Genomic imprinting in development, growth, behavior and stem cells

Genes that are subject to genomic imprinting in mammals are preferentially expressed from a single parental allele. This imprinted expression of a small number of genes is crucial for normal development, as these genes often directly regulate fetal growth. Recent work has also demonstrated intricate...

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Bibliographic Details
Published in:Development (Cambridge) Vol. 141; no. 9; p. 1805
Main Authors: Plasschaert, Robert N, Bartolomei, Marisa S
Format: Journal Article
Language:English
Published: England 01.05.2014
Subjects:
Animals
Behavior
Cellular Reprogramming - genetics
Genomic Imprinting
Growth and Development - genetics
Humans
Nervous System - embryology
Stem Cells - metabolism
Fetal growth
DNA methylation
Behavior
Imprinted genes
Neuronal development
Induced pluripotency
ISSN:1477-9129, 1477-9129
Online Access:Get more information
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Summary:Genes that are subject to genomic imprinting in mammals are preferentially expressed from a single parental allele. This imprinted expression of a small number of genes is crucial for normal development, as these genes often directly regulate fetal growth. Recent work has also demonstrated intricate roles for imprinted genes in the brain, with important consequences on behavior and neuronal function. Finally, new studies have revealed the importance of proper expression of specific imprinted genes in induced pluripotent stem cells and in adult stem cells. As we review here, these findings highlight the complex nature and developmental importance of imprinted genes.
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ISSN:1477-9129
1477-9129
DOI:10.1242/dev.101428