The interferon response at the intersection of genome integrity and innate immunity

In recent years, numerous reports indicated that, besides pathogen infections, DNA replication stress and defective DNA repair can trigger the innate immune response by introducing a state of viral mimicry, due to cytosolic accumulation of the self-nucleic acid species, which culminates in the activ...

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Bibliographic Details
Published in:	DNA repair Vol. 145; p. 103786
Main Authors:	Duzanic, Filip D., Penengo, Lorenza
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.01.2025
Subjects:	Animals cGAS-STING pathway Cytokines - metabolism DNA Repair DNA Replication DNA replication fork dynamics and plasticity DNA replication stress Genome integrity Genomic Instability Humans Immunity, Innate Innate immunity Interferon response Interferon Stimulated Genes (ISGs) Interferon Type I - metabolism Interferons - metabolism ISG15 and ISGylation Signal Transduction Ubiquitination and ubiquitin-like modifications Ubiquitins ISG15 and ISGylation Interferon response cGAS-STING pathway DNA replication fork dynamics and plasticity Genome integrity Innate immunity Interferon Stimulated Genes (ISGs) Ubiquitination and ubiquitin-like modifications DNA replication stress
ISSN:	1568-7864, 1568-7856, 1568-7856
Online Access:	Get full text
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