Association of periodontal infections with atherosclerotic and pulmonary diseases

Chronic infections may influence the severity and/or course of a number of systemic diseases. Periodontal diseases are localized chronic inflammatory conditions of the gingiva and underlying bone and connective tissues induced by bacteria and bacterial products of dental plaque. This paper will disc...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of periodontal research Vol. 34; no. 7; pp. 340 - 345
Main Authors:	Scannapieco, F. A., Genco, R. J.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01.10.1999
Subjects:	Alveolar Process - microbiology Arteriosclerosis - etiology Bacterial Infections Brain Ischemia - etiology cardiovascular disease Chronic Disease chronic obstructive pulmonary disease Connective Tissue - microbiology coronary artery disease Coronary Disease - etiology Dental Plaque - microbiology Gingivitis - microbiology Humans Lung Diseases - etiology Periodontal Diseases - microbiology pneumonia Respiratory Tract Infections - microbiology Stroke - etiology
ISSN:	0022-3484, 1600-0765
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Chronic infections may influence the severity and/or course of a number of systemic diseases. Periodontal diseases are localized chronic inflammatory conditions of the gingiva and underlying bone and connective tissues induced by bacteria and bacterial products of dental plaque. This paper will discuss the evidence for the role of periodontal disease in the pathogenesis of 2 important systemic diseases, atherosclerosis and pulmonary infections. Both epidemiological and laboratory studies are reviewed to assess the biological basis for the association of periodontal infections and these important diseases. Several potential mechanisms by which periodontal diseases may influence these conditions are also discussed.
AbstractList	Chronic infections may influence the severity and/or course of a number of systemic diseases. Periodontal diseases are localized chronic inflammatory conditions of the gingiva and underlying bone and connective tissues induced by bacteria and bacterial products of dental plaque. This paper will discuss the evidence for the role of periodontal disease in the pathogenesis of 2 important systemic diseases, atherosclerosis and pulmonary infections. Both epidemiological and laboratory studies are reviewed to assess the biological basis for the association of periodontal infections and these important diseases. Several potential mechanisms by which periodontal diseases may influence these conditions are also discussed. Chronic infections may influence the severity and/or course of a number of systemic diseases. Periodontal diseases are localized chronic inflammatory conditions of the gingiva and underlying bone and connective tissues induced by bacteria and bacterial products of dental plaque. This paper will discuss the evidence for the role of periodontal disease in the pathogenesis of 2 important systemic diseases, atherosclerosis and pulmonary infections. Both epidemiological and laboratory studies are reviewed to assess the biological basis for the association of periodontal infections and these important diseases. Several potential mechanisms by which periodontal diseases may influence these conditions are also discussed.Chronic infections may influence the severity and/or course of a number of systemic diseases. Periodontal diseases are localized chronic inflammatory conditions of the gingiva and underlying bone and connective tissues induced by bacteria and bacterial products of dental plaque. This paper will discuss the evidence for the role of periodontal disease in the pathogenesis of 2 important systemic diseases, atherosclerosis and pulmonary infections. Both epidemiological and laboratory studies are reviewed to assess the biological basis for the association of periodontal infections and these important diseases. Several potential mechanisms by which periodontal diseases may influence these conditions are also discussed.
Author	Scannapieco, F. A. Genco, R. J.
Author_xml	– sequence: 1 givenname: F. A. surname: Scannapieco fullname: Scannapieco, F. A. email: fas1@acsu.buffalo.edu organization: Department of Oral Biology, University at Buffalo, Slate University of New York, Buffalo, NY, USA – sequence: 2 givenname: R. J. surname: Genco fullname: Genco, R. J. organization: Department of Oral Biology, University at Buffalo, Slate University of New York, Buffalo, NY, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/10685358$$D View this record in MEDLINE/PubMed
BookMark	eNqVkEtPJCEURslEo-3jL0wqLtxVCc3bhfERnzFONDOazIbQQEXa6qIt6Nj-eym7xxhXDgsI8N3D5WyAlTa0DoAdBCuUx964QgzCEnJGKySlrNIIDocMV_MfYPBxtQIGMB-XmAiyDjZiHMO8Z1yugXUEmaCYigG4PYoxGK-TD20R6mLqOh9saJNuCt_WzvQXsXjx6bHQ6dF1IZomz8mbQre2mM6aSWh191pYH52OLm6B1Vo30W0v103w5-z098lFef3r_PLk6Lo0BApY1hwJgcjISma5ZtYOcU2EJIZTITWinJORk9oOa2MRtIIwhHP7DGtpGNUab4LdBXfaheeZi0lNfDSuaXTrwiwqJgmmjIoc_LkMzkYTZ9W085PcsPonIQf2FwGTfxc7V3-KqN64Gqteq-q1qt64WhpX81x8-KXY-PSuM3XaN99DHCwQL75xr__xuLq6O8UEZkC5APiY3PwDoLsnxTjmVD3cnKu7M3r_9_iBqHv8BstZrJA
CitedBy_id	crossref_primary_10_1002_pmic_200400922 crossref_primary_10_1007_s10096_012_1710_y crossref_primary_10_1016_S0738_081X_01_00191_2 crossref_primary_10_1007_s00784_009_0346_5 crossref_primary_10_1371_journal_pone_0270177 crossref_primary_10_4049_jimmunol_1002943 crossref_primary_10_1139_cjm_2016_0603 crossref_primary_10_1902_jop_2011_100449 crossref_primary_10_1111_j_1600_0765_2012_01494_x crossref_primary_10_1161_01_HYP_0000056525_17476_D7 crossref_primary_10_1111_j_1601_0825_2000_tb00126_x crossref_primary_10_1111_omi_12003 crossref_primary_10_1902_jop_2011_110482 crossref_primary_10_1111_odi_12122 crossref_primary_10_1034_j_1600_0463_2002_1101203_x crossref_primary_10_1038_s41415_020_1747_8 crossref_primary_10_1111_j_1600_051X_2007_01127_x crossref_primary_10_1155_2016_3507503 crossref_primary_10_1182_blood_2005_09_010116 crossref_primary_10_1016_j_jamda_2016_12_082 crossref_primary_10_4037_ajcc2004_13_1_24 crossref_primary_10_4037_ajcc2004_13_1_25 crossref_primary_10_1111_jcpe_12204 crossref_primary_10_1902_jop_2007_060392 crossref_primary_10_1067_moe_2003_22 crossref_primary_10_1097_rnj_0000000000000301 crossref_primary_10_2147_JIR_S326896 crossref_primary_10_1371_journal_pone_0087449 crossref_primary_10_1111_jre_12004 crossref_primary_10_2492_inflammregen_27_107 crossref_primary_10_1016_j_cden_2016_08_003 crossref_primary_10_1111_j_1600_0765_2011_01464_x crossref_primary_10_1111_j_1752_7325_2004_tb02744_x crossref_primary_10_1111_j_1834_7819_2007_tb00470_x crossref_primary_10_1093_hmg_ddp508 crossref_primary_10_1034_j_1600_051X_2002_291108_x crossref_primary_10_1016_j_ijpp_2014_03_003 crossref_primary_10_1016_j_rmed_2021_106475 crossref_primary_10_1177_154405910608500202 crossref_primary_10_4103_JISPPD_JISPPD_268_20 crossref_primary_10_1080_20002297_2021_1957351 crossref_primary_10_1111_j_1754_4505_2002_tb01204_x crossref_primary_10_1155_2014_636893 crossref_primary_10_1902_jop_2012_110472 crossref_primary_10_1007_s40496_020_00248_4 crossref_primary_10_3390_microorganisms11020318 crossref_primary_10_3390_vaccines6020021 crossref_primary_10_1128_JB_185_18_5591_5601_2003 crossref_primary_10_1007_s10096_015_2555_y crossref_primary_10_1016_j_joen_2015_08_031 crossref_primary_10_1155_2016_7517928 crossref_primary_10_1002_cre2_589 crossref_primary_10_1902_jop_2011_100582 crossref_primary_10_1007_s00134_013_3049_y crossref_primary_10_1074_jbc_M007146200 crossref_primary_10_1007_s00408_011_9297_0 crossref_primary_10_1046_j_0906_6713_2002_003425_x crossref_primary_10_1111_1556_4029_13592 crossref_primary_10_1186_s12890_019_1017_1 crossref_primary_10_1371_journal_pone_0202791 crossref_primary_10_36377_1683_2981_2021_19_1_18_22 crossref_primary_10_1111_j_1752_7325_2000_tb03339_x crossref_primary_10_1111_jre_12280 crossref_primary_10_1016_j_ajoms_2013_05_001 crossref_primary_10_1111_j_1601_1546_2004_00096_x crossref_primary_10_1007_s40496_020_00255_5 crossref_primary_10_1002_ca_20041 crossref_primary_10_1186_s13005_021_00267_1 crossref_primary_10_1093_ije_dyh375 crossref_primary_10_1096_fj_02_0708com crossref_primary_10_1128_IAI_01209_07 crossref_primary_10_1111_j_1462_5822_2005_00513_x crossref_primary_10_1007_s11684_016_0476_5 crossref_primary_10_1177_154411130301400303 crossref_primary_10_4103_jomfp_jomfp_277_24 crossref_primary_10_1016_j_injms_2015_02_003
