Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties

•Ocular drug delivery is a field in which regular ADME tools are not useful.•Pharmacokinetics based dosing aid for ocular drug delivery is presented.•User-friendly dosing aid guides early stage design of delivery systems.•Guidance for the delivery route, dosing and formulation design is presented. O...

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Vydané v:Drug discovery today Ročník 24; číslo 8; s. 1446 - 1457
Hlavní autori: Subrizi, Astrid, del Amo, Eva M., Korzhikov-Vlakh, Viktor, Tennikova, Tatiana, Ruponen, Marika, Urtti, Arto
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Elsevier Ltd 01.08.2019
Predmet:
Administration, Ophthalmic
Biological Availability
Drug Delivery Systems - methods
Eye - drug effects
Humans
Ophthalmic Solutions - therapeutic use
ISSN:1359-6446, 1878-5832, 1878-5832
On-line prístup:Získať plný text
Tagy: Pridať tag
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Abstract •Ocular drug delivery is a field in which regular ADME tools are not useful.•Pharmacokinetics based dosing aid for ocular drug delivery is presented.•User-friendly dosing aid guides early stage design of delivery systems.•Guidance for the delivery route, dosing and formulation design is presented. Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling. Successful drug delivery to ocular targets depends on ocular biology, drug properties, and formulation characteristics. A multifactorial design aid for ocular drug delivery is presented.
AbstractList •Ocular drug delivery is a field in which regular ADME tools are not useful.•Pharmacokinetics based dosing aid for ocular drug delivery is presented.•User-friendly dosing aid guides early stage design of delivery systems.•Guidance for the delivery route, dosing and formulation design is presented. Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling. Successful drug delivery to ocular targets depends on ocular biology, drug properties, and formulation characteristics. A multifactorial design aid for ocular drug delivery is presented.
Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling.Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling.
Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling.
Author Urtti, Arto
Subrizi, Astrid
Tennikova, Tatiana
del Amo, Eva M.
Korzhikov-Vlakh, Viktor
Ruponen, Marika
Author_xml – sequence: 1
  givenname: Astrid
  surname: Subrizi
  fullname: Subrizi, Astrid
  organization: School of Pharmacy, University of Eastern Finland, Kuopio, Finland
– sequence: 2
  givenname: Eva M.
  orcidid: 0000-0002-5705-4515
  surname: del Amo
  fullname: del Amo, Eva M.
  organization: School of Pharmacy, University of Manchester, Manchester, UK
– sequence: 3
  givenname: Viktor
  orcidid: 0000-0002-3509-3978
  surname: Korzhikov-Vlakh
  fullname: Korzhikov-Vlakh, Viktor
  organization: Institute of Chemistry, Saint-Petersburg State University, St Petersburg, Russian Federation
– sequence: 4
  givenname: Tatiana
  surname: Tennikova
  fullname: Tennikova, Tatiana
  organization: Institute of Chemistry, Saint-Petersburg State University, St Petersburg, Russian Federation
– sequence: 5
  givenname: Marika
  surname: Ruponen
  fullname: Ruponen, Marika
  organization: School of Pharmacy, University of Eastern Finland, Kuopio, Finland
– sequence: 6
  givenname: Arto
  surname: Urtti
  fullname: Urtti, Arto
  email: arto.urtti@uef.fi
  organization: School of Pharmacy, University of Eastern Finland, Kuopio, Finland
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30738982$$D View this record in MEDLINE/PubMed
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Snippet •Ocular drug delivery is a field in which regular ADME tools are not useful.•Pharmacokinetics based dosing aid for ocular drug delivery is...
Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the...
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SubjectTerms Administration, Ophthalmic
Biological Availability
Drug Delivery Systems - methods
Eye - drug effects
Humans
Ophthalmic Solutions - therapeutic use
Title Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties
URI https://dx.doi.org/10.1016/j.drudis.2019.02.001
https://www.ncbi.nlm.nih.gov/pubmed/30738982
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