Preventive effect of Bacillus mojavensis levan against carbon tetrachloride and cisplatin toxicity: in vivo study

This study is the first to investigate the hepato- and nephron-preventive effect of levan from Bacillus mojavensis (BM-levan) against toxicity induced by carbon tetrachloride (CCl 4 ) and cisplatin. Thirty-six male albino rats weighing between 230 and 250 g were used for this experiment. The groups...

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Vydané v:	Environmental science and pollution research international Ročník 28; číslo 36; s. 50117 - 50126
Hlavní autori:	Haddar, Anissa, Feriani, Anouar, Hamed, Mariem, Sila, Assaad, Ellouz-Chaabouni, Semia
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2021 Springer Nature B.V
Predmet:	Alanine Alanine transaminase albino Animal models Animals antioxidant activity Antioxidants Antioxidants - metabolism Aquatic Pollution Aspartate aminotransferase aspartate transaminase Atmospheric Protection/Air Quality Control/Air Pollution Bacillus Bacillus mojavensis Biocompatibility Biomarkers Biomedical materials Body weight Carbon Carbon tetrachloride Carbon Tetrachloride - toxicity Catalase Chemical and Drug Induced Liver Injury - metabolism Chemotherapy Cholesterol Cisplatin Cisplatin - toxicity Creatinine Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Fructans - metabolism Glutathione Glutathione peroxidase High density lipoprotein high density lipoprotein cholesterol Histology In vivo methods and tests Kidneys Levan lipid composition Lipid Peroxidation Lipids Liver Liver - metabolism Low density lipoprotein low density lipoprotein cholesterol Male males Oxidative Stress Peroxidase Peroxidation Plant Extracts - metabolism Rats Research Article Scavenging Superoxide dismutase Superoxide Dismutase - metabolism Supplements Toxicity Triglycerides Urea Uric acid Waste Water Technology Water Management Water Pollution Control Levan Hepato- and nephron-protective Antioxidant activity Carbon tetrachloride Cisplatin Bacillus mojavensis
ISSN:	0944-1344, 1614-7499, 1614-7499
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Shrnutí:	This study is the first to investigate the hepato- and nephron-preventive effect of levan from Bacillus mojavensis (BM-levan) against toxicity induced by carbon tetrachloride (CCl 4 ) and cisplatin. Thirty-six male albino rats weighing between 230 and 250 g were used for this experiment. The groups received multiples doses of BM-levan and were compared to the untreated group. The in vitro and in vivo biological potentials of BM-levan were evaluated by measuring its antioxidant capacity as well as its hepato- and nephron-protective activities in rat models. The investigations highlighted a significant in vitro antioxidant activity indicated by the radical-scavenging capacity, the reducing power, and the total antioxidant activity measurement. In addition, results demonstrate that BM-levan supplementation during 8 weeks (100 mg/kg body weight) significantly ( p < 0.05 ) decreased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities and remarkably ( p < 0.05 ) attenuated the altered lipid profile by decreasing the levels of triglycerides (TG) and total cholesterol (TC), LDL cholesterol (LDL-C) and by enhancing the HDL cholesterol (HDL-C) content, when compared with the CCl 4 group. BM-levan also reduced the content of plasma renal biomarkers (urea, creatinine, and uric acid) in the cisplatin-treated group. Moreover, BM-levan inhibited hepatic and renal oxidative stress generated by CCl 4 and cisplatin administration, through the enhancement of the antioxidant catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) and the diminishment of lipid peroxidation. The harmful effects of CCl 4 or cisplatin on hepatic and renal histology were found to be decreased by the addition of BM-levan. Therefore, BM-levan has proved promising for biomedical applications thanks to its in vitro and in vivo antioxidant properties.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0944-1344 1614-7499 1614-7499
DOI:	10.1007/s11356-021-14147-3