Cites_doi	10.1136/bmj.306.6879.688 10.1161/01.CIR.99.2.237 10.1093/clinids/13.Supplement_9.S737 10.1111/j.1600-0765.1996.tb00508.x 10.1111/j.1600-0765.1986.tb01472.x 10.1164/ajrccm/146.4.1067 10.1902/annals.1998.3.1.262 10.1902/jop.1996.67.10s.1138 10.1111/j.1600-0765.1983.tb00393.x 10.1128/IAI.66.4.1660-1665.1998 10.1111/j.1365-2249.1997.270-ce1162.x 10.1902/jop.1999.70.7.793 10.1126/science.283.5406.1335 10.1128/IAI.66.11.5337-5343.1998 10.1159/000212649 10.1056/NEJM196911202812101 10.1111/j.1754-4505.1999.tb01413.x 10.1902/annals.1998.3.1.257 10.1161/01.STR.28.9.1724 10.1111/j.1574-6968.1998.tb13208.x 10.1006/mpat.1998.0277 10.1056/NEJM199711063371906 10.1128/IAI.66.11.5307-5313.1998 10.1111/j.1749-6632.1996.tb52959.x 10.1056/NEJM199901143400207 10.1164/ajrccm.156.5.96-04076 10.1136/bmj.298.6676.779 10.1016/0021-9150(93)90263-T 10.1097/00000441-198605000-00013 10.1902/jop.1996.67.10s.1114 10.1001/jama.1992.03490010070032 10.1097/00003246-199206000-00007 10.1007/BF01705418 10.1159/000022055 10.1016/S0140-6736(96)07493-4 10.1111/j.1741-2358.1997.00009.x 10.1111/j.1574-6968.1994.tb07271.x 10.1016/S0140-6736(97)03079-1 10.1902/jop.1996.67.10s.1123 10.1016/0003-9969(95)00089-5 10.1161/01.CIR.98.8.731 10.1177/10454411940050030201 10.1001/jama.279.18.1477 10.1902/jop.1968.39.2.93 10.1111/j.1600-0765.1996.tb00473.x 10.1177/00220345960750090301 10.1097/00003246-199802000-00032 10.1038/nm0697-600 10.1902/annals.1998.3.1.251 10.1093/infdis/143.6.784 10.1111/j.1365-2796.1989.tb00060.x 10.1093/clinids/20.3.588 10.1111/j.1600-0765.1985.tb00850.x
ContentType	Journal Article
DBID	BSCLL AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1111/j.1600-0765.1999.tb02263.x
DatabaseName	Istex CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	CrossRef MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Dentistry
EISSN	1600-0765
EndPage	345
ExternalDocumentID	10685358 10_1111_j_1600_0765_1999_tb02263_x JRE340 ark_67375_WNG_RF5VZBW4_V
Genre	article Journal Article Review
GroupedDBID	--- .3N .GA .GJ .Y3 05W 0R~ 10A 1OB 1OC 29L 31~ 33P 34H 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A03 AAESR AAEVG AAHQN AAIPD AAKAS AAMMB AAMNL AANHP AANLZ AAONW AASGY AAWTL AAXRX AAYCA AAZKR ABCQN ABCUV ABEML ABJNI ABLJU ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCZN ACGFS ACGOF ACMXC ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZCM ADZMN AEFGJ AEIGN AEIMD AENEX AEUYR AEYWJ AFBPY AFEBI AFFNX AFFPM AFGKR AFWVQ AFZJQ AGHNM AGQPQ AGXDD AGYGG AHBTC AHEFC AIACR AIDQK AIDYY AIQQE AITYG AIURR ALAGY ALMA_UNASSIGNED_HOLDINGS ALVPJ AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CAG COF CS3 CWXXS D-E D-F DC6 DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EBD EBS EJD F00 F01 F04 F5P FEDTE FUBAC FZ0 G-S G.N GODZA H.T H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OVD P2P P2W P2X P4D PALCI Q.N Q11 QB0 R.K RIWAO RJQFR ROL RX1 SAMSI SUPJJ TEORI UB1 W8V W99 WBKPD WBNRW WIH WIJ WIK WOHZO WPGGZ WQJ WXSBR XG1 YFH ZGI ZZTAW ~IA ~WT AAHHS ACCFJ AEEZP AEQDE AEUQT AFPWT AIWBW AJBDE ALUQN WRC AAYXX CITATION O8X CGR CUY CVF ECM EIF NPM PKN 7X8
ID	FETCH-LOGICAL-c4080-f718814bd96d7a6dd23f4894c7589a15774be9ad2fcd10d8461302663a9c65aa3
IEDL.DBID	DRFUL
ISICitedReferencesCount	83
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000085053700002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0022-3484
IngestDate	Wed Oct 01 13:01:22 EDT 2025 Wed Feb 19 02:35:08 EST 2025 Sat Nov 29 06:41:49 EST 2025 Tue Nov 18 20:47:27 EST 2025 Wed Jan 22 16:23:01 EST 2025 Tue Nov 11 03:32:27 EST 2025
IsPeerReviewed	true
IsScholarly	true
Issue	7
Language	English
License	http://onlinelibrary.wiley.com/termsAndConditions#vor
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c4080-f718814bd96d7a6dd23f4894c7589a15774be9ad2fcd10d8461302663a9c65aa3
Notes	ArticleID:JRE340 ark:/67375/WNG-RF5VZBW4-V istex:D1D91FFA79E937FE6558BAF7E65D0754A880A6A7 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
PMID	10685358
PQID	69435658
PQPubID	23479
PageCount	6
ParticipantIDs	proquest_miscellaneous_69435658 pubmed_primary_10685358 crossref_primary_10_1111_j_1600_0765_1999_tb02263_x crossref_citationtrail_10_1111_j_1600_0765_1999_tb02263_x wiley_primary_10_1111_j_1600_0765_1999_tb02263_x_JRE340 istex_primary_ark_67375_WNG_RF5VZBW4_V
PublicationCentury	1900
PublicationDate	October 1999
PublicationDateYYYYMMDD	1999-10-01
PublicationDate_xml	– month: 10 year: 1999 text: October 1999
PublicationDecade	1990
PublicationPlace	Oxford, UK
PublicationPlace_xml	– name: Oxford, UK – name: United States
PublicationTitle	Journal of periodontal research
PublicationTitleAlternate	J Periodontal Res
PublicationYear	1999
Publisher	Blackwell Publishing Ltd
Publisher_xml	– name: Blackwell Publishing Ltd
References	Haraszthy VI, Zambon JJ, Trevisan M, Shah R, Zeid M, Genco RJ. Identification of pathogens in atheromatous plaques. J Dent Res 1998; 77(special issue): abstract 273. Wilson M, Reddi K, Henderson B. Cytokine-inducing components of periodontopathogenic bacteria. J Periodont Res 1996; 31: 393-407. Murphy TF, Sethi S. Bacterial infection in chronic obstructive pulmonary disease. Am Rev Respir Dis 1992; 146: 1067-1083. Fourrier F, Duvivier B, Boutigny H, Roussel-Delvallez M, Chopin C. Colonization of dental plaque: a source of nosocomial infections in intensive care unit patients. Crit Care Med 1998; 26: 301-308. Pederson ED, Stanke SR, Whitener SJ, Sebastiani PT, Lamberts BL, Turner DW. Salivary levels of alpha 2-macroglobulin, alpha 1-antitrypsin, C-reactive protein, cathepsin G and elastase in humans with or without destructive periodontal disease. Arch Oral Biol 1995; 40: 1151-1155. Scannapieco FA, Mylotte JM. Relationships between periodontal disease and bacterial pneumonia. J Periodontol 1996; 67: 1114-1122. Thorn DH, Grayston JT, Siscovick DS, Wang S, Weiss NS, Daling JR. Association of prior infection with Chlamydia pneumoniae and angiographically demonstrated coronary artery disease. J Amer Med Assoc 1992; 268: 68-72. Wu T, Trevisan M, Genco RJ, Falkner KL, Dorn JP, Sempos CT. Possible biological pathways linking periodontal infection to cardiovascular disease: The Third National Health and Nutrition Examination Survey. Am J Epidemiol 1998; 147: 66(abstract). Bachmaier K, Neu N, de la Maza LM, Pal S, Hessel A, Penninger JM. Chlamydia infections and heart disease linked through antigenic mimicry. Science 1999; 283: 1335-1339. Ridker PM, Buring JE, Shih J, Matias M, Hennekens CH. Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation 1998; 98: 731-733. Zambon JJ, Nakamura M, Slots J. Effect of periodontal therapy on salivary enzyme activity. J Periodont Res 1985; 20: 652-659. Grau AJ, Buggle F, Ziegler C et al. Association between acute cerebrovascular ischemia and chronic and recurrent infection. Stroke 1997; 28: 1724-1729. Breslow JL. Cardiovascular disease burden increases, NIH funding decreases. Nat Med 1997; 3: 600-601. Paunio K, Impivaara O, Tiekso J, Maki J. Missing teeth and ischaemic heart disease in men aged 45-64 years. Eur Heart J 1993; 14(suppl):54-56. Finegold SM. Aspiration pneumonia. Rev Infect Dis 1991; 13(S):S737-S742. Danesh J, Collins R, Appleby P, Peto R. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA 1998; 279: 1477-1482. Fagon JY, Chastre J. Severe exacerbations of COPD patients: the role of pulmonary infections. Semin Respir Infect 1996; 11: 109-118. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 1999; 340: 115-126. Goulhen F, Hafezi A, Uitto VJ et al. Subcellular localization and cytotoxic activity of the GroEL-like protein isolated from Actinobacillus actinomycetemcomitans. Infect Immun 1998; 66: 5307-5313. Chiu B, Viira E, Evans RT, Genco RJ. Detection of an odontopathogen: Porphyromonas ginghalis in atherosclerotic plaques: an immunohistochemical and in situ hybridization study. Appl Immunohistochem Mol Morph 1999; in press. Beck J, Garcia J, Heiss G, Vokonas P, Offenbacher S. Periodontal disease and cardiovascular disease. J Periodontol 1996; 67: 1123-1137. Syrjänen J, Peltola J, Valtonen V, Livanainen M, Kaste M, Huttunen JK. Dental infections in association with cerebral infarction in young and middle-aged men. J Intern Med 1989; 255: 179-184. Herzberg MC, Meyer MW. Effects of oral flora on platelets: possible consequences in cardiovascular disease. J Periodontol 1996; 67(suppl): 1138-1142. Woods DE, Straus DC, Johanson WG, Bass JA. Role of fibronectin in the prevention of adherence of Pseudomonas aeruginosa to buccal cells. J Infect Dis 1981; 143: 784-790. Ebersole JL, Machen RL, Steffen MJ, Willmann DE. Systemic acute-phase reactants, C-reactive protein and haptoglobin, in adult periodontitis. Clin Exp Immunol 1997; 107: 347-352. Johanson WG, Pierce AK, Sanford AK. Changing pharyngeal bacterial flora of hospitilized patients. Emergence of gram negative bacilli. N Engl J Med 1969; 281: 1137-1140. Mattila KJ, Valle MS, Nieminen MS, Valtonen VV, Hietaniemi KL. Dental infections and coronary atherosclerosis. Atherosclerosis 1993; 103: 205-211. Schreiner A. Anaerobic pulmonary infections. Scand J Infect Dis 1979; 19(suppl):77-79. Scannapieco FA. Role of oral bacteria in respiratory infection. J Periodontol 1999; 70: 793-802. Genco RJ, Chadda S, Grossi S et al. Periodontal disease is a predictor of cardiovascular disease in a Native American population. J Dent Res 1997; 76(special issue): abstract 3158. Scannapieco FA, Papandonatos GD, Dunford RG. Associations between oral conditions and respiratory disease in a national sample survey population. Ann Periodontol 1998; 3: 251-256. Mattila KJ, Valtonen W, Nieminen M, Huttunen JK. Dental infection and the risk of new coronary events: prospective study of patients with documented coronary artery disease. Ciin Infect Dis 1995; 20: 588-592. Gibbons RJ, Etherden I. Fibronectin-degrading enzymes in saliva and their relation to oral cleanliness. J Periodont Res 1986; 21: 386-395. Society AT. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1995; 152(pt 2):S77-121. Toews GB. Nosocomial pneumonia. Am J Med Sci 1986; 291: 355-367. Mattila KJ, Nieminen MS, Valtonen W et al. Association between dental health and acute myocardial infarction. Br Med J 1989; 298: 779-782. Braunwald E. Shattuck Lecture - cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities. N Engl J Med 1997; 337: 1360-1369. Harvard School of Public Health B, Massachusetts. Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet 1997; 349: 1269-1276. Nakamura M, Slots J. Salivary enzymes. Origin and relationship to periodontal disease. J Periodont Res 1983; 18: 559-569. Limeback H. Implications of oral infections on systemic diseases in the institutionalized elderly with a special focus on pneumonia. Ann Periodontol 1998; 3: 262-275. Estes RJ, Meduri GU. The pathogenesis of ventilator-associated pneumonia: mechanisms of bacterial translocation and airway inoculation. Intensive Care Med 1995; 21: 365-383. Russell SL, Boylan RJ, Kaslick RS, Scannapieco FA, Katz RV. Respiratory pathogen colonization of the dental plaque of institutionalized elders. Spec Care Dent 1999; 19: 1-7. Preston AJ, Gosney MA, Noon S, Martin MV. Oral flora of elderly patients following acute medical admission. Gerontology 1999; 45: 49-52. Scannapieco FA. Saliva-bacterium interactions in oral microbial ecology. Crit Rev Oral Biol Med 1994; 5: 203-248. Wu T, Trevisan M, Genco RJ, Falkner KL, Dorn JP, Sempos CT. An examination of the relation between periodontal health status and cardiovascular risk factors: Serum total and HDL cholesterol, C-reactive protein, and plasma fibrinogen. Am J Epidemiol 1999; in press. Bentley DW. Bacterial pneumonia in the elderly: clinical features, diagnosis, etiology, and treatment. Gerontology 1984; 30: 297-307. Zhang J, Dong H, Kashket S, Duncan MJ. IL-8 degradation by Porphyromonas gingivalis proteases. Microb Pathog 1999; 26: 275-280. Joshipura KJ, Rimm EB, Douglass CW, Trichopoulos D, Ascherio A, Willet WC. Poor oral health and coronary heart disease. J Dent Res 1996; 75: 1631-1636. Kadri R, Devine D, Ashraf W. Purification and functional analysis of the DnaK homologue from Prevotella intermedia OMZ 326. FEMS Microbiol Lett 1998; 167: 63-68. Scannapieco FA, Ho AW. Association of periodontal disease and chronic lung disease: analysis of NHANES III. J Dent Res 1999; 78(Sp. Iss.):abstract 3491. DeStefano F, Anda RF, Kahn HS, Williamson DF, Russell CM. Dental disease and risk of coronary heart disease and mortality. Br. Med J 1993; 306: 688-691. Scannapieco FA, Stewart EM, Mylotte JM. Colonization of dental plaque by respiratory pathogens in medical intensive care patients. Crit Care Med 1992; 20: 740-745. Limeback H. The relationship between oral health and systemic infections among elderly residents of chronic care facilities. A review 1988; 7: 131-137. Mojon P, Budtz-Jargensen E, Michel JP, Limeback H. Oral health and history of respiratory tract infection in frail institutionalised elders. Gerodontology 1997; 14: 9-16. Reddi K, Wilson M, Nair S, Poole S, Henderson B. Comparison of the pro-inflammatory cytokine-stimulating activity of the surface-associated proteins of periodontopathic bacteria. J Periodont Res 1996; 31: 120-130. Koenig W, Sund M, Frohlich M et al. C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992. Circulation 1999; 99: 237-242. Garrouste-Orgeas M, Chevret S, Arlet G et al. Oropharyngeal or gastric colonization and nosocomial pneumonia in adult intensive care unit patients. A prospective study based on genomic DNA analysis. Am J Respir Crit Care Med 1997; 156: 1647-1655. Hayes C, Sparrow D, Cohen M, Vokonas P, Garcia RI. Periodontal disease and pulmonary function: the VA longitudinal study. Ann Periodontol 1998; 3: 257-261. Svanborg C, Hedlund M, Connell H et al. Bacterial adherence and mucosal cytokine responses. Receptors and transmembrane signaling. Ann NY Acad Sci 1996; 797: 177-190. Shklair IL, Lovmg RH, Leberman OF, Rau CF. C-Reactive protein and periodontal disease. J Periodonlol 1968; 39: 93-95. Darveau RP, Belton CM, Reife RA, Lamont RJ. Local chemokine paralysis, a novel pathogenic mechanism for Porphyromonas gingivalis. Infect Immun 1998; 66: 1660-1665. Maeda H, Miyamoto M, Hongyo H, Nagai A, Kurihara H, Muryama Y. Heat shock protein 60 (GroEL) from Porphyromonas gingivali 1991; 13 1997; 350 1997; 156 1981; 143 1999; 45 1999; 283 1998; 279 