Microvascular Impairment in Patients With Cerebral Small Vessel Disease Assessed With Arterial Spin Labeling Magnetic Resonance Imaging: A Pilot Study

In this pilot study, we investigated microvascular impairment in patients with cerebral small vessel disease (CSVD) using non-invasive arterial spin labeling (ASL) magnetic resonance imaging (MRI). This method enabled us to measure the perfusion parameters, cerebral blood flow (CBF), and arterial tr...

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Vydané v:	Frontiers in aging neuroscience Ročník 14; s. 871612
Hlavní autori:	Neumann, Katja, Günther, Matthias, Düzel, Emrah, Schreiber, Stefanie
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland Frontiers Research Foundation 19.05.2022 Frontiers Media S.A
Predmet:	Aging Neuroscience Alzheimer's disease arterial spin labeling arterial transit time Blood flow Cerebral blood flow cerebral small vessel disease Cerebrovascular disease clearance Dementia Magnetic resonance imaging Metabolism Microvasculature Neuroimaging Perfusion Spin labeling Substantia alba Substantia grisea Vascular diseases Germany T1-relaxation magnetic resonance imaging perfusion cerebral blood flow cerebral small vessel disease clearance arterial spin labeling arterial transit time
ISSN:	1663-4365, 1663-4365
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Abstract	In this pilot study, we investigated microvascular impairment in patients with cerebral small vessel disease (CSVD) using non-invasive arterial spin labeling (ASL) magnetic resonance imaging (MRI). This method enabled us to measure the perfusion parameters, cerebral blood flow (CBF), and arterial transit time (ATT), and the effective T1-relaxation time (T1eff) to research a novel approach of assessing perivascular clearance. CSVD severity was characterized using the Standards for Reporting Vascular Changes on Neuroimaging (STRIVE) and included a rating of white matter hyperintensities (WMHs), lacunes, enlarged perivascular spaces (EPVSs), and cerebral microbleeds (CMBs). Here, we found that CBF decreases and ATT increases with increasing CSVD severity in patients, most prominent for a white matter (WM) region-of-interest, whereas this relation was almost equally driven by WMHs, lacunes, EPVSs, and CMBs. Additionally, we observed a longer mean T1eff of gray matter and WM in patients with CSVD compared to elderly controls, providing an indication of impaired clearance in patients. Mainly T1eff of WM was associated with CSVD burden, whereas lobar lacunes and CMBs contributed primary to this relation compared to EPVSs of the centrum semiovale. Our results complement previous findings of CSVD-related hypoperfusion by the observation of retarded arterial blood arrival times in brain tissue and by an increased T1eff as potential indication of impaired clearance rates using ASL.
AbstractList	In this pilot study, we investigated microvascular impairment in patients with cerebral small vessel disease (CSVD) using non-invasive arterial spin labeling (ASL) magnetic resonance imaging (MRI). This method enabled us to measure the perfusion parameters, cerebral blood flow (CBF), and arterial transit time (ATT), and the effective T1-relaxation time (T1eff) to research a novel approach of assessing perivascular clearance. CSVD severity was characterized using the Standards for Reporting Vascular Changes on Neuroimaging (STRIVE) and included a rating of white matter hyperintensities (WMHs), lacunes, enlarged perivascular spaces (EPVSs), and cerebral microbleeds (CMBs). Here, we found that CBF decreases and ATT increases with increasing CSVD severity in patients, most prominent for a white matter (WM) region-of-interest, whereas this relation was almost equally driven by WMHs, lacunes, EPVSs, and CMBs. Additionally, we observed a longer mean T1eff of gray matter and WM in patients with CSVD compared to elderly controls, providing an indication of impaired clearance in patients. Mainly T1eff of WM was associated with CSVD burden, whereas lobar lacunes and CMBs contributed primary to this relation compared to EPVSs of the centrum semiovale. Our results complement previous findings of CSVD-related hypoperfusion by the observation of retarded arterial blood arrival times in brain tissue and by an increased T1eff as potential indication of impaired clearance rates using ASL.In this pilot study, we investigated microvascular impairment in patients with cerebral small vessel disease (CSVD) using non-invasive arterial spin labeling (ASL) magnetic resonance imaging (MRI). This method enabled us to measure the perfusion parameters, cerebral blood flow (CBF), and arterial transit time (ATT), and the effective T1-relaxation time (T1eff) to research a novel approach of assessing perivascular clearance. CSVD severity was characterized using the Standards for Reporting Vascular Changes on Neuroimaging (STRIVE) and included a rating of white matter hyperintensities (WMHs), lacunes, enlarged perivascular spaces (EPVSs), and cerebral microbleeds (CMBs). Here, we found that CBF decreases and ATT increases with increasing CSVD severity in patients, most prominent for a white matter (WM) region-of-interest, whereas this relation was almost equally driven by WMHs, lacunes, EPVSs, and CMBs. Additionally, we observed a longer mean T1eff of gray matter and WM in patients with CSVD compared to elderly controls, providing an indication of impaired clearance in patients. Mainly T1eff of WM was associated with CSVD burden, whereas lobar lacunes and CMBs contributed primary to this relation compared to EPVSs of the centrum semiovale. Our results complement previous findings of CSVD-related hypoperfusion by the observation of retarded arterial blood arrival times in brain