Obesity and the Obesity Paradox in Heart Failure

Obesity continues to be a public health problem in the general population, and also significantly increases the risk for the development of new-onset heart failure (HF). However, in patients with already-established, chronic HF, overweight and mild to moderate obesity is associated with substantiall...

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Bibliographic Details
Published in:Progress in cardiovascular diseases Vol. 61; no. 2; pp. 151 - 156
Main Authors: Horwich, Tamara B., Fonarow, Gregg C., Clark, Adrienne L.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.07.2018
Subjects:
Body mass index
Heart failure
Obesity paradox
Waist circumference
Heart failure
Heart failure with preserved ejection fraction
Body fat
United States
Cardiovascular disease
Oxygen uptake
Epicardial adipose tissue
Right ventricle or ventricular
Body mass index
Waist circumference
Bioelectrical impedance analysis
Computed tomography
Left ventricular ejection fraction
Obesity paradox
Cardiorespiratory fitness
Minute ventilation/carbon dioxide production
Dual energy x-ray absorptiometry
Heart Failure with reduced ejection fraction
ISSN:0033-0620, 1873-1740, 1532-8643, 1873-1740
Online Access:Get full text
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Summary:Obesity continues to be a public health problem in the general population, and also significantly increases the risk for the development of new-onset heart failure (HF). However, in patients with already-established, chronic HF, overweight and mild to moderate obesity is associated with substantially improved survival compared to normal weight patients; this has been termed the “obesity paradox”. The majority of studies measure obesity by body mass index, but studies utilizing less-frequently used measures of body fat and body composition, including waist circumference, waist-hip ratio, skinfold estimates, and bioelectrical impedance analysis also confirm the obesity paradox in HF. Other areas of investigation such as the relationship of the obesity paradox to cardiorespiratory fitness, gender, and race are also discussed. Finally, this review explores various explanations for the obesity paradox, and summarizes the current evidence for intentional weight loss treatments for HF in context.
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ISSN:0033-0620
1873-1740
1532-8643
1873-1740
DOI:10.1016/j.pcad.2018.05.005