1983; 18 1997; 3 1985; 20 1996; 75 1996; 31 1995; 20 1997; 349 1997; 107 1990 1999; 19 1997; 14 1995; 21 1999; 99 1998; 98 1998; 167 1996; 67 1998; 26 1979; 19 1997; 337 1993; 306 1989; 255 1992; 146 1992; 268 1999; 26 1989; 298 1999; 340 1997; 28 1994 1993 1993; 103 1995; 152 1998; 66 1999 1996; 11 1993; 14 1994; 124 1995; 40 1984; 30 1969; 281 1968; 39 1997; 76 1986; 21 1988; 7 1999; 78 1986; 291 1998; 3 1998; 147 1992; 20 1996; 797 1999; 70 1994; 5 1998; 77 Haraszthy VI (e_1_2_1_20_2) 1998; 77 Wu T (e_1_2_1_30_2) 1999 e_1_2_1_41_2 e_1_2_1_64_2 Schreiner A. (e_1_2_1_45_2) 1979; 19 e_1_2_1_66_2 e_1_2_1_60_2 e_1_2_1_43_2 e_1_2_1_62_2 e_1_2_1_26_2 e_1_2_1_49_2 e_1_2_1_24_2 e_1_2_1_47_2 e_1_2_1_68_2 e_1_2_1_28_2 Wu T (e_1_2_1_19_2) 1998; 147 e_1_2_1_6_2 e_1_2_1_54_2 e_1_2_1_56_2 e_1_2_1_2_2 Genco RJ (e_1_2_1_16_2) 1997; 76 e_1_2_1_12_2 e_1_2_1_33_2 e_1_2_1_10_2 e_1_2_1_31_2 e_1_2_1_52_2 Paunio K (e_1_2_1_11_2) 1993; 14 e_1_2_1_14_2 Limeback H. (e_1_2_1_50_2) 1988; 7 e_1_2_1_58_2 e_1_2_1_8_2 e_1_2_1_18_2 Society AT. (e_1_2_1_35_2) 1995; 152 e_1_2_1_40_2 e_1_2_1_65_2 (e_1_2_1_4_2) 1993 e_1_2_1_67_2 e_1_2_1_23_2 Donowitz GR (e_1_2_1_39_2) 1990 e_1_2_1_44_2 e_1_2_1_61_2 Deshpande RG (e_1_2_1_22_2) 1998; 66 Fagon JY (e_1_2_1_37_2) 1996; 11 e_1_2_1_42_2 Levison ME. (e_1_2_1_46_2) 1994 e_1_2_1_63_2 Chiu B (e_1_2_1_21_2) 1999 e_1_2_1_27_2 e_1_2_1_48_2 e_1_2_1_25_2 e_1_2_1_29_2 Scannapieco FA (e_1_2_1_57_2) 1999; 78 Thorn DH (e_1_2_1_7_2) 1992; 268 e_1_2_1_53_2 e_1_2_1_55_2 e_1_2_1_5_2 e_1_2_1_34_2 e_1_2_1_3_2 e_1_2_1_32_2 e_1_2_1_51_2 e_1_2_1_15_2 e_1_2_1_38_2 e_1_2_1_13_2 e_1_2_1_36_2 e_1_2_1_17_2 e_1_2_1_59_2 e_1_2_1_9_2
References_xml	– reference: Ridker PM, Buring JE, Shih J, Matias M, Hennekens CH. Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation 1998; 98: 731-733. – reference: Limeback H. Implications of oral infections on systemic diseases in the institutionalized elderly with a special focus on pneumonia. Ann Periodontol 1998; 3: 262-275. – reference: Genco RJ, Chadda S, Grossi S et al. Periodontal disease is a predictor of cardiovascular disease in a Native American population. J Dent Res 1997; 76(special issue): abstract 3158. – reference: Zhang J, Dong H, Kashket S, Duncan MJ. IL-8 degradation by Porphyromonas gingivalis proteases. Microb Pathog 1999; 26: 275-280. – reference: Toews GB. Nosocomial pneumonia. Am J Med Sci 1986; 291: 355-367. – reference: Thorn DH, Grayston JT, Siscovick DS, Wang S, Weiss NS, Daling JR. Association of prior infection with Chlamydia pneumoniae and angiographically demonstrated coronary artery disease. J Amer Med Assoc 1992; 268: 68-72. – reference: Russell SL, Boylan RJ, Kaslick RS, Scannapieco FA, Katz RV. Respiratory pathogen colonization of the dental plaque of institutionalized elders. Spec Care Dent 1999; 19: 1-7. – reference: Wu T, Trevisan M, Genco RJ, Falkner KL, Dorn JP, Sempos CT. Possible biological pathways linking periodontal infection to cardiovascular disease: The Third National Health and Nutrition Examination Survey. Am J Epidemiol 1998; 147: 66(abstract). – reference: Chiu B, Viira E, Evans RT, Genco RJ. Detection of an odontopathogen: Porphyromonas ginghalis in atherosclerotic plaques: an immunohistochemical and in situ hybridization study. Appl Immunohistochem Mol Morph 1999; in press. – reference: Deshpande RG, Khan MB, Genco CA. Invasion of aortic and heart endothelial cells by Porphyromonas ginghalis. Infect Immun 1998; 66: 5337-5343. – reference: Mattila KJ, Nieminen MS, Valtonen W et al. Association between dental health and acute myocardial infarction. Br Med J 1989; 298: 779-782. – reference: Svanborg C, Hedlund M, Connell H et al. Bacterial adherence and mucosal cytokine responses. Receptors and transmembrane signaling. Ann NY Acad Sci 1996; 797: 177-190. – reference: Hayes C, Sparrow D, Cohen M, Vokonas P, Garcia RI. Periodontal disease and pulmonary function: the VA longitudinal study. Ann Periodontol 1998; 3: 257-261. – reference: Wilson M, Reddi K, Henderson B. Cytokine-inducing components of periodontopathogenic bacteria. J Periodont Res 1996; 31: 393-407. – reference: Bachmaier K, Neu N, de la Maza LM, Pal S, Hessel A, Penninger JM. Chlamydia infections and heart disease linked through antigenic mimicry. Science 1999; 283: 1335-1339. – reference: Society AT. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1995; 152(pt 2):S77-121. – reference: Mojon P, Budtz-Jargensen E, Michel JP, Limeback H. Oral health and history of respiratory tract infection in frail institutionalised elders. Gerodontology 1997; 14: 9-16. – reference: Nakamura M, Slots J. Salivary enzymes. Origin and relationship to periodontal disease. J Periodont Res 1983; 18: 559-569. – reference: Scannapieco FA. Saliva-bacterium interactions in oral microbial ecology. Crit Rev Oral Biol Med 1994; 5: 203-248. – reference: Koenig W, Sund M, Frohlich M et al. C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992. Circulation 1999; 99: 237-242. – reference: Murphy TF, Sethi S. Bacterial infection in chronic obstructive pulmonary disease. Am Rev Respir Dis 1992; 146: 1067-1083. – reference: Goulhen F, Hafezi A, Uitto VJ et al. Subcellular localization and cytotoxic activity of the GroEL-like protein isolated from Actinobacillus actinomycetemcomitans. Infect Immun 1998; 66: 5307-5313. – reference: Grau AJ, Buggle F, Ziegler C et al. Association between acute cerebrovascular ischemia and chronic and recurrent infection. Stroke 1997; 28: 1724-1729. – reference: Syrjänen J, Peltola J, Valtonen V, Livanainen M, Kaste M, Huttunen JK. Dental infections in association with cerebral infarction in young and middle-aged men. J Intern Med 1989; 255: 179-184. – reference: Danesh J, Collins R, Peto R. Chronic infections and coronary heart disease: is there a link Lancet 1997; 350: 430-436. – reference: Ebersole JL, Machen RL, Steffen MJ, Willmann DE. Systemic acute-phase reactants, C-reactive protein and haptoglobin, in adult periodontitis. Clin Exp Immunol 1997; 107: 347-352. – reference: Haraszthy VI, Zambon JJ, Trevisan M, Shah R, Zeid M, Genco RJ. Identification of pathogens in atheromatous plaques. J Dent Res 1998; 77(special issue): abstract 273. – reference: Wu T, Trevisan M, Genco RJ, Falkner KL, Dorn JP, Sempos CT. An examination of the relation between periodontal health status and cardiovascular risk factors: Serum total and HDL cholesterol, C-reactive protein, and plasma fibrinogen. Am J Epidemiol 1999; in press. – reference: Finegold SM. Aspiration pneumonia. Rev Infect Dis 1991; 13(S):S737-S742. – reference: Joshipura KJ, Rimm EB, Douglass CW, Trichopoulos D, Ascherio A, Willet WC. Poor oral health and coronary heart disease. J Dent Res 1996; 75: 1631-1636. – reference: Herzberg MC, Meyer MW. Effects of oral flora on platelets: possible consequences in cardiovascular disease. J Periodontol 1996; 67(suppl): 1138-1142. – reference: Mattila KJ, Valle MS, Nieminen MS, Valtonen VV, Hietaniemi KL. Dental infections and coronary atherosclerosis. Atherosclerosis 1993; 103: 205-211. – reference: Woods DE, Straus DC, Johanson WG, Bass JA. Role of fibronectin in the prevention of adherence of Pseudomonas aeruginosa to buccal cells. J Infect Dis 1981; 143: 784-790. – reference: Braunwald E. Shattuck Lecture - cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities. N Engl J Med 1997; 337: 1360-1369. – reference: Breslow JL. Cardiovascular disease burden increases, NIH funding decreases. Nat Med 1997; 3: 600-601. – reference: Gibbons RJ, Etherden I. Fibronectin-degrading enzymes in saliva and their relation to oral cleanliness. J Periodont Res 1986; 21: 386-395. – reference: Scannapieco FA, Stewart EM, Mylotte JM. Colonization of dental plaque by respiratory pathogens in medical intensive care patients. Crit Care Med 1992; 20: 740-745. – reference: Limeback H. The relationship between oral health and systemic infections among elderly residents of chronic care facilities. A review 1988; 7: 131-137. – reference: Beck J, Garcia J, Heiss G, Vokonas P, Offenbacher S. Periodontal disease and cardiovascular disease. J Periodontol 1996; 67: 1123-1137. – reference: Pederson ED, Stanke SR, Whitener SJ, Sebastiani PT, Lamberts BL, Turner DW. Salivary levels of alpha 2-macroglobulin, alpha 1-antitrypsin, C-reactive protein, cathepsin G and elastase in humans with or without destructive periodontal disease. Arch Oral Biol 1995; 40: 1151-1155. – reference: Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 1999; 340: 115-126. – reference: Scannapieco FA, Ho AW. Association of periodontal disease and chronic lung disease: analysis of NHANES III. J Dent Res 1999; 78(Sp. Iss.):abstract 3491. – reference: Harvard School of Public Health B, Massachusetts. Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet 1997; 349: 1269-1276. – reference: Scannapieco FA, Papandonatos GD, Dunford RG. Associations between oral conditions and respiratory disease in a national sample survey population. Ann Periodontol 1998; 3: 251-256. – reference: Johanson WG, Pierce AK, Sanford AK. Changing pharyngeal bacterial flora of hospitilized patients. Emergence of gram negative bacilli. N Engl J Med 1969; 281: 1137-1140. – reference: Shklair IL, Lovmg RH, Leberman OF, Rau CF. C-Reactive protein and periodontal disease. J Periodonlol 1968; 39: 93-95. – reference: Kadri R, Devine D, Ashraf W. Purification and functional analysis of the DnaK homologue from Prevotella intermedia OMZ 326. FEMS Microbiol Lett 1998; 167: 63-68. – reference: Schreiner A. Anaerobic pulmonary infections. Scand J Infect Dis 1979; 19(suppl):77-79. – reference: Reddi K, Wilson M, Nair S, Poole S, Henderson B. Comparison of the pro-inflammatory cytokine-stimulating activity of the surface-associated proteins of periodontopathic bacteria. J Periodont Res 1996; 31: 120-130. – reference: Fagon JY, Chastre J. Severe exacerbations of COPD patients: the role of pulmonary infections. Semin Respir Infect 1996; 11: 109-118. – reference: Scannapieco FA, Mylotte JM. Relationships between periodontal disease and bacterial pneumonia. J Periodontol 1996; 67: 1114-1122. – reference: Preston AJ, Gosney MA, Noon S, Martin MV. Oral flora of elderly patients following acute medical admission. Gerontology 1999; 45: 49-52. – reference: Darveau RP, Belton CM, Reife RA, Lamont RJ. Local chemokine paralysis, a novel pathogenic mechanism for Porphyromonas gingivalis. Infect Immun 1998; 66: 1660-1665. – reference: Paunio K, Impivaara O, Tiekso J, Maki J. Missing teeth and ischaemic heart disease in men aged 45-64 years. Eur Heart J 1993; 14(suppl):54-56. – reference: DeStefano F, Anda RF, Kahn HS, Williamson DF, Russell CM. Dental disease and risk of coronary heart disease and mortality. Br. Med J 1993; 306: 688-691. – reference: Bentley DW. Bacterial pneumonia in the elderly: clinical features, diagnosis, etiology, and treatment. Gerontology 1984; 30: 297-307. – reference: Danesh J, Collins R, Appleby P, Peto R. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA 1998; 279: 1477-1482. – reference: Garrouste-Orgeas M, Chevret S, Arlet G et al. Oropharyngeal or gastric colonization and nosocomial pneumonia in adult intensive care unit patients. A prospective study based on genomic DNA analysis. Am J Respir Crit Care Med 1997; 156: 1647-1655. – reference: Estes RJ, Meduri GU. The pathogenesis of ventilator-associated pneumonia: mechanisms of bacterial translocation and airway inoculation. Intensive Care Med 1995; 21: 365-383. – reference: Zambon JJ, Nakamura M, Slots J. Effect of periodontal therapy on salivary enzyme activity. J Periodont Res 1985; 20: 652-659. – reference: Fourrier F, Duvivier B, Boutigny H, Roussel-Delvallez M, Chopin C. Colonization of dental plaque: a source of nosocomial infections in intensive care unit patients. Crit Care Med 1998; 26: 301-308. – reference: Mattila KJ, Valtonen W, Nieminen M, Huttunen JK. Dental infection and the risk of new coronary events: prospective study of patients with documented coronary artery disease. Ciin Infect Dis 1995; 20: 588-592. – reference: Scannapieco FA. Role of oral bacteria in respiratory infection. J Periodontol 1999; 70: 793-802. – reference: Maeda H, Miyamoto M, Hongyo H, Nagai A, Kurihara H, Muryama Y. Heat shock protein 60 (GroEL) from Porphyromonas gingivalis: molecular cloning and sequence analysis of its gene and purification of the recombinant protein. FEMS Microbiol Lett 1994; 124: 121-122. – volume: 103 start-page: 205 year: 1993 end-page: 211 article-title: Dental infections and coronary atherosclerosis publication-title: Atherosclerosis – volume: 76 start-page: 3158 issue: special issue year: 1997 article-title: Periodontal disease is a predictor of cardiovascular disease in a Native American population publication-title: J Dent Res – volume: 3 start-page: 257 year: 1998 end-page: 261 article-title: Periodontal disease and pulmonary function: the VA longitudinal study publication-title: Ann Periodontol – volume: 45 start-page: 49 year: 1999 end-page: 52 article-title: Oral flora of elderly patients following acute medical admission publication-title: Gerontology – volume: 14 start-page: 54 issue: suppl year: 1993 end-page: 56 article-title: Missing teeth and ischaemic heart disease in men aged 45–64 years publication-title: Eur Heart J – volume: 20 start-page: 588 year: 1995 end-page: 592 article-title: Dental infection and the risk of new coronary events: prospective study of patients with documented coronary artery disease publication-title: Ciin Infect Dis – volume: 152 start-page: S77 issue: pt 2 year: 1995 end-page: 121 article-title: Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease publication-title: Am J Respir Crit Care Med – volume: 66 start-page: 1660 year: 1998 end-page: 1665 article-title: Local chemokine paralysis, a novel pathogenic mechanism for publication-title: Infect Immun – volume: 70 start-page: 793 year: 1999 end-page: 802 article-title: Role of oral bacteria in respiratory infection publication-title: J Periodontol – volume: 279 start-page: 1477 year: 1998 end-page: 1482 article-title: Association of fibrinogen, C‐reactive protein, albumin, or leukocyte count with coronary heart disease: meta‐analyses of prospective studies publication-title: JAMA – year: 1999 article-title: An examination of the relation between periodontal health status and cardiovascular risk factors: Serum total and HDL cholesterol, C‐reactive protein, and plasma fibrinogen publication-title: Am J Epidemiol – volume: 11 start-page: 109 year: 1996 end-page: 118 article-title: Severe exacerbations of COPD patients: the role of pulmonary infections publication-title: Semin Respir Infect – volume: 28 start-page: 1724 year: 1997 end-page: 1729 article-title: Association between acute cerebrovascular ischemia and chronic and recurrent infection publication-title: Stroke – volume: 20 start-page: 740 year: 1992 end-page: 745 article-title: Colonization of dental plaque by respiratory pathogens in medical intensive care patients publication-title: Crit Care Med – volume: 3 start-page: 600 year: 1997 end-page: 601 article-title: Cardiovascular disease burden increases, NIH funding decreases publication-title: Nat Med – volume: 40 start-page: 1151 year: 1995 end-page: 1155 article-title: Salivary levels of alpha 2‐macroglobulin, alpha 1‐antitrypsin, C‐reactive protein, cathepsin G and elastase in humans with or without destructive periodontal disease publication-title: Arch Oral Biol – volume: 31 start-page: 393 year: 1996 end-page: 407 article-title: Cytokine‐inducing components of periodontopathogenic bacteria publication-title: J Periodont Res – volume: 30 start-page: 297 year: 1984 end-page: 307 article-title: Bacterial pneumonia in the elderly: clinical features, diagnosis, etiology, and treatment publication-title: Gerontology – start-page: 540 year: 1990 end-page: 555 – volume: 147 start-page: 66 year: 1998 article-title: Possible biological pathways linking periodontal infection to cardiovascular disease: The Third National Health and Nutrition Examination Survey publication-title: Am J Epidemiol – volume: 19 start-page: 77 issue: suppl year: 1979 end-page: 79 article-title: Anaerobic pulmonary infections publication-title: Scand J Infect Dis – volume: 66 start-page: 5337 year: 1998 end-page: 5343 article-title: Invasion of aortic and heart endothelial cells by publication-title: Infect Immun – volume: 13 start-page: S737 issue: S year: 1991 end-page: S742 article-title: Aspiration pneumonia publication-title: Rev Infect Dis – volume: 337 start-page: 1360 year: 1997 end-page: 1369 article-title: Shattuck Lecture ‐ cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities publication-title: N Engl J Med – volume: 75 start-page: 1631 year: 1996 end-page: 1636 article-title: Poor oral health and coronary heart disease publication-title: J Dent Res – volume: 3 start-page: 262 year: 1998 end-page: 275 article-title: Implications of oral infections on systemic diseases in the institutionalized elderly with a special focus on pneumonia publication-title: Ann Periodontol – volume: 143 start-page: 784 year: 1981 end-page: 790 article-title: Role of fibronectin in the prevention of adherence of to buccal cells publication-title: J Infect Dis – volume: 18 start-page: 559 year: 1983 end-page: 569 article-title: Salivary enzymes. Origin and relationship to periodontal disease publication-title: J Periodont Res – volume: 349 start-page: 1269 year: 1997 end-page: 1276 article-title: Mortality by cause for eight regions of the world: Global Burden of Disease Study publication-title: Lancet – volume: 67 start-page: 1138 issue: suppl year: 1996 end-page: 1142 article-title: Effects of oral flora on platelets: possible consequences in cardiovascular disease publication-title: J Periodontol – volume: 67 start-page: 1114 year: 1996 end-page: 1122 article-title: Relationships between periodontal disease and bacterial pneumonia publication-title: J Periodontol – volume: 797 start-page: 177 year: 1996 end-page: 190 article-title: Bacterial adherence and mucosal cytokine responses. Receptors and transmembrane signaling publication-title: Ann NY Acad Sci – year: 1993 – volume: 5 start-page: 203 year: 1994 end-page: 248 article-title: Saliva‐bacterium interactions in oral microbial ecology publication-title: Crit Rev Oral Biol Med – volume: 291 start-page: 355 year: 1986 end-page: 367 article-title: Nosocomial pneumonia publication-title: Am J Med Sci – volume: 67 start-page: 1123 year: 1996 end-page: 1137 article-title: Periodontal disease and cardiovascular disease publication-title: J Periodontol – volume: 14 start-page: 9 year: 1997 end-page: 16 article-title: Oral health and history of respiratory tract infection in frail institutionalised elders publication-title: Gerodontology – volume: 66 start-page: 5307 year: 1998 end-page: 5313 article-title: Subcellular localization and cytotoxic activity of the GroEL‐like protein isolated from publication-title: Infect Immun – volume: 268 start-page: 68 year: 1992 end-page: 72 article-title: Association of prior infection with and angiographically demonstrated coronary artery disease publication-title: J Amer Med Assoc – volume: 3 start-page: 251 year: 1998 end-page: 256 article-title: Associations between oral conditions and respiratory disease in a national sample survey population publication-title: Ann Periodontol – volume: 21 start-page: 386 year: 1986 end-page: 395 article-title: Fibronectin‐degrading enzymes in saliva and their relation to oral cleanliness publication-title: J Periodont Res – volume: 281 start-page: 1137 year: 1969 end-page: 1140 article-title: Changing pharyngeal bacterial flora of hospitilized patients. Emergence of gram negative bacilli publication-title: N Engl J Med – start-page: 1184 year: 1994 end-page: 1191 – volume: 306 start-page: 688 year: 1993 end-page: 691 article-title: Dental disease and risk of coronary heart disease and mortality publication-title: Br. Med J – year: 1999 article-title: Detection of an odontopathogen: in atherosclerotic plaques: an immunohistochemical and hybridization study publication-title: Appl Immunohistochem Mol Morph – volume: 98 start-page: 731 year: 1998 end-page: 733 article-title: Prospective study of C‐reactive protein and the risk of future cardiovascular events among apparently healthy women publication-title: Circulation – volume: 99 start-page: 237 year: 1999 end-page: 242 article-title: C‐Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle‐aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992 publication-title: Circulation – volume: 167 start-page: 63 year: 1998 end-page: 68 article-title: Purification and functional analysis of the DnaK homologue from OMZ 326 publication-title: FEMS Microbiol Lett – volume: 31 start-page: 120 year: 1996 end-page: 130 article-title: Comparison of the pro‐inflammatory cytokine‐stimulating activity of the surface‐associated proteins of periodontopathic bacteria publication-title: J Periodont Res – volume: 340 start-page: 115 year: 1999 end-page: 126 article-title: Atherosclerosis — an inflammatory disease publication-title: N Engl J Med – volume: 26 start-page: 275 year: 1999 end-page: 280 article-title: IL‐8 degradation by proteases publication-title: Microb Pathog – volume: 255 start-page: 179 year: 1989 end-page: 184 article-title: Dental infections in association with cerebral infarction in young and middle‐aged men publication-title: J Intern Med – volume: 107 start-page: 347 year: 1997 end-page: 352 article-title: Systemic acute‐phase reactants, C‐reactive protein and haptoglobin, in adult periodontitis publication-title: Clin Exp Immunol – volume: 26 start-page: 301 year: 1998 end-page: 308 article-title: Colonization of dental plaque: a source of nosocomial infections in intensive care unit patients publication-title: Crit Care Med – volume: 283 start-page: 1335 year: 1999 end-page: 1339 article-title: Chlamydia infections and heart disease linked through antigenic mimicry publication-title: Science – volume: 21 start-page: 365 year: 1995 end-page: 383 article-title: The pathogenesis of ventilator‐associated pneumonia: mechanisms of bacterial translocation and airway inoculation publication-title: Intensive Care Med – volume: 39 start-page: 93 year: 1968 end-page: 95 article-title: C‐Reactive protein and periodontal disease publication-title: J Periodonlol – volume: 124 start-page: 121 year: 1994 end-page: 122 article-title: Heat shock protein 60 (GroEL) from : molecular cloning and sequence analysis of its gene and purification of the recombinant protein publication-title: FEMS Microbiol Lett – volume: 156 start-page: 1647 year: 1997 end-page: 1655 article-title: Oropharyngeal or gastric colonization and nosocomial