tissue and by an increased T1eff as potential indication of impaired clearance rates using ASL. In this pilot study, we investigated microvascular impairment in patients with cerebral small vessel disease (CSVD) using non-invasive arterial spin labeling (ASL) magnetic resonance imaging (MRI). This method enabled us to measure the perfusion parameters, cerebral blood flow (CBF), and arterial transit time (ATT), and the effective T1-relaxation time (T1eff) to research a novel approach of assessing perivascular clearance. CSVD severity was characterized using the Standards for Reporting Vascular Changes on Neuroimaging (STRIVE) and included a rating of white matter hyperintensities (WMHs), lacunes, enlarged perivascular spaces (EPVSs), and cerebral microbleeds (CMBs). Here, we found that CBF decreases and ATT increases with increasing CSVD severity in patients, most prominent for a white matter (WM) region-of-interest, whereas this relation was almost equally driven by WMHs, lacunes, EPVSs, and CMBs. Additionally, we observed a longer mean T1eff of gray matter and WM in patients with CSVD compared to elderly controls, providing an indication of impaired clearance in patients. Mainly T1eff of WM was associated with CSVD burden, whereas lobar lacunes and CMBs contributed primary to this relation compared to EPVSs of the centrum semiovale. Our results complement previous findings of CSVD-related hypoperfusion by the observation of retarded arterial blood arrival times in brain tissue and by an increased T1eff as potential indication of impaired clearance rates using ASL. In this pilot study we investigated microvascular impairment in cerebral small vessel disease (CSVD) patients using non-invasive arterial spin labeling (ASL) magnetic resonance imaging (MRI). This method enabled us to measure the perfusion parameters cerebral blood flow (CBF) and arterial transit time (ATT), and the effective T1-relaxation time (T1eff) to research a novel approach of assessing perivascular clearance. CSVD severity was characterized using the Standards for Reporting Vascular Changes on Neuroimaging (STRIVE) and included a rating of white matter hyperintensities (WMH), lacunes, enlarged perivascular spaces (EPVS) and cerebral microbleeds (CMB). Here we found, that CBF decreases and ATT increases with increasing CSVD severity in patients, most prominent for a white matter (WM) region-of-interest, whereas this relation was almost equally driven by WMH, lacunes, EPVS and CMB. Additionally, we observed a longer mean T1eff of grey matter and WM in CSVD patients compared to elderly controls, providing an indication of impaired clearance in patients. Mainly T1eff of WM was associated to CSVD burden, whereas lobar lacunes and CMB contributed primary to this relation compared to EPVS of the centrum semiovale. Our results complement previous findings of CSVD related hypoperfusion by the observation of retarded arterial blood arrival times in brain tissue, and by an increased T1eff as potential indication of impaired clearance rates using ASL.
Author	Neumann, Katja Günther, Matthias Schreiber, Stefanie Düzel, Emrah
AuthorAffiliation	2 Fraunhofer Institute for Digital Medicine MEVIS , Bremen , Germany 7 Center for Behavioral Brain Science , Magdeburg , Germany 6 Institute of Cognitive Neuroscience, University College London , London , United Kingdom 1 German Center for Neurodegenerative Diseases (DZNE) , Magdeburg , Germany 4 mediri GmbH , Heidelberg , Germany 8 Department of Neurology, Otto-von-Guericke University Magdeburg , Magdeburg , Germany 3 MR-Imaging and Spectroscopy, University of Bremen , Bremen , Germany 5 Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg , Magdeburg , Germany
AuthorAffiliation_xml	– name: 5 Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg , Magdeburg , Germany – name: 4 mediri GmbH , Heidelberg , Germany – name: 2 Fraunhofer Institute for Digital Medicine MEVIS , Bremen , Germany – name: 1 German Center for Neurodegenerative Diseases (DZNE) , Magdeburg , Germany – name: 3 MR-Imaging and Spectroscopy, University of Bremen , Bremen , Germany – name: 6 Institute of Cognitive Neuroscience, University College London , London , United Kingdom – name: 8 Department of Neurology, Otto-von-Guericke University Magdeburg , Magdeburg , Germany – name: 7 Center for Behavioral Brain Science , Magdeburg , Germany
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/35663571$$D View this record in MEDLINE/PubMed
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Keywords	T1-relaxation magnetic resonance imaging perfusion cerebral blood flow cerebral small vessel disease clearance arterial spin labeling arterial transit time
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Edited by: Zhendong Liu, Shandong First Medical University, China Reviewed by: Rahul Pratap Kotian, Gulf Medical University, United Arab Emirates; Xiaoniu Liang, Fudan University, China; Antonio Coca, University of Barcelona, Spain This article was submitted to Neuroinflammation and Neuropathy, a section of the journal Frontiers in Aging Neuroscience
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SubjectTerms	Aging Neuroscience Alzheimer's disease arterial spin labeling arterial transit time Blood flow Cerebral blood flow cerebral small vessel disease Cerebrovascular disease clearance Dementia Magnetic resonance imaging Metabolism Microvasculature Neuroimaging Perfusion Spin labeling Substantia alba Substantia grisea Vascular diseases
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Title	Microvascular Impairment in Patients With Cerebral Small Vessel Disease Assessed With Arterial Spin Labeling Magnetic Resonance Imaging: A Pilot Study
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