Genomic imprinting in development, growth, behavior and stem cells

Genes that are subject to genomic imprinting in mammals are preferentially expressed from a single parental allele. This imprinted expression of a small number of genes is crucial for normal development, as these genes often directly regulate fetal growth. Recent work has also demonstrated intricate...

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Vydané v:Development (Cambridge) Ročník 141; číslo 9; s. 1805
Hlavní autori: Plasschaert, Robert N, Bartolomei, Marisa S
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England 01.05.2014
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ISSN:1477-9129, 1477-9129
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Abstract Genes that are subject to genomic imprinting in mammals are preferentially expressed from a single parental allele. This imprinted expression of a small number of genes is crucial for normal development, as these genes often directly regulate fetal growth. Recent work has also demonstrated intricate roles for imprinted genes in the brain, with important consequences on behavior and neuronal function. Finally, new studies have revealed the importance of proper expression of specific imprinted genes in induced pluripotent stem cells and in adult stem cells. As we review here, these findings highlight the complex nature and developmental importance of imprinted genes.
AbstractList Genes that are subject to genomic imprinting in mammals are preferentially expressed from a single parental allele. This imprinted expression of a small number of genes is crucial for normal development, as these genes often directly regulate fetal growth. Recent work has also demonstrated intricate roles for imprinted genes in the brain, with important consequences on behavior and neuronal function. Finally, new studies have revealed the importance of proper expression of specific imprinted genes in induced pluripotent stem cells and in adult stem cells. As we review here, these findings highlight the complex nature and developmental importance of imprinted genes.
Genes that are subject to genomic imprinting in mammals are preferentially expressed from a single parental allele. This imprinted expression of a small number of genes is crucial for normal development, as these genes often directly regulate fetal growth. Recent work has also demonstrated intricate roles for imprinted genes in the brain, with important consequences on behavior and neuronal function. Finally, new studies have revealed the importance of proper expression of specific imprinted genes in induced pluripotent stem cells and in adult stem cells. As we review here, these findings highlight the complex nature and developmental importance of imprinted genes.Genes that are subject to genomic imprinting in mammals are preferentially expressed from a single parental allele. This imprinted expression of a small number of genes is crucial for normal development, as these genes often directly regulate fetal growth. Recent work has also demonstrated intricate roles for imprinted genes in the brain, with important consequences on behavior and neuronal function. Finally, new studies have revealed the importance of proper expression of specific imprinted genes in induced pluripotent stem cells and in adult stem cells. As we review here, these findings highlight the complex nature and developmental importance of imprinted genes.
Author Bartolomei, Marisa S
Plasschaert, Robert N
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  organization: Department of Cell & Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
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  givenname: Marisa S
  surname: Bartolomei
  fullname: Bartolomei, Marisa S
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24757003$$D View this record in MEDLINE/PubMed
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Issue 9
Keywords Fetal growth
DNA methylation
Behavior
Imprinted genes
Neuronal development
Induced pluripotency
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Snippet Genes that are subject to genomic imprinting in mammals are preferentially expressed from a single parental allele. This imprinted expression of a small number...
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SubjectTerms Animals
Behavior
Cellular Reprogramming - genetics
Genomic Imprinting
Growth and Development - genetics
Humans
Nervous System - embryology
Stem Cells - metabolism
Title Genomic imprinting in development, growth, behavior and stem cells
URI https://www.ncbi.nlm.nih.gov/pubmed/24757003
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