pneumonia in adult intensive care unit patients. A prospective study based on genomic DNA analysis publication-title: Am J Respir Crit Care Med – volume: 7 start-page: 131 year: 1988 end-page: 137 article-title: The relationship between oral health and systemic infections among elderly residents of chronic care facilities publication-title: A review – volume: 350 start-page: 430 year: 1997 end-page: 436 article-title: Chronic infections and coronary heart disease: is there a link publication-title: Lancet – volume: 146 start-page: 1067 year: 1992 end-page: 1083 article-title: Bacterial infection in chronic obstructive pulmonary disease publication-title: Am Rev Respir Dis – volume: 19 start-page: 1 year: 1999 end-page: 7 article-title: Respiratory pathogen colonization of the dental plaque of institutionalized elders publication-title: Spec Care Dent – volume: 20 start-page: 652 year: 1985 end-page: 659 article-title: Effect of periodontal therapy on salivary enzyme activity publication-title: J Periodont Res – volume: 298 start-page: 779 year: 1989 end-page: 782 article-title: Association between dental health and acute myocardial infarction publication-title: Br Med J – volume: 78 start-page: 3491 issue: Sp. Iss year: 1999 article-title: Association of periodontal disease and chronic lung disease: analysis of NHANES III publication-title: J Dent Res – volume: 77 start-page: 273 issue: special issue year: 1998 article-title: Identification of pathogens in atheromatous plaques publication-title: J Dent Res – ident: e_1_2_1_12_2 doi: 10.1136/bmj.306.6879.688 – ident: e_1_2_1_29_2 doi: 10.1161/01.CIR.99.2.237 – ident: e_1_2_1_40_2 doi: 10.1093/clinids/13.Supplement_9.S737 – ident: e_1_2_1_65_2 doi: 10.1111/j.1600-0765.1996.tb00508.x – ident: e_1_2_1_62_2 doi: 10.1111/j.1600-0765.1986.tb01472.x – ident: e_1_2_1_36_2 doi: 10.1164/ajrccm/146.4.1067 – volume: 11 start-page: 109 year: 1996 ident: e_1_2_1_37_2 article-title: Severe exacerbations of COPD patients: the role of pulmonary infections publication-title: Semin Respir Infect – ident: e_1_2_1_51_2 doi: 10.1902/annals.1998.3.1.262 – ident: e_1_2_1_23_2 doi: 10.1902/jop.1996.67.10s.1138 – ident: e_1_2_1_60_2 doi: 10.1111/j.1600-0765.1983.tb00393.x – ident: e_1_2_1_67_2 doi: 10.1128/IAI.66.4.1660-1665.1998 – ident: e_1_2_1_26_2 doi: 10.1111/j.1365-2249.1997.270-ce1162.x – ident: e_1_2_1_58_2 doi: 10.1902/jop.1999.70.7.793 – ident: e_1_2_1_31_2 doi: 10.1126/science.283.5406.1335 – volume: 66 start-page: 5337 year: 1998 ident: e_1_2_1_22_2 article-title: Invasion of aortic and heart endothelial cells by Porphyromonas ginghalis publication-title: Infect Immun doi: 10.1128/IAI.66.11.5337-5343.1998 – ident: e_1_2_1_44_2 doi: 10.1159/000212649 – ident: e_1_2_1_38_2 doi: 10.1056/NEJM196911202812101 – ident: e_1_2_1_53_2 doi: 10.1111/j.1754-4505.1999.tb01413.x – ident: e_1_2_1_56_2 doi: 10.1902/annals.1998.3.1.257 – ident: e_1_2_1_18_2 doi: 10.1161/01.STR.28.9.1724 – ident: e_1_2_1_33_2 doi: 10.1111/j.1574-6968.1998.tb13208.x – ident: e_1_2_1_68_2 doi: 10.1006/mpat.1998.0277 – ident: e_1_2_1_2_2 doi: 10.1056/NEJM199711063371906 – ident: e_1_2_1_32_2 doi: 10.1128/IAI.66.11.5307-5313.1998 – volume: 7 start-page: 131 year: 1988 ident: e_1_2_1_50_2 article-title: The relationship between oral health and systemic infections among elderly residents of chronic care facilities publication-title: A review – ident: e_1_2_1_66_2 doi: 10.1111/j.1749-6632.1996.tb52959.x – ident: e_1_2_1_6_2 doi: 10.1056/NEJM199901143400207 – ident: e_1_2_1_41_2 doi: 10.1164/ajrccm.156.5.96-04076 – ident: e_1_2_1_9_2 doi: 10.1136/bmj.298.6676.779 – volume: 77 start-page: 273 year: 1998 ident: e_1_2_1_20_2 article-title: Identification of pathogens in atheromatous plaques publication-title: J Dent Res – volume: 76 start-page: 3158 year: 1997 ident: e_1_2_1_16_2 article-title: Periodontal disease is a predictor of cardiovascular disease in a Native American population publication-title: J Dent Res – ident: e_1_2_1_10_2 doi: 10.1016/0021-9150(93)90263-T – ident: e_1_2_1_43_2 doi: 10.1097/00000441-198605000-00013 – start-page: 1184 volume-title: Harrison's principles of internal medicine year: 1994 ident: e_1_2_1_46_2 – volume: 19 start-page: 77 year: 1979 ident: e_1_2_1_45_2 article-title: Anaerobic pulmonary infections publication-title: Scand J Infect Dis – ident: e_1_2_1_48_2 doi: 10.1902/jop.1996.67.10s.1114 – volume: 268 start-page: 68 year: 1992 ident: e_1_2_1_7_2 article-title: Association of prior infection with Chlamydia pneumoniae and angiographically demonstrated coronary artery disease publication-title: J Amer Med Assoc doi: 10.1001/jama.1992.03490010070032 – ident: e_1_2_1_47_2 doi: 10.1097/00003246-199206000-00007 – ident: e_1_2_1_42_2 doi: 10.1007/BF01705418 – ident: e_1_2_1_54_2 doi: 10.1159/000022055 – year: 1999 ident: e_1_2_1_30_2 article-title: An examination of the relation between periodontal health status and cardiovascular risk factors: Serum total and HDL cholesterol, C‐reactive protein, and plasma fibrinogen publication-title: Am J Epidemiol – ident: e_1_2_1_5_2 doi: 10.1016/S0140-6736(96)07493-4 – ident: e_1_2_1_52_2 doi: 10.1111/j.1741-2358.1997.00009.x – volume: 147 start-page: 66 year: 1998 ident: e_1_2_1_19_2 article-title: Possible biological pathways linking periodontal infection to cardiovascular disease: The Third National Health and Nutrition Examination Survey publication-title: Am J Epidemiol – ident: e_1_2_1_34_2 doi: 10.1111/j.1574-6968.1994.tb07271.x – ident: e_1_2_1_8_2 doi: 10.1016/S0140-6736(97)03079-1 – ident: e_1_2_1_14_2 doi: 10.1902/jop.1996.67.10s.1123 – ident: e_1_2_1_25_2 doi: 10.1016/0003-9969(95)00089-5 – ident: e_1_2_1_28_2 doi: 10.1161/01.CIR.98.8.731 – ident: e_1_2_1_63_2 doi: 10.1177/10454411940050030201 – ident: e_1_2_1_27_2 doi: 10.1001/jama.279.18.1477 – ident: e_1_2_1_24_2 doi: 10.1902/jop.1968.39.2.93 – ident: e_1_2_1_64_2 doi: 10.1111/j.1600-0765.1996.tb00473.x – volume: 152 start-page: S77 issue: 2 year: 1995 ident: e_1_2_1_35_2 article-title: Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease publication-title: Am J Respir Crit Care Med – ident: e_1_2_1_15_2 doi: 10.1177/00220345960750090301 – ident: e_1_2_1_49_2 doi: 10.1097/00003246-199802000-00032 – ident: e_1_2_1_3_2 doi: 10.1038/nm0697-600 – ident: e_1_2_1_55_2 doi: 10.1902/annals.1998.3.1.251 – volume: 14 start-page: 54 year: 1993 ident: e_1_2_1_11_2 article-title: Missing teeth and ischaemic heart disease in men aged 45–64 years publication-title: Eur Heart J – ident: e_1_2_1_59_2 doi: 10.1093/infdis/143.6.784 – ident: e_1_2_1_17_2 doi: 10.1111/j.1365-2796.1989.tb00060.x – ident: e_1_2_1_13_2 doi: 10.1093/clinids/20.3.588 – volume-title: Vital statistics of the United States year: 1993 ident: e_1_2_1_4_2 – volume: 78 start-page: 3491 year: 1999 ident: e_1_2_1_57_2 article-title: Association of periodontal disease and chronic lung disease: analysis of NHANES III publication-title: J Dent Res – year: 1999 ident: e_1_2_1_21_2 article-title: Detection of an odontopathogen: Porphyromonas ginghalis in atherosclerotic plaques: an immunohistochemical and in situ hybridization study publication-title: Appl Immunohistochem Mol Morph – ident: e_1_2_1_61_2 doi: 10.1111/j.1600-0765.1985.tb00850.x – start-page: 540 volume-title: Principles and practice of infectious diseases year: 1990 ident: e_1_2_1_39_2
SSID	ssj0002679
Score	1.8552369
SecondaryResourceType	review_article
Snippet	Chronic infections may influence the severity and/or course of a number of systemic diseases. Periodontal diseases are localized chronic inflammatory...
