09.020
– volume: 241
  start-page: 47
  year: 2002
  ident: 10.1016/j.drudis.2019.02.001_bib0240
  article-title: In vitro and in vivo evaluation of Pluronic F127-based ocular delivery system for timolol maleate
  publication-title: Int. J. Pharm.
  doi: 10.1016/S0378-5173(02)00234-X
– volume: 29
  start-page: 215
  year: 2003
  ident: 10.1016/j.drudis.2019.02.001_bib0290
  article-title: Ophthalmic delivery of ciprofloxacin hydrochloride from different polymer formulations: In vitro and in vivo studies
  publication-title: Drug Dev. Ind. Pharm.
  doi: 10.1081/DDC-120016729
– volume: 69
  start-page: 391
  year: 1980
  ident: 10.1016/j.drudis.2019.02.001_bib0225
  article-title: Effect of particle-size on ophthalmic bioavailability of dexamethasone suspensions in rabbits
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.2600690407
– volume: 11
  start-page: 541
  year: 2012
  ident: 10.1016/j.drudis.2019.02.001_bib0025
  article-title: Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd3745
– volume: 109
  start-page: 224
  year: 2016
  ident: 10.1016/j.drudis.2019.02.001_bib0265
  article-title: Topical ophthalmic lipid nanoparticle formulations (SLN, NLC) of indomethacin for delivery to the posterior segment ocular tissues
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2016.10.015
– volume: 58
  start-page: 1131
  year: 2006
  ident: 10.1016/j.drudis.2019.02.001_bib0170
  article-title: Challenges and obstacles of ocular pharmacokinetics and drug delivery
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2006.07.027
– volume: 57
  start-page: 134
  year: 2017
  ident: 10.1016/j.drudis.2019.02.001_bib0315
  article-title: Pharmacokinetic aspects of retinal drug delivery
  publication-title: Prog. Retin. Eye Res.
  doi: 10.1016/j.preteyeres.2016.12.001
– volume: 123
  start-page: 106
  year: 2018
  ident: 10.1016/j.drudis.2019.02.001_bib0365
  article-title: Esterase activity in porcine and albino rabbit ocular tissues
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2018.07.034
– volume: 87
  start-page: 1479
  year: 1998
  ident: 10.1016/j.drudis.2019.02.001_bib0110
  article-title: Permeability of cornea, sclera, and conjunctiva: A literature analysis for drug delivery to the eye
  publication-title: J. Pharm. Sci.
  doi: 10.1021/js9802594
– volume: 23
  start-page: 1587
  year: 2002
  ident: 10.1016/j.drudis.2019.02.001_bib0445
  article-title: Ocular disposition and tolerance of ganciclovir-loaded albumin nanoparticles after intravitreal injection in rats
  publication-title: Biomaterials
  doi: 10.1016/S0142-9612(01)00284-8
– volume: 69
  start-page: 875
  year: 1980
  ident: 10.1016/j.drudis.2019.02.001_bib0505
  article-title: Mechanisms of anterior segment absorption of pilocarpine following subconjunctival injection in albino rabbits
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.2600690806
– volume: 10
  start-page: 1152
  year: 2016
  ident: 10.1016/j.drudis.2019.02.001_bib0450
  article-title: Poly(ortho ester) nanoparticles targeted for chronic intraocular diseases: ocular safety and localization after intravitreal injection
  publication-title: Nanotoxicology
  doi: 10.1080/17435390.2016.1181808
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Snippet •Ocular drug delivery is a field in which regular ADME tools are not useful.•Pharmacokinetics based dosing aid for ocular drug delivery is...
Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the...
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SubjectTerms Administration, Ophthalmic
Biological Availability
Drug Delivery Systems - methods
Eye - drug effects
Humans
Ophthalmic Solutions - therapeutic use
Title Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties
URI https://dx.doi.org/10.1016/j.drudis.2019.02.001
https://www.ncbi.nlm.nih.gov/pubmed/30738982
https://www.proquest.com/docview/2183646186
Volume 24
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