SourceID	proquest pubmed crossref wiley istex
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	340
SubjectTerms	Alveolar Process - microbiology Arteriosclerosis - etiology Bacterial Infections Brain Ischemia - etiology cardiovascular disease Chronic Disease chronic obstructive pulmonary disease Connective Tissue - microbiology coronary artery disease Coronary Disease - etiology Dental Plaque - microbiology Gingivitis - microbiology Humans Lung Diseases - etiology Periodontal Diseases - microbiology pneumonia Respiratory Tract Infections - microbiology Stroke - etiology
Title	Association of periodontal infections with atherosclerotic and pulmonary diseases
URI	https://api.istex.fr/ark:/67375/WNG-RF5VZBW4-V/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1600-0765.1999.tb02263.x https://www.ncbi.nlm.nih.gov/pubmed/10685358 https://www.proquest.com/docview/69435658
Volume	34
WOSCitedRecordID	wos000085053700002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVWIB databaseName: Wiley Online Library - Journals customDbUrl: eissn: 1600-0765 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0002679 issn: 0022-3484 databaseCode: DRFUL dateStart: 19970101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3dT9swED9BiwQvGxtfhQF-mHgLahPHjh_HR0EIVaPio9qL5djJC1WCGjrx5-8udaNWGtI27Tk5xznf-X5n3wfAV9zu8hxdqyCNbTfgKBNBohIRoOl3ZJAQgpi62YQcDJLRSH336dGUCzOrD9EcuJFm1Ps1KbhJq2UlF5QVLUVMKXeKzjgRS0SniCjbIQpy3IL2xbD_cNvszKGQqqkezhPui5D6yJ53RlsyWG3i_dvv0OgyuK2tU__j__2vTfjgUSr7NhOrT7CSFZ9h_YIii6g53BbcLSwrK3NG9ZLRwaXUSjaP7yoqRqe8rMaYZYUDTUocj5nCsZfpGOUfJ8n8DVG1DQ_9y_vz68B3ZwgsR5gZ5LjMSY-nTgknjXAujHKeKG7RA1GmFyOuTDNlXJhb1-s6xDl0R4oAxygrYmOiHWgVZZHtAcP3QmfR1XQ8pet-ZdFvkZJ6gPS4zeIOqPkSaOtLl1MHjbFecGGQaZqYpolp2jNNv3UgamhfZgU8_ojqpF7phsRMnikETsb6aXClh_348cfZE9ePHTiei4JGxaTbFlNk5bTSQiESRXzXgd2ZhCx8XiBIoieyFoS_mJe-GV5GvLv_z5QHsFEXnqjDEb9A63UyzQ5hzf5E-ZkcwaocJUdebX4BPa8Tjw
linkProvider	Wiley-Blackwell
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT8MwDLYmhgQX3o_xWg6IW9G2pmlzBLbx2iaYeIlLlCXtBdSijaH9fOyuqzYJJECc26SpY8efHT8ADvG4iyI0rZyeZyoOR55wAhkIB1W_JYWEEESnzSb8Tid4epI3BWhPcmHG9SFyhxtJRnpek4CTQ3pWygWlRfvCo5w7SU5OBBPuMULKIke-QoYv1rvN-1Z-NNeEL_Py4TzgWRXSLLTnm9lmNFaRiD_6Co7OottUPTWX__nHVmApw6nsZMxYq1AI4zVYqFNsEbWHW4fbqY1lScSoYjKauJRcySYRXvGAkZ-XpSgzGeBE_QTnYzq27G34ihKAq2TZHdFgA-6bjbuzCyfrz-AYjkDTiXCjgyrvWSmsr4W1NTfigeQGbRCpqx4iy14ota1FxlYrFpEO3ZIixNHSCE9rdxPm4iQOt4HhezVr0Ni0vEcX_tKg5eL71AWkyk3olUBO9kCZrHg59dB4VVNGDBJNEdEUEU1lRFOjErj52LdxCY8fjTpKtzofovsvFATne-qxc666Te_h-fSRq4cSlCe8oFA06b5Fx2EyHCghEYsiwivB1phFpj4vECbREz_lhF-sS111Gy6v7Px5ZBkWLu7aLdW67FzvwmJahiINTtyDuff-MNyHefOBvNQ_yKTnE0y4Fpc
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT8MwDLbQhoAL78d45oC4FW1rmjZHYJT3BBMvcYmypL0wtdPGED8fu-uqTQIJEOfWaerYyef4BbCP210co2nltD1TdTjKhBPIQDh49Fs6kBCC6KzZhN9sBs_P8nYKbka5MMP6EMWFG2lGtl-TgkddG09quaC0aF94lHMn6ZITwYR7iJCyzKmrTAnKjVb4cF1szXXhy6J8OA94XoU0D-35ZrSJE6tMzP_4Co5OotvseAoX_vnHFmE-x6nsaChYSzAVJcsw26DYImoPtwJ3YwvL0phRxWQ0cSm5ko0ivJI-o3telqHMtI8D9VIcj-nEsu6ggxqAs2S5j6i_Cg_h6f3JuZP3Z3AMR6DpxLjQQY23rRTW18LauhvzQHKDNojUNQ-RZTuS2tZjY2tVi0iHvKQIcbQ0wtPaXYNSkibRBjB8r24NGpuWt8nhLw1aLr5PXUBq3EReBeRoDZTJi5dTD42OGjNikGmKmKaIaSpnmvqogFvQdoclPH5EdZAtdUGie68UBOd76ql5plqh9_hy_MTVYwX2RrKgUDXJ36KTKB30lZCIRRHhVWB9KCJjnxcIk-iJn0nCL-alLlunLq9u_plyD2ZuG6G6vmhebcFcVoUii03chtJbbxDtwLR5R1Hq7ebK8wm0YhYS
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Association+of+periodontal+infections+with+atherosclerotic+and+pulmonary+diseases&rft.jtitle=Journal+of+periodontal+research&rft.au=Scannapieco%2C+F.+A.&rft.au=Genco%2C+R.+J.&rft.date=1999-10-01&rft.pub=Blackwell+Publishing+Ltd&rft.issn=0022-3484&rft.eissn=1600-0765&rft.volume=34&rft.issue=7&rft.spage=340&rft.epage=345&rft_id=info:doi/10.1111%2Fj.1600-0765.1999.tb02263.x&rft.externalDBID=n%2Fa&rft.externalDocID=ark_67375_WNG_RF5VZBW4_V
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3484&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3484&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3484